Status
±
Terminal Output
| Builder file created | |
| Configuration file | |
| ProBound run | |
| Sequence logos |
Terminal output
Pipeline Output:
> Converts the configuration file to work on run server, checks input OK > Builds configuration file OK > Runs ProBound OK > Runs Model Viewer ! ERROR: fitViewer failed 1 OK
Configuration Builder File
±
ProBound builder configuration file:
[{"function": "optimizerSetting", "pseudocount": 20, "nThreads": 20, "lambdaL2": 1e-06}, {"function": "addTable", "leftFlank": "", "nColumns": 2, "modeledColumns": [0, 1], "countTableFile": "/public_html/public/jobs/2c9e093384f7/countTable.0.tsv.gz", "rightFlank": "", "inputFileType": "tsv.gz", "variableRegionLength": 200}, {"function": "addSELEX", "cumulativeEnrichment": true, "modelType": "SELEX"}, {"function": "addNS"}, {"function": "addBindingMode", "flankLength": 0, "positionBias": true, "dinucleotideDistance": 0, "size": 15}, {"function": "addBindingMode", "flankLength": 0, "positionBias": true, "dinucleotideDistance": 0, "size": 10}, {"function": "addBindingMode", "flankLength": 0, "positionBias": true, "dinucleotideDistance": 0, "size": 10}, {"function": "addBindingMode", "flankLength": 0, "positionBias": true, "dinucleotideDistance": 0, "size": 10}, {"function": "bindingModeSeed", "index": 1, "mononucleotideString": "AG.ACA...TGT.CT"}, {"function": "symmetry", "index": 1, "symmetryString": "abcdefg1GFEDCBA"}, {"function": "bindingModeConstraints", "index": 1, "positionBiasBinWidth": 5}, {"function": "bindingModeConstraints", "index": 2, "maxSize": 18, "fittingStages": [{"optimizeMotifShiftHeuristic": true}, {"optimizeSize": true}], "positionBiasBinWidth": 5}, {"function": "bindingModeConstraints", "index": 3, "maxSize": 18, "fittingStages": [{"optimizeMotifShiftHeuristic": true}, {"optimizeSize": true}], "positionBiasBinWidth": 5}, {"function": "bindingModeConstraints", "index": 4, "maxSize": 18, "fittingStages": [{"optimizeMotifShiftHeuristic": true}, {"optimizeSize": true}], "positionBiasBinWidth": 5}, {"function": "output", "outputPath": "/public_html/public/jobs/2c9e093384f7", "baseName": "fit", "storeHessian": false, "printTrajectory": false}]Configuration File
±
ProBound configuration file:
{
"modelSeeding": {"bindingModes": [
{"seedScale": 1},
{
"seedScale": 1,
"mononucleotideString": "AG.ACA...TGT.CT"
}
]},
"optimizerSetting": {
"nThreads": 20,
"likelihoodThreshold": 0,
"lambdaL2": 1.0E-6,
"pseudocount": 20,
"patternSearchSettings": {},
"minimizerType": "lbfgs",
"nRetries": 3,
"hkSettings": {},
"output": {
"storeHessian": false,
"outputPath": "/public_html/public/jobs/2c9e093384f7",
"printTrajectory": false,
"baseName": "fit",
"printPSAM": false,
"verbose": true
},
"lbfgsSettings": {},
"sgdSettings": {},
"fixedLibrarySize": false,
"expBound": 40,
"slbfgs_plsSettings": {},
"slbfgsSettings": {}
},
"modelSettings": {
"enrichmentModel": [{
"r0KUsed": 1,
"round": 1,
"bindingSaturation": false,
"cumulativeEnrichment": true,
"concentration": 1,
"modelType": "SELEX",
"bindingModeInteractions": [-1],
"r0KsTested": [1],
"bindingModes": [-1],
"modifications": []
}],
"countTable": [{
"leftFlank": "",
"transliterate": {
"in": [],
"out": []
},
"variableRegionLength": 200,
"modeledColumns": [
0,
1
],
"inputFileType": "tsv.gz",
"nColumns": 2,
"rightFlank": "",
"countTableFile": "/public_html/public/jobs/2c9e093384f7/countTable.0.tsv.gz"
}],
"bindingModeInteractions": [],
"bindingModes": [
{
"size": 0,
"fitLogActivity": true,
"flankLength": 0,
"dinucleotideDistance": 0,
"positionBias": false,
"singleStrand": false,
"modifications": []
},
{
"size": 15,
"fitLogActivity": true,
"flankLength": 0,
"dinucleotideDistance": 0,
"positionBias": true,
"singleStrand": false,
"modifications": []
},
{
"size": 10,
"fitLogActivity": true,
"flankLength": 0,
"dinucleotideDistance": 0,
"positionBias": true,
"singleStrand": false,
"modifications": []
},
{
"size": 10,
"fitLogActivity": true,
"flankLength": 0,
"dinucleotideDistance": 0,
"positionBias": true,
"singleStrand": false,
"modifications": []
},
{
"size": 10,
"fitLogActivity": true,
"flankLength": 0,
"dinucleotideDistance": 0,
"positionBias": true,
"singleStrand": false,
"modifications": []
}
],
"letterComplement": "C-G,A-T"
},
"modelFittingConstraints": {
"enrichmentModel": [{
"fitDelta": [false],
"roundSpecificGamma": true,
"fitRho": false,
"roundSpecificDelta": true,
"fitGamma": false,
"trySaturation": false,
"roundSpecificRho": true
}],
"nShifts": 0,
"countTable": [{}],
"addBindingModesSequentially": true,
"flankLengths": [0],
"bindingModeInteractions": [],
"singleModeLengthSweep": false,
"bindingModes": [
{
"maxFlankLength": -1,
"positionBiasBinWidth": 1,
"optimizeSizeHeuristic": false,
"maxSize": -1,
"optimizeFlankLength": false,
"symmetryString": "null",
"roundSpecificActivity": true,
"informationThreshold": 0.1,
"optimizeMotifShift": false,
"fittingStages": [],
"optimizeMotifShiftHeuristic": false,
"experimentSpecificPositionBias": true,
"minSize": -1,
"experimentSpecificActivity": true,
"optimizeSize": false
},
{
"maxFlankLength": -1,
"positionBiasBinWidth": 5,
"optimizeSizeHeuristic": false,
"maxSize": -1,
"symmetryString": "abcdefg1GFEDCBA",
"optimizeFlankLength": false,
"roundSpecificActivity": true,
"informationThreshold": 0.1,
"optimizeMotifShift": false,
"fittingStages": [],
"optimizeMotifShiftHeuristic": false,
"experimentSpecificPositionBias": true,
"minSize": -1,
"experimentSpecificActivity": true,
"optimizeSize": false
},
{
"maxFlankLength": -1,
"positionBiasBinWidth": 5,
"maxSize": 18,
"optimizeSizeHeuristic": false,
"optimizeFlankLength": false,
"symmetryString": "null",
"roundSpecificActivity": true,
"informationThreshold": 0.1,
"optimizeMotifShift": false,
"fittingStages": [
{"optimizeMotifShiftHeuristic": true},
{"optimizeSize": true}
],
"optimizeMotifShiftHeuristic": false,
"experimentSpecificPositionBias": true,
"minSize": -1,
"experimentSpecificActivity": true,
"optimizeSize": false
},
{
"maxFlankLength": -1,
"positionBiasBinWidth": 5,
"maxSize": 18,
"optimizeSizeHeuristic": false,
"optimizeFlankLength": false,
"symmetryString": "null",
"roundSpecificActivity": true,
"informationThreshold": 0.1,
"optimizeMotifShift": false,
"fittingStages": [
{"optimizeMotifShiftHeuristic": true},
{"optimizeSize": true}
],
"optimizeMotifShiftHeuristic": false,
"experimentSpecificPositionBias": true,
"minSize": -1,
"experimentSpecificActivity": true,
"optimizeSize": false
},
{
"maxFlankLength": -1,
"positionBiasBinWidth": 5,
"maxSize": 18,
"optimizeSizeHeuristic": false,
"optimizeFlankLength": false,
"symmetryString": "null",
"roundSpecificActivity": true,
"informationThreshold": 0.1,
"optimizeMotifShift": false,
"fittingStages": [
{"optimizeMotifShiftHeuristic": true},
{"optimizeSize": true}
],
"optimizeMotifShiftHeuristic": false,
"experimentSpecificPositionBias": true,
"minSize": -1,
"experimentSpecificActivity": true,
"optimizeSize": false
}
]
}
}Probound Text Output
±
Output from ProBound:
> Reading configuration JSON object and validating general schema.
> Validating configuration schema.
{"enrichmentModel":[{"fitDelta":[false],"roundSpecificGamma":true,"fitRho":false,"roundSpecificDelta":true,"fitGamma":false,"trySaturation":false,"roundSpecificRho":true}],"nShifts":0,"countTable":[{}],"addBindingModesSequentially":true,"flankLengths":[0],"bindingModeInteractions":[],"singleModeLengthSweep":false,"bindingModes":[{"maxFlankLength":-1,"positionBiasBinWidth":1,"optimizeSizeHeuristic":false,"maxSize":-1,"optimizeFlankLength":false,"symmetryString":"null","roundSpecificActivity":true,"informationThreshold":0.1,"optimizeMotifShift":false,"fittingStages":[],"optimizeMotifShiftHeuristic":false,"experimentSpecificPositionBias":true,"minSize":-1,"experimentSpecificActivity":true,"optimizeSize":false},{"maxFlankLength":-1,"positionBiasBinWidth":5,"optimizeSizeHeuristic":false,"maxSize":-1,"symmetryString":"abcdefg1GFEDCBA","optimizeFlankLength":false,"roundSpecificActivity":true,"informationThreshold":0.1,"optimizeMotifShift":false,"fittingStages":[],"optimizeMotifShiftHeuristic":false,"experimentSpecificPositionBias":true,"minSize":-1,"experimentSpecificActivity":true,"optimizeSize":false},{"maxFlankLength":-1,"positionBiasBinWidth":5,"maxSize":18,"optimizeSizeHeuristic":false,"optimizeFlankLength":false,"symmetryString":"null","roundSpecificActivity":true,"informationThreshold":0.1,"optimizeMotifShift":false,"fittingStages":[{"optimizeMotifShiftHeuristic":true},{"optimizeSize":true}],"optimizeMotifShiftHeuristic":false,"experimentSpecificPositionBias":true,"minSize":-1,"experimentSpecificActivity":true,"optimizeSize":false},{"maxFlankLength":-1,"positionBiasBinWidth":5,"maxSize":18,"optimizeSizeHeuristic":false,"optimizeFlankLength":false,"symmetryString":"null","roundSpecificActivity":true,"informationThreshold":0.1,"optimizeMotifShift":false,"fittingStages":[{"optimizeMotifShiftHeuristic":true},{"optimizeSize":true}],"optimizeMotifShiftHeuristic":false,"experimentSpecificPositionBias":true,"minSize":-1,"experimentSpecificActivity":true,"optimizeSize":false},{"maxFlankLength":-1,"positionBiasBinWidth":5,"maxSize":18,"optimizeSizeHeuristic":false,"optimizeFlankLength":false,"symmetryString":"null","roundSpecificActivity":true,"informationThreshold":0.1,"optimizeMotifShift":false,"fittingStages":[{"optimizeMotifShiftHeuristic":true},{"optimizeSize":true}],"optimizeMotifShiftHeuristic":false,"experimentSpecificPositionBias":true,"minSize":-1,"experimentSpecificActivity":true,"optimizeSize":false}]}
Entry=bindingModes, aEntry=[{"maxFlankLength":-1,"positionBiasBinWidth":1,"optimizeSizeHeuristic":false,"maxSize":-1,"optimizeFlankLength":false,"symmetryString":"null","roundSpecificActivity":true,"informationThreshold":0.1,"optimizeMotifShift":false,"fittingStages":[],"optimizeMotifShiftHeuristic":false,"experimentSpecificPositionBias":true,"minSize":-1,"experimentSpecificActivity":true,"optimizeSize":false},{"maxFlankLength":-1,"positionBiasBinWidth":5,"optimizeSizeHeuristic":false,"maxSize":-1,"symmetryString":"abcdefg1GFEDCBA","optimizeFlankLength":false,"roundSpecificActivity":true,"informationThreshold":0.1,"optimizeMotifShift":false,"fittingStages":[],"optimizeMotifShiftHeuristic":false,"experimentSpecificPositionBias":true,"minSize":-1,"experimentSpecificActivity":true,"optimizeSize":false},{"maxFlankLength":-1,"positionBiasBinWidth":5,"maxSize":18,"optimizeSizeHeuristic":false,"optimizeFlankLength":false,"symmetryString":"null","roundSpecificActivity":true,"informationThreshold":0.1,"optimizeMotifShift":false,"fittingStages":[{"optimizeMotifShiftHeuristic":true},{"optimizeSize":true}],"optimizeMotifShiftHeuristic":false,"experimentSpecificPositionBias":true,"minSize":-1,"experimentSpecificActivity":true,"optimizeSize":false},{"maxFlankLength":-1,"positionBiasBinWidth":5,"maxSize":18,"optimizeSizeHeuristic":false,"optimizeFlankLength":false,"symmetryString":"null","roundSpecificActivity":true,"informationThreshold":0.1,"optimizeMotifShift":false,"fittingStages":[{"optimizeMotifShiftHeuristic":true},{"optimizeSize":true}],"optimizeMotifShiftHeuristic":false,"experimentSpecificPositionBias":true,"minSize":-1,"experimentSpecificActivity":true,"optimizeSize":false},{"maxFlankLength":-1,"positionBiasBinWidth":5,"maxSize":18,"optimizeSizeHeuristic":false,"optimizeFlankLength":false,"symmetryString":"null","roundSpecificActivity":true,"informationThreshold":0.1,"optimizeMotifShift":false,"fittingStages":[{"optimizeMotifShiftHeuristic":true},{"optimizeSize":true}],"optimizeMotifShiftHeuristic":false,"experimentSpecificPositionBias":true,"minSize":-1,"experimentSpecificActivity":true,"optimizeSize":false}]
Entry=bindingModeInteractions, aEntry=[]
Entry=countTable, aEntry=[{}]
Entry=enrichmentModel, aEntry=[{"fitDelta":[false],"roundSpecificGamma":true,"fitRho":false,"roundSpecificDelta":true,"fitGamma":false,"trySaturation":false,"roundSpecificRho":true}]
> Builds likelihood object.
>> Creating CombinedLikelihood object.
Alphabet
========
Letter Complement: C-G,A-T
Letter Order: ACGT
Optimizer settings:
===================
lambdaL2 = 1.0E-6
pseudocount = 20.0
expBound = 40.0
fixedLibrarySize = false
>> Determining fitting order.
Summary of experiments
======================
Experiment 0:
-------------
Count table: Count table 0
Enrichment model: SELEX enrichment model 0
Concentration: 1.0
Binding modes:
Binding mode 0
Binding mode 1
Binding mode 2
Binding mode 3
Binding mode 4
Binding mode interactions:
NONE
> Builds optimizer.
> Using LBFGS.
> Starting optimization.
==================================
== Starts fiting Binding mode 0 ==
==================================
> Optimizing h (component0-0-h).
>> Starting new optimization: component0-0-h. (2021-05-21 13:51:06.857).
>>> Packing before optimization
Packing: {"enrichmentModel":[{}],"countTable":[{"h":[0,1]}],"bindingModeInteractions":[],"bindingModes":[{},{},{},{},{}]}
Value and gradient before optimization:
=======================================
value = 4.496408271102599
gradient = {0.4999,-0.4999}
gradient norm = 0.7069309058523578
Starting Function Value: 4.496408271102599
Iterations Fnc. Calls Likelihood Distance Moved Step Alpha Gradient Norm
1 3 1.097439413867220 5.000000000000000 7.072827002762626 0.526449230370432
2 5 0.820454971061975 2.086550119006907 0.143065670811371 0.334984584050951
3 6 0.695111095466913 0.811393878456556 1.000000000000000 0.041578536336488
4 7 0.693389371908307 0.089590743309910 1.000000000000000 0.003168930377214
5 8 0.693379329740554 0.006344645827849 1.000000000000000 0.000003384265196
6 9 0.693379329729062 0.006344645827849 1.000000000000000 0.000000000022361
Convergence criteria met.
After: gradient norm = 2.236050747541068E-11
>>> Parameters after optimization
Count Table 0:
---------------
h: {-4.4961,4.4961}
Binding mode 0:
---------------
Mononucleotide: {}
Activity(exp=0): {-8.9922,-8.9922}
Binding mode 1:
---------------
Mononucleotide: {0.0000,-1.0000,-1.0000,-1.0000,-1.0000,-1.0000,0.0000,-1.0000,0.0000,0.0000,0.0000,0.0000,0.0000,-1.0000,-1.0000,-1.0000,-1.0000,0.0000,-1.0000,-1.0000,0.0000,-1.0000,-1.0000,-1.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,-1.0000,-1.0000,-1.0000,0.0000,-1.0000,-1.0000,0.0000,-1.0000,-1.0000,-1.0000,-1.0000,0.0000,0.0000,0.0000,0.0000,0.0000,-1.0000,0.0000,-1.0000,-1.0000,-1.0000,-1.0000,-1.0000,0.0000}
Activity(exp=0): {0.0000,0.0000}
Position Bias(exp=0, s=0): {0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000}
Position Bias(exp=0, s=1): {0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000}
Binding mode 2:
---------------
Mononucleotide: {-0.0032,0.0031,0.0001,0.0000,-0.0020,-0.0025,-0.0010,0.0034,0.0025,-0.0013,-0.0009,0.0026,-0.0000,0.0027,0.0009,0.0010,0.0036,0.0042,0.0017,-0.0047,0.0005,0.0042,-0.0005,-0.0016,0.0020,0.0049,0.0020,-0.0020,-0.0002,0.0003,0.0044,-0.0048,-0.0048,-0.0047,0.0002,-0.0010,-0.0007,0.0010,-0.0010,-0.0017}
Activity(exp=0): {0.0000,0.0000}
Position Bias(exp=0, s=0): {0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000}
Position Bias(exp=0, s=1): {0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000}
Binding mode 3:
---------------
Mononucleotide: {0.0002,-0.0031,-0.0030,0.0016,0.0011,-0.0023,0.0007,0.0027,0.0021,-0.0016,-0.0046,0.0022,-0.0032,-0.0032,0.0013,-0.0036,-0.0041,-0.0023,0.0019,-0.0038,0.0042,0.0021,-0.0004,-0.0030,-0.0028,-0.0014,-0.0001,0.0032,-0.0037,0.0022,-0.0016,-0.0048,0.0012,-0.0023,0.0035,0.0001,0.0034,0.0024,0.0018,0.0006}
Activity(exp=0): {0.0000,0.0000}
Position Bias(exp=0, s=0): {0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000}
Position Bias(exp=0, s=1): {0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000}
Binding mode 4:
---------------
Mononucleotide: {-0.0011,0.0038,0.0009,-0.0045,0.0004,-0.0014,0.0020,-0.0042,-0.0012,-0.0020,0.0048,0.0042,-0.0042,-0.0022,0.0035,0.0044,0.0018,0.0043,-0.0001,-0.0004,-0.0005,-0.0025,0.0021,-0.0036,0.0023,-0.0024,-0.0045,0.0025,-0.0021,0.0024,-0.0031,-0.0001,0.0008,-0.0032,0.0022,-0.0041,0.0018,-0.0033,-0.0024,0.0034}
Activity(exp=0): {0.0000,0.0000}
Position Bias(exp=0, s=0): {0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000}
Position Bias(exp=0, s=1): {0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000}
> Initial optimization (component0-1-f0).
>> Starting new optimization: component0-1-f0. (2021-05-21 13:51:07.993).
>>> Packing before optimization
Packing: {"enrichmentModel":[{}],"countTable":[{"h":[2,3]}],"bindingModeInteractions":[],"bindingModes":[{"mononucleotide":[],"activity":[[0,1]]},{},{},{},{}]}
Value and gradient before optimization:
=======================================
value = 0.6933793297291306
gradient = {-0.0000,-0.0000,-0.0000,0.0000}
gradient norm = 3.242173876697879E-5
Starting Function Value: 0.6933793297291306
Iterations Fnc. Calls Likelihood Distance Moved Step Alpha Gradient Norm
1 3 0.693379326694355 0.000182708055179 5.635356465341657 0.000057740065892
2 6 0.693379229334089 0.003535494558598 21.000000000000000 0.000089784875127
3 7 0.693370694118378 0.409065525521516 1.000000000000000 0.002097003598507
4 8 0.693357089694731 0.789698312686792 1.000000000000000 0.003969968755912
5 9 0.693321266045459 2.349845351191460 1.000000000000000 0.006744912028308
6 10 0.693265095176988 4.157359199485462 1.000000000000000 0.008266329293042
7 11 0.693206591854468 4.955503041499753 1.000000000000000 0.006363818471461
8 12 0.693181215766653 2.153608496598758 1.000000000000000 0.002347320481155
9 13 0.693177354528701 0.253108749471199 1.000000000000000 0.000279655620881
10 14 0.693177183567255 0.302185937188284 1.000000000000000 0.000008372352995
11 15 0.693177181448535 0.043991942209723 1.000000000000000 0.000002518060863
12 16 0.693177181441891 0.043991942209723 1.000000000000000 0.000000091592414
Convergence criteria met.
After: gradient norm = 9.159241438956353E-8
>>> Parameters after optimization
Count Table 0:
---------------
h: {-0.0000,0.0000}
Binding mode 0:
---------------
Mononucleotide: {}
Activity(exp=0): {-0.0000,-0.0000}
Binding mode 1:
---------------
Mononucleotide: {0.0000,-1.0000,-1.0000,-1.0000,-1.0000,-1.0000,0.0000,-1.0000,0.0000,0.0000,0.0000,0.0000,0.0000,-1.0000,-1.0000,-1.0000,-1.0000,0.0000,-1.0000,-1.0000,0.0000,-1.0000,-1.0000,-1.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,-1.0000,-1.0000,-1.0000,0.0000,-1.0000,-1.0000,0.0000,-1.0000,-1.0000,-1.0000,-1.0000,0.0000,0.0000,0.0000,0.0000,0.0000,-1.0000,0.0000,-1.0000,-1.0000,-1.0000,-1.0000,-1.0000,0.0000}
Activity(exp=0): {0.0000,0.0000}
Position Bias(exp=0, s=0): {0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000}
Position Bias(exp=0, s=1): {0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000}
Binding mode 2:
---------------
Mononucleotide: {-0.0032,0.0031,0.0001,0.0000,-0.0020,-0.0025,-0.0010,0.0034,0.0025,-0.0013,-0.0009,0.0026,-0.0000,0.0027,0.0009,0.0010,0.0036,0.0042,0.0017,-0.0047,0.0005,0.0042,-0.0005,-0.0016,0.0020,0.0049,0.0020,-0.0020,-0.0002,0.0003,0.0044,-0.0048,-0.0048,-0.0047,0.0002,-0.0010,-0.0007,0.0010,-0.0010,-0.0017}
Activity(exp=0): {0.0000,0.0000}
Position Bias(exp=0, s=0): {0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000}
Position Bias(exp=0, s=1): {0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000}
Binding mode 3:
---------------
Mononucleotide: {0.0002,-0.0031,-0.0030,0.0016,0.0011,-0.0023,0.0007,0.0027,0.0021,-0.0016,-0.0046,0.0022,-0.0032,-0.0032,0.0013,-0.0036,-0.0041,-0.0023,0.0019,-0.0038,0.0042,0.0021,-0.0004,-0.0030,-0.0028,-0.0014,-0.0001,0.0032,-0.0037,0.0022,-0.0016,-0.0048,0.0012,-0.0023,0.0035,0.0001,0.0034,0.0024,0.0018,0.0006}
Activity(exp=0): {0.0000,0.0000}
Position Bias(exp=0, s=0): {0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000}
Position Bias(exp=0, s=1): {0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000}
Binding mode 4:
---------------
Mononucleotide: {-0.0011,0.0038,0.0009,-0.0045,0.0004,-0.0014,0.0020,-0.0042,-0.0012,-0.0020,0.0048,0.0042,-0.0042,-0.0022,0.0035,0.0044,0.0018,0.0043,-0.0001,-0.0004,-0.0005,-0.0025,0.0021,-0.0036,0.0023,-0.0024,-0.0045,0.0025,-0.0021,0.0024,-0.0031,-0.0001,0.0008,-0.0032,0.0022,-0.0041,0.0018,-0.0033,-0.0024,0.0034}
Activity(exp=0): {0.0000,0.0000}
Position Bias(exp=0, s=0): {0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000}
Position Bias(exp=0, s=1): {0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000}
Suggested variations:
key=0;0;0, description = Initial model.
> Optimizing variation "Initial model." (component0-2-variation0).
>> Starting new optimization: component0-2-variation0. (2021-05-21 13:51:09.891).
>>> Packing before optimization
Packing: {"enrichmentModel":[{}],"countTable":[{"h":[2,3]}],"bindingModeInteractions":[],"bindingModes":[{"mononucleotide":[],"activity":[[0,1]]},{},{},{},{}]}
Value and gradient before optimization:
=======================================
value = 0.6931771814418914
gradient = {-0.0000,-0.0000,0.0000,-0.0000}
gradient norm = 9.159241438948155E-8
Already at minimum!
After: gradient norm = 9.159241438948155E-8
>>> Parameters after optimization
Count Table 0:
---------------
h: {-0.0000,0.0000}
Binding mode 0:
---------------
Mononucleotide: {}
Activity(exp=0): {-0.0000,-0.0000}
Binding mode 1:
---------------
Mononucleotide: {0.0000,-1.0000,-1.0000,-1.0000,-1.0000,-1.0000,0.0000,-1.0000,0.0000,0.0000,0.0000,0.0000,0.0000,-1.0000,-1.0000,-1.0000,-1.0000,0.0000,-1.0000,-1.0000,0.0000,-1.0000,-1.0000,-1.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,-1.0000,-1.0000,-1.0000,0.0000,-1.0000,-1.0000,0.0000,-1.0000,-1.0000,-1.0000,-1.0000,0.0000,0.0000,0.0000,0.0000,0.0000,-1.0000,0.0000,-1.0000,-1.0000,-1.0000,-1.0000,-1.0000,0.0000}
Activity(exp=0): {0.0000,0.0000}
Position Bias(exp=0, s=0): {0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000}
Position Bias(exp=0, s=1): {0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000}
Binding mode 2:
---------------
Mononucleotide: {-0.0032,0.0031,0.0001,0.0000,-0.0020,-0.0025,-0.0010,0.0034,0.0025,-0.0013,-0.0009,0.0026,-0.0000,0.0027,0.0009,0.0010,0.0036,0.0042,0.0017,-0.0047,0.0005,0.0042,-0.0005,-0.0016,0.0020,0.0049,0.0020,-0.0020,-0.0002,0.0003,0.0044,-0.0048,-0.0048,-0.0047,0.0002,-0.0010,-0.0007,0.0010,-0.0010,-0.0017}
Activity(exp=0): {0.0000,0.0000}
Position Bias(exp=0, s=0): {0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000}
Position Bias(exp=0, s=1): {0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000}
Binding mode 3:
---------------
Mononucleotide: {0.0002,-0.0031,-0.0030,0.0016,0.0011,-0.0023,0.0007,0.0027,0.0021,-0.0016,-0.0046,0.0022,-0.0032,-0.0032,0.0013,-0.0036,-0.0041,-0.0023,0.0019,-0.0038,0.0042,0.0021,-0.0004,-0.0030,-0.0028,-0.0014,-0.0001,0.0032,-0.0037,0.0022,-0.0016,-0.0048,0.0012,-0.0023,0.0035,0.0001,0.0034,0.0024,0.0018,0.0006}
Activity(exp=0): {0.0000,0.0000}
Position Bias(exp=0, s=0): {0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000}
Position Bias(exp=0, s=1): {0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000}
Binding mode 4:
---------------
Mononucleotide: {-0.0011,0.0038,0.0009,-0.0045,0.0004,-0.0014,0.0020,-0.0042,-0.0012,-0.0020,0.0048,0.0042,-0.0042,-0.0022,0.0035,0.0044,0.0018,0.0043,-0.0001,-0.0004,-0.0005,-0.0025,0.0021,-0.0036,0.0023,-0.0024,-0.0045,0.0025,-0.0021,0.0024,-0.0031,-0.0001,0.0008,-0.0032,0.0022,-0.0041,0.0018,-0.0033,-0.0024,0.0034}
Activity(exp=0): {0.0000,0.0000}
Position Bias(exp=0, s=0): {0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000}
Position Bias(exp=0, s=1): {0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000}
The Likelihood DID NOT improve. Discarding fit component0-2-variation0.
> No varitions possible for Binding mode 0.
> Optimizing the full model (component0-4-all).
>> Starting new optimization: component0-4-all. (2021-05-21 13:51:09.985).
>>> Packing before optimization
Packing: {"enrichmentModel":[{}],"countTable":[{"h":[2,3]}],"bindingModeInteractions":[],"bindingModes":[{"mononucleotide":[],"activity":[[0,1]]},{},{},{},{}]}
Value and gradient before optimization:
=======================================
value = 0.6931771814418913
gradient = {-0.0000,-0.0000,0.0000,-0.0000}
gradient norm = 9.159241438989149E-8
Already at minimum!
After: gradient norm = 9.159241438989149E-8
>>> Parameters after optimization
Count Table 0:
---------------
h: {-0.0000,0.0000}
Binding mode 0:
---------------
Mononucleotide: {}
Activity(exp=0): {-0.0000,-0.0000}
Binding mode 1:
---------------
Mononucleotide: {0.0000,-1.0000,-1.0000,-1.0000,-1.0000,-1.0000,0.0000,-1.0000,0.0000,0.0000,0.0000,0.0000,0.0000,-1.0000,-1.0000,-1.0000,-1.0000,0.0000,-1.0000,-1.0000,0.0000,-1.0000,-1.0000,-1.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,-1.0000,-1.0000,-1.0000,0.0000,-1.0000,-1.0000,0.0000,-1.0000,-1.0000,-1.0000,-1.0000,0.0000,0.0000,0.0000,0.0000,0.0000,-1.0000,0.0000,-1.0000,-1.0000,-1.0000,-1.0000,-1.0000,0.0000}
Activity(exp=0): {0.0000,0.0000}
Position Bias(exp=0, s=0): {0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000}
Position Bias(exp=0, s=1): {0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000}
Binding mode 2:
---------------
Mononucleotide: {-0.0032,0.0031,0.0001,0.0000,-0.0020,-0.0025,-0.0010,0.0034,0.0025,-0.0013,-0.0009,0.0026,-0.0000,0.0027,0.0009,0.0010,0.0036,0.0042,0.0017,-0.0047,0.0005,0.0042,-0.0005,-0.0016,0.0020,0.0049,0.0020,-0.0020,-0.0002,0.0003,0.0044,-0.0048,-0.0048,-0.0047,0.0002,-0.0010,-0.0007,0.0010,-0.0010,-0.0017}
Activity(exp=0): {0.0000,0.0000}
Position Bias(exp=0, s=0): {0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000}
Position Bias(exp=0, s=1): {0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000}
Binding mode 3:
---------------
Mononucleotide: {0.0002,-0.0031,-0.0030,0.0016,0.0011,-0.0023,0.0007,0.0027,0.0021,-0.0016,-0.0046,0.0022,-0.0032,-0.0032,0.0013,-0.0036,-0.0041,-0.0023,0.0019,-0.0038,0.0042,0.0021,-0.0004,-0.0030,-0.0028,-0.0014,-0.0001,0.0032,-0.0037,0.0022,-0.0016,-0.0048,0.0012,-0.0023,0.0035,0.0001,0.0034,0.0024,0.0018,0.0006}
Activity(exp=0): {0.0000,0.0000}
Position Bias(exp=0, s=0): {0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000}
Position Bias(exp=0, s=1): {0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000}
Binding mode 4:
---------------
Mononucleotide: {-0.0011,0.0038,0.0009,-0.0045,0.0004,-0.0014,0.0020,-0.0042,-0.0012,-0.0020,0.0048,0.0042,-0.0042,-0.0022,0.0035,0.0044,0.0018,0.0043,-0.0001,-0.0004,-0.0005,-0.0025,0.0021,-0.0036,0.0023,-0.0024,-0.0045,0.0025,-0.0021,0.0024,-0.0031,-0.0001,0.0008,-0.0032,0.0022,-0.0041,0.0018,-0.0033,-0.0024,0.0034}
Activity(exp=0): {0.0000,0.0000}
Position Bias(exp=0, s=0): {0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000}
Position Bias(exp=0, s=1): {0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000}
==================================
== Starts fiting Binding mode 1 ==
==================================
> Optimizing h (component1-0-h).
>> Starting new optimization: component1-0-h. (2021-05-21 13:51:10.437).
>>> Packing before optimization
Packing: {"enrichmentModel":[{}],"countTable":[{"h":[0,1]}],"bindingModeInteractions":[],"bindingModes":[{},{},{},{},{}]}
Value and gradient before optimization:
=======================================
value = 1.5975358814213405
gradient = {-0.4583,0.4583}
gradient norm = 0.648071649594114
Starting Function Value: 1.5975358814213405
Iterations Fnc. Calls Likelihood Distance Moved Step Alpha Gradient Norm
1 2 1.012256596996219 1.000000000000000 1.543039262134516 0.493383827222629
2 4 0.676302377473878 1.160414180311078 0.363818051377505 0.037069191207765
3 5 0.674990416800443 0.094267445606878 1.000000000000000 0.009251758720483
4 6 0.674903365691893 0.018828190339404 1.000000000000000 0.000005217608779
5 7 0.674903365664210 0.018828190339404 1.000000000000000 0.000000000443924
Convergence criteria met.
After: gradient norm = 4.439236432978373E-10
>>> Parameters after optimization
Count Table 0:
---------------
h: {1.5810,-1.5810}
Binding mode 0:
---------------
Mononucleotide: {}
Activity(exp=0): {-0.0000,-0.0000}
Binding mode 1:
---------------
Mononucleotide: {0.0000,-1.0000,-1.0000,-1.0000,-1.0000,-1.0000,0.0000,-1.0000,0.0000,0.0000,0.0000,0.0000,0.0000,-1.0000,-1.0000,-1.0000,-1.0000,0.0000,-1.0000,-1.0000,0.0000,-1.0000,-1.0000,-1.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,-1.0000,-1.0000,-1.0000,0.0000,-1.0000,-1.0000,0.0000,-1.0000,-1.0000,-1.0000,-1.0000,0.0000,0.0000,0.0000,0.0000,0.0000,-1.0000,0.0000,-1.0000,-1.0000,-1.0000,-1.0000,-1.0000,0.0000}
Activity(exp=0): {3.5081,3.5081}
Position Bias(exp=0, s=0): {0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000}
Position Bias(exp=0, s=1): {0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000}
Binding mode 2:
---------------
Mononucleotide: {-0.0032,0.0031,0.0001,0.0000,-0.0020,-0.0025,-0.0010,0.0034,0.0025,-0.0013,-0.0009,0.0026,-0.0000,0.0027,0.0009,0.0010,0.0036,0.0042,0.0017,-0.0047,0.0005,0.0042,-0.0005,-0.0016,0.0020,0.0049,0.0020,-0.0020,-0.0002,0.0003,0.0044,-0.0048,-0.0048,-0.0047,0.0002,-0.0010,-0.0007,0.0010,-0.0010,-0.0017}
Activity(exp=0): {0.0000,0.0000}
Position Bias(exp=0, s=0): {0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000}
Position Bias(exp=0, s=1): {0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000}
Binding mode 3:
---------------
Mononucleotide: {0.0002,-0.0031,-0.0030,0.0016,0.0011,-0.0023,0.0007,0.0027,0.0021,-0.0016,-0.0046,0.0022,-0.0032,-0.0032,0.0013,-0.0036,-0.0041,-0.0023,0.0019,-0.0038,0.0042,0.0021,-0.0004,-0.0030,-0.0028,-0.0014,-0.0001,0.0032,-0.0037,0.0022,-0.0016,-0.0048,0.0012,-0.0023,0.0035,0.0001,0.0034,0.0024,0.0018,0.0006}
Activity(exp=0): {0.0000,0.0000}
Position Bias(exp=0, s=0): {0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000}
Position Bias(exp=0, s=1): {0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000}
Binding mode 4:
---------------
Mononucleotide: {-0.0011,0.0038,0.0009,-0.0045,0.0004,-0.0014,0.0020,-0.0042,-0.0012,-0.0020,0.0048,0.0042,-0.0042,-0.0022,0.0035,0.0044,0.0018,0.0043,-0.0001,-0.0004,-0.0005,-0.0025,0.0021,-0.0036,0.0023,-0.0024,-0.0045,0.0025,-0.0021,0.0024,-0.0031,-0.0001,0.0008,-0.0032,0.0022,-0.0041,0.0018,-0.0033,-0.0024,0.0034}
Activity(exp=0): {0.0000,0.0000}
Position Bias(exp=0, s=0): {0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000}
Position Bias(exp=0, s=1): {0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000}
> Initial optimization (component1-1-f1).
>> Starting new optimization: component1-1-f1. (2021-05-21 13:51:17.998).
>>> Packing before optimization
Packing: {"enrichmentModel":[{}],"countTable":[{"h":[32,33]}],"bindingModeInteractions":[],"bindingModes":[{},{"mononucleotide":[1,0,3,2,5,4,7,6,9,8,11,10,13,12,15,14,17,16,19,18,21,20,23,22,25,24,27,26,29,28,28,29,26,27,24,25,22,23,20,21,18,19,16,17,14,15,12,13,10,11,8,9,6,7,4,5,2,3,0,1],"activity":[[30,31]]},{},{},{}]}
Value and gradient before optimization:
=======================================
value = 0.6836506279089647
gradient = {0.0052,-0.0067,-0.0029,0.0037,0.0056,-0.0090,-0.0067,0.0094,0.0098,-0.0119,-0.0078,0.0092,0.0096,-0.0162,-0.0021,0.0080,0.0056,-0.0083,-0.0057,0.0077,0.0088,-0.0106,-0.0037,0.0049,0.0077,-0.0075,-0.0089,0.0080,0.0104,-0.0108,0.0000,-0.0003,0.0000,-0.0000}
gradient norm = 0.04522621147422862
Starting Function Value: 0.6836506279089647
Iterations Fnc. Calls Likelihood Distance Moved Step Alpha Gradient Norm
1 3 0.675992699394058 0.296722456117956 6.560851471873515 0.116680520564393
2 4 0.669687104362952 0.337338322449073 1.000000000000000 0.011349982375535
3 5 0.669567514884005 0.011798707823793 1.000000000000000 0.010583985506687
4 6 0.666607997810060 0.354298843383655 1.000000000000000 0.042600144942829
5 8 0.663169256483275 0.437708242792659 0.202299419064343 0.017852369854532
6 10 0.662123422742872 0.228916358830115 0.208665407981686 0.018640733813173
7 11 0.661737583381032 0.124347441576532 1.000000000000000 0.019956393490212
8 12 0.661257533900262 0.084006460613504 1.000000000000000 0.014383138326573
9 13 0.660584678236537 0.300463773217650 1.000000000000000 0.028161205489621
10 14 0.660430001355983 0.061658354813260 1.000000000000000 0.006208420171802
11 15 0.660348653452711 0.041050476308935 1.000000000000000 0.003472492004697
12 16 0.660101066545214 0.193566748407462 1.000000000000000 0.008898746312804
13 17 0.660042656466733 0.067538029579918 1.000000000000000 0.011556270600765
14 18 0.659933013081043 0.121079467857123 1.000000000000000 0.013573501497911
15 19 0.659729016923771 0.202824070449027 1.000000000000000 0.009493724102866
16 20 0.659551153157250 0.204348249961042 1.000000000000000 0.003055630770268
17 21 0.659490103704923 0.066584834498550 1.000000000000000 0.004176629791901
18 22 0.659440889728473 0.049921046195487 1.000000000000000 0.002729430316121
19 23 0.659420372122705 0.051172097195420 1.000000000000000 0.003516451644981
20 24 0.659392320587818 0.044563343487712 1.000000000000000 0.004872851216935
21 25 0.659355911890620 0.101787198497364 1.000000000000000 0.003859043878966
22 26 0.659337407790370 0.050069545207407 1.000000000000000 0.001755710524443
23 27 0.659302915774683 0.134176345505292 1.000000000000000 0.002489401706182
24 28 0.659287933142980 0.079745013873230 1.000000000000000 0.003793814827835
25 29 0.659269062274493 0.106667933604535 1.000000000000000 0.003543313029525
26 30 0.659200327450037 0.262268716820176 1.000000000000000 0.001788932510896
27 32 0.659141855616438 0.292310832046668 0.187390444366604 0.010611332971295
28 33 0.659022301134633 0.150043296486008 1.000000000000000 0.008978858380318
29 34 0.658786438560310 0.209064425602945 1.000000000000000 0.003739730030276
30 36 0.658751373934708 0.106036502260636 0.249631459485329 0.009977151146989
31 37 0.658680423477383 0.114743327449873 1.000000000000000 0.009537843636839
32 38 0.658558384106708 0.126336395020665 1.000000000000000 0.008205028920765
33 39 0.658485212180236 0.117567145617157 1.000000000000000 0.000678005424928
34 40 0.658475336283763 0.109289545292750 1.000000000000000 0.006469377765943
35 41 0.658462413541008 0.030952684232075 1.000000000000000 0.003221232954820
36 42 0.658451355994692 0.027412975152284 1.000000000000000 0.001589314520121
37 43 0.658439190300165 0.062591516662393 1.000000000000000 0.000720504596786
38 44 0.658432612536218 0.046796518016387 1.000000000000000 0.000582853964795
39 45 0.658416953471242 0.066855146921218 1.000000000000000 0.000589517078927
40 46 0.658410262093601 0.049139912114352 1.000000000000000 0.000786394319054
41 47 0.658406322098702 0.029142461592376 1.000000000000000 0.000525629005905
42 48 0.658403711441906 0.033961265442716 1.000000000000000 0.000365413110760
43 49 0.658402490795307 0.018196601620359 1.000000000000000 0.000132739059123
44 50 0.658401408793562 0.028109783040814 1.000000000000000 0.000245804448427
45 51 0.658401217989192 0.003942169892265 1.000000000000000 0.000211178065879
46 52 0.658400752708403 0.011898909304034 1.000000000000000 0.000105100391370
47 53 0.658400554849393 0.007495171049390 1.000000000000000 0.000067285696828
48 54 0.658400374527257 0.007928500286581 1.000000000000000 0.000046768324991
49 55 0.658400222738706 0.008133285752283 1.000000000000000 0.000037713913716
50 56 0.658400136113995 0.005970636933230 1.000000000000000 0.000037517405826
51 57 0.658400046483979 0.007501392740332 1.000000000000000 0.000043538273419
52 58 0.658399900997164 0.014507643449251 1.000000000000000 0.000035418567833
53 59 0.658399660851603 0.027823954611216 1.000000000000000 0.000044813332893
54 60 0.658399259713127 0.051093711485939 1.000000000000000 0.000102860458180
55 61 0.658398588287753 0.090959904669210 1.000000000000000 0.000184354936491
56 62 0.658397440399072 0.154231547732099 1.000000000000000 0.000274707573801
57 63 0.658395093821986 0.312021746478658 1.000000000000000 0.000376917894707
58 64 0.658390395322513 0.625893299381416 1.000000000000000 0.000482040650335
59 65 0.658381798187305 1.184654828069194 1.000000000000000 0.000516204055559
60 66 0.658370364282065 2.575870048326440 1.000000000000000 0.000690785443913
61 67 0.658364558424310 1.050362872459662 1.000000000000000 0.000461437099039
62 68 0.658358633801841 0.378751781156876 1.000000000000000 0.000185064420585
63 69 0.658357053545245 0.075065798452949 1.000000000000000 0.000140472398196
64 70 0.658356901989507 0.049994482137018 1.000000000000000 0.000027769569383
65 71 0.658356869233510 0.029754937895587 1.000000000000000 0.000029096911088
66 72 0.658356851630311 0.011418812518467 1.000000000000000 0.000038137293465
67 73 0.658356814055224 0.021475621632490 1.000000000000000 0.000037814840974
68 74 0.658356789766600 0.007836712273170 1.000000000000000 0.000018748106661
69 75 0.658356781349516 0.006699596675817 1.000000000000000 0.000008241085694
70 76 0.658356776763114 0.007279904221461 1.000000000000000 0.000017940481474
71 77 0.658356772767906 0.004913942835792 1.000000000000000 0.000023193733472
72 78 0.658356766933163 0.002408356256167 1.000000000000000 0.000019855598493
73 79 0.658356756803696 0.005185607636095 1.000000000000000 0.000010354687216
74 80 0.658356740837137 0.012419426990074 1.000000000000000 0.000024368606840
75 81 0.658356724360432 0.013193806239886 1.000000000000000 0.000047476817897
76 82 0.658356692858367 0.021118827294074 1.000000000000000 0.000074394467657
77 83 0.658356634483487 0.031109720327897 1.000000000000000 0.000093383557207
78 84 0.658356480062074 0.072051780675760 1.000000000000000 0.000112518835836
79 85 0.658356045779897 0.203647604106958 1.000000000000000 0.000155278336568
80 86 0.658355244111441 0.394210942445578 1.000000000000000 0.000200733337895
81 87 0.658354292868526 0.501380501953923 1.000000000000000 0.000190566041989
82 89 0.658354141009222 0.100209526448134 0.314687184925232 0.000185110934550
83 90 0.658353704186489 0.195898006230366 1.000000000000000 0.000030715624305
84 91 0.658353634576093 0.042452961943308 1.000000000000000 0.000028991785908
85 92 0.658353629349864 0.033663898843026 1.000000000000000 0.000013596066476
86 93 0.658353629060605 0.005568967561706 1.000000000000000 0.000004279980638
87 94 0.658353629013597 0.000355176543182 1.000000000000000 0.000000739300228
88 95 0.658353629000205 0.001208585656365 1.000000000000000 0.000001221188336
89 96 0.658353628993218 0.000818263860305 1.000000000000000 0.000001200637316
90 97 0.658353628974499 0.000818263860305 1.000000000000000 0.000000354595368
Convergence criteria met.
After: gradient norm = 3.5459536760641713E-7
>>> Parameters after optimization
Count Table 0:
---------------
h: {0.6987,-0.6987}
Binding mode 0:
---------------
Mononucleotide: {}
Activity(exp=0): {-0.0000,-0.0000}
Binding mode 1:
---------------
Mononucleotide: {-0.0122,-0.9113,-0.0855,-0.6263,-0.3169,-1.4677,0.5287,-0.3794,0.0446,-0.9438,-0.5188,-0.2055,1.0246,-1.4032,-0.9929,-0.2638,-0.6754,0.8997,-1.5661,-0.2935,0.4320,-1.5489,-0.1715,-0.3471,-0.4141,-0.6312,-0.4742,-0.1041,-0.0691,-0.7427,-0.7427,-0.0691,-0.1041,-0.4742,-0.6312,-0.4141,-0.3471,-0.1715,-1.5489,0.4320,-0.2935,-1.5661,0.8997,-0.6754,-0.2638,-0.9929,-1.4032,1.0246,-0.2055,-0.5188,-0.9438,0.0446,-0.3794,0.5287,-1.4677,-0.3169,-0.6263,-0.0855,-0.9113,-0.0122}
Activity(exp=0): {0.1234,-1.7250}
Position Bias(exp=0, s=0): {0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000}
Position Bias(exp=0, s=1): {0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000}
Binding mode 2:
---------------
Mononucleotide: {-0.0032,0.0031,0.0001,0.0000,-0.0020,-0.0025,-0.0010,0.0034,0.0025,-0.0013,-0.0009,0.0026,-0.0000,0.0027,0.0009,0.0010,0.0036,0.0042,0.0017,-0.0047,0.0005,0.0042,-0.0005,-0.0016,0.0020,0.0049,0.0020,-0.0020,-0.0002,0.0003,0.0044,-0.0048,-0.0048,-0.0047,0.0002,-0.0010,-0.0007,0.0010,-0.0010,-0.0017}
Activity(exp=0): {0.0000,0.0000}
Position Bias(exp=0, s=0): {0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000}
Position Bias(exp=0, s=1): {0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000}
Binding mode 3:
---------------
Mononucleotide: {0.0002,-0.0031,-0.0030,0.0016,0.0011,-0.0023,0.0007,0.0027,0.0021,-0.0016,-0.0046,0.0022,-0.0032,-0.0032,0.0013,-0.0036,-0.0041,-0.0023,0.0019,-0.0038,0.0042,0.0021,-0.0004,-0.0030,-0.0028,-0.0014,-0.0001,0.0032,-0.0037,0.0022,-0.0016,-0.0048,0.0012,-0.0023,0.0035,0.0001,0.0034,0.0024,0.0018,0.0006}
Activity(exp=0): {0.0000,0.0000}
Position Bias(exp=0, s=0): {0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000}
Position Bias(exp=0, s=1): {0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000}
Binding mode 4:
---------------
Mononucleotide: {-0.0011,0.0038,0.0009,-0.0045,0.0004,-0.0014,0.0020,-0.0042,-0.0012,-0.0020,0.0048,0.0042,-0.0042,-0.0022,0.0035,0.0044,0.0018,0.0043,-0.0001,-0.0004,-0.0005,-0.0025,0.0021,-0.0036,0.0023,-0.0024,-0.0045,0.0025,-0.0021,0.0024,-0.0031,-0.0001,0.0008,-0.0032,0.0022,-0.0041,0.0018,-0.0033,-0.0024,0.0034}
Activity(exp=0): {0.0000,0.0000}
Position Bias(exp=0, s=0): {0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000}
Position Bias(exp=0, s=1): {0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000}
Suggested variations:
key=15;0;0, description = Initial model.
> Optimizing variation "Initial model." (component1-2-variation0).
>> Starting new optimization: component1-2-variation0. (2021-05-21 13:54:14.092).
>>> Packing before optimization
Packing: {"enrichmentModel":[{}],"countTable":[{"h":[32,33]}],"bindingModeInteractions":[],"bindingModes":[{},{"mononucleotide":[1,0,3,2,5,4,7,6,9,8,11,10,13,12,15,14,17,16,19,18,21,20,23,22,25,24,27,26,29,28,28,29,26,27,24,25,22,23,20,21,18,19,16,17,14,15,12,13,10,11,8,9,6,7,4,5,2,3,0,1],"activity":[[30,31]]},{},{},{}]}
Value and gradient before optimization:
=======================================
value = 0.658353628974499
gradient = {0.0000,-0.0000,-0.0000,-0.0000,0.0000,0.0000,-0.0000,-0.0000,-0.0000,-0.0000,0.0000,0.0000,0.0000,-0.0000,-0.0000,0.0000,-0.0000,0.0000,-0.0000,0.0000,0.0000,-0.0000,-0.0000,-0.0000,0.0000,-0.0000,0.0000,-0.0000,-0.0000,0.0000,0.0000,-0.0000,0.0000,-0.0000}
gradient norm = 3.545953676068126E-7
Already at minimum!
After: gradient norm = 3.545953676068126E-7
>>> Parameters after optimization
Count Table 0:
---------------
h: {0.6987,-0.6987}
Binding mode 0:
---------------
Mononucleotide: {}
Activity(exp=0): {-0.0000,-0.0000}
Binding mode 1:
---------------
Mononucleotide: {-0.0122,-0.9113,-0.0855,-0.6263,-0.3169,-1.4677,0.5287,-0.3794,0.0446,-0.9438,-0.5188,-0.2055,1.0246,-1.4032,-0.9929,-0.2638,-0.6754,0.8997,-1.5661,-0.2935,0.4320,-1.5489,-0.1715,-0.3471,-0.4141,-0.6312,-0.4742,-0.1041,-0.0691,-0.7427,-0.7427,-0.0691,-0.1041,-0.4742,-0.6312,-0.4141,-0.3471,-0.1715,-1.5489,0.4320,-0.2935,-1.5661,0.8997,-0.6754,-0.2638,-0.9929,-1.4032,1.0246,-0.2055,-0.5188,-0.9438,0.0446,-0.3794,0.5287,-1.4677,-0.3169,-0.6263,-0.0855,-0.9113,-0.0122}
Activity(exp=0): {0.1234,-1.7250}
Position Bias(exp=0, s=0): {0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000}
Position Bias(exp=0, s=1): {0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000}
Binding mode 2:
---------------
Mononucleotide: {-0.0032,0.0031,0.0001,0.0000,-0.0020,-0.0025,-0.0010,0.0034,0.0025,-0.0013,-0.0009,0.0026,-0.0000,0.0027,0.0009,0.0010,0.0036,0.0042,0.0017,-0.0047,0.0005,0.0042,-0.0005,-0.0016,0.0020,0.0049,0.0020,-0.0020,-0.0002,0.0003,0.0044,-0.0048,-0.0048,-0.0047,0.0002,-0.0010,-0.0007,0.0010,-0.0010,-0.0017}
Activity(exp=0): {0.0000,0.0000}
Position Bias(exp=0, s=0): {0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000}
Position Bias(exp=0, s=1): {0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000}
Binding mode 3:
---------------
Mononucleotide: {0.0002,-0.0031,-0.0030,0.0016,0.0011,-0.0023,0.0007,0.0027,0.0021,-0.0016,-0.0046,0.0022,-0.0032,-0.0032,0.0013,-0.0036,-0.0041,-0.0023,0.0019,-0.0038,0.0042,0.0021,-0.0004,-0.0030,-0.0028,-0.0014,-0.0001,0.0032,-0.0037,0.0022,-0.0016,-0.0048,0.0012,-0.0023,0.0035,0.0001,0.0034,0.0024,0.0018,0.0006}
Activity(exp=0): {0.0000,0.0000}
Position Bias(exp=0, s=0): {0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000}
Position Bias(exp=0, s=1): {0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000}
Binding mode 4:
---------------
Mononucleotide: {-0.0011,0.0038,0.0009,-0.0045,0.0004,-0.0014,0.0020,-0.0042,-0.0012,-0.0020,0.0048,0.0042,-0.0042,-0.0022,0.0035,0.0044,0.0018,0.0043,-0.0001,-0.0004,-0.0005,-0.0025,0.0021,-0.0036,0.0023,-0.0024,-0.0045,0.0025,-0.0021,0.0024,-0.0031,-0.0001,0.0008,-0.0032,0.0022,-0.0041,0.0018,-0.0033,-0.0024,0.0034}
Activity(exp=0): {0.0000,0.0000}
Position Bias(exp=0, s=0): {0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000}
Position Bias(exp=0, s=1): {0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000}
The Likelihood DID NOT improve. Discarding fit component1-2-variation0.
> No varitions possible for Binding mode 1.
> Unfreezing component (component1-3-f0).
>> Starting new optimization: component1-3-f0. (2021-05-21 13:54:16.016).
>>> Packing before optimization
Packing: {"enrichmentModel":[{}],"countTable":[{"h":[108,109]}],"bindingModeInteractions":[],"bindingModes":[{},{"mononucleotide":[1,0,3,2,5,4,7,6,9,8,11,10,13,12,15,14,17,16,19,18,21,20,23,22,25,24,27,26,29,28,28,29,26,27,24,25,22,23,20,21,18,19,16,17,14,15,12,13,10,11,8,9,6,7,4,5,2,3,0,1],"activity":[[106,107]],"positionBias":[[[30,30,30,30,30,31,31,31,31,31,32,32,32,32,32,33,33,33,33,33,34,34,34,34,34,35,35,35,35,35,36,36,36,36,36,37,37,37,37,37,38,38,38,38,38,39,39,39,39,39,40,40,40,40,40,41,41,41,41,41,42,42,42,42,42,43,43,43,43,43,44,44,44,44,44,45,45,45,45,45,46,46,46,46,46,47,47,47,47,47,48,48,48,48,48,49,49,49,49,49,50,50,50,50,50,51,51,51,51,51,52,52,52,52,52,53,53,53,53,53,54,54,54,54,54,55,55,55,55,55,56,56,56,56,56,57,57,57,57,57,58,58,58,58,58,59,59,59,59,59,60,60,60,60,60,61,61,61,61,61,62,62,62,62,62,63,63,63,63,63,64,64,64,64,64,65,65,65,65,65,66,66,66,66,66,67],[68,68,68,68,68,69,69,69,69,69,70,70,70,70,70,71,71,71,71,71,72,72,72,72,72,73,73,73,73,73,74,74,74,74,74,75,75,75,75,75,76,76,76,76,76,77,77,77,77,77,78,78,78,78,78,79,79,79,79,79,80,80,80,80,80,81,81,81,81,81,82,82,82,82,82,83,83,83,83,83,84,84,84,84,84,85,85,85,85,85,86,86,86,86,86,87,87,87,87,87,88,88,88,88,88,89,89,89,89,89,90,90,90,90,90,91,91,91,91,91,92,92,92,92,92,93,93,93,93,93,94,94,94,94,94,95,95,95,95,95,96,96,96,96,96,97,97,97,97,97,98,98,98,98,98,99,99,99,99,99,100,100,100,100,100,101,101,101,101,101,102,102,102,102,102,103,103,103,103,103,104,104,104,104,104,105]]]},{},{},{}]}
Value and gradient before optimization:
=======================================
value = 0.6583536289744997
gradient = {0.0000,-0.0000,-0.0000,-0.0000,0.0000,0.0000,-0.0000,-0.0000,-0.0000,-0.0000,0.0000,0.0000,0.0000,-0.0000,-0.0000,0.0000,-0.0000,0.0000,-0.0000,0.0000,0.0000,-0.0000,-0.0000,-0.0000,0.0000,-0.0000,0.0000,-0.0000,-0.0000,0.0000,-0.0001,-0.0001,-0.0001,-0.0001,-0.0001,-0.0001,-0.0001,-0.0002,-0.0001,-0.0002,-0.0002,-0.0001,-0.0001,-0.0002,-0.0001,-0.0001,-0.0002,-0.0001,-0.0001,-0.0001,-0.0001,-0.0000,0.0000,0.0001,0.0001,0.0001,0.0001,0.0001,0.0002,0.0002,0.0002,0.0002,0.0003,0.0002,0.0002,0.0002,0.0003,0.0001,0.0003,0.0002,0.0002,0.0002,0.0003,0.0002,0.0002,0.0002,0.0002,0.0001,0.0001,0.0001,0.0001,0.0001,0.0000,0.0000,-0.0001,-0.0001,-0.0001,-0.0001,-0.0001,-0.0002,-0.0001,-0.0002,-0.0001,-0.0001,-0.0002,-0.0002,-0.0001,-0.0001,-0.0001,-0.0001,-0.0001,-0.0001,-0.0001,-0.0001,-0.0001,-0.0000,0.0000,-0.0000,0.0000,-0.0000}
gradient norm = 0.0012500094847591114
Starting Function Value: 0.6583536289744997
Iterations Fnc. Calls Likelihood Distance Moved Step Alpha Gradient Norm
1 2 0.657278201369218 1.000000000000000 799.99392980022820 0.002935313830590
2 4 0.657205321808616 0.145614124821289 0.023760437588973 0.014870278755364
3 5 0.655948626254453 2.663193226356988 1.000000000000000 0.017304048356098
4 6 0.655827414639054 0.249915649175526 1.000000000000000 0.004676360142100
5 7 0.655786782776720 0.466841048480526 1.000000000000000 0.002003630848388
6 8 0.655776119146650 0.099258289289081 1.000000000000000 0.002238059827767
7 9 0.655748520241798 0.158449752056052 1.000000000000000 0.001968398134853
8 10 0.655734668430624 0.095803572183626 1.000000000000000 0.000451251362768
9 11 0.655732243277844 0.054122258738778 1.000000000000000 0.000563831973073
10 12 0.655729949193834 0.020650249071379 1.000000000000000 0.000764443931579
11 13 0.655724127444508 0.030068902135170 1.000000000000000 0.000916681213214
12 14 0.655717321367130 0.046441585183300 1.000000000000000 0.000925531505619
13 15 0.655711730592965 0.168388357639727 1.000000000000000 0.000793223075085
14 16 0.655709394559659 0.012180512429418 1.000000000000000 0.000538848852446
15 17 0.655707267025263 0.018505721844234 1.000000000000000 0.000369798922040
16 18 0.655704498773537 0.029564093156646 1.000000000000000 0.000297367738832
17 19 0.655700428155562 0.050494479457085 1.000000000000000 0.000463111760548
18 20 0.655695938943972 0.059738896400099 1.000000000000000 0.000548530646464
19 21 0.655688240846673 0.106891132914405 1.000000000000000 0.000312061845160
20 22 0.655681613722294 0.118393082023636 1.000000000000000 0.000233142217064
21 23 0.655675691381624 0.091080714616932 1.000000000000000 0.000303571571145
22 24 0.655669592503300 0.108321266635892 1.000000000000000 0.000239161834423
23 25 0.655663864202565 0.106627725834753 1.000000000000000 0.000343095602541
24 26 0.655659497514185 0.099103838767162 1.000000000000000 0.000166461506888
25 27 0.655658250790082 0.029323144877637 1.000000000000000 0.000122909369082
26 28 0.655656624109122 0.032472446256702 1.000000000000000 0.000156061644102
27 29 0.655652379910997 0.104692362779095 1.000000000000000 0.000254417831210
28 30 0.655648086304823 0.124283927627356 1.000000000000000 0.000295775729370
29 31 0.655642818209659 0.206027504975882 1.000000000000000 0.000281106363827
30 32 0.655638712493603 0.207786058791276 1.000000000000000 0.000242946896108
31 33 0.655636234748099 0.031531305670241 1.000000000000000 0.000185416633215
32 34 0.655634759937220 0.039918961511042 1.000000000000000 0.000124964714092
33 35 0.655633741020918 0.031001695980725 1.000000000000000 0.000151229531945
34 36 0.655632394199295 0.070908494415611 1.000000000000000 0.000076676937523
35 37 0.655631450216829 0.065764556865471 1.000000000000000 0.000103470935885
36 38 0.655630241694959 0.066451840503368 1.000000000000000 0.000136495709302
37 39 0.655627864465619 0.123832749689616 1.000000000000000 0.000131477452915
38 40 0.655625528385723 0.202765486511043 1.000000000000000 0.000541633933181
39 41 0.655623746940858 0.033626363980516 1.000000000000000 0.000143074799658
40 42 0.655622262068085 0.052771497786868 1.000000000000000 0.000159691486339
41 43 0.655621680994582 0.035087702851542 1.000000000000000 0.000108280743379
42 44 0.655620967819256 0.061042640602832 1.000000000000000 0.000057664071898
43 45 0.655620677665719 0.023229345674974 1.000000000000000 0.000078454762243
44 46 0.655620182400316 0.032801677141574 1.000000000000000 0.000086758119110
45 47 0.655619355833438 0.045486443535113 1.000000000000000 0.000071094240758
46 48 0.655618348175622 0.088395359385887 1.000000000000000 0.000127172021887
47 49 0.655617707437852 0.040284648566472 1.000000000000000 0.000135874305059
48 50 0.655616902275796 0.066152103646071 1.000000000000000 0.000091199481131
49 51 0.655616304790417 0.052374604677434 1.000000000000000 0.000060418056312
50 52 0.655615840176248 0.044171253810642 1.000000000000000 0.000043603375477
51 53 0.655615543761508 0.028333141824482 1.000000000000000 0.000056136880006
52 54 0.655615236889564 0.028606441985415 1.000000000000000 0.000056253942283
53 55 0.655614584191999 0.065725140269191 1.000000000000000 0.000078297878113
54 56 0.655613878231098 0.123272265146795 1.000000000000000 0.000120405811473
55 57 0.655613169809737 0.076414124628236 1.000000000000000 0.000062992169292
56 58 0.655612863305241 0.010651893424390 1.000000000000000 0.000035607368702
57 59 0.655612702199316 0.013760460592295 1.000000000000000 0.000034706622853
58 60 0.655612539677029 0.014845696407343 1.000000000000000 0.000035334116970
59 61 0.655612021303221 0.092606201917275 1.000000000000000 0.000080778178415
60 62 0.655611735206700 0.036787784865560 1.000000000000000 0.000042825243296
61 63 0.655611518062981 0.037055199515653 1.000000000000000 0.000035427612709
62 64 0.655611244767460 0.047469396680818 1.000000000000000 0.000041533576134
63 65 0.655610864344839 0.064949381644978 1.000000000000000 0.000033846827480
64 66 0.655610520333773 0.062482393837896 1.000000000000000 0.000072140169440
65 67 0.655610290463944 0.043373709655778 1.000000000000000 0.000033140752351
66 68 0.655610158336895 0.034809962415875 1.000000000000000 0.000051099328711
67 69 0.655610047763370 0.025682221902839 1.000000000000000 0.000038114884417
68 70 0.655609992059912 0.027220103052787 1.000000000000000 0.000032843150758
69 71 0.655609973212629 0.004546013642404 1.000000000000000 0.000025988432602
70 72 0.655609965849137 0.006219850770220 1.000000000000000 0.000015943843652
71 73 0.655609956324364 0.002859088446596 1.000000000000000 0.000017276817525
72 74 0.655609912446115 0.011263979512479 1.000000000000000 0.000018489601033
73 75 0.655609822907404 0.024064716569927 1.000000000000000 0.000018592896642
74 76 0.655609754211699 0.032692757446056 1.000000000000000 0.000038003367415
75 77 0.655609687143707 0.010961712869508 1.000000000000000 0.000018423484658
76 78 0.655609623495052 0.015770665457385 1.000000000000000 0.000014958559824
77 79 0.655609580036287 0.014457747389146 1.000000000000000 0.000015884144143
78 80 0.655609529131007 0.022794795018499 1.000000000000000 0.000011842829092
79 81 0.655609485807659 0.017777689363923 1.000000000000000 0.000009651896025
80 82 0.655609399541766 0.039059158736887 1.000000000000000 0.000018886160961
81 83 0.655609316356876 0.037584884552585 1.000000000000000 0.000027707093742
82 84 0.655609245911462 0.046815743905422 1.000000000000000 0.000022977156690
83 85 0.655609202340035 0.017794982111276 1.000000000000000 0.000012880357788
84 86 0.655609184796910 0.007990102417401 1.000000000000000 0.000009142844135
85 87 0.655609161007346 0.007547109512881 1.000000000000000 0.000016349912269
86 88 0.655609139024281 0.008246504980817 1.000000000000000 0.000023271080566
87 89 0.655609104079712 0.021023996360425 1.000000000000000 0.000030278091491
88 90 0.655609075760235 0.026867129154867 1.000000000000000 0.000019067420611
89 91 0.655609064317252 0.017258028849635 1.000000000000000 0.000005978960837
90 92 0.655609060229065 0.006443304417858 1.000000000000000 0.000010952421357
91 93 0.655609056864178 0.004270141373118 1.000000000000000 0.000015413465586
92 94 0.655609048757089 0.006011688304738 1.000000000000000 0.000025637824457
93 95 0.655609033091397 0.011405978518456 1.000000000000000 0.000028987671044
94 96 0.655609012269942 0.014843386264711 1.000000000000000 0.000026555528568
95 97 0.655608994515299 0.018417462142653 1.000000000000000 0.000013672363365
96 98 0.655608988053903 0.005082589157777 1.000000000000000 0.000009878084375
97 99 0.655608981169973 0.004711428486951 1.000000000000000 0.000015707346999
98 100 0.655608976226951 0.003975264356841 1.000000000000000 0.000015391480886
99 101 0.655608966868307 0.010347535789687 1.000000000000000 0.000014080997189
100 102 0.655608959468025 0.011424065036434 1.000000000000000 0.000005678160471
101 103 0.655608956239217 0.007098110638996 1.000000000000000 0.000003261647954
102 104 0.655608954195526 0.003253836663716 1.000000000000000 0.000007933722553
103 105 0.655608951607410 0.004204281772850 1.000000000000000 0.000010442785797
104 106 0.655608947121737 0.006039538283962 1.000000000000000 0.000023950547777
105 108 0.655608945331611 0.004565501265954 0.226825813087736 0.000026616162785
106 109 0.655608939596056 0.007713604860061 1.000000000000000 0.000005589070051
107 110 0.655608936977364 0.004268869153801 1.000000000000000 0.000006487261991
108 111 0.655608936350747 0.001145497372930 1.000000000000000 0.000002826286537
109 112 0.655608936091147 0.000788553535386 1.000000000000000 0.000002500035336
110 113 0.655608935826005 0.000668983224017 1.000000000000000 0.000005595287078
111 114 0.655608935191673 0.001159024549587 1.000000000000000 0.000010385194845
112 115 0.655608933971567 0.002063925300273 1.000000000000000 0.000014838634371
113 116 0.655608932131061 0.003599896234316 1.000000000000000 0.000015299336651
114 118 0.655608930636000 0.004113475711195 0.476839079776117 0.000010360045545
115 120 0.655608930322793 0.001631505411328 0.092376502625375 0.000022606011462
116 121 0.655608929041979 0.002608221675256 1.000000000000000 0.000012699856598
117 122 0.655608928460636 0.002544155879605 1.000000000000000 0.000001551162059
118 123 0.655608928432993 0.000207630714892 1.000000000000000 0.000001574236452
119 124 0.655608928314497 0.000302959756812 1.000000000000000 0.000002062885824
120 125 0.655608927850122 0.000894721135335 1.000000000000000 0.000003418825944
121 126 0.655608926883319 0.001869189535827 1.000000000000000 0.000006385836360
122 127 0.655608925203145 0.004773338342177 1.000000000000000 0.000005165871205
123 128 0.655608924463528 0.008338466591679 1.000000000000000 0.000017010548431
124 129 0.655608922416048 0.001755430349839 1.000000000000000 0.000006262067640
125 130 0.655608921646796 0.001512612869182 1.000000000000000 0.000001532788785
126 131 0.655608921457129 0.001181252278361 1.000000000000000 0.000001484543736
127 132 0.655608921115133 0.001113268784281 1.000000000000000 0.000001271461318
128 133 0.655608920258975 0.003154151267441 1.000000000000000 0.000002347596669
129 134 0.655608919850463 0.003412623583021 1.000000000000000 0.000006753000546
130 135 0.655608919195296 0.001045805678935 1.000000000000000 0.000002838605448
131 136 0.655608918548736 0.001504665116838 1.000000000000000 0.000003423592856
132 137 0.655608918256705 0.001122248330533 1.000000000000000 0.000004407720310
133 138 0.655608917751323 0.002035636337394 1.000000000000000 0.000004997336056
134 140 0.655608917472927 0.001808034094588 0.382752332786234 0.000003091885645
135 141 0.655608917018140 0.002348456971371 1.000000000000000 0.000002361899770
136 142 0.655608916784383 0.000933977838917 1.000000000000000 0.000001102444606
137 143 0.655608916620607 0.000710965834689 1.000000000000000 0.000002043316827
138 144 0.655608916516661 0.000389372221663 1.000000000000000 0.000002874135858
139 145 0.655608916287507 0.000800120784357 1.000000000000000 0.000003357768170
140 146 0.655608916092456 0.002354697074942 1.000000000000000 0.000007151277085
141 147 0.655608915626933 0.001288110253582 1.000000000000000 0.000002448766987
142 148 0.655608915188598 0.002006386037192 1.000000000000000 0.000002160019124
143 149 0.655608914841362 0.002069187429449 1.000000000000000 0.000001919489309
144 150 0.655608914483673 0.002491393083951 1.000000000000000 0.000002638384107
145 151 0.655608914001064 0.003312324518857 1.000000000000000 0.000001718150535
146 152 0.655608913757470 0.001371466975282 1.000000000000000 0.000001350570984
147 153 0.655608913562134 0.001048022962725 1.000000000000000 0.000001131273368
148 154 0.655608913386716 0.000913052794774 1.000000000000000 0.000001239706701
149 155 0.655608913007054 0.002351952164743 1.000000000000000 0.000002392464601
150 156 0.655608912490028 0.003517362059750 1.000000000000000 0.000002694164650
151 158 0.655608912398991 0.000856572622593 0.135520244821326 0.000004313276588
152 159 0.655608912051052 0.002275932348717 1.000000000000000 0.000002496140666
153 160 0.655608911876437 0.000883874468085 1.000000000000000 0.000000827359240
154 161 0.655608911802549 0.000516616919796 1.000000000000000 0.000000968705520
155 162 0.655608911737715 0.000436401750158 1.000000000000000 0.000001242460271
156 163 0.655608911597394 0.000714495814423 1.000000000000000 0.000001153468586
157 164 0.655608911317523 0.001858166237987 1.000000000000000 0.000001102273037
158 165 0.655608911264088 0.004347001630020 1.000000000000000 0.000002668742682
159 166 0.655608910850087 0.000707389950116 1.000000000000000 0.000001875538841
160 167 0.655608910674487 0.000628852947587 1.000000000000000 0.000000929770137
161 168 0.655608910443003 0.001593657862324 1.000000000000000 0.000000920377181
162 169 0.655608910253433 0.001556682890716 1.000000000000000 0.000001031271778
163 170 0.655608910177919 0.003272866185927 1.000000000000000 0.000002674087636
164 171 0.655608909888243 0.000545613624894 1.000000000000000 0.000001122002418
165 172 0.655608909778287 0.000545613624894 1.000000000000000 0.000000670449544
Convergence criteria met.
After: gradient norm = 6.704495441764858E-7
>>> Parameters after optimization
Count Table 0:
---------------
h: {0.6739,-0.6739}
Binding mode 0:
---------------
Mononucleotide: {}
Activity(exp=0): {-0.0000,-0.0000}
Binding mode 1:
---------------
Mononucleotide: {-0.0182,-0.9597,-0.0936,-0.6206,-0.3182,-1.4961,0.5023,-0.3801,0.0433,-0.9799,-0.5348,-0.2188,1.0114,-1.3720,-1.0694,-0.2621,-0.6763,0.8432,-1.5798,-0.2791,0.4179,-1.5507,-0.2346,-0.3247,-0.4063,-0.6666,-0.5157,-0.1016,-0.0719,-0.7732,-0.7732,-0.0719,-0.1016,-0.5157,-0.6666,-0.4063,-0.3247,-0.2346,-1.5507,0.4179,-0.2791,-1.5798,0.8432,-0.6763,-0.2621,-1.0694,-1.3720,1.0114,-0.2188,-0.5348,-0.9799,0.0433,-0.3801,0.5023,-1.4961,-0.3182,-0.6206,-0.0936,-0.9597,-0.0182}
Activity(exp=0): {0.0528,-1.7175}
Position Bias(exp=0, s=0): {-0.0893,-0.0893,-0.0893,-0.0893,-0.0893,0.4148,0.4148,0.4148,0.4148,0.4148,0.3165,0.3165,0.3165,0.3165,0.3165,0.6724,0.6724,0.6724,0.6724,0.6724,0.4553,0.4553,0.4553,0.4553,0.4553,0.4161,0.4161,0.4161,0.4161,0.4161,0.3645,0.3645,0.3645,0.3645,0.3645,0.7789,0.7789,0.7789,0.7789,0.7789,0.5001,0.5001,0.5001,0.5001,0.5001,0.6588,0.6588,0.6588,0.6588,0.6588,0.4306,0.4306,0.4306,0.4306,0.4306,0.4142,0.4142,0.4142,0.4142,0.4142,0.2234,0.2234,0.2234,0.2234,0.2234,0.7309,0.7309,0.7309,0.7309,0.7309,0.4454,0.4454,0.4454,0.4454,0.4454,0.4533,0.4533,0.4533,0.4533,0.4533,0.8247,0.8247,0.8247,0.8247,0.8247,0.7568,0.7568,0.7568,0.7568,0.7568,0.6312,0.6312,0.6312,0.6312,0.6312,0.3787,0.3787,0.3787,0.3787,0.3787,0.0948,0.0948,0.0948,0.0948,0.0948,0.1922,0.1922,0.1922,0.1922,0.1922,-0.2832,-0.2832,-0.2832,-0.2832,-0.2832,0.1350,0.1350,0.1350,0.1350,0.1350,-0.2035,-0.2035,-0.2035,-0.2035,-0.2035,-0.2639,-0.2639,-0.2639,-0.2639,-0.2639,-0.2727,-0.2727,-0.2727,-0.2727,-0.2727,-0.6932,-0.6932,-0.6932,-0.6932,-0.6932,-0.6405,-0.6405,-0.6405,-0.6405,-0.6405,-0.8126,-0.8126,-0.8126,-0.8126,-0.8126,-0.4047,-0.4047,-0.4047,-0.4047,-0.4047,-0.5945,-0.5945,-0.5945,-0.5945,-0.5945,-1.2519,-1.2519,-1.2519,-1.2519,-1.2519,-1.0130,-1.0130,-1.0130,-1.0130,-1.0130,-0.8896,-0.8896,-0.8896,-0.8896,-0.8896,-0.9430,-0.9430,-0.9430,-0.9430,-0.9430,-1.3300,-1.3300,-1.3300,-1.3300,-1.3300,-1.6969}
Position Bias(exp=0, s=1): {-1.4418,-1.4418,-1.4418,-1.4418,-1.4418,-0.9693,-0.9693,-0.9693,-0.9693,-0.9693,-0.7149,-0.7149,-0.7149,-0.7149,-0.7149,-1.0838,-1.0838,-1.0838,-1.0838,-1.0838,-1.2331,-1.2331,-1.2331,-1.2331,-1.2331,-0.8716,-0.8716,-0.8716,-0.8716,-0.8716,-0.8064,-0.8064,-0.8064,-0.8064,-0.8064,-0.5140,-0.5140,-0.5140,-0.5140,-0.5140,-0.7053,-0.7053,-0.7053,-0.7053,-0.7053,-0.2786,-0.2786,-0.2786,-0.2786,-0.2786,-0.3244,-0.3244,-0.3244,-0.3244,-0.3244,0.0094,0.0094,0.0094,0.0094,0.0094,-0.2711,-0.2711,-0.2711,-0.2711,-0.2711,-0.4684,-0.4684,-0.4684,-0.4684,-0.4684,0.1438,0.1438,0.1438,0.1438,0.1438,0.0498,0.0498,0.0498,0.0498,0.0498,0.5023,0.5023,0.5023,0.5023,0.5023,0.3728,0.3728,0.3728,0.3728,0.3728,-0.1066,-0.1066,-0.1066,-0.1066,-0.1066,0.2794,0.2794,0.2794,0.2794,0.2794,0.1495,0.1495,0.1495,0.1495,0.1495,0.6369,0.6369,0.6369,0.6369,0.6369,0.5111,0.5111,0.5111,0.5111,0.5111,0.5742,0.5742,0.5742,0.5742,0.5742,0.4465,0.4465,0.4465,0.4465,0.4465,0.5653,0.5653,0.5653,0.5653,0.5653,0.7413,0.7413,0.7413,0.7413,0.7413,0.5374,0.5374,0.5374,0.5374,0.5374,0.4315,0.4315,0.4315,0.4315,0.4315,0.2986,0.2986,0.2986,0.2986,0.2986,0.2785,0.2785,0.2785,0.2785,0.2785,0.5343,0.5343,0.5343,0.5343,0.5343,0.2314,0.2314,0.2314,0.2314,0.2314,0.1508,0.1508,0.1508,0.1508,0.1508,0.4260,0.4260,0.4260,0.4260,0.4260,0.2724,0.2724,0.2724,0.2724,0.2724,0.7760,0.7760,0.7760,0.7760,0.7760,1.3251}
Binding mode 2:
---------------
Mononucleotide: {-0.0032,0.0031,0.0001,0.0000,-0.0020,-0.0025,-0.0010,0.0034,0.0025,-0.0013,-0.0009,0.0026,-0.0000,0.0027,0.0009,0.0010,0.0036,0.0042,0.0017,-0.0047,0.0005,0.0042,-0.0005,-0.0016,0.0020,0.0049,0.0020,-0.0020,-0.0002,0.0003,0.0044,-0.0048,-0.0048,-0.0047,0.0002,-0.0010,-0.0007,0.0010,-0.0010,-0.0017}
Activity(exp=0): {0.0000,0.0000}
Position Bias(exp=0, s=0): {0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000}
Position Bias(exp=0, s=1): {0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000}
Binding mode 3:
---------------
Mononucleotide: {0.0002,-0.0031,-0.0030,0.0016,0.0011,-0.0023,0.0007,0.0027,0.0021,-0.0016,-0.0046,0.0022,-0.0032,-0.0032,0.0013,-0.0036,-0.0041,-0.0023,0.0019,-0.0038,0.0042,0.0021,-0.0004,-0.0030,-0.0028,-0.0014,-0.0001,0.0032,-0.0037,0.0022,-0.0016,-0.0048,0.0012,-0.0023,0.0035,0.0001,0.0034,0.0024,0.0018,0.0006}
Activity(exp=0): {0.0000,0.0000}
Position Bias(exp=0, s=0): {0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000}
Position Bias(exp=0, s=1): {0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000}
Binding mode 4:
---------------
Mononucleotide: {-0.0011,0.0038,0.0009,-0.0045,0.0004,-0.0014,0.0020,-0.0042,-0.0012,-0.0020,0.0048,0.0042,-0.0042,-0.0022,0.0035,0.0044,0.0018,0.0043,-0.0001,-0.0004,-0.0005,-0.0025,0.0021,-0.0036,0.0023,-0.0024,-0.0045,0.0025,-0.0021,0.0024,-0.0031,-0.0001,0.0008,-0.0032,0.0022,-0.0041,0.0018,-0.0033,-0.0024,0.0034}
Activity(exp=0): {0.0000,0.0000}
Position Bias(exp=0, s=0): {0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000}
Position Bias(exp=0, s=1): {0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000}
> Optimizing the full model (component1-4-all).
>> Starting new optimization: component1-4-all. (2021-05-21 13:59:49.266).
>>> Packing before optimization
Packing: {"enrichmentModel":[{}],"countTable":[{"h":[110,111]}],"bindingModeInteractions":[],"bindingModes":[{"mononucleotide":[],"activity":[[0,1]]},{"mononucleotide":[3,2,5,4,7,6,9,8,11,10,13,12,15,14,17,16,19,18,21,20,23,22,25,24,27,26,29,28,31,30,30,31,28,29,26,27,24,25,22,23,20,21,18,19,16,17,14,15,12,13,10,11,8,9,6,7,4,5,2,3],"activity":[[108,109]],"positionBias":[[[32,32,32,32,32,33,33,33,33,33,34,34,34,34,34,35,35,35,35,35,36,36,36,36,36,37,37,37,37,37,38,38,38,38,38,39,39,39,39,39,40,40,40,40,40,41,41,41,41,41,42,42,42,42,42,43,43,43,43,43,44,44,44,44,44,45,45,45,45,45,46,46,46,46,46,47,47,47,47,47,48,48,48,48,48,49,49,49,49,49,50,50,50,50,50,51,51,51,51,51,52,52,52,52,52,53,53,53,53,53,54,54,54,54,54,55,55,55,55,55,56,56,56,56,56,57,57,57,57,57,58,58,58,58,58,59,59,59,59,59,60,60,60,60,60,61,61,61,61,61,62,62,62,62,62,63,63,63,63,63,64,64,64,64,64,65,65,65,65,65,66,66,66,66,66,67,67,67,67,67,68,68,68,68,68,69],[70,70,70,70,70,71,71,71,71,71,72,72,72,72,72,73,73,73,73,73,74,74,74,74,74,75,75,75,75,75,76,76,76,76,76,77,77,77,77,77,78,78,78,78,78,79,79,79,79,79,80,80,80,80,80,81,81,81,81,81,82,82,82,82,82,83,83,83,83,83,84,84,84,84,84,85,85,85,85,85,86,86,86,86,86,87,87,87,87,87,88,88,88,88,88,89,89,89,89,89,90,90,90,90,90,91,91,91,91,91,92,92,92,92,92,93,93,93,93,93,94,94,94,94,94,95,95,95,95,95,96,96,96,96,96,97,97,97,97,97,98,98,98,98,98,99,99,99,99,99,100,100,100,100,100,101,101,101,101,101,102,102,102,102,102,103,103,103,103,103,104,104,104,104,104,105,105,105,105,105,106,106,106,106,106,107]]]},{},{},{}]}
Value and gradient before optimization:
=======================================
value = 0.6556089097782866
gradient = {-0.0000,-0.0000,-0.0000,0.0000,-0.0000,0.0000,0.0000,-0.0000,0.0000,-0.0000,0.0000,0.0000,-0.0000,-0.0000,0.0000,0.0000,-0.0000,-0.0000,0.0000,-0.0000,-0.0000,0.0000,0.0000,-0.0000,-0.0000,0.0000,-0.0000,-0.0000,-0.0000,0.0000,-0.0000,0.0000,-0.0000,-0.0000,-0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,-0.0000,-0.0000,-0.0000,0.0000,0.0000,-0.0000,-0.0000,0.0000,0.0000,0.0000,-0.0000,-0.0000,0.0000,0.0000,-0.0000,-0.0000,0.0000,0.0000,-0.0000,0.0000,0.0000,-0.0000,-0.0000,0.0000,-0.0000,0.0000,0.0000,-0.0000,-0.0000,0.0000,-0.0000,0.0000,0.0000,-0.0000,0.0000,0.0000,-0.0000,-0.0000,0.0000,0.0000,-0.0000,0.0000,-0.0000,0.0000,-0.0000,-0.0000,0.0000,0.0000,-0.0000,-0.0000,0.0000,0.0000,-0.0000,-0.0000,-0.0000,0.0000,0.0000,0.0000,-0.0000,0.0000,0.0000,0.0000,-0.0000,-0.0000,-0.0000,0.0000,0.0000,-0.0000,0.0000,-0.0000}
gradient norm = 2.3478005675493862E-6
Starting Function Value: 0.6556089097782866
Iterations Fnc. Calls Likelihood Distance Moved Step Alpha Gradient Norm
1 3 0.655608909718152 0.000044238063072 18.842342779751352 0.000010119423733
2 4 0.655608909625433 0.000059725611035 1.000000000000000 0.000006644738432
3 5 0.655608909544263 0.000081486752386 1.000000000000000 0.000003603486403
4 6 0.655608909478845 0.000075027136747 1.000000000000000 0.000005509932587
5 7 0.655608909308775 0.000190587622369 1.000000000000000 0.000010753528946
6 8 0.655608908996569 0.000350284769529 1.000000000000000 0.000015727490351
7 9 0.655608908533668 0.000520738034914 1.000000000000000 0.000015655653377
8 10 0.655608907518124 0.001163548324165 1.000000000000000 0.000017530452712
9 11 0.655608905511797 0.002190212457866 1.000000000000000 0.000008170104254
10 12 0.655608903549402 0.002118443425691 1.000000000000000 0.000007167341645
11 13 0.655608901942937 0.001807347100169 1.000000000000000 0.000013513941001
12 14 0.655608900224316 0.001853640323477 1.000000000000000 0.000014795558282
13 15 0.655608894093326 0.006994159113562 1.000000000000000 0.000031315650606
14 16 0.655608889139063 0.006743091792174 1.000000000000000 0.000021657450878
15 17 0.655608885336123 0.004339621579563 1.000000000000000 0.000018626549244
16 18 0.655608877211810 0.009548458941726 1.000000000000000 0.000044720816797
17 19 0.655608869080609 0.009889815451994 1.000000000000000 0.000063614312554
18 20 0.655608858603938 0.012694832261023 1.000000000000000 0.000067819688072
19 21 0.655608834748468 0.028682251693460 1.000000000000000 0.000045781407418
20 22 0.655608811266514 0.032834726696608 1.000000000000000 0.000027210364848
21 23 0.655608797336242 0.016263526102144 1.000000000000000 0.000024739063431
22 24 0.655608787454900 0.010664654562667 1.000000000000000 0.000040809128410
23 25 0.655608780344608 0.005523316799740 1.000000000000000 0.000035875350387
24 26 0.655608759015469 0.020931706809892 1.000000000000000 0.000018862535560
25 27 0.655608738566810 0.027086787709626 1.000000000000000 0.000031136193328
26 28 0.655608719117512 0.030416282558168 1.000000000000000 0.000056075305660
27 29 0.655608697942658 0.031526033262252 1.000000000000000 0.000063847997726
28 30 0.655608652421182 0.056387119364581 1.000000000000000 0.000052410237590
29 31 0.655608591966218 0.077900713874595 1.000000000000000 0.000028682839524
30 32 0.655608552107969 0.048368838119570 1.000000000000000 0.000032990369013
31 33 0.655608526919141 0.025671550518800 1.000000000000000 0.000043369272477
32 34 0.655608493590028 0.030925654691641 1.000000000000000 0.000053657599912
33 35 0.655608448902733 0.062838141365281 1.000000000000000 0.000026069173485
34 36 0.655608441618365 0.013485219798287 1.000000000000000 0.000008192450356
35 37 0.655608439922030 0.002465147496678 1.000000000000000 0.000009000782288
36 38 0.655608438098647 0.001664977561325 1.000000000000000 0.000010653853495
37 39 0.655608430838431 0.007312276320914 1.000000000000000 0.000011850382262
38 40 0.655608413097520 0.021029250268294 1.000000000000000 0.000015837170584
39 41 0.655608395211663 0.033503728223452 1.000000000000000 0.000017492270854
40 42 0.655608382919919 0.010970974554137 1.000000000000000 0.000009301004199
41 43 0.655608374123686 0.009358245776275 1.000000000000000 0.000008813017887
42 44 0.655608368613103 0.006141814209143 1.000000000000000 0.000007558012081
43 45 0.655608357262727 0.015072122380092 1.000000000000000 0.000009421140752
44 46 0.655608347704656 0.016072667595394 1.000000000000000 0.000016223104121
45 47 0.655608343486836 0.007402142378231 1.000000000000000 0.000006349968571
46 48 0.655608342124508 0.000941700380892 1.000000000000000 0.000005585531665
47 49 0.655608338840335 0.002707648203866 1.000000000000000 0.000006113758507
48 50 0.655608335764814 0.004468054119827 1.000000000000000 0.000006411413215
49 51 0.655608331780924 0.005394665771167 1.000000000000000 0.000013197296893
50 52 0.655608328423346 0.005762893225912 1.000000000000000 0.000005914966483
51 53 0.655608326238544 0.004357565874971 1.000000000000000 0.000005135487388
52 54 0.655608323969883 0.003925362359971 1.000000000000000 0.000006555968022
53 55 0.655608321083670 0.005135579107676 1.000000000000000 0.000005490593201
54 56 0.655608318513120 0.004297411935708 1.000000000000000 0.000006286532514
55 57 0.655608316913886 0.003109948811532 1.000000000000000 0.000007096733969
56 58 0.655608316442778 0.000526428093076 1.000000000000000 0.000003030210205
57 59 0.655608315976066 0.000699366413551 1.000000000000000 0.000003977668540
58 60 0.655608315352203 0.000819004666289 1.000000000000000 0.000003879725913
59 61 0.655608313320307 0.003925360466298 1.000000000000000 0.000005511895398
60 62 0.655608311434366 0.004356734485091 1.000000000000000 0.000003308974320
61 63 0.655608309565624 0.005299287359626 1.000000000000000 0.000003442070036
62 64 0.655608306893025 0.006757437501999 1.000000000000000 0.000013438105233
63 65 0.655608305726936 0.002355716342192 1.000000000000000 0.000006326933742
64 66 0.655608305175487 0.000750420681502 1.000000000000000 0.000002196901363
65 67 0.655608305029705 0.000350008467672 1.000000000000000 0.000002314784542
66 68 0.655608304848619 0.000290226560972 1.000000000000000 0.000002006974404
67 69 0.655608304469534 0.000669579975240 1.000000000000000 0.000001856651986
68 70 0.655608303565223 0.002049512556195 1.000000000000000 0.000003086359686
69 71 0.655608302392163 0.003239504585480 1.000000000000000 0.000003900377488
70 72 0.655608301134692 0.004477114802814 1.000000000000000 0.000003006542532
71 73 0.655608300511347 0.002423958232963 1.000000000000000 0.000001376162389
72 74 0.655608300304801 0.000416712346244 1.000000000000000 0.000000961201276
73 75 0.655608300164749 0.000419907616157 1.000000000000000 0.000001337126279
74 76 0.655608299932514 0.000596464014208 1.000000000000000 0.000001996005195
75 77 0.655608299512432 0.001343533818858 1.000000000000000 0.000002137322836
76 78 0.655608298679040 0.003574544036038 1.000000000000000 0.000004830231603
77 79 0.655608298199169 0.002653141154380 1.000000000000000 0.000002413271612
78 80 0.655608298042574 0.002653141154380 1.000000000000000 0.000000666001051
Convergence criteria met.
After: gradient norm = 6.660010506773849E-7
>>> Parameters after optimization
Count Table 0:
---------------
h: {0.9710,-0.9710}
Binding mode 0:
---------------
Mononucleotide: {}
Activity(exp=0): {-0.0000,0.5943}
Binding mode 1:
---------------
Mononucleotide: {0.0149,-0.9265,-0.0604,-0.5874,-0.2850,-1.4631,0.5356,-0.3469,0.0757,-0.9475,-0.5024,-0.1863,1.0447,-1.3391,-1.0362,-0.2288,-0.6431,0.8764,-1.5467,-0.2460,0.4511,-1.5177,-0.2014,-0.2914,-0.3739,-0.6342,-0.4833,-0.0692,-0.0395,-0.7408,-0.7408,-0.0395,-0.0692,-0.4833,-0.6342,-0.3739,-0.2914,-0.2014,-1.5177,0.4511,-0.2460,-1.5467,0.8764,-0.6431,-0.2288,-1.0362,-1.3391,1.0447,-0.1863,-0.5024,-0.9475,0.0757,-0.3469,0.5356,-1.4631,-0.2850,-0.5874,-0.0604,-0.9265,0.0149}
Activity(exp=0): {0.0027,-1.6185}
Position Bias(exp=0, s=0): {-0.0903,-0.0903,-0.0903,-0.0903,-0.0903,0.4150,0.4150,0.4150,0.4150,0.4150,0.3175,0.3175,0.3175,0.3175,0.3175,0.6735,0.6735,0.6735,0.6735,0.6735,0.4540,0.4540,0.4540,0.4540,0.4540,0.4108,0.4108,0.4108,0.4108,0.4108,0.3573,0.3573,0.3573,0.3573,0.3573,0.7753,0.7753,0.7753,0.7753,0.7753,0.4989,0.4989,0.4989,0.4989,0.4989,0.6625,0.6625,0.6625,0.6625,0.6625,0.4374,0.4374,0.4374,0.4374,0.4374,0.4208,0.4208,0.4208,0.4208,0.4208,0.2289,0.2289,0.2289,0.2289,0.2289,0.7337,0.7337,0.7337,0.7337,0.7337,0.4481,0.4481,0.4481,0.4481,0.4481,0.4568,0.4568,0.4568,0.4568,0.4568,0.8279,0.8279,0.8279,0.8279,0.8279,0.7587,0.7587,0.7587,0.7587,0.7587,0.6322,0.6322,0.6322,0.6322,0.6322,0.3789,0.3789,0.3789,0.3789,0.3789,0.0935,0.0935,0.0935,0.0935,0.0935,0.1913,0.1913,0.1913,0.1913,0.1913,-0.2843,-0.2843,-0.2843,-0.2843,-0.2843,0.1358,0.1358,0.1358,0.1358,0.1358,-0.2010,-0.2010,-0.2010,-0.2010,-0.2010,-0.2620,-0.2620,-0.2620,-0.2620,-0.2620,-0.2727,-0.2727,-0.2727,-0.2727,-0.2727,-0.6945,-0.6945,-0.6945,-0.6945,-0.6945,-0.6405,-0.6405,-0.6405,-0.6405,-0.6405,-0.8122,-0.8122,-0.8122,-0.8122,-0.8122,-0.4054,-0.4054,-0.4054,-0.4054,-0.4054,-0.5933,-0.5933,-0.5933,-0.5933,-0.5933,-1.2505,-1.2505,-1.2505,-1.2505,-1.2505,-1.0124,-1.0124,-1.0124,-1.0124,-1.0124,-0.8888,-0.8888,-0.8888,-0.8888,-0.8888,-0.9426,-0.9426,-0.9426,-0.9426,-0.9426,-1.3300,-1.3300,-1.3300,-1.3300,-1.3300,-1.6929}
Position Bias(exp=0, s=1): {-1.4399,-1.4399,-1.4399,-1.4399,-1.4399,-0.9680,-0.9680,-0.9680,-0.9680,-0.9680,-0.7144,-0.7144,-0.7144,-0.7144,-0.7144,-1.0826,-1.0826,-1.0826,-1.0826,-1.0826,-1.2330,-1.2330,-1.2330,-1.2330,-1.2330,-0.8715,-0.8715,-0.8715,-0.8715,-0.8715,-0.8069,-0.8069,-0.8069,-0.8069,-0.8069,-0.5140,-0.5140,-0.5140,-0.5140,-0.5140,-0.7035,-0.7035,-0.7035,-0.7035,-0.7035,-0.2756,-0.2756,-0.2756,-0.2756,-0.2756,-0.3225,-0.3225,-0.3225,-0.3225,-0.3225,0.0097,0.0097,0.0097,0.0097,0.0097,-0.2721,-0.2721,-0.2721,-0.2721,-0.2721,-0.4686,-0.4686,-0.4686,-0.4686,-0.4686,0.1451,0.1451,0.1451,0.1451,0.1451,0.0533,0.0533,0.0533,0.0533,0.0533,0.5044,0.5044,0.5044,0.5044,0.5044,0.3740,0.3740,0.3740,0.3740,0.3740,-0.1058,-0.1058,-0.1058,-0.1058,-0.1058,0.2783,0.2783,0.2783,0.2783,0.2783,0.1465,0.1465,0.1465,0.1465,0.1465,0.6355,0.6355,0.6355,0.6355,0.6355,0.5090,0.5090,0.5090,0.5090,0.5090,0.5723,0.5723,0.5723,0.5723,0.5723,0.4433,0.4433,0.4433,0.4433,0.4433,0.5614,0.5614,0.5614,0.5614,0.5614,0.7377,0.7377,0.7377,0.7377,0.7377,0.5343,0.5343,0.5343,0.5343,0.5343,0.4333,0.4333,0.4333,0.4333,0.4333,0.3045,0.3045,0.3045,0.3045,0.3045,0.2881,0.2881,0.2881,0.2881,0.2881,0.5406,0.5406,0.5406,0.5406,0.5406,0.2349,0.2349,0.2349,0.2349,0.2349,0.1508,0.1508,0.1508,0.1508,0.1508,0.4268,0.4268,0.4268,0.4268,0.4268,0.2740,0.2740,0.2740,0.2740,0.2740,0.7771,0.7771,0.7771,0.7771,0.7771,1.3253}
Binding mode 2:
---------------
Mononucleotide: {-0.0032,0.0031,0.0001,0.0000,-0.0020,-0.0025,-0.0010,0.0034,0.0025,-0.0013,-0.0009,0.0026,-0.0000,0.0027,0.0009,0.0010,0.0036,0.0042,0.0017,-0.0047,0.0005,0.0042,-0.0005,-0.0016,0.0020,0.0049,0.0020,-0.0020,-0.0002,0.0003,0.0044,-0.0048,-0.0048,-0.0047,0.0002,-0.0010,-0.0007,0.0010,-0.0010,-0.0017}
Activity(exp=0): {0.0000,0.0000}
Position Bias(exp=0, s=0): {0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000}
Position Bias(exp=0, s=1): {0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000}
Binding mode 3:
---------------
Mononucleotide: {0.0002,-0.0031,-0.0030,0.0016,0.0011,-0.0023,0.0007,0.0027,0.0021,-0.0016,-0.0046,0.0022,-0.0032,-0.0032,0.0013,-0.0036,-0.0041,-0.0023,0.0019,-0.0038,0.0042,0.0021,-0.0004,-0.0030,-0.0028,-0.0014,-0.0001,0.0032,-0.0037,0.0022,-0.0016,-0.0048,0.0012,-0.0023,0.0035,0.0001,0.0034,0.0024,0.0018,0.0006}
Activity(exp=0): {0.0000,0.0000}
Position Bias(exp=0, s=0): {0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000}
Position Bias(exp=0, s=1): {0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000}
Binding mode 4:
---------------
Mononucleotide: {-0.0011,0.0038,0.0009,-0.0045,0.0004,-0.0014,0.0020,-0.0042,-0.0012,-0.0020,0.0048,0.0042,-0.0042,-0.0022,0.0035,0.0044,0.0018,0.0043,-0.0001,-0.0004,-0.0005,-0.0025,0.0021,-0.0036,0.0023,-0.0024,-0.0045,0.0025,-0.0021,0.0024,-0.0031,-0.0001,0.0008,-0.0032,0.0022,-0.0041,0.0018,-0.0033,-0.0024,0.0034}
Activity(exp=0): {0.0000,0.0000}
Position Bias(exp=0, s=0): {0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000}
Position Bias(exp=0, s=1): {0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000}
==================================
== Starts fiting Binding mode 2 ==
==================================
> Optimizing h (component2-0-h).
>> Starting new optimization: component2-0-h. (2021-05-21 14:02:20.932).
>>> Packing before optimization
Packing: {"enrichmentModel":[{}],"countTable":[{"h":[0,1]}],"bindingModeInteractions":[],"bindingModes":[{},{},{},{},{}]}
Value and gradient before optimization:
=======================================
value = 1.057597585316304
gradient = {-0.3652,0.3652}
gradient norm = 0.5164585252714343
Starting Function Value: 1.057597585316304
Iterations Fnc. Calls Likelihood Distance Moved Step Alpha Gradient Norm
1 2 0.700330864840098 1.000000000000000 1.936263903232949 0.156374011472326
2 3 0.678386947914959 0.434270304552911 1.000000000000000 0.056825410323673
3 4 0.675128720989111 0.115748851660670 1.000000000000000 0.000590927187042
4 5 0.675128369794675 0.001191283635993 1.000000000000000 0.000001320293463
5 6 0.675128369792922 0.001191283635993 1.000000000000000 0.000000000001132
Convergence criteria met.
After: gradient norm = 1.132407425185938E-12
>>> Parameters after optimization
Count Table 0:
---------------
h: {1.9041,-1.9041}
Binding mode 0:
---------------
Mononucleotide: {}
Activity(exp=0): {-0.0000,0.5943}
Binding mode 1:
---------------
Mononucleotide: {0.0149,-0.9265,-0.0604,-0.5874,-0.2850,-1.4631,0.5356,-0.3469,0.0757,-0.9475,-0.5024,-0.1863,1.0447,-1.3391,-1.0362,-0.2288,-0.6431,0.8764,-1.5467,-0.2460,0.4511,-1.5177,-0.2014,-0.2914,-0.3739,-0.6342,-0.4833,-0.0692,-0.0395,-0.7408,-0.7408,-0.0395,-0.0692,-0.4833,-0.6342,-0.3739,-0.2914,-0.2014,-1.5177,0.4511,-0.2460,-1.5467,0.8764,-0.6431,-0.2288,-1.0362,-1.3391,1.0447,-0.1863,-0.5024,-0.9475,0.0757,-0.3469,0.5356,-1.4631,-0.2850,-0.5874,-0.0604,-0.9265,0.0149}
Activity(exp=0): {0.0027,-1.6185}
Position Bias(exp=0, s=0): {-0.0903,-0.0903,-0.0903,-0.0903,-0.0903,0.4150,0.4150,0.4150,0.4150,0.4150,0.3175,0.3175,0.3175,0.3175,0.3175,0.6735,0.6735,0.6735,0.6735,0.6735,0.4540,0.4540,0.4540,0.4540,0.4540,0.4108,0.4108,0.4108,0.4108,0.4108,0.3573,0.3573,0.3573,0.3573,0.3573,0.7753,0.7753,0.7753,0.7753,0.7753,0.4989,0.4989,0.4989,0.4989,0.4989,0.6625,0.6625,0.6625,0.6625,0.6625,0.4374,0.4374,0.4374,0.4374,0.4374,0.4208,0.4208,0.4208,0.4208,0.4208,0.2289,0.2289,0.2289,0.2289,0.2289,0.7337,0.7337,0.7337,0.7337,0.7337,0.4481,0.4481,0.4481,0.4481,0.4481,0.4568,0.4568,0.4568,0.4568,0.4568,0.8279,0.8279,0.8279,0.8279,0.8279,0.7587,0.7587,0.7587,0.7587,0.7587,0.6322,0.6322,0.6322,0.6322,0.6322,0.3789,0.3789,0.3789,0.3789,0.3789,0.0935,0.0935,0.0935,0.0935,0.0935,0.1913,0.1913,0.1913,0.1913,0.1913,-0.2843,-0.2843,-0.2843,-0.2843,-0.2843,0.1358,0.1358,0.1358,0.1358,0.1358,-0.2010,-0.2010,-0.2010,-0.2010,-0.2010,-0.2620,-0.2620,-0.2620,-0.2620,-0.2620,-0.2727,-0.2727,-0.2727,-0.2727,-0.2727,-0.6945,-0.6945,-0.6945,-0.6945,-0.6945,-0.6405,-0.6405,-0.6405,-0.6405,-0.6405,-0.8122,-0.8122,-0.8122,-0.8122,-0.8122,-0.4054,-0.4054,-0.4054,-0.4054,-0.4054,-0.5933,-0.5933,-0.5933,-0.5933,-0.5933,-1.2505,-1.2505,-1.2505,-1.2505,-1.2505,-1.0124,-1.0124,-1.0124,-1.0124,-1.0124,-0.8888,-0.8888,-0.8888,-0.8888,-0.8888,-0.9426,-0.9426,-0.9426,-0.9426,-0.9426,-1.3300,-1.3300,-1.3300,-1.3300,-1.3300,-1.6929}
Position Bias(exp=0, s=1): {-1.4399,-1.4399,-1.4399,-1.4399,-1.4399,-0.9680,-0.9680,-0.9680,-0.9680,-0.9680,-0.7144,-0.7144,-0.7144,-0.7144,-0.7144,-1.0826,-1.0826,-1.0826,-1.0826,-1.0826,-1.2330,-1.2330,-1.2330,-1.2330,-1.2330,-0.8715,-0.8715,-0.8715,-0.8715,-0.8715,-0.8069,-0.8069,-0.8069,-0.8069,-0.8069,-0.5140,-0.5140,-0.5140,-0.5140,-0.5140,-0.7035,-0.7035,-0.7035,-0.7035,-0.7035,-0.2756,-0.2756,-0.2756,-0.2756,-0.2756,-0.3225,-0.3225,-0.3225,-0.3225,-0.3225,0.0097,0.0097,0.0097,0.0097,0.0097,-0.2721,-0.2721,-0.2721,-0.2721,-0.2721,-0.4686,-0.4686,-0.4686,-0.4686,-0.4686,0.1451,0.1451,0.1451,0.1451,0.1451,0.0533,0.0533,0.0533,0.0533,0.0533,0.5044,0.5044,0.5044,0.5044,0.5044,0.3740,0.3740,0.3740,0.3740,0.3740,-0.1058,-0.1058,-0.1058,-0.1058,-0.1058,0.2783,0.2783,0.2783,0.2783,0.2783,0.1465,0.1465,0.1465,0.1465,0.1465,0.6355,0.6355,0.6355,0.6355,0.6355,0.5090,0.5090,0.5090,0.5090,0.5090,0.5723,0.5723,0.5723,0.5723,0.5723,0.4433,0.4433,0.4433,0.4433,0.4433,0.5614,0.5614,0.5614,0.5614,0.5614,0.7377,0.7377,0.7377,0.7377,0.7377,0.5343,0.5343,0.5343,0.5343,0.5343,0.4333,0.4333,0.4333,0.4333,0.4333,0.3045,0.3045,0.3045,0.3045,0.3045,0.2881,0.2881,0.2881,0.2881,0.2881,0.5406,0.5406,0.5406,0.5406,0.5406,0.2349,0.2349,0.2349,0.2349,0.2349,0.1508,0.1508,0.1508,0.1508,0.1508,0.4268,0.4268,0.4268,0.4268,0.4268,0.2740,0.2740,0.2740,0.2740,0.2740,0.7771,0.7771,0.7771,0.7771,0.7771,1.3253}
Binding mode 2:
---------------
Mononucleotide: {-0.0032,0.0031,0.0001,0.0000,-0.0020,-0.0025,-0.0010,0.0034,0.0025,-0.0013,-0.0009,0.0026,-0.0000,0.0027,0.0009,0.0010,0.0036,0.0042,0.0017,-0.0047,0.0005,0.0042,-0.0005,-0.0016,0.0020,0.0049,0.0020,-0.0020,-0.0002,0.0003,0.0044,-0.0048,-0.0048,-0.0047,0.0002,-0.0010,-0.0007,0.0010,-0.0010,-0.0017}
Activity(exp=0): {-2.8905,-2.3459}
Position Bias(exp=0, s=0): {0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000}
Position Bias(exp=0, s=1): {0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000}
Binding mode 3:
---------------
Mononucleotide: {0.0002,-0.0031,-0.0030,0.0016,0.0011,-0.0023,0.0007,0.0027,0.0021,-0.0016,-0.0046,0.0022,-0.0032,-0.0032,0.0013,-0.0036,-0.0041,-0.0023,0.0019,-0.0038,0.0042,0.0021,-0.0004,-0.0030,-0.0028,-0.0014,-0.0001,0.0032,-0.0037,0.0022,-0.0016,-0.0048,0.0012,-0.0023,0.0035,0.0001,0.0034,0.0024,0.0018,0.0006}
Activity(exp=0): {0.0000,0.0000}
Position Bias(exp=0, s=0): {0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000}
Position Bias(exp=0, s=1): {0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000}
Binding mode 4:
---------------
Mononucleotide: {-0.0011,0.0038,0.0009,-0.0045,0.0004,-0.0014,0.0020,-0.0042,-0.0012,-0.0020,0.0048,0.0042,-0.0042,-0.0022,0.0035,0.0044,0.0018,0.0043,-0.0001,-0.0004,-0.0005,-0.0025,0.0021,-0.0036,0.0023,-0.0024,-0.0045,0.0025,-0.0021,0.0024,-0.0031,-0.0001,0.0008,-0.0032,0.0022,-0.0041,0.0018,-0.0033,-0.0024,0.0034}
Activity(exp=0): {0.0000,0.0000}
Position Bias(exp=0, s=0): {0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000}
Position Bias(exp=0, s=1): {0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000}
> Initial optimization (component2-1-f1).
>> Starting new optimization: component2-1-f1. (2021-05-21 14:02:31.536).
>>> Packing before optimization
Packing: {"enrichmentModel":[{}],"countTable":[{"h":[42,43]}],"bindingModeInteractions":[],"bindingModes":[{},{},{"mononucleotide":[0,1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19,20,21,22,23,24,25,26,27,28,29,30,31,32,33,34,35,36,37,38,39],"activity":[[40,41]]},{},{}]}
Value and gradient before optimization:
=======================================
value = 0.6806735581894567
gradient = {-0.0010,0.0066,0.0067,-0.0011,-0.0010,0.0066,0.0067,-0.0010,-0.0010,0.0066,0.0067,-0.0010,-0.0010,0.0066,0.0067,-0.0010,-0.0010,0.0066,0.0066,-0.0010,-0.0010,0.0067,0.0066,-0.0010,-0.0011,0.0067,0.0066,-0.0010,-0.0011,0.0066,0.0066,-0.0010,-0.0010,0.0066,0.0066,-0.0010,-0.0011,0.0067,0.0066,-0.0010,-0.0000,0.0112,0.0000,-0.0000}
gradient norm = 0.03206324466238249
Starting Function Value: 0.6806735581894567
Iterations Fnc. Calls Likelihood Distance Moved Step Alpha Gradient Norm
1 3 0.678539355854252 0.136389864292177 4.253776114311782 0.057685780797143
2 4 0.675342898092615 0.118124384406323 1.000000000000000 0.051473379172221
3 5 0.661869117714106 1.543487650686769 1.000000000000000 0.095176015405218
4 6 0.658073692028307 0.376976744727339 1.000000000000000 0.012679645073908
5 7 0.657090918707758 0.194406713470591 1.000000000000000 0.014104156046901
6 8 0.654470192654799 0.605331360919161 1.000000000000000 0.036196624719732
7 9 0.653345849937391 0.125565656058178 1.000000000000000 0.024387763447579
8 10 0.652232499244973 0.185320354867319 1.000000000000000 0.007842576937654
9 12 0.651989942314070 0.141094989930951 0.449602111938368 0.013543011007468
10 13 0.651568828507382 0.174889073056406 1.000000000000000 0.004758329568850
11 14 0.651470130399526 0.101400654761488 1.000000000000000 0.003684035331457
12 15 0.651402162310057 0.101663506283155 1.000000000000000 0.000444748089291
13 16 0.651386224147389 0.130636364070779 1.000000000000000 0.003663954289678
14 17 0.651368144734114 0.016940219967837 1.000000000000000 0.000353791575787
15 18 0.651362858379214 0.040164174755759 1.000000000000000 0.000548421254660
16 19 0.651355861540078 0.067454898551770 1.000000000000000 0.000757486751753
17 20 0.651343531033749 0.094302300885411 1.000000000000000 0.000907979648808
18 21 0.651307945660288 0.254033822096907 1.000000000000000 0.000898645093639
19 23 0.651260809415774 0.246706831343002 0.320432554678168 0.000334759367544
20 25 0.651220645038817 0.381865712060645 0.209318958809377 0.003874537161334
21 26 0.651189667408738 0.127045035954226 1.000000000000000 0.002295073293746
22 27 0.651138795739579 0.489239184448343 1.000000000000000 0.004655027240641
23 28 0.651104794277862 0.072968790628100 1.000000000000000 0.000940979266776
24 29 0.651072976495174 0.298105588732629 1.000000000000000 0.000624455403380
25 30 0.651064798226706 0.203446460034978 1.000000000000000 0.000824316754075
26 31 0.651061615539905 0.044546946983634 1.000000000000000 0.000182373712790
27 32 0.651060543864882 0.045496657935585 1.000000000000000 0.000371846302881
28 33 0.651058931028823 0.058906544337566 1.000000000000000 0.000510717961440
29 34 0.651055192491991 0.124534404624761 1.000000000000000 0.000566554394709
30 35 0.651046579306834 0.271540454059482 1.000000000000000 0.000160657610035
31 37 0.651039637921989 0.237380063769219 0.486996799396036 0.000791795657110
32 38 0.651033153484767 0.289087055036291 1.000000000000000 0.001435263035788
33 39 0.651030413407092 0.119380175506319 1.000000000000000 0.000258613577691
34 40 0.651029017185933 0.038157396712674 1.000000000000000 0.000164782996160
35 41 0.651025986250903 0.085709471764214 1.000000000000000 0.000562367119299
36 42 0.651020432131229 0.108840151686022 1.000000000000000 0.001232133143954
37 44 0.651008440707439 0.178447643099906 0.499698209293428 0.002620846778842
38 46 0.650992589518099 0.156877139906120 0.353831919612396 0.003948566909352
39 48 0.650963899100644 0.194932706667865 0.366155217482653 0.005508430250561
40 49 0.650917480078385 0.532678115983200 1.000000000000000 0.011427493013016
41 50 0.650844224235470 0.289670271773749 1.000000000000000 0.003946879303628
42 51 0.650754209168310 0.610191505729998 1.000000000000000 0.005685573798116
43 52 0.650666745945996 0.378820346734057 1.000000000000000 0.007982633197446
44 53 0.650555485781430 0.632875355922616 1.000000000000000 0.009885885824108
45 54 0.650454476449856 0.148147770208400 1.000000000000000 0.002807306883691
46 55 0.650390205345429 0.361774702782129 1.000000000000000 0.000770718913816
47 56 0.650375050687870 0.336299747422369 1.000000000000000 0.001808119986168
48 57 0.650352408880642 0.042673665056922 1.000000000000000 0.000940741386373
49 58 0.650325332018055 0.150895911267858 1.000000000000000 0.002651199679207
50 59 0.650283343924489 0.339945999044962 1.000000000000000 0.002508036320451
51 61 0.650197484022874 0.371123858490886 0.316236149095685 0.000760094380203
52 63 0.650061400936278 0.683088474481223 0.207945814193275 0.007975364841422
53 64 0.649717361208732 0.637307745741264 1.000000000000000 0.013329046849880
54 66 0.649191939550769 0.880481845662226 0.378214897510860 0.019614757807668
55 68 0.648896274122686 0.598995416771147 0.482263332295899 0.017088552480855
56 69 0.648730954115555 0.712481524005665 1.000000000000000 0.029209291524741
57 70 0.647708799560651 0.219653031801022 1.000000000000000 0.003423936751001
58 72 0.647045146115018 0.503463909516338 0.471601227388160 0.003562769490035
59 74 0.646082351850022 0.526529663125498 0.142066018405648 0.010782376989964
60 76 0.644989534641882 0.599280635005706 0.429580399979755 0.017778917324126
61 77 0.644086662527613 0.721136982899655 1.000000000000000 0.014511199306442
62 78 0.643580881865100 0.598117279969608 1.000000000000000 0.008384858524353
63 79 0.643390362906508 0.296671929547714 1.000000000000000 0.004465102853422
64 80 0.643216977445271 0.451324902272548 1.000000000000000 0.001850902868826
65 81 0.643153380310962 0.257494499097402 1.000000000000000 0.002286874129120
66 82 0.643048642953870 0.281312039521701 1.000000000000000 0.000869859744197
67 83 0.642918714042631 0.435213011675032 1.000000000000000 0.001863998313669
68 84 0.642858870103420 0.274489701288208 1.000000000000000 0.001945374079005
69 85 0.642768215898041 0.296725910740893 1.000000000000000 0.001026948516194
70 86 0.642706358089834 0.499852497797729 1.000000000000000 0.001130045139377
71 87 0.642695064595589 0.103839204930814 1.000000000000000 0.000632730908062
72 88 0.642688822548741 0.102427205673821 1.000000000000000 0.000716704697458
73 89 0.642680139416429 0.075605813457678 1.000000000000000 0.000401182903682
74 90 0.642650301148109 0.396726387325597 1.000000000000000 0.000454799552239
75 91 0.642641110065316 0.183173529789604 1.000000000000000 0.000625916800862
76 92 0.642633366487256 0.137744091568579 1.000000000000000 0.000592841566627
77 93 0.642617938051527 0.258467351457371 1.000000000000000 0.000204100076768
78 94 0.642615086784075 0.104683342519819 1.000000000000000 0.000269283605064
79 95 0.642613630568016 0.037000763144524 1.000000000000000 0.000191368079094
80 96 0.642611347871083 0.093517749213896 1.000000000000000 0.000437805255445
81 97 0.642610634364846 0.039763892352612 1.000000000000000 0.000346684830205
82 98 0.642610087294548 0.042781606175671 1.000000000000000 0.000108543615142
83 99 0.642609852287928 0.029863856218979 1.000000000000000 0.000107152801287
84 100 0.642609658051694 0.024300338195886 1.000000000000000 0.000209928535931
85 101 0.642609385860836 0.027190933019909 1.000000000000000 0.000277778678414
86 102 0.642609043709645 0.021904747414452 1.000000000000000 0.000250969531232
87 103 0.642608557785594 0.026564739006530 1.000000000000000 0.000097670405743
88 104 0.642608351065753 0.026488528497665 1.000000000000000 0.000026554843508
89 105 0.642608306674728 0.009073659642563 1.000000000000000 0.000040042472617
90 106 0.642608252327732 0.006414248528026 1.000000000000000 0.000029079654405
91 107 0.642608128627504 0.013536928380595 1.000000000000000 0.000024323429683
92 108 0.642608003058005 0.017841816959998 1.000000000000000 0.000044234422002
93 109 0.642607902788547 0.017021494213276 1.000000000000000 0.000040034625774
94 110 0.642607752916517 0.023962968813437 1.000000000000000 0.000022592805052
95 111 0.642607665801927 0.020339659657566 1.000000000000000 0.000015676845503
96 112 0.642607639430657 0.009197520994757 1.000000000000000 0.000017536553497
97 113 0.642607549174184 0.020415307733200 1.000000000000000 0.000036691784434
98 114 0.642607414092798 0.042882210571222 1.000000000000000 0.000040272269802
99 115 0.642607199882891 0.062331185130403 1.000000000000000 0.000024357850183
100 116 0.642606956409620 0.077461861633348 1.000000000000000 0.000023784008748
101 117 0.642606761863609 0.075692292434075 1.000000000000000 0.000037810887838
102 118 0.642606457715412 0.091847551961602 1.000000000000000 0.000053967265060
103 119 0.642605587431850 0.301275789544701 1.000000000000000 0.000075078060082
104 120 0.642604583939573 0.354884790288002 1.000000000000000 0.000103665466080
105 121 0.642603302336849 0.486806001500751 1.000000000000000 0.000069311359323
106 122 0.642602417436757 0.296902346217636 1.000000000000000 0.000046794858296
107 123 0.642601446459483 0.305900516292606 1.000000000000000 0.000032493410228
108 124 0.642600614950062 0.275113379380135 1.000000000000000 0.000055472047014
109 125 0.642599865737411 0.272307944558678 1.000000000000000 0.000043546298489
110 126 0.642599305218947 0.268408534389421 1.000000000000000 0.000044788945879
111 127 0.642599228820748 0.018293997174298 1.000000000000000 0.000019627899365
112 128 0.642599214308412 0.014200076710993 1.000000000000000 0.000008077809954
113 129 0.642599206564730 0.006704728136802 1.000000000000000 0.000008275001517
114 130 0.642599195334750 0.004399176433970 1.000000000000000 0.000018228123247
115 131 0.642599180774739 0.008793549045001 1.000000000000000 0.000025101070556
116 132 0.642599167469009 0.014373305770935 1.000000000000000 0.000022829785928
117 134 0.642599164949312 0.004524286369458 0.146487570859452 0.000016530503431
118 135 0.642599159322315 0.007765705948464 1.000000000000000 0.000006343779592
119 136 0.642599157163616 0.002194690348899 1.000000000000000 0.000004501391937
120 137 0.642599155634118 0.001464487689004 1.000000000000000 0.000008503679044
121 138 0.642599153452564 0.002257384111940 1.000000000000000 0.000010968616169
122 139 0.642599150929125 0.002513164417446 1.000000000000000 0.000007977451993
123 140 0.642599149348303 0.002213845002363 1.000000000000000 0.000002233201402
124 141 0.642599148785999 0.001462465919280 1.000000000000000 0.000002991396685
125 142 0.642599148491446 0.000886157666737 1.000000000000000 0.000004188067411
126 143 0.642599147997001 0.001181400310706 1.000000000000000 0.000004078107276
127 144 0.642599147253300 0.002142334893509 1.000000000000000 0.000003841764654
128 146 0.642599146895354 0.002142334893509 0.377663928654799 0.000000710605536
Convergence criteria met.
After: gradient norm = 7.106055363062788E-7
>>> Parameters after optimization
Count Table 0:
---------------
h: {1.1048,-1.1048}
Binding mode 0:
---------------
Mononucleotide: {}
Activity(exp=0): {-0.0000,0.5943}
Binding mode 1:
---------------
Mononucleotide: {0.0149,-0.9265,-0.0604,-0.5874,-0.2850,-1.4631,0.5356,-0.3469,0.0757,-0.9475,-0.5024,-0.1863,1.0447,-1.3391,-1.0362,-0.2288,-0.6431,0.8764,-1.5467,-0.2460,0.4511,-1.5177,-0.2014,-0.2914,-0.3739,-0.6342,-0.4833,-0.0692,-0.0395,-0.7408,-0.7408,-0.0395,-0.0692,-0.4833,-0.6342,-0.3739,-0.2914,-0.2014,-1.5177,0.4511,-0.2460,-1.5467,0.8764,-0.6431,-0.2288,-1.0362,-1.3391,1.0447,-0.1863,-0.5024,-0.9475,0.0757,-0.3469,0.5356,-1.4631,-0.2850,-0.5874,-0.0604,-0.9265,0.0149}
Activity(exp=0): {0.0027,-1.6185}
Position Bias(exp=0, s=0): {-0.0903,-0.0903,-0.0903,-0.0903,-0.0903,0.4150,0.4150,0.4150,0.4150,0.4150,0.3175,0.3175,0.3175,0.3175,0.3175,0.6735,0.6735,0.6735,0.6735,0.6735,0.4540,0.4540,0.4540,0.4540,0.4540,0.4108,0.4108,0.4108,0.4108,0.4108,0.3573,0.3573,0.3573,0.3573,0.3573,0.7753,0.7753,0.7753,0.7753,0.7753,0.4989,0.4989,0.4989,0.4989,0.4989,0.6625,0.6625,0.6625,0.6625,0.6625,0.4374,0.4374,0.4374,0.4374,0.4374,0.4208,0.4208,0.4208,0.4208,0.4208,0.2289,0.2289,0.2289,0.2289,0.2289,0.7337,0.7337,0.7337,0.7337,0.7337,0.4481,0.4481,0.4481,0.4481,0.4481,0.4568,0.4568,0.4568,0.4568,0.4568,0.8279,0.8279,0.8279,0.8279,0.8279,0.7587,0.7587,0.7587,0.7587,0.7587,0.6322,0.6322,0.6322,0.6322,0.6322,0.3789,0.3789,0.3789,0.3789,0.3789,0.0935,0.0935,0.0935,0.0935,0.0935,0.1913,0.1913,0.1913,0.1913,0.1913,-0.2843,-0.2843,-0.2843,-0.2843,-0.2843,0.1358,0.1358,0.1358,0.1358,0.1358,-0.2010,-0.2010,-0.2010,-0.2010,-0.2010,-0.2620,-0.2620,-0.2620,-0.2620,-0.2620,-0.2727,-0.2727,-0.2727,-0.2727,-0.2727,-0.6945,-0.6945,-0.6945,-0.6945,-0.6945,-0.6405,-0.6405,-0.6405,-0.6405,-0.6405,-0.8122,-0.8122,-0.8122,-0.8122,-0.8122,-0.4054,-0.4054,-0.4054,-0.4054,-0.4054,-0.5933,-0.5933,-0.5933,-0.5933,-0.5933,-1.2505,-1.2505,-1.2505,-1.2505,-1.2505,-1.0124,-1.0124,-1.0124,-1.0124,-1.0124,-0.8888,-0.8888,-0.8888,-0.8888,-0.8888,-0.9426,-0.9426,-0.9426,-0.9426,-0.9426,-1.3300,-1.3300,-1.3300,-1.3300,-1.3300,-1.6929}
Position Bias(exp=0, s=1): {-1.4399,-1.4399,-1.4399,-1.4399,-1.4399,-0.9680,-0.9680,-0.9680,-0.9680,-0.9680,-0.7144,-0.7144,-0.7144,-0.7144,-0.7144,-1.0826,-1.0826,-1.0826,-1.0826,-1.0826,-1.2330,-1.2330,-1.2330,-1.2330,-1.2330,-0.8715,-0.8715,-0.8715,-0.8715,-0.8715,-0.8069,-0.8069,-0.8069,-0.8069,-0.8069,-0.5140,-0.5140,-0.5140,-0.5140,-0.5140,-0.7035,-0.7035,-0.7035,-0.7035,-0.7035,-0.2756,-0.2756,-0.2756,-0.2756,-0.2756,-0.3225,-0.3225,-0.3225,-0.3225,-0.3225,0.0097,0.0097,0.0097,0.0097,0.0097,-0.2721,-0.2721,-0.2721,-0.2721,-0.2721,-0.4686,-0.4686,-0.4686,-0.4686,-0.4686,0.1451,0.1451,0.1451,0.1451,0.1451,0.0533,0.0533,0.0533,0.0533,0.0533,0.5044,0.5044,0.5044,0.5044,0.5044,0.3740,0.3740,0.3740,0.3740,0.3740,-0.1058,-0.1058,-0.1058,-0.1058,-0.1058,0.2783,0.2783,0.2783,0.2783,0.2783,0.1465,0.1465,0.1465,0.1465,0.1465,0.6355,0.6355,0.6355,0.6355,0.6355,0.5090,0.5090,0.5090,0.5090,0.5090,0.5723,0.5723,0.5723,0.5723,0.5723,0.4433,0.4433,0.4433,0.4433,0.4433,0.5614,0.5614,0.5614,0.5614,0.5614,0.7377,0.7377,0.7377,0.7377,0.7377,0.5343,0.5343,0.5343,0.5343,0.5343,0.4333,0.4333,0.4333,0.4333,0.4333,0.3045,0.3045,0.3045,0.3045,0.3045,0.2881,0.2881,0.2881,0.2881,0.2881,0.5406,0.5406,0.5406,0.5406,0.5406,0.2349,0.2349,0.2349,0.2349,0.2349,0.1508,0.1508,0.1508,0.1508,0.1508,0.4268,0.4268,0.4268,0.4268,0.4268,0.2740,0.2740,0.2740,0.2740,0.2740,0.7771,0.7771,0.7771,0.7771,0.7771,1.3253}
Binding mode 2:
---------------
Mononucleotide: {-1.5003,-0.8833,-1.8571,1.1707,-1.4170,-2.5087,0.9533,-0.0976,1.3201,-1.2514,-1.7718,-1.3669,-1.2816,-0.3908,-0.1079,-1.2897,-1.0315,-1.8886,-1.5381,1.3882,-0.0542,0.8446,-2.5836,-1.2769,1.3892,-1.9818,-0.8178,-1.6596,-1.7156,-0.5207,-1.1145,0.2808,-0.5704,-0.6960,-1.1208,-0.6828,-0.7854,-0.6653,-0.8121,-0.8072}
Activity(exp=0): {0.0000,-3.0700}
Position Bias(exp=0, s=0): {0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000}
Position Bias(exp=0, s=1): {0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000}
Binding mode 3:
---------------
Mononucleotide: {0.0002,-0.0031,-0.0030,0.0016,0.0011,-0.0023,0.0007,0.0027,0.0021,-0.0016,-0.0046,0.0022,-0.0032,-0.0032,0.0013,-0.0036,-0.0041,-0.0023,0.0019,-0.0038,0.0042,0.0021,-0.0004,-0.0030,-0.0028,-0.0014,-0.0001,0.0032,-0.0037,0.0022,-0.0016,-0.0048,0.0012,-0.0023,0.0035,0.0001,0.0034,0.0024,0.0018,0.0006}
Activity(exp=0): {0.0000,0.0000}
Position Bias(exp=0, s=0): {0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000}
Position Bias(exp=0, s=1): {0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000}
Binding mode 4:
---------------
Mononucleotide: {-0.0011,0.0038,0.0009,-0.0045,0.0004,-0.0014,0.0020,-0.0042,-0.0012,-0.0020,0.0048,0.0042,-0.0042,-0.0022,0.0035,0.0044,0.0018,0.0043,-0.0001,-0.0004,-0.0005,-0.0025,0.0021,-0.0036,0.0023,-0.0024,-0.0045,0.0025,-0.0021,0.0024,-0.0031,-0.0001,0.0008,-0.0032,0.0022,-0.0041,0.0018,-0.0033,-0.0024,0.0034}
Activity(exp=0): {0.0000,0.0000}
Position Bias(exp=0, s=0): {0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000}
Position Bias(exp=0, s=1): {0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000}
Suggested variations:
key=10;0;0, description = Initial model.
> Optimizing variation "Initial model." (component2-2-variation0).
>> Starting new optimization: component2-2-variation0. (2021-05-21 14:08:29.46).
>>> Packing before optimization
Packing: {"enrichmentModel":[{}],"countTable":[{"h":[42,43]}],"bindingModeInteractions":[],"bindingModes":[{},{},{"mononucleotide":[0,1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19,20,21,22,23,24,25,26,27,28,29,30,31,32,33,34,35,36,37,38,39],"activity":[[40,41]]},{},{}]}
Value and gradient before optimization:
=======================================
value = 0.642599146895354
gradient = {0.0000,0.0000,-0.0000,-0.0000,-0.0000,-0.0000,0.0000,0.0000,-0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,-0.0000,-0.0000,-0.0000,0.0000,-0.0000,0.0000,0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,0.0000,0.0000,0.0000,-0.0000,-0.0000,-0.0000,-0.0000,0.0000,0.0000,-0.0000,-0.0000,0.0000,0.0000,0.0000,0.0000,-0.0000,0.0000}
gradient norm = 7.106055363064066E-7
Already at minimum!
After: gradient norm = 7.106055363064066E-7
>>> Parameters after optimization
Count Table 0:
---------------
h: {1.1048,-1.1048}
Binding mode 0:
---------------
Mononucleotide: {}
Activity(exp=0): {-0.0000,0.5943}
Binding mode 1:
---------------
Mononucleotide: {0.0149,-0.9265,-0.0604,-0.5874,-0.2850,-1.4631,0.5356,-0.3469,0.0757,-0.9475,-0.5024,-0.1863,1.0447,-1.3391,-1.0362,-0.2288,-0.6431,0.8764,-1.5467,-0.2460,0.4511,-1.5177,-0.2014,-0.2914,-0.3739,-0.6342,-0.4833,-0.0692,-0.0395,-0.7408,-0.7408,-0.0395,-0.0692,-0.4833,-0.6342,-0.3739,-0.2914,-0.2014,-1.5177,0.4511,-0.2460,-1.5467,0.8764,-0.6431,-0.2288,-1.0362,-1.3391,1.0447,-0.1863,-0.5024,-0.9475,0.0757,-0.3469,0.5356,-1.4631,-0.2850,-0.5874,-0.0604,-0.9265,0.0149}
Activity(exp=0): {0.0027,-1.6185}
Position Bias(exp=0, s=0): {-0.0903,-0.0903,-0.0903,-0.0903,-0.0903,0.4150,0.4150,0.4150,0.4150,0.4150,0.3175,0.3175,0.3175,0.3175,0.3175,0.6735,0.6735,0.6735,0.6735,0.6735,0.4540,0.4540,0.4540,0.4540,0.4540,0.4108,0.4108,0.4108,0.4108,0.4108,0.3573,0.3573,0.3573,0.3573,0.3573,0.7753,0.7753,0.7753,0.7753,0.7753,0.4989,0.4989,0.4989,0.4989,0.4989,0.6625,0.6625,0.6625,0.6625,0.6625,0.4374,0.4374,0.4374,0.4374,0.4374,0.4208,0.4208,0.4208,0.4208,0.4208,0.2289,0.2289,0.2289,0.2289,0.2289,0.7337,0.7337,0.7337,0.7337,0.7337,0.4481,0.4481,0.4481,0.4481,0.4481,0.4568,0.4568,0.4568,0.4568,0.4568,0.8279,0.8279,0.8279,0.8279,0.8279,0.7587,0.7587,0.7587,0.7587,0.7587,0.6322,0.6322,0.6322,0.6322,0.6322,0.3789,0.3789,0.3789,0.3789,0.3789,0.0935,0.0935,0.0935,0.0935,0.0935,0.1913,0.1913,0.1913,0.1913,0.1913,-0.2843,-0.2843,-0.2843,-0.2843,-0.2843,0.1358,0.1358,0.1358,0.1358,0.1358,-0.2010,-0.2010,-0.2010,-0.2010,-0.2010,-0.2620,-0.2620,-0.2620,-0.2620,-0.2620,-0.2727,-0.2727,-0.2727,-0.2727,-0.2727,-0.6945,-0.6945,-0.6945,-0.6945,-0.6945,-0.6405,-0.6405,-0.6405,-0.6405,-0.6405,-0.8122,-0.8122,-0.8122,-0.8122,-0.8122,-0.4054,-0.4054,-0.4054,-0.4054,-0.4054,-0.5933,-0.5933,-0.5933,-0.5933,-0.5933,-1.2505,-1.2505,-1.2505,-1.2505,-1.2505,-1.0124,-1.0124,-1.0124,-1.0124,-1.0124,-0.8888,-0.8888,-0.8888,-0.8888,-0.8888,-0.9426,-0.9426,-0.9426,-0.9426,-0.9426,-1.3300,-1.3300,-1.3300,-1.3300,-1.3300,-1.6929}
Position Bias(exp=0, s=1): {-1.4399,-1.4399,-1.4399,-1.4399,-1.4399,-0.9680,-0.9680,-0.9680,-0.9680,-0.9680,-0.7144,-0.7144,-0.7144,-0.7144,-0.7144,-1.0826,-1.0826,-1.0826,-1.0826,-1.0826,-1.2330,-1.2330,-1.2330,-1.2330,-1.2330,-0.8715,-0.8715,-0.8715,-0.8715,-0.8715,-0.8069,-0.8069,-0.8069,-0.8069,-0.8069,-0.5140,-0.5140,-0.5140,-0.5140,-0.5140,-0.7035,-0.7035,-0.7035,-0.7035,-0.7035,-0.2756,-0.2756,-0.2756,-0.2756,-0.2756,-0.3225,-0.3225,-0.3225,-0.3225,-0.3225,0.0097,0.0097,0.0097,0.0097,0.0097,-0.2721,-0.2721,-0.2721,-0.2721,-0.2721,-0.4686,-0.4686,-0.4686,-0.4686,-0.4686,0.1451,0.1451,0.1451,0.1451,0.1451,0.0533,0.0533,0.0533,0.0533,0.0533,0.5044,0.5044,0.5044,0.5044,0.5044,0.3740,0.3740,0.3740,0.3740,0.3740,-0.1058,-0.1058,-0.1058,-0.1058,-0.1058,0.2783,0.2783,0.2783,0.2783,0.2783,0.1465,0.1465,0.1465,0.1465,0.1465,0.6355,0.6355,0.6355,0.6355,0.6355,0.5090,0.5090,0.5090,0.5090,0.5090,0.5723,0.5723,0.5723,0.5723,0.5723,0.4433,0.4433,0.4433,0.4433,0.4433,0.5614,0.5614,0.5614,0.5614,0.5614,0.7377,0.7377,0.7377,0.7377,0.7377,0.5343,0.5343,0.5343,0.5343,0.5343,0.4333,0.4333,0.4333,0.4333,0.4333,0.3045,0.3045,0.3045,0.3045,0.3045,0.2881,0.2881,0.2881,0.2881,0.2881,0.5406,0.5406,0.5406,0.5406,0.5406,0.2349,0.2349,0.2349,0.2349,0.2349,0.1508,0.1508,0.1508,0.1508,0.1508,0.4268,0.4268,0.4268,0.4268,0.4268,0.2740,0.2740,0.2740,0.2740,0.2740,0.7771,0.7771,0.7771,0.7771,0.7771,1.3253}
Binding mode 2:
---------------
Mononucleotide: {-1.5003,-0.8833,-1.8571,1.1707,-1.4170,-2.5087,0.9533,-0.0976,1.3201,-1.2514,-1.7718,-1.3669,-1.2816,-0.3908,-0.1079,-1.2897,-1.0315,-1.8886,-1.5381,1.3882,-0.0542,0.8446,-2.5836,-1.2769,1.3892,-1.9818,-0.8178,-1.6596,-1.7156,-0.5207,-1.1145,0.2808,-0.5704,-0.6960,-1.1208,-0.6828,-0.7854,-0.6653,-0.8121,-0.8072}
Activity(exp=0): {0.0000,-3.0700}
Position Bias(exp=0, s=0): {0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000}
Position Bias(exp=0, s=1): {0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000}
Binding mode 3:
---------------
Mononucleotide: {0.0002,-0.0031,-0.0030,0.0016,0.0011,-0.0023,0.0007,0.0027,0.0021,-0.0016,-0.0046,0.0022,-0.0032,-0.0032,0.0013,-0.0036,-0.0041,-0.0023,0.0019,-0.0038,0.0042,0.0021,-0.0004,-0.0030,-0.0028,-0.0014,-0.0001,0.0032,-0.0037,0.0022,-0.0016,-0.0048,0.0012,-0.0023,0.0035,0.0001,0.0034,0.0024,0.0018,0.0006}
Activity(exp=0): {0.0000,0.0000}
Position Bias(exp=0, s=0): {0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000}
Position Bias(exp=0, s=1): {0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000}
Binding mode 4:
---------------
Mononucleotide: {-0.0011,0.0038,0.0009,-0.0045,0.0004,-0.0014,0.0020,-0.0042,-0.0012,-0.0020,0.0048,0.0042,-0.0042,-0.0022,0.0035,0.0044,0.0018,0.0043,-0.0001,-0.0004,-0.0005,-0.0025,0.0021,-0.0036,0.0023,-0.0024,-0.0045,0.0025,-0.0021,0.0024,-0.0031,-0.0001,0.0008,-0.0032,0.0022,-0.0041,0.0018,-0.0033,-0.0024,0.0034}
Activity(exp=0): {0.0000,0.0000}
Position Bias(exp=0, s=0): {0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000}
Position Bias(exp=0, s=1): {0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000}
The Likelihood DID NOT improve. Discarding fit component2-2-variation0.
Suggested variations:
key=10;0;1, description = Heuristic shift (1).
> Optimizing variation "Heuristic shift (1)." (component2-2-variation1).
>> Starting new optimization: component2-2-variation1. (2021-05-21 14:08:31.985).
>>> Packing before optimization
Packing: {"enrichmentModel":[{}],"countTable":[{"h":[42,43]}],"bindingModeInteractions":[],"bindingModes":[{},{},{"mononucleotide":[0,1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19,20,21,22,23,24,25,26,27,28,29,30,31,32,33,34,35,36,37,38,39],"activity":[[40,41]]},{},{}]}
Value and gradient before optimization:
=======================================
value = 0.6492700110442782
gradient = {0.0045,0.0063,0.0044,0.0049,0.0011,0.0007,0.0006,0.0177,0.0010,0.0005,0.0146,0.0041,0.0171,0.0010,0.0007,0.0013,0.0026,0.0066,0.0084,0.0026,0.0016,0.0006,0.0008,0.0172,0.0042,0.0143,0.0004,0.0012,0.0180,0.0006,0.0007,0.0008,0.0014,0.0050,0.0034,0.0103,0.0058,0.0050,0.0034,0.0059,0.0000,0.0201,-0.0432,0.0432}
gradient norm = 0.07945498386284974
Starting Function Value: 0.6492700110442782
Iterations Fnc. Calls Likelihood Distance Moved Step Alpha Gradient Norm
1 3 0.643757499174745 0.139305748205057 1.753266333116596 0.010936804927623
2 4 0.643557034358360 0.019456671035663 1.000000000000000 0.009879285340070
3 5 0.642662317906082 0.179915565965925 1.000000000000000 0.004217690633796
4 6 0.642639657691865 0.012951239559631 1.000000000000000 0.000877724733121
5 7 0.642636828558961 0.008138939661162 1.000000000000000 0.000558999122878
6 8 0.642635646455861 0.003684602044299 1.000000000000000 0.000695177964914
7 9 0.642625630233282 0.035149157811706 1.000000000000000 0.001630146853822
8 10 0.642609649550505 0.064232155381784 1.000000000000000 0.002377853698668
9 11 0.642581067978339 0.135038039743694 1.000000000000000 0.002455263265479
10 12 0.642540379932150 0.202732710268885 1.000000000000000 0.000407794457943
11 13 0.642529376508563 0.128528943939894 1.000000000000000 0.001206135479622
12 14 0.642525851686876 0.023485639955873 1.000000000000000 0.001175244819566
13 15 0.642508292009498 0.157268645598762 1.000000000000000 0.001153356475953
14 16 0.642486512828941 0.250449029655837 1.000000000000000 0.001650058067205
15 17 0.642474062049239 0.146870287288635 1.000000000000000 0.000686201340683
16 18 0.642470342651454 0.064520547587980 1.000000000000000 0.000434521011251
17 19 0.642466151283695 0.067511615952419 1.000000000000000 0.000220217450181
18 20 0.642462596894579 0.088086341865074 1.000000000000000 0.000224821616791
19 21 0.642456984044269 0.053094681282544 1.000000000000000 0.000450876558894
20 22 0.642452745884804 0.086773234450230 1.000000000000000 0.000254738213828
21 23 0.642451344158953 0.079486154445837 1.000000000000000 0.000315848964615
22 24 0.642450001764403 0.021835973397799 1.000000000000000 0.000124571421276
23 25 0.642449091284328 0.033733275701038 1.000000000000000 0.000263009122686
24 26 0.642448646647152 0.010473013620668 1.000000000000000 0.000231622166731
25 27 0.642446272455781 0.064211069676034 1.000000000000000 0.000066151424959
26 28 0.642445584797007 0.024082206047368 1.000000000000000 0.000102121494293
27 29 0.642445153877930 0.016993402589216 1.000000000000000 0.000075545791743
28 30 0.642444454684945 0.023954850371140 1.000000000000000 0.000047136640161
29 31 0.642443396059010 0.053095150076772 1.000000000000000 0.000124093875761
30 32 0.642442893182116 0.032207368297243 1.000000000000000 0.000110150599385
31 33 0.642442066949863 0.059984135053500 1.000000000000000 0.000042806462756
32 34 0.642441833804428 0.015920804801567 1.000000000000000 0.000024031534970
33 35 0.642441644277400 0.016689575124775 1.000000000000000 0.000033097065306
34 36 0.642441421754879 0.022135942142423 1.000000000000000 0.000035035196192
35 37 0.642441094334532 0.043644777849398 1.000000000000000 0.000015370012041
36 38 0.642441038437543 0.012181617261689 1.000000000000000 0.000007684551143
37 39 0.642441015510955 0.005801719972462 1.000000000000000 0.000007710813268
38 40 0.642440980157756 0.009827582658740 1.000000000000000 0.000010000361307
39 41 0.642440920737423 0.019697967334270 1.000000000000000 0.000012339720762
40 42 0.642440862250160 0.023886069311049 1.000000000000000 0.000007599787855
41 43 0.642440823155324 0.020166769179360 1.000000000000000 0.000004694376478
42 44 0.642440791747114 0.017456504543152 1.000000000000000 0.000008958383506
43 45 0.642440758864860 0.021604060533167 1.000000000000000 0.000010377981162
44 46 0.642440707997720 0.029382670262054 1.000000000000000 0.000012753055265
45 47 0.642440565835141 0.096903790174107 1.000000000000000 0.000011140881164
46 48 0.642440415446940 0.105781859497721 1.000000000000000 0.000012993204634
47 49 0.642440145064585 0.193607917288617 1.000000000000000 0.000028165513448
48 50 0.642439844986319 0.244531699586252 1.000000000000000 0.000022988175633
49 51 0.642439572762433 0.198606661584627 1.000000000000000 0.000017808389581
50 52 0.642439310542996 0.213511192961478 1.000000000000000 0.000043134875993
51 53 0.642439225729371 0.051181072055060 1.000000000000000 0.000025363549230
52 54 0.642439166455499 0.024941937291497 1.000000000000000 0.000018005820179
53 55 0.642439097568460 0.041382125042367 1.000000000000000 0.000009764031255
54 56 0.642439043963845 0.056482991956691 1.000000000000000 0.000005972240977
55 57 0.642439010990306 0.042063687485461 1.000000000000000 0.000004959508951
56 58 0.642438985538610 0.031811277215674 1.000000000000000 0.000005042092616
57 59 0.642438965065346 0.021181206865025 1.000000000000000 0.000005005851874
58 60 0.642438946116166 0.020807985860670 1.000000000000000 0.000004184655818
59 61 0.642438935602387 0.009722786423338 1.000000000000000 0.000001863169122
60 62 0.642438931324654 0.005624240339590 1.000000000000000 0.000001303510203
61 63 0.642438928990133 0.004830551548917 1.000000000000000 0.000001338150495
62 64 0.642438928008701 0.004604237174161 1.000000000000000 0.000001085732977
63 65 0.642438927922485 0.000902648521558 1.000000000000000 0.000000954367185
64 66 0.642438927899369 0.000902648521558 1.000000000000000 0.000000234087184
Convergence criteria met.
After: gradient norm = 2.340871837795095E-7
>>> Parameters after optimization
Count Table 0:
---------------
h: {1.1003,-1.1003}
Binding mode 0:
---------------
Mononucleotide: {}
Activity(exp=0): {-0.0000,0.5943}
Binding mode 1:
---------------
Mononucleotide: {0.0149,-0.9265,-0.0604,-0.5874,-0.2850,-1.4631,0.5356,-0.3469,0.0757,-0.9475,-0.5024,-0.1863,1.0447,-1.3391,-1.0362,-0.2288,-0.6431,0.8764,-1.5467,-0.2460,0.4511,-1.5177,-0.2014,-0.2914,-0.3739,-0.6342,-0.4833,-0.0692,-0.0395,-0.7408,-0.7408,-0.0395,-0.0692,-0.4833,-0.6342,-0.3739,-0.2914,-0.2014,-1.5177,0.4511,-0.2460,-1.5467,0.8764,-0.6431,-0.2288,-1.0362,-1.3391,1.0447,-0.1863,-0.5024,-0.9475,0.0757,-0.3469,0.5356,-1.4631,-0.2850,-0.5874,-0.0604,-0.9265,0.0149}
Activity(exp=0): {0.0027,-1.6185}
Position Bias(exp=0, s=0): {-0.0903,-0.0903,-0.0903,-0.0903,-0.0903,0.4150,0.4150,0.4150,0.4150,0.4150,0.3175,0.3175,0.3175,0.3175,0.3175,0.6735,0.6735,0.6735,0.6735,0.6735,0.4540,0.4540,0.4540,0.4540,0.4540,0.4108,0.4108,0.4108,0.4108,0.4108,0.3573,0.3573,0.3573,0.3573,0.3573,0.7753,0.7753,0.7753,0.7753,0.7753,0.4989,0.4989,0.4989,0.4989,0.4989,0.6625,0.6625,0.6625,0.6625,0.6625,0.4374,0.4374,0.4374,0.4374,0.4374,0.4208,0.4208,0.4208,0.4208,0.4208,0.2289,0.2289,0.2289,0.2289,0.2289,0.7337,0.7337,0.7337,0.7337,0.7337,0.4481,0.4481,0.4481,0.4481,0.4481,0.4568,0.4568,0.4568,0.4568,0.4568,0.8279,0.8279,0.8279,0.8279,0.8279,0.7587,0.7587,0.7587,0.7587,0.7587,0.6322,0.6322,0.6322,0.6322,0.6322,0.3789,0.3789,0.3789,0.3789,0.3789,0.0935,0.0935,0.0935,0.0935,0.0935,0.1913,0.1913,0.1913,0.1913,0.1913,-0.2843,-0.2843,-0.2843,-0.2843,-0.2843,0.1358,0.1358,0.1358,0.1358,0.1358,-0.2010,-0.2010,-0.2010,-0.2010,-0.2010,-0.2620,-0.2620,-0.2620,-0.2620,-0.2620,-0.2727,-0.2727,-0.2727,-0.2727,-0.2727,-0.6945,-0.6945,-0.6945,-0.6945,-0.6945,-0.6405,-0.6405,-0.6405,-0.6405,-0.6405,-0.8122,-0.8122,-0.8122,-0.8122,-0.8122,-0.4054,-0.4054,-0.4054,-0.4054,-0.4054,-0.5933,-0.5933,-0.5933,-0.5933,-0.5933,-1.2505,-1.2505,-1.2505,-1.2505,-1.2505,-1.0124,-1.0124,-1.0124,-1.0124,-1.0124,-0.8888,-0.8888,-0.8888,-0.8888,-0.8888,-0.9426,-0.9426,-0.9426,-0.9426,-0.9426,-1.3300,-1.3300,-1.3300,-1.3300,-1.3300,-1.6929}
Position Bias(exp=0, s=1): {-1.4399,-1.4399,-1.4399,-1.4399,-1.4399,-0.9680,-0.9680,-0.9680,-0.9680,-0.9680,-0.7144,-0.7144,-0.7144,-0.7144,-0.7144,-1.0826,-1.0826,-1.0826,-1.0826,-1.0826,-1.2330,-1.2330,-1.2330,-1.2330,-1.2330,-0.8715,-0.8715,-0.8715,-0.8715,-0.8715,-0.8069,-0.8069,-0.8069,-0.8069,-0.8069,-0.5140,-0.5140,-0.5140,-0.5140,-0.5140,-0.7035,-0.7035,-0.7035,-0.7035,-0.7035,-0.2756,-0.2756,-0.2756,-0.2756,-0.2756,-0.3225,-0.3225,-0.3225,-0.3225,-0.3225,0.0097,0.0097,0.0097,0.0097,0.0097,-0.2721,-0.2721,-0.2721,-0.2721,-0.2721,-0.4686,-0.4686,-0.4686,-0.4686,-0.4686,0.1451,0.1451,0.1451,0.1451,0.1451,0.0533,0.0533,0.0533,0.0533,0.0533,0.5044,0.5044,0.5044,0.5044,0.5044,0.3740,0.3740,0.3740,0.3740,0.3740,-0.1058,-0.1058,-0.1058,-0.1058,-0.1058,0.2783,0.2783,0.2783,0.2783,0.2783,0.1465,0.1465,0.1465,0.1465,0.1465,0.6355,0.6355,0.6355,0.6355,0.6355,0.5090,0.5090,0.5090,0.5090,0.5090,0.5723,0.5723,0.5723,0.5723,0.5723,0.4433,0.4433,0.4433,0.4433,0.4433,0.5614,0.5614,0.5614,0.5614,0.5614,0.7377,0.7377,0.7377,0.7377,0.7377,0.5343,0.5343,0.5343,0.5343,0.5343,0.4333,0.4333,0.4333,0.4333,0.4333,0.3045,0.3045,0.3045,0.3045,0.3045,0.2881,0.2881,0.2881,0.2881,0.2881,0.5406,0.5406,0.5406,0.5406,0.5406,0.2349,0.2349,0.2349,0.2349,0.2349,0.1508,0.1508,0.1508,0.1508,0.1508,0.4268,0.4268,0.4268,0.4268,0.4268,0.2740,0.2740,0.2740,0.2740,0.2740,0.7771,0.7771,0.7771,0.7771,0.7771,1.3253}
Binding mode 2:
---------------
Mononucleotide: {-0.1385,-1.0409,-0.7536,-1.1615,-1.6366,-0.8444,-1.9205,1.3074,-1.4299,-2.5729,0.8036,0.1052,1.2995,-1.2096,-1.9156,-1.2682,-1.1411,-0.6578,0.0979,-1.3930,-1.1538,-1.7919,-1.5984,1.4500,-0.3137,1.0345,-2.4802,-1.3346,1.2354,-1.9726,-0.7631,-1.5936,-1.4220,-0.6110,-0.8346,-0.2264,-0.5210,-0.6034,-1.3380,-0.6316}
Activity(exp=0): {-0.0000,-3.0940}
Position Bias(exp=0, s=0): {0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000}
Position Bias(exp=0, s=1): {0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000}
Binding mode 3:
---------------
Mononucleotide: {0.0002,-0.0031,-0.0030,0.0016,0.0011,-0.0023,0.0007,0.0027,0.0021,-0.0016,-0.0046,0.0022,-0.0032,-0.0032,0.0013,-0.0036,-0.0041,-0.0023,0.0019,-0.0038,0.0042,0.0021,-0.0004,-0.0030,-0.0028,-0.0014,-0.0001,0.0032,-0.0037,0.0022,-0.0016,-0.0048,0.0012,-0.0023,0.0035,0.0001,0.0034,0.0024,0.0018,0.0006}
Activity(exp=0): {0.0000,0.0000}
Position Bias(exp=0, s=0): {0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000}
Position Bias(exp=0, s=1): {0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000}
Binding mode 4:
---------------
Mononucleotide: {-0.0011,0.0038,0.0009,-0.0045,0.0004,-0.0014,0.0020,-0.0042,-0.0012,-0.0020,0.0048,0.0042,-0.0042,-0.0022,0.0035,0.0044,0.0018,0.0043,-0.0001,-0.0004,-0.0005,-0.0025,0.0021,-0.0036,0.0023,-0.0024,-0.0045,0.0025,-0.0021,0.0024,-0.0031,-0.0001,0.0008,-0.0032,0.0022,-0.0041,0.0018,-0.0033,-0.0024,0.0034}
Activity(exp=0): {0.0000,0.0000}
Position Bias(exp=0, s=0): {0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000}
Position Bias(exp=0, s=1): {0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000}
The Likelihood DID improve.
Suggested variations:
key=11;0;2, description = Expands to the left.
key=11;0;1, description = Expands to the right.
> Optimizing variation "Expands to the left." (component2-2-variation2).
>> Starting new optimization: component2-2-variation2. (2021-05-21 14:11:14.271).
>>> Packing before optimization
Packing: {"enrichmentModel":[{}],"countTable":[{"h":[46,47]}],"bindingModeInteractions":[],"bindingModes":[{},{},{"mononucleotide":[0,1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19,20,21,22,23,24,25,26,27,28,29,30,31,32,33,34,35,36,37,38,39,40,41,42,43],"activity":[[44,45]]},{},{}]}
Value and gradient before optimization:
=======================================
value = 0.6430681807204908
gradient = {0.0000,0.0000,-0.0001,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,0.0000,-0.0000,0.0000,-0.0000,-0.0000,0.0003,-0.0003}
gradient norm = 3.9416881273090175E-4
Starting Function Value: 0.6430681807204908
Iterations Fnc. Calls Likelihood Distance Moved Step Alpha Gradient Norm
1 3 0.643068012918944 0.000812537056746 2.061393571745442 0.000119763158665
2 4 0.643067982889135 0.000271564502383 1.000000000000000 0.000118307409169
3 5 0.643067657381839 0.004914517617641 1.000000000000000 0.000149799786170
4 6 0.643067397284469 0.004009233456069 1.000000000000000 0.000186202293008
5 7 0.643065727120048 0.036235755229119 1.000000000000000 0.000299723395002
6 8 0.643064919860523 0.021780604424424 1.000000000000000 0.000205635183382
7 9 0.643064181126482 0.025207543161730 1.000000000000000 0.000083702427761
8 10 0.643063813599562 0.013791802582304 1.000000000000000 0.000194844292501
9 11 0.643063275755813 0.020297307810417 1.000000000000000 0.000304752233361
10 12 0.643062508083405 0.030942306534650 1.000000000000000 0.000324430586553
11 13 0.643061011746089 0.058923086499959 1.000000000000000 0.000310414897677
12 14 0.643060023477419 0.061318068944896 1.000000000000000 0.000489334148671
13 15 0.643059537938315 0.012030141403966 1.000000000000000 0.000213897942910
14 16 0.643059402356596 0.006791061899872 1.000000000000000 0.000149718871867
15 17 0.643059174147457 0.013358700552386 1.000000000000000 0.000091289094782
16 18 0.643058827166131 0.024753049199210 1.000000000000000 0.000090792379148
17 19 0.643058535258898 0.024394474572095 1.000000000000000 0.000096174969332
18 20 0.643058249895401 0.018323639856924 1.000000000000000 0.000077778152886
19 21 0.643057788157179 0.029487766788424 1.000000000000000 0.000056276290055
20 22 0.643057433454183 0.026128960338087 1.000000000000000 0.000079934424094
21 23 0.643057180813469 0.021313416557874 1.000000000000000 0.000073894381794
22 24 0.643056940587749 0.020305691476046 1.000000000000000 0.000043812654587
23 25 0.643056658950400 0.031869183996776 1.000000000000000 0.000040101269295
24 26 0.643056493843064 0.023928069883446 1.000000000000000 0.000062424034170
25 27 0.643056307863505 0.028640673624697 1.000000000000000 0.000056212734196
26 28 0.643056041733371 0.042364887124618 1.000000000000000 0.000029660087588
27 29 0.643055930718119 0.021624168597427 1.000000000000000 0.000018778340181
28 30 0.643055865094746 0.014551902637999 1.000000000000000 0.000023689187002
29 31 0.643055769386103 0.019001204871767 1.000000000000000 0.000039389309475
30 32 0.643055484875383 0.069213980669090 1.000000000000000 0.000057774987588
31 33 0.643055234241439 0.062492203320134 1.000000000000000 0.000094709849523
32 34 0.643054938054425 0.082996770225357 1.000000000000000 0.000035216389350
33 35 0.643054843627674 0.010069652312273 1.000000000000000 0.000020109107906
34 36 0.643054767754011 0.012329462751717 1.000000000000000 0.000022326800263
35 37 0.643054610146768 0.035255110980672 1.000000000000000 0.000032167085424
36 38 0.643054389209301 0.059292108666939 1.000000000000000 0.000023263695127
37 39 0.643054204525566 0.057351128388684 1.000000000000000 0.000107302800706
38 40 0.643053898182470 0.070795414627960 1.000000000000000 0.000044754746422
39 41 0.643053759591294 0.027109733909868 1.000000000000000 0.000072583199839
40 42 0.643053603621452 0.028556379120386 1.000000000000000 0.000028006802604
41 43 0.643053510378754 0.049486629175458 1.000000000000000 0.000079560427753
42 44 0.643053427044582 0.031256226080208 1.000000000000000 0.000059787332888
43 45 0.643053340994216 0.020159839453115 1.000000000000000 0.000026642012902
44 46 0.643053201384579 0.043025636365263 1.000000000000000 0.000047632456445
45 47 0.643053088878564 0.030657556187681 1.000000000000000 0.000072067983282
46 48 0.643052980223939 0.026832901069639 1.000000000000000 0.000049122576068
47 49 0.643052905631755 0.010837799352819 1.000000000000000 0.000041508769372
48 50 0.643052822165181 0.036325365400693 1.000000000000000 0.000087283870547
49 51 0.643052771270778 0.021372691561568 1.000000000000000 0.000017579231024
50 52 0.643052749192358 0.012291632829568 1.000000000000000 0.000022410997750
51 53 0.643052715003910 0.019510100745688 1.000000000000000 0.000017730344333
52 54 0.643052668192209 0.018615550476839 1.000000000000000 0.000006135777207
53 55 0.643052648680297 0.009103196565888 1.000000000000000 0.000017300006440
54 56 0.643052642193977 0.004361819944636 1.000000000000000 0.000015287163209
55 57 0.643052622320215 0.008472159887778 1.000000000000000 0.000009512343154
56 58 0.643052581142300 0.021795032037134 1.000000000000000 0.000011953597473
57 59 0.643052565032223 0.009348432416197 1.000000000000000 0.000017288223145
58 60 0.643052551812009 0.008027110026636 1.000000000000000 0.000013933945029
59 61 0.643052536076998 0.009231608906453 1.000000000000000 0.000006763121764
60 62 0.643052509911890 0.020478181189477 1.000000000000000 0.000015920092756
61 63 0.643052491223604 0.017170468123114 1.000000000000000 0.000026802229821
62 64 0.643052471496156 0.020296477203464 1.000000000000000 0.000030114404783
63 65 0.643052434793661 0.027006144842680 1.000000000000000 0.000028047782308
64 66 0.643052358631709 0.067758680448686 1.000000000000000 0.000008575443391
65 67 0.643052330058036 0.025959069737025 1.000000000000000 0.000009608815504
66 68 0.643052309664929 0.014753303380020 1.000000000000000 0.000012427639626
67 69 0.643052271456805 0.023308788907297 1.000000000000000 0.000008103886494
68 70 0.643052178997386 0.072420735421981 1.000000000000000 0.000015639579576
69 71 0.643052084261309 0.081740245505139 1.000000000000000 0.000047470076684
70 72 0.643051963221772 0.132377246570817 1.000000000000000 0.000058017225032
71 73 0.643051839227928 0.107424997653984 1.000000000000000 0.000091735346210
72 74 0.643051716263095 0.134503069976313 1.000000000000000 0.000032568803378
73 75 0.643051675207337 0.022709048331672 1.000000000000000 0.000031512470592
74 76 0.643051568105324 0.086818895830614 1.000000000000000 0.000014181847826
75 77 0.643051497377989 0.041067138265879 1.000000000000000 0.000020207548121
76 78 0.643051424929264 0.067042530000003 1.000000000000000 0.000036102636160
77 79 0.643051379704325 0.052154388629348 1.000000000000000 0.000022558002540
78 80 0.643051328005736 0.075781659927000 1.000000000000000 0.000022099814274
79 81 0.643051308667447 0.025402897483535 1.000000000000000 0.000041528491324
80 82 0.643051287317016 0.018755235945807 1.000000000000000 0.000054430255420
81 83 0.643051262835024 0.015020372545027 1.000000000000000 0.000053488749326
82 84 0.643051215225720 0.048197419316403 1.000000000000000 0.000020972872210
83 85 0.643051207376389 0.011055253941971 1.000000000000000 0.000004675304534
84 86 0.643051206387348 0.002992618434720 1.000000000000000 0.000002207575831
85 87 0.643051206102825 0.000645124908941 1.000000000000000 0.000002326843187
86 88 0.643051205418915 0.001502242359286 1.000000000000000 0.000002732424654
87 89 0.643051203700764 0.003487160444172 1.000000000000000 0.000003316679051
88 90 0.643051201048972 0.005034106132270 1.000000000000000 0.000003253821456
89 91 0.643051198900264 0.004040002522041 1.000000000000000 0.000001827952535
90 92 0.643051198179040 0.004040002522041 1.000000000000000 0.000000749591133
Convergence criteria met.
After: gradient norm = 7.495911328199863E-7
>>> Parameters after optimization
Count Table 0:
---------------
h: {1.1002,-1.1002}
Binding mode 0:
---------------
Mononucleotide: {}
Activity(exp=0): {-0.0000,0.5943}
Binding mode 1:
---------------
Mononucleotide: {0.0149,-0.9265,-0.0604,-0.5874,-0.2850,-1.4631,0.5356,-0.3469,0.0757,-0.9475,-0.5024,-0.1863,1.0447,-1.3391,-1.0362,-0.2288,-0.6431,0.8764,-1.5467,-0.2460,0.4511,-1.5177,-0.2014,-0.2914,-0.3739,-0.6342,-0.4833,-0.0692,-0.0395,-0.7408,-0.7408,-0.0395,-0.0692,-0.4833,-0.6342,-0.3739,-0.2914,-0.2014,-1.5177,0.4511,-0.2460,-1.5467,0.8764,-0.6431,-0.2288,-1.0362,-1.3391,1.0447,-0.1863,-0.5024,-0.9475,0.0757,-0.3469,0.5356,-1.4631,-0.2850,-0.5874,-0.0604,-0.9265,0.0149}
Activity(exp=0): {0.0027,-1.6185}
Position Bias(exp=0, s=0): {-0.0903,-0.0903,-0.0903,-0.0903,-0.0903,0.4150,0.4150,0.4150,0.4150,0.4150,0.3175,0.3175,0.3175,0.3175,0.3175,0.6735,0.6735,0.6735,0.6735,0.6735,0.4540,0.4540,0.4540,0.4540,0.4540,0.4108,0.4108,0.4108,0.4108,0.4108,0.3573,0.3573,0.3573,0.3573,0.3573,0.7753,0.7753,0.7753,0.7753,0.7753,0.4989,0.4989,0.4989,0.4989,0.4989,0.6625,0.6625,0.6625,0.6625,0.6625,0.4374,0.4374,0.4374,0.4374,0.4374,0.4208,0.4208,0.4208,0.4208,0.4208,0.2289,0.2289,0.2289,0.2289,0.2289,0.7337,0.7337,0.7337,0.7337,0.7337,0.4481,0.4481,0.4481,0.4481,0.4481,0.4568,0.4568,0.4568,0.4568,0.4568,0.8279,0.8279,0.8279,0.8279,0.8279,0.7587,0.7587,0.7587,0.7587,0.7587,0.6322,0.6322,0.6322,0.6322,0.6322,0.3789,0.3789,0.3789,0.3789,0.3789,0.0935,0.0935,0.0935,0.0935,0.0935,0.1913,0.1913,0.1913,0.1913,0.1913,-0.2843,-0.2843,-0.2843,-0.2843,-0.2843,0.1358,0.1358,0.1358,0.1358,0.1358,-0.2010,-0.2010,-0.2010,-0.2010,-0.2010,-0.2620,-0.2620,-0.2620,-0.2620,-0.2620,-0.2727,-0.2727,-0.2727,-0.2727,-0.2727,-0.6945,-0.6945,-0.6945,-0.6945,-0.6945,-0.6405,-0.6405,-0.6405,-0.6405,-0.6405,-0.8122,-0.8122,-0.8122,-0.8122,-0.8122,-0.4054,-0.4054,-0.4054,-0.4054,-0.4054,-0.5933,-0.5933,-0.5933,-0.5933,-0.5933,-1.2505,-1.2505,-1.2505,-1.2505,-1.2505,-1.0124,-1.0124,-1.0124,-1.0124,-1.0124,-0.8888,-0.8888,-0.8888,-0.8888,-0.8888,-0.9426,-0.9426,-0.9426,-0.9426,-0.9426,-1.3300,-1.3300,-1.3300,-1.3300,-1.3300,-1.6929}
Position Bias(exp=0, s=1): {-1.4399,-1.4399,-1.4399,-1.4399,-1.4399,-0.9680,-0.9680,-0.9680,-0.9680,-0.9680,-0.7144,-0.7144,-0.7144,-0.7144,-0.7144,-1.0826,-1.0826,-1.0826,-1.0826,-1.0826,-1.2330,-1.2330,-1.2330,-1.2330,-1.2330,-0.8715,-0.8715,-0.8715,-0.8715,-0.8715,-0.8069,-0.8069,-0.8069,-0.8069,-0.8069,-0.5140,-0.5140,-0.5140,-0.5140,-0.5140,-0.7035,-0.7035,-0.7035,-0.7035,-0.7035,-0.2756,-0.2756,-0.2756,-0.2756,-0.2756,-0.3225,-0.3225,-0.3225,-0.3225,-0.3225,0.0097,0.0097,0.0097,0.0097,0.0097,-0.2721,-0.2721,-0.2721,-0.2721,-0.2721,-0.4686,-0.4686,-0.4686,-0.4686,-0.4686,0.1451,0.1451,0.1451,0.1451,0.1451,0.0533,0.0533,0.0533,0.0533,0.0533,0.5044,0.5044,0.5044,0.5044,0.5044,0.3740,0.3740,0.3740,0.3740,0.3740,-0.1058,-0.1058,-0.1058,-0.1058,-0.1058,0.2783,0.2783,0.2783,0.2783,0.2783,0.1465,0.1465,0.1465,0.1465,0.1465,0.6355,0.6355,0.6355,0.6355,0.6355,0.5090,0.5090,0.5090,0.5090,0.5090,0.5723,0.5723,0.5723,0.5723,0.5723,0.4433,0.4433,0.4433,0.4433,0.4433,0.5614,0.5614,0.5614,0.5614,0.5614,0.7377,0.7377,0.7377,0.7377,0.7377,0.5343,0.5343,0.5343,0.5343,0.5343,0.4333,0.4333,0.4333,0.4333,0.4333,0.3045,0.3045,0.3045,0.3045,0.3045,0.2881,0.2881,0.2881,0.2881,0.2881,0.5406,0.5406,0.5406,0.5406,0.5406,0.2349,0.2349,0.2349,0.2349,0.2349,0.1508,0.1508,0.1508,0.1508,0.1508,0.4268,0.4268,0.4268,0.4268,0.4268,0.2740,0.2740,0.2740,0.2740,0.2740,0.7771,0.7771,0.7771,0.7771,0.7771,1.3253}
Binding mode 2:
---------------
Mononucleotide: {-0.8840,-0.9369,-0.3621,-0.6974,-0.2111,-0.7123,-0.8590,-1.0992,-1.6383,-0.8749,-1.7098,1.3414,-1.5230,-2.4760,0.8874,0.2300,1.4426,-1.3868,-1.6775,-1.2599,-1.1821,-0.3932,-0.0276,-1.2787,-1.0509,-1.8387,-1.3945,1.4025,-0.3713,1.0514,-2.4507,-1.1110,1.3010,-2.0361,-0.6443,-1.5021,-1.3479,-0.4136,-1.0974,-0.0227,-0.4731,-0.9390,-0.9910,-0.4785}
Activity(exp=0): {-0.0000,-2.8816}
Position Bias(exp=0, s=0): {0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000}
Position Bias(exp=0, s=1): {0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000}
Binding mode 3:
---------------
Mononucleotide: {0.0002,-0.0031,-0.0030,0.0016,0.0011,-0.0023,0.0007,0.0027,0.0021,-0.0016,-0.0046,0.0022,-0.0032,-0.0032,0.0013,-0.0036,-0.0041,-0.0023,0.0019,-0.0038,0.0042,0.0021,-0.0004,-0.0030,-0.0028,-0.0014,-0.0001,0.0032,-0.0037,0.0022,-0.0016,-0.0048,0.0012,-0.0023,0.0035,0.0001,0.0034,0.0024,0.0018,0.0006}
Activity(exp=0): {0.0000,0.0000}
Position Bias(exp=0, s=0): {0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000}
Position Bias(exp=0, s=1): {0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000}
Binding mode 4:
---------------
Mononucleotide: {-0.0011,0.0038,0.0009,-0.0045,0.0004,-0.0014,0.0020,-0.0042,-0.0012,-0.0020,0.0048,0.0042,-0.0042,-0.0022,0.0035,0.0044,0.0018,0.0043,-0.0001,-0.0004,-0.0005,-0.0025,0.0021,-0.0036,0.0023,-0.0024,-0.0045,0.0025,-0.0021,0.0024,-0.0031,-0.0001,0.0008,-0.0032,0.0022,-0.0041,0.0018,-0.0033,-0.0024,0.0034}
Activity(exp=0): {0.0000,0.0000}
Position Bias(exp=0, s=0): {0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000}
Position Bias(exp=0, s=1): {0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000}
The Likelihood DID NOT improve. Discarding fit component2-2-variation2.
> Optimizing variation "Expands to the right." (component2-2-variation3).
>> Starting new optimization: component2-2-variation3. (2021-05-21 14:15:06.551).
>>> Packing before optimization
Packing: {"enrichmentModel":[{}],"countTable":[{"h":[46,47]}],"bindingModeInteractions":[],"bindingModes":[{},{},{"mononucleotide":[0,1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19,20,21,22,23,24,25,26,27,28,29,30,31,32,33,34,35,36,37,38,39,40,41,42,43],"activity":[[44,45]]},{},{}]}
Value and gradient before optimization:
=======================================
value = 0.6430099951155218
gradient = {-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0001,-0.0000,-0.0000,-0.0001,-0.0000,-0.0001,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0001,-0.0000,-0.0001,-0.0000,-0.0000,-0.0001,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,0.0000,-0.0001,-0.0001,0.0001,-0.0000,-0.0001,0.0003,-0.0003}
gradient norm = 4.416798802117849E-4
Starting Function Value: 0.6430099951155218
Iterations Fnc. Calls Likelihood Distance Moved Step Alpha Gradient Norm
1 3 0.643009774461187 0.000951309247129 2.153843291825873 0.000166696449919
2 4 0.643009714888406 0.000388337403248 1.000000000000000 0.000171721739914
3 5 0.643007837384650 0.019004290271853 1.000000000000000 0.000541412319987
4 6 0.643006638837870 0.013753913067215 1.000000000000000 0.000572861693615
5 7 0.643003281603522 0.069053486708049 1.000000000000000 0.001334508150704
6 8 0.643001689974332 0.003896146201120 1.000000000000000 0.000419040405843
7 9 0.643001424844845 0.004642253999365 1.000000000000000 0.000062057871551
8 10 0.643001408001527 0.000713395977129 1.000000000000000 0.000065416994555
9 11 0.643001353108499 0.001363817881267 1.000000000000000 0.000071969998008
10 12 0.643001032035603 0.009713966383635 1.000000000000000 0.000116264285364
11 13 0.643000678693353 0.013536249248106 1.000000000000000 0.000122027715899
12 14 0.643000014444446 0.024954826113601 1.000000000000000 0.000099942757359
13 15 0.642998549779477 0.073058874146268 1.000000000000000 0.000100376958684
14 16 0.642997587123012 0.064288763884138 1.000000000000000 0.000182178653799
15 17 0.642996788972993 0.050265534403092 1.000000000000000 0.000165814461083
16 18 0.642995756702566 0.053969302090558 1.000000000000000 0.000122073974074
17 19 0.642994167636422 0.097388275520177 1.000000000000000 0.000138672700018
18 20 0.642992635042403 0.106484136907811 1.000000000000000 0.000190519522694
19 21 0.642991210223522 0.084631544475374 1.000000000000000 0.000080548474388
20 22 0.642990493697891 0.081420173783092 1.000000000000000 0.000198527925371
21 23 0.642990414230331 0.041555581089113 1.000000000000000 0.000452034660559
22 24 0.642989864464046 0.020092510719393 1.000000000000000 0.000107778417265
23 25 0.642989661229527 0.009046004738946 1.000000000000000 0.000058387496649
24 26 0.642989325646568 0.018695060012231 1.000000000000000 0.000146521858689
25 27 0.642989160595366 0.015403551612021 1.000000000000000 0.000125102980085
26 28 0.642988847908299 0.023752695906346 1.000000000000000 0.000094023290693
27 29 0.642988102482237 0.073242575154042 1.000000000000000 0.000052905391323
28 30 0.642987771104784 0.037924346822053 1.000000000000000 0.000067037172274
29 31 0.642987512529076 0.026758390328615 1.000000000000000 0.000072678718284
30 32 0.642987209450047 0.026273210174954 1.000000000000000 0.000052600337682
31 33 0.642986669664258 0.049577150097323 1.000000000000000 0.000064851976662
32 34 0.642986231222089 0.048216467495515 1.000000000000000 0.000139362498173
33 35 0.642985911815224 0.036251307936700 1.000000000000000 0.000106443239161
34 36 0.642985670727891 0.048567611144529 1.000000000000000 0.000199421664792
35 37 0.642985440333435 0.020383363786263 1.000000000000000 0.000051578651368
36 38 0.642985336051216 0.015319564951606 1.000000000000000 0.000064935153390
37 39 0.642985180722843 0.024075435113783 1.000000000000000 0.000098709109648
38 40 0.642985054603347 0.024384346509423 1.000000000000000 0.000102408243456
39 41 0.642984831974002 0.035602756647480 1.000000000000000 0.000066171400602
40 42 0.642984664307416 0.029516965837739 1.000000000000000 0.000022128733720
41 43 0.642984622614628 0.006533848768729 1.000000000000000 0.000028937100158
42 44 0.642984593117094 0.007098081302844 1.000000000000000 0.000042014826520
43 45 0.642984559581042 0.005357840544799 1.000000000000000 0.000047106162250
44 46 0.642984473779324 0.015530172352929 1.000000000000000 0.000040027374752
45 47 0.642984385206836 0.023462672312881 1.000000000000000 0.000025305903847
46 48 0.642984322447606 0.024091144599746 1.000000000000000 0.000010401696599
47 49 0.642984297455169 0.012662227574760 1.000000000000000 0.000012998775572
48 50 0.642984279640275 0.006694866709901 1.000000000000000 0.000013517178241
49 51 0.642984247921677 0.010188063181833 1.000000000000000 0.000010931894863
50 52 0.642984209419067 0.015555729479194 1.000000000000000 0.000011373500144
51 53 0.642984170942790 0.020805550672765 1.000000000000000 0.000012692595764
52 54 0.642984152697745 0.012321389449565 1.000000000000000 0.000013351362762
53 55 0.642984143683290 0.007125438212830 1.000000000000000 0.000008509931166
54 56 0.642984132782175 0.006207385578922 1.000000000000000 0.000014490434808
55 57 0.642984117988514 0.009868300355728 1.000000000000000 0.000007555882366
56 58 0.642984107190496 0.007039811508616 1.000000000000000 0.000009036450231
57 59 0.642984084966792 0.014607754978465 1.000000000000000 0.000016212969832
58 60 0.642984059345909 0.020157372198277 1.000000000000000 0.000018198082477
59 61 0.642984021531998 0.024460613111895 1.000000000000000 0.000010078291885
60 62 0.642983942294172 0.062078782053050 1.000000000000000 0.000023874253832
61 63 0.642983898683589 0.035173280869535 1.000000000000000 0.000037714787822
62 64 0.642983837899304 0.047438041077823 1.000000000000000 0.000042322282995
63 65 0.642983700259705 0.111033463973740 1.000000000000000 0.000048456368237
64 66 0.642983485543669 0.165245842977155 1.000000000000000 0.000042119127411
65 67 0.642983126081961 0.287710517937902 1.000000000000000 0.000030599276526
66 68 0.642982813858237 0.286365628601529 1.000000000000000 0.000021185324809
67 69 0.642982671105466 0.117313263943242 1.000000000000000 0.000011898235125
68 70 0.642982616546110 0.015991951031213 1.000000000000000 0.000021935616080
69 71 0.642982591636862 0.013496930349068 1.000000000000000 0.000014728362856
70 72 0.642982566314388 0.011780956557926 1.000000000000000 0.000007109630601
71 73 0.642982538879476 0.035679649888992 1.000000000000000 0.000012897181092
72 74 0.642982523004966 0.032676359374091 1.000000000000000 0.000014054560847
73 75 0.642982509663889 0.017138172153201 1.000000000000000 0.000005425561786
74 76 0.642982504988704 0.005078186696854 1.000000000000000 0.000003817148671
75 77 0.642982503713120 0.001887110433063 1.000000000000000 0.000005171158075
76 78 0.642982501799813 0.002415697535570 1.000000000000000 0.000004096039153
77 79 0.642982499889373 0.003544916863378 1.000000000000000 0.000001321046828
78 80 0.642982498856948 0.003686710581113 1.000000000000000 0.000002758571297
79 81 0.642982498618700 0.000832581199413 1.000000000000000 0.000002777025400
80 82 0.642982498135216 0.001550310715181 1.000000000000000 0.000001616191788
81 83 0.642982497961510 0.001550310715181 1.000000000000000 0.000000570008097
Convergence criteria met.
After: gradient norm = 5.700080971334903E-7
>>> Parameters after optimization
Count Table 0:
---------------
h: {1.1008,-1.1008}
Binding mode 0:
---------------
Mononucleotide: {}
Activity(exp=0): {-0.0000,0.5943}
Binding mode 1:
---------------
Mononucleotide: {0.0149,-0.9265,-0.0604,-0.5874,-0.2850,-1.4631,0.5356,-0.3469,0.0757,-0.9475,-0.5024,-0.1863,1.0447,-1.3391,-1.0362,-0.2288,-0.6431,0.8764,-1.5467,-0.2460,0.4511,-1.5177,-0.2014,-0.2914,-0.3739,-0.6342,-0.4833,-0.0692,-0.0395,-0.7408,-0.7408,-0.0395,-0.0692,-0.4833,-0.6342,-0.3739,-0.2914,-0.2014,-1.5177,0.4511,-0.2460,-1.5467,0.8764,-0.6431,-0.2288,-1.0362,-1.3391,1.0447,-0.1863,-0.5024,-0.9475,0.0757,-0.3469,0.5356,-1.4631,-0.2850,-0.5874,-0.0604,-0.9265,0.0149}
Activity(exp=0): {0.0027,-1.6185}
Position Bias(exp=0, s=0): {-0.0903,-0.0903,-0.0903,-0.0903,-0.0903,0.4150,0.4150,0.4150,0.4150,0.4150,0.3175,0.3175,0.3175,0.3175,0.3175,0.6735,0.6735,0.6735,0.6735,0.6735,0.4540,0.4540,0.4540,0.4540,0.4540,0.4108,0.4108,0.4108,0.4108,0.4108,0.3573,0.3573,0.3573,0.3573,0.3573,0.7753,0.7753,0.7753,0.7753,0.7753,0.4989,0.4989,0.4989,0.4989,0.4989,0.6625,0.6625,0.6625,0.6625,0.6625,0.4374,0.4374,0.4374,0.4374,0.4374,0.4208,0.4208,0.4208,0.4208,0.4208,0.2289,0.2289,0.2289,0.2289,0.2289,0.7337,0.7337,0.7337,0.7337,0.7337,0.4481,0.4481,0.4481,0.4481,0.4481,0.4568,0.4568,0.4568,0.4568,0.4568,0.8279,0.8279,0.8279,0.8279,0.8279,0.7587,0.7587,0.7587,0.7587,0.7587,0.6322,0.6322,0.6322,0.6322,0.6322,0.3789,0.3789,0.3789,0.3789,0.3789,0.0935,0.0935,0.0935,0.0935,0.0935,0.1913,0.1913,0.1913,0.1913,0.1913,-0.2843,-0.2843,-0.2843,-0.2843,-0.2843,0.1358,0.1358,0.1358,0.1358,0.1358,-0.2010,-0.2010,-0.2010,-0.2010,-0.2010,-0.2620,-0.2620,-0.2620,-0.2620,-0.2620,-0.2727,-0.2727,-0.2727,-0.2727,-0.2727,-0.6945,-0.6945,-0.6945,-0.6945,-0.6945,-0.6405,-0.6405,-0.6405,-0.6405,-0.6405,-0.8122,-0.8122,-0.8122,-0.8122,-0.8122,-0.4054,-0.4054,-0.4054,-0.4054,-0.4054,-0.5933,-0.5933,-0.5933,-0.5933,-0.5933,-1.2505,-1.2505,-1.2505,-1.2505,-1.2505,-1.0124,-1.0124,-1.0124,-1.0124,-1.0124,-0.8888,-0.8888,-0.8888,-0.8888,-0.8888,-0.9426,-0.9426,-0.9426,-0.9426,-0.9426,-1.3300,-1.3300,-1.3300,-1.3300,-1.3300,-1.6929}
Position Bias(exp=0, s=1): {-1.4399,-1.4399,-1.4399,-1.4399,-1.4399,-0.9680,-0.9680,-0.9680,-0.9680,-0.9680,-0.7144,-0.7144,-0.7144,-0.7144,-0.7144,-1.0826,-1.0826,-1.0826,-1.0826,-1.0826,-1.2330,-1.2330,-1.2330,-1.2330,-1.2330,-0.8715,-0.8715,-0.8715,-0.8715,-0.8715,-0.8069,-0.8069,-0.8069,-0.8069,-0.8069,-0.5140,-0.5140,-0.5140,-0.5140,-0.5140,-0.7035,-0.7035,-0.7035,-0.7035,-0.7035,-0.2756,-0.2756,-0.2756,-0.2756,-0.2756,-0.3225,-0.3225,-0.3225,-0.3225,-0.3225,0.0097,0.0097,0.0097,0.0097,0.0097,-0.2721,-0.2721,-0.2721,-0.2721,-0.2721,-0.4686,-0.4686,-0.4686,-0.4686,-0.4686,0.1451,0.1451,0.1451,0.1451,0.1451,0.0533,0.0533,0.0533,0.0533,0.0533,0.5044,0.5044,0.5044,0.5044,0.5044,0.3740,0.3740,0.3740,0.3740,0.3740,-0.1058,-0.1058,-0.1058,-0.1058,-0.1058,0.2783,0.2783,0.2783,0.2783,0.2783,0.1465,0.1465,0.1465,0.1465,0.1465,0.6355,0.6355,0.6355,0.6355,0.6355,0.5090,0.5090,0.5090,0.5090,0.5090,0.5723,0.5723,0.5723,0.5723,0.5723,0.4433,0.4433,0.4433,0.4433,0.4433,0.5614,0.5614,0.5614,0.5614,0.5614,0.7377,0.7377,0.7377,0.7377,0.7377,0.5343,0.5343,0.5343,0.5343,0.5343,0.4333,0.4333,0.4333,0.4333,0.4333,0.3045,0.3045,0.3045,0.3045,0.3045,0.2881,0.2881,0.2881,0.2881,0.2881,0.5406,0.5406,0.5406,0.5406,0.5406,0.2349,0.2349,0.2349,0.2349,0.2349,0.1508,0.1508,0.1508,0.1508,0.1508,0.4268,0.4268,0.4268,0.4268,0.4268,0.2740,0.2740,0.2740,0.2740,0.2740,0.7771,0.7771,0.7771,0.7771,0.7771,1.3253}
Binding mode 2:
---------------
Mononucleotide: {0.1393,-1.2655,-0.4460,-1.3069,-1.5941,-0.7529,-1.9436,1.4116,-1.2478,-2.5012,0.8972,-0.0273,1.3682,-1.3696,-1.8368,-1.0409,-1.2507,-0.1911,-0.2145,-1.2227,-1.2404,-1.7225,-1.4013,1.4851,-0.0168,1.0074,-2.4659,-1.4038,1.2580,-1.8192,-0.7776,-1.5403,-1.1060,-0.7650,-0.6228,-0.3853,-0.4856,-0.4942,-1.2543,-0.6449,-0.7522,-0.6169,-0.6894,-0.8193}
Activity(exp=0): {-0.0000,-2.8790}
Position Bias(exp=0, s=0): {0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000}
Position Bias(exp=0, s=1): {0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000}
Binding mode 3:
---------------
Mononucleotide: {0.0002,-0.0031,-0.0030,0.0016,0.0011,-0.0023,0.0007,0.0027,0.0021,-0.0016,-0.0046,0.0022,-0.0032,-0.0032,0.0013,-0.0036,-0.0041,-0.0023,0.0019,-0.0038,0.0042,0.0021,-0.0004,-0.0030,-0.0028,-0.0014,-0.0001,0.0032,-0.0037,0.0022,-0.0016,-0.0048,0.0012,-0.0023,0.0035,0.0001,0.0034,0.0024,0.0018,0.0006}
Activity(exp=0): {0.0000,0.0000}
Position Bias(exp=0, s=0): {0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000}
Position Bias(exp=0, s=1): {0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000}
Binding mode 4:
---------------
Mononucleotide: {-0.0011,0.0038,0.0009,-0.0045,0.0004,-0.0014,0.0020,-0.0042,-0.0012,-0.0020,0.0048,0.0042,-0.0042,-0.0022,0.0035,0.0044,0.0018,0.0043,-0.0001,-0.0004,-0.0005,-0.0025,0.0021,-0.0036,0.0023,-0.0024,-0.0045,0.0025,-0.0021,0.0024,-0.0031,-0.0001,0.0008,-0.0032,0.0022,-0.0041,0.0018,-0.0033,-0.0024,0.0034}
Activity(exp=0): {0.0000,0.0000}
Position Bias(exp=0, s=0): {0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000}
Position Bias(exp=0, s=1): {0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000}
The Likelihood DID NOT improve. Discarding fit component2-2-variation3.
> No varitions possible for Binding mode 2.
> Unfreezing component (component2-3-f0).
>> Starting new optimization: component2-3-f0. (2021-05-21 14:18:37.015).
>>> Packing before optimization
Packing: {"enrichmentModel":[{}],"countTable":[{"h":[120,121]}],"bindingModeInteractions":[],"bindingModes":[{},{},{"mononucleotide":[0,1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19,20,21,22,23,24,25,26,27,28,29,30,31,32,33,34,35,36,37,38,39],"activity":[[118,119]],"positionBias":[[[40,40,40,40,40,41,41,41,41,41,42,42,42,42,42,43,43,43,43,43,44,44,44,44,44,45,45,45,45,45,46,46,46,46,46,47,47,47,47,47,48,48,48,48,48,49,49,49,49,49,50,50,50,50,50,51,51,51,51,51,52,52,52,52,52,53,53,53,53,53,54,54,54,54,54,55,55,55,55,55,56,56,56,56,56,57,57,57,57,57,58,58,58,58,58,59,59,59,59,59,60,60,60,60,60,61,61,61,61,61,62,62,62,62,62,63,63,63,63,63,64,64,64,64,64,65,65,65,65,65,66,66,66,66,66,67,67,67,67,67,68,68,68,68,68,69,69,69,69,69,70,70,70,70,70,71,71,71,71,71,72,72,72,72,72,73,73,73,73,73,74,74,74,74,74,75,75,75,75,75,76,76,76,76,76,77,77,77,77,77,78],[79,79,79,79,79,80,80,80,80,80,81,81,81,81,81,82,82,82,82,82,83,83,83,83,83,84,84,84,84,84,85,85,85,85,85,86,86,86,86,86,87,87,87,87,87,88,88,88,88,88,89,89,89,89,89,90,90,90,90,90,91,91,91,91,91,92,92,92,92,92,93,93,93,93,93,94,94,94,94,94,95,95,95,95,95,96,96,96,96,96,97,97,97,97,97,98,98,98,98,98,99,99,99,99,99,100,100,100,100,100,101,101,101,101,101,102,102,102,102,102,103,103,103,103,103,104,104,104,104,104,105,105,105,105,105,106,106,106,106,106,107,107,107,107,107,108,108,108,108,108,109,109,109,109,109,110,110,110,110,110,111,111,111,111,111,112,112,112,112,112,113,113,113,113,113,114,114,114,114,114,115,115,115,115,115,116,116,116,116,116,117]]]},{},{}]}
Value and gradient before optimization:
=======================================
value = 0.6424389278993697
gradient = {-0.0000,-0.0000,0.0000,0.0000,-0.0000,-0.0000,0.0000,-0.0000,0.0000,-0.0000,-0.0000,0.0000,-0.0000,-0.0000,-0.0000,0.0000,-0.0000,-0.0000,0.0000,-0.0000,0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,0.0000,-0.0000,-0.0000,-0.0000,0.0000,-0.0000,-0.0000,0.0000,0.0000,-0.0000,0.0000,-0.0000,-0.0000,-0.0000,-0.0000,0.0000,0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0001,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0001,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0001,0.0000,0.0001,0.0001,0.0001,0.0001,0.0001,0.0000,0.0001,0.0001,0.0001,0.0001,0.0001,0.0000,0.0001,0.0001,0.0000,-0.0000,0.0000,-0.0000,0.0000,0.0000,-0.0000,0.0000,-0.0000,-0.0000,0.0000,-0.0000,-0.0000,-0.0000,-0.0001,-0.0001,-0.0000,-0.0000,-0.0001,-0.0000,-0.0000,-0.0000,0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,0.0000,-0.0000,0.0000,-0.0000,-0.0000,0.0000,-0.0000}
gradient norm = 3.246866056996525E-4
Starting Function Value: 0.6424389278993697
Iterations Fnc. Calls Likelihood Distance Moved Step Alpha Gradient Norm
1 2 0.642176519996564 1.000000000000000 3079.8929874090280 0.000705037279569
2 4 0.642170239207997 0.045636406912038 0.010879156535837 0.001841792825157
3 5 0.641998176992845 1.631717865722503 1.000000000000000 0.001100986219646
4 6 0.641992435118924 0.193266617421201 1.000000000000000 0.000540351751713
5 7 0.641989805804100 0.033232475591702 1.000000000000000 0.000192116623676
6 8 0.641989015318678 0.012780005489548 1.000000000000000 0.000194021525155
7 9 0.641986174208583 0.040767299515313 1.000000000000000 0.000340993560282
8 10 0.641984176737925 0.026742854936673 1.000000000000000 0.000299487720069
9 11 0.641981708620637 0.035165541024658 1.000000000000000 0.000151098660329
10 12 0.641979397367703 0.054236197971260 1.000000000000000 0.000162889983517
11 13 0.641978401425926 0.030156897273661 1.000000000000000 0.000208879369980
12 14 0.641976533312094 0.054072159145451 1.000000000000000 0.000181546061229
13 15 0.641972546944585 0.123118017156438 1.000000000000000 0.000144242998535
14 16 0.641967528619318 0.180350460647113 1.000000000000000 0.000126437803038
15 17 0.641963467087293 0.179526328863384 1.000000000000000 0.000149167009357
16 18 0.641961623310914 0.096002409408899 1.000000000000000 0.000093528140011
17 19 0.641960444154112 0.047785825407313 1.000000000000000 0.000087370015671
18 20 0.641957972525095 0.122839730356028 1.000000000000000 0.000172578365733
19 21 0.641956856723091 0.083821647305208 1.000000000000000 0.000098822692953
20 22 0.641956338174282 0.040545766393256 1.000000000000000 0.000052691721462
21 23 0.641955469218304 0.079630106620819 1.000000000000000 0.000077239314154
22 24 0.641954669381616 0.069455090624397 1.000000000000000 0.000111266451499
23 25 0.641953167954799 0.125159081215997 1.000000000000000 0.000095614791377
24 26 0.641950778275912 0.190394036002896 1.000000000000000 0.000069947562295
25 27 0.641949060877298 0.140446572404154 1.000000000000000 0.000055687801209
26 28 0.641948166995805 0.047878799696505 1.000000000000000 0.000064020019851
27 29 0.641947102800007 0.070632144560964 1.000000000000000 0.000076980597677
28 30 0.641945532578834 0.120152081465198 1.000000000000000 0.000267151822455
29 31 0.641943148714033 0.231108916267179 1.000000000000000 0.000165377833186
30 32 0.641941991594207 0.060300332674164 1.000000000000000 0.000147407084864
31 33 0.641938367377783 0.219431059457145 1.000000000000000 0.000173071148504
32 34 0.641937439740375 0.146309965540618 1.000000000000000 0.000089084377728
33 35 0.641936678648021 0.104638940756434 1.000000000000000 0.000208178289225
34 36 0.641936233200555 0.032447773869899 1.000000000000000 0.000062253866060
35 37 0.641935864748355 0.015908040990133 1.000000000000000 0.000134372188734
36 38 0.641935547559622 0.018685757931440 1.000000000000000 0.000193353182424
37 39 0.641934854013446 0.054102969277945 1.000000000000000 0.000219854431832
38 40 0.641933263787906 0.105755684626984 1.000000000000000 0.000221468091886
39 41 0.641929918656504 0.230980613915670 1.000000000000000 0.000202231382262
40 42 0.641926992488773 0.265852500884841 1.000000000000000 0.000120160320176
41 43 0.641925393402099 0.103199218749727 1.000000000000000 0.000066761849532
42 44 0.641924478328072 0.095523786543740 1.000000000000000 0.000044166570713
43 45 0.641923723048039 0.056241202546222 1.000000000000000 0.000109567277887
44 46 0.641922397491034 0.134799585946298 1.000000000000000 0.000179761933408
45 47 0.641922006630376 0.037113961859215 1.000000000000000 0.000129831360266
46 48 0.641921678775532 0.051615416891950 1.000000000000000 0.000070869623138
47 49 0.641921473461734 0.036355911578905 1.000000000000000 0.000050251592632
48 50 0.641921371719262 0.022825590011886 1.000000000000000 0.000083280348744
49 51 0.641921244402161 0.019493131114953 1.000000000000000 0.000096098765277
50 52 0.641920986499240 0.032915227934834 1.000000000000000 0.000074796189749
51 53 0.641920720087857 0.034833006303250 1.000000000000000 0.000036785838694
52 54 0.641920564495525 0.022430752481528 1.000000000000000 0.000034112322207
53 55 0.641920463735432 0.014404060698832 1.000000000000000 0.000050968674920
54 56 0.641920327381242 0.017091273366347 1.000000000000000 0.000062676790485
55 57 0.641920069500795 0.036810949131409 1.000000000000000 0.000067109323257
56 58 0.641919696201040 0.061080693650854 1.000000000000000 0.000079577317000
57 59 0.641919417370209 0.059462850344954 1.000000000000000 0.000038832867913
58 60 0.641919309125411 0.031033665816644 1.000000000000000 0.000015035164011
59 61 0.641919255234856 0.015647561717442 1.000000000000000 0.000031567500701
60 62 0.641919198486640 0.014590604542163 1.000000000000000 0.000046613869833
61 63 0.641919118664530 0.018958017406633 1.000000000000000 0.000054956842222
62 64 0.641918990912641 0.030591964132357 1.000000000000000 0.000052002374828
63 65 0.641918814369147 0.048061250779390 1.000000000000000 0.000032639530461
64 66 0.641918715793559 0.031996203288568 1.000000000000000 0.000010576793942
65 67 0.641918674543978 0.013811281951404 1.000000000000000 0.000022255373082
66 68 0.641918639382350 0.009493650297949 1.000000000000000 0.000034202770025
67 69 0.641918584570524 0.016828081724882 1.000000000000000 0.000033231005729
68 70 0.641918493289974 0.035560793150926 1.000000000000000 0.000033397813360
69 71 0.641918412242225 0.038730882756332 1.000000000000000 0.000021673195218
70 72 0.641918374762507 0.024321043942316 1.000000000000000 0.000026296060486
71 73 0.641918322843193 0.024710535692687 1.000000000000000 0.000033512211790
72 74 0.641918267401980 0.035713737983336 1.000000000000000 0.000017860547939
73 75 0.641918247614575 0.014489677095469 1.000000000000000 0.000019953655600
74 76 0.641918231449721 0.008241647124911 1.000000000000000 0.000006591020770
75 77 0.641918216155075 0.010261386980303 1.000000000000000 0.000016624224051
76 78 0.641918203652962 0.007390657412337 1.000000000000000 0.000028911171811
77 79 0.641918177224012 0.018593011231096 1.000000000000000 0.000041171764212
78 80 0.641918151694273 0.021370535938786 1.000000000000000 0.000037275358118
79 81 0.641918113824499 0.031390861048142 1.000000000000000 0.000014936596311
80 82 0.641918093684819 0.022820935788693 1.000000000000000 0.000014810762952
81 83 0.641918087915723 0.004795802512481 1.000000000000000 0.000022315687033
82 84 0.641918080884266 0.003941373071298 1.000000000000000 0.000023335381116
83 85 0.641918055611962 0.016378369848490 1.000000000000000 0.000019389399749
84 86 0.641918018139294 0.035164112062392 1.000000000000000 0.000006076642756
85 87 0.641918007581388 0.014932251374941 1.000000000000000 0.000011685939521
86 88 0.641918001372909 0.007333315086085 1.000000000000000 0.000013495929549
87 89 0.641917990641051 0.009168267352456 1.000000000000000 0.000008484590841
88 90 0.641917977612616 0.013710553899959 1.000000000000000 0.000007156194148
89 91 0.641917971185450 0.007850234471754 1.000000000000000 0.000013587437381
90 92 0.641917965519182 0.007352455571776 1.000000000000000 0.000016213482940
91 93 0.641917959971419 0.006514070288109 1.000000000000000 0.000011602669965
92 94 0.641917955021036 0.007659457312510 1.000000000000000 0.000003292077520
93 95 0.641917953070162 0.003853303028013 1.000000000000000 0.000008421557218
94 96 0.641917950918101 0.003944023046063 1.000000000000000 0.000014632918097
95 97 0.641917947233864 0.005898794400185 1.000000000000000 0.000020685713380
96 98 0.641917940582763 0.010323748023390 1.000000000000000 0.000024393018332
97 99 0.641917931936456 0.014080104911224 1.000000000000000 0.000019464840501
98 100 0.641917925968623 0.011064380718951 1.000000000000000 0.000006967275575
99 101 0.641917924220485 0.004049055529844 1.000000000000000 0.000003881623026
100 102 0.641917923712052 0.001507709992433 1.000000000000000 0.000006708449996
101 103 0.641917922888844 0.001625356360399 1.000000000000000 0.000009412055081
102 104 0.641917921078628 0.002052789841447 1.000000000000000 0.000012108991403
103 105 0.641917918439490 0.004756641460388 1.000000000000000 0.000008591838098
104 107 0.641917916851252 0.005037389144993 0.392119662228105 0.000013705323072
105 108 0.641917915322873 0.004389157572888 1.000000000000000 0.000003955216297
106 109 0.641917914753555 0.003753090440301 1.000000000000000 0.000002558782571
107 110 0.641917914637273 0.000720480878756 1.000000000000000 0.000002545991062
108 111 0.641917913899766 0.002194472106338 1.000000000000000 0.000002268987781
109 112 0.641917912813018 0.003561964116628 1.000000000000000 0.000001976853431
110 114 0.641917912170976 0.002884325216247 0.484080964651684 0.000010514695483
111 115 0.641917911003674 0.001923822004283 1.000000000000000 0.000006929152387
112 116 0.641917908734581 0.005066825375266 1.000000000000000 0.000003309296111
113 117 0.641917907917664 0.002785502053540 1.000000000000000 0.000003675152640
114 118 0.641917907518960 0.002127178190974 1.000000000000000 0.000003528331331
115 119 0.641917907352326 0.001005912371174 1.000000000000000 0.000001099972642
116 120 0.641917907303144 0.001005912371174 1.000000000000000 0.000000861681686
Convergence criteria met.
After: gradient norm = 8.616816863070591E-7
>>> Parameters after optimization
Count Table 0:
---------------
h: {1.1067,-1.1067}
Binding mode 0:
---------------
Mononucleotide: {}
Activity(exp=0): {-0.0000,0.5943}
Binding mode 1:
---------------
Mononucleotide: {0.0149,-0.9265,-0.0604,-0.5874,-0.2850,-1.4631,0.5356,-0.3469,0.0757,-0.9475,-0.5024,-0.1863,1.0447,-1.3391,-1.0362,-0.2288,-0.6431,0.8764,-1.5467,-0.2460,0.4511,-1.5177,-0.2014,-0.2914,-0.3739,-0.6342,-0.4833,-0.0692,-0.0395,-0.7408,-0.7408,-0.0395,-0.0692,-0.4833,-0.6342,-0.3739,-0.2914,-0.2014,-1.5177,0.4511,-0.2460,-1.5467,0.8764,-0.6431,-0.2288,-1.0362,-1.3391,1.0447,-0.1863,-0.5024,-0.9475,0.0757,-0.3469,0.5356,-1.4631,-0.2850,-0.5874,-0.0604,-0.9265,0.0149}
Activity(exp=0): {0.0027,-1.6185}
Position Bias(exp=0, s=0): {-0.0903,-0.0903,-0.0903,-0.0903,-0.0903,0.4150,0.4150,0.4150,0.4150,0.4150,0.3175,0.3175,0.3175,0.3175,0.3175,0.6735,0.6735,0.6735,0.6735,0.6735,0.4540,0.4540,0.4540,0.4540,0.4540,0.4108,0.4108,0.4108,0.4108,0.4108,0.3573,0.3573,0.3573,0.3573,0.3573,0.7753,0.7753,0.7753,0.7753,0.7753,0.4989,0.4989,0.4989,0.4989,0.4989,0.6625,0.6625,0.6625,0.6625,0.6625,0.4374,0.4374,0.4374,0.4374,0.4374,0.4208,0.4208,0.4208,0.4208,0.4208,0.2289,0.2289,0.2289,0.2289,0.2289,0.7337,0.7337,0.7337,0.7337,0.7337,0.4481,0.4481,0.4481,0.4481,0.4481,0.4568,0.4568,0.4568,0.4568,0.4568,0.8279,0.8279,0.8279,0.8279,0.8279,0.7587,0.7587,0.7587,0.7587,0.7587,0.6322,0.6322,0.6322,0.6322,0.6322,0.3789,0.3789,0.3789,0.3789,0.3789,0.0935,0.0935,0.0935,0.0935,0.0935,0.1913,0.1913,0.1913,0.1913,0.1913,-0.2843,-0.2843,-0.2843,-0.2843,-0.2843,0.1358,0.1358,0.1358,0.1358,0.1358,-0.2010,-0.2010,-0.2010,-0.2010,-0.2010,-0.2620,-0.2620,-0.2620,-0.2620,-0.2620,-0.2727,-0.2727,-0.2727,-0.2727,-0.2727,-0.6945,-0.6945,-0.6945,-0.6945,-0.6945,-0.6405,-0.6405,-0.6405,-0.6405,-0.6405,-0.8122,-0.8122,-0.8122,-0.8122,-0.8122,-0.4054,-0.4054,-0.4054,-0.4054,-0.4054,-0.5933,-0.5933,-0.5933,-0.5933,-0.5933,-1.2505,-1.2505,-1.2505,-1.2505,-1.2505,-1.0124,-1.0124,-1.0124,-1.0124,-1.0124,-0.8888,-0.8888,-0.8888,-0.8888,-0.8888,-0.9426,-0.9426,-0.9426,-0.9426,-0.9426,-1.3300,-1.3300,-1.3300,-1.3300,-1.3300,-1.6929}
Position Bias(exp=0, s=1): {-1.4399,-1.4399,-1.4399,-1.4399,-1.4399,-0.9680,-0.9680,-0.9680,-0.9680,-0.9680,-0.7144,-0.7144,-0.7144,-0.7144,-0.7144,-1.0826,-1.0826,-1.0826,-1.0826,-1.0826,-1.2330,-1.2330,-1.2330,-1.2330,-1.2330,-0.8715,-0.8715,-0.8715,-0.8715,-0.8715,-0.8069,-0.8069,-0.8069,-0.8069,-0.8069,-0.5140,-0.5140,-0.5140,-0.5140,-0.5140,-0.7035,-0.7035,-0.7035,-0.7035,-0.7035,-0.2756,-0.2756,-0.2756,-0.2756,-0.2756,-0.3225,-0.3225,-0.3225,-0.3225,-0.3225,0.0097,0.0097,0.0097,0.0097,0.0097,-0.2721,-0.2721,-0.2721,-0.2721,-0.2721,-0.4686,-0.4686,-0.4686,-0.4686,-0.4686,0.1451,0.1451,0.1451,0.1451,0.1451,0.0533,0.0533,0.0533,0.0533,0.0533,0.5044,0.5044,0.5044,0.5044,0.5044,0.3740,0.3740,0.3740,0.3740,0.3740,-0.1058,-0.1058,-0.1058,-0.1058,-0.1058,0.2783,0.2783,0.2783,0.2783,0.2783,0.1465,0.1465,0.1465,0.1465,0.1465,0.6355,0.6355,0.6355,0.6355,0.6355,0.5090,0.5090,0.5090,0.5090,0.5090,0.5723,0.5723,0.5723,0.5723,0.5723,0.4433,0.4433,0.4433,0.4433,0.4433,0.5614,0.5614,0.5614,0.5614,0.5614,0.7377,0.7377,0.7377,0.7377,0.7377,0.5343,0.5343,0.5343,0.5343,0.5343,0.4333,0.4333,0.4333,0.4333,0.4333,0.3045,0.3045,0.3045,0.3045,0.3045,0.2881,0.2881,0.2881,0.2881,0.2881,0.5406,0.5406,0.5406,0.5406,0.5406,0.2349,0.2349,0.2349,0.2349,0.2349,0.1508,0.1508,0.1508,0.1508,0.1508,0.4268,0.4268,0.4268,0.4268,0.4268,0.2740,0.2740,0.2740,0.2740,0.2740,0.7771,0.7771,0.7771,0.7771,0.7771,1.3253}
Binding mode 2:
---------------
Mononucleotide: {0.1469,-1.3902,-0.5647,-1.2626,-1.6522,-0.8703,-1.9766,1.4287,-1.3613,-2.5694,0.7922,0.0680,1.2710,-1.4085,-1.8680,-1.0650,-1.3016,-0.2387,-0.2940,-1.2362,-1.3355,-1.7768,-1.3980,1.4398,-0.1634,0.9700,-2.5687,-1.3084,1.1227,-1.8582,-0.8539,-1.4810,-1.1258,-0.7815,-0.6399,-0.5232,-0.5373,-0.5573,-1.2975,-0.6783}
Activity(exp=0): {-0.0000,-3.0705}
Position Bias(exp=0, s=0): {0.7331,0.7331,0.7331,0.7331,0.7331,0.4044,0.4044,0.4044,0.4044,0.4044,-0.0997,-0.0997,-0.0997,-0.0997,-0.0997,-0.1766,-0.1766,-0.1766,-0.1766,-0.1766,-0.0141,-0.0141,-0.0141,-0.0141,-0.0141,0.0295,0.0295,0.0295,0.0295,0.0295,0.2641,0.2641,0.2641,0.2641,0.2641,-0.1623,-0.1623,-0.1623,-0.1623,-0.1623,0.2506,0.2506,0.2506,0.2506,0.2506,0.4660,0.4660,0.4660,0.4660,0.4660,0.2738,0.2738,0.2738,0.2738,0.2738,0.5175,0.5175,0.5175,0.5175,0.5175,0.4910,0.4910,0.4910,0.4910,0.4910,0.2284,0.2284,0.2284,0.2284,0.2284,0.1871,0.1871,0.1871,0.1871,0.1871,0.2609,0.2609,0.2609,0.2609,0.2609,-0.3491,-0.3491,-0.3491,-0.3491,-0.3491,0.2947,0.2947,0.2947,0.2947,0.2947,0.0409,0.0409,0.0409,0.0409,0.0409,0.0631,0.0631,0.0631,0.0631,0.0631,-0.0180,-0.0180,-0.0180,-0.0180,-0.0180,0.1735,0.1735,0.1735,0.1735,0.1735,0.3441,0.3441,0.3441,0.3441,0.3441,0.2672,0.2672,0.2672,0.2672,0.2672,0.3332,0.3332,0.3332,0.3332,0.3332,0.1373,0.1373,0.1373,0.1373,0.1373,-0.1750,-0.1750,-0.1750,-0.1750,-0.1750,0.0934,0.0934,0.0934,0.0934,0.0934,-0.3424,-0.3424,-0.3424,-0.3424,-0.3424,-0.2249,-0.2249,-0.2249,-0.2249,-0.2249,-0.4223,-0.4223,-0.4223,-0.4223,-0.4223,-0.4237,-0.4237,-0.4237,-0.4237,-0.4237,0.1359,0.1359,0.1359,0.1359,0.1359,-0.7776,-0.7776,-0.7776,-0.7776,-0.7776,-0.6493,-0.6493,-0.6493,-0.6493,-0.6493,-0.4622,-0.4622,-0.4622,-0.4622,-0.4622,-0.8187,-0.8187,-0.8187,-0.8187,-0.8187,-0.8368,-0.8368,-0.8368,-0.8368,-0.8368,-0.3664}
Position Bias(exp=0, s=1): {-1.0007,-1.0007,-1.0007,-1.0007,-1.0007,-0.3313,-0.3313,-0.3313,-0.3313,-0.3313,-0.6309,-0.6309,-0.6309,-0.6309,-0.6309,-0.7875,-0.7875,-0.7875,-0.7875,-0.7875,-0.4007,-0.4007,-0.4007,-0.4007,-0.4007,-0.3437,-0.3437,-0.3437,-0.3437,-0.3437,-0.7121,-0.7121,-0.7121,-0.7121,-0.7121,-0.7648,-0.7648,-0.7648,-0.7648,-0.7648,0.1328,0.1328,0.1328,0.1328,0.1328,0.2700,0.2700,0.2700,0.2700,0.2700,-0.3749,-0.3749,-0.3749,-0.3749,-0.3749,0.2759,0.2759,0.2759,0.2759,0.2759,-0.4409,-0.4409,-0.4409,-0.4409,-0.4409,-0.2991,-0.2991,-0.2991,-0.2991,-0.2991,0.2482,0.2482,0.2482,0.2482,0.2482,-0.3609,-0.3609,-0.3609,-0.3609,-0.3609,0.1657,0.1657,0.1657,0.1657,0.1657,0.3398,0.3398,0.3398,0.3398,0.3398,0.0337,0.0337,0.0337,0.0337,0.0337,0.3316,0.3316,0.3316,0.3316,0.3316,0.5173,0.5173,0.5173,0.5173,0.5173,0.5376,0.5376,0.5376,0.5376,0.5376,0.5662,0.5662,0.5662,0.5662,0.5662,0.6402,0.6402,0.6402,0.6402,0.6402,0.0409,0.0409,0.0409,0.0409,0.0409,0.0075,0.0075,0.0075,0.0075,0.0075,0.3289,0.3289,0.3289,0.3289,0.3289,0.2334,0.2334,0.2334,0.2334,0.2334,0.4920,0.4920,0.4920,0.4920,0.4920,0.3658,0.3658,0.3658,0.3658,0.3658,0.2050,0.2050,0.2050,0.2050,0.2050,0.2610,0.2610,0.2610,0.2610,0.2610,0.3442,0.3442,0.3442,0.3442,0.3442,0.0853,0.0853,0.0853,0.0853,0.0853,0.4507,0.4507,0.4507,0.4507,0.4507,0.2552,0.2552,0.2552,0.2552,0.2552,-0.4270,-0.4270,-0.4270,-0.4270,-0.4270,-0.4704,-0.4704,-0.4704,-0.4704,-0.4704,-1.4156}
Binding mode 3:
---------------
Mononucleotide: {0.0002,-0.0031,-0.0030,0.0016,0.0011,-0.0023,0.0007,0.0027,0.0021,-0.0016,-0.0046,0.0022,-0.0032,-0.0032,0.0013,-0.0036,-0.0041,-0.0023,0.0019,-0.0038,0.0042,0.0021,-0.0004,-0.0030,-0.0028,-0.0014,-0.0001,0.0032,-0.0037,0.0022,-0.0016,-0.0048,0.0012,-0.0023,0.0035,0.0001,0.0034,0.0024,0.0018,0.0006}
Activity(exp=0): {0.0000,0.0000}
Position Bias(exp=0, s=0): {0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000}
Position Bias(exp=0, s=1): {0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000}
Binding mode 4:
---------------
Mononucleotide: {-0.0011,0.0038,0.0009,-0.0045,0.0004,-0.0014,0.0020,-0.0042,-0.0012,-0.0020,0.0048,0.0042,-0.0042,-0.0022,0.0035,0.0044,0.0018,0.0043,-0.0001,-0.0004,-0.0005,-0.0025,0.0021,-0.0036,0.0023,-0.0024,-0.0045,0.0025,-0.0021,0.0024,-0.0031,-0.0001,0.0008,-0.0032,0.0022,-0.0041,0.0018,-0.0033,-0.0024,0.0034}
Activity(exp=0): {0.0000,0.0000}
Position Bias(exp=0, s=0): {0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000}
Position Bias(exp=0, s=1): {0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000}
> Optimizing the full model (component2-4-all).
>> Starting new optimization: component2-4-all. (2021-05-21 14:23:46.049).
>>> Packing before optimization
Packing: {"enrichmentModel":[{}],"countTable":[{"h":[230,231]}],"bindingModeInteractions":[],"bindingModes":[{"mononucleotide":[],"activity":[[0,1]]},{"mononucleotide":[3,2,5,4,7,6,9,8,11,10,13,12,15,14,17,16,19,18,21,20,23,22,25,24,27,26,29,28,31,30,30,31,28,29,26,27,24,25,22,23,20,21,18,19,16,17,14,15,12,13,10,11,8,9,6,7,4,5,2,3],"activity":[[108,109]],"positionBias":[[[32,32,32,32,32,33,33,33,33,33,34,34,34,34,34,35,35,35,35,35,36,36,36,36,36,37,37,37,37,37,38,38,38,38,38,39,39,39,39,39,40,40,40,40,40,41,41,41,41,41,42,42,42,42,42,43,43,43,43,43,44,44,44,44,44,45,45,45,45,45,46,46,46,46,46,47,47,47,47,47,48,48,48,48,48,49,49,49,49,49,50,50,50,50,50,51,51,51,51,51,52,52,52,52,52,53,53,53,53,53,54,54,54,54,54,55,55,55,55,55,56,56,56,56,56,57,57,57,57,57,58,58,58,58,58,59,59,59,59,59,60,60,60,60,60,61,61,61,61,61,62,62,62,62,62,63,63,63,63,63,64,64,64,64,64,65,65,65,65,65,66,66,66,66,66,67,67,67,67,67,68,68,68,68,68,69],[70,70,70,70,70,71,71,71,71,71,72,72,72,72,72,73,73,73,73,73,74,74,74,74,74,75,75,75,75,75,76,76,76,76,76,77,77,77,77,77,78,78,78,78,78,79,79,79,79,79,80,80,80,80,80,81,81,81,81,81,82,82,82,82,82,83,83,83,83,83,84,84,84,84,84,85,85,85,85,85,86,86,86,86,86,87,87,87,87,87,88,88,88,88,88,89,89,89,89,89,90,90,90,90,90,91,91,91,91,91,92,92,92,92,92,93,93,93,93,93,94,94,94,94,94,95,95,95,95,95,96,96,96,96,96,97,97,97,97,97,98,98,98,98,98,99,99,99,99,99,100,100,100,100,100,101,101,101,101,101,102,102,102,102,102,103,103,103,103,103,104,104,104,104,104,105,105,105,105,105,106,106,106,106,106,107]]]},{"mononucleotide":[110,111,112,113,114,115,116,117,118,119,120,121,122,123,124,125,126,127,128,129,130,131,132,133,134,135,136,137,138,139,140,141,142,143,144,145,146,147,148,149],"activity":[[228,229]],"positionBias":[[[150,150,150,150,150,151,151,151,151,151,152,152,152,152,152,153,153,153,153,153,154,154,154,154,154,155,155,155,155,155,156,156,156,156,156,157,157,157,157,157,158,158,158,158,158,159,159,159,159,159,160,160,160,160,160,161,161,161,161,161,162,162,162,162,162,163,163,163,163,163,164,164,164,164,164,165,165,165,165,165,166,166,166,166,166,167,167,167,167,167,168,168,168,168,168,169,169,169,169,169,170,170,170,170,170,171,171,171,171,171,172,172,172,172,172,173,173,173,173,173,174,174,174,174,174,175,175,175,175,175,176,176,176,176,176,177,177,177,177,177,178,178,178,178,178,179,179,179,179,179,180,180,180,180,180,181,181,181,181,181,182,182,182,182,182,183,183,183,183,183,184,184,184,184,184,185,185,185,185,185,186,186,186,186,186,187,187,187,187,187,188],[189,189,189,189,189,190,190,190,190,190,191,191,191,191,191,192,192,192,192,192,193,193,193,193,193,194,194,194,194,194,195,195,195,195,195,196,196,196,196,196,197,197,197,197,197,198,198,198,198,198,199,199,199,199,199,200,200,200,200,200,201,201,201,201,201,202,202,202,202,202,203,203,203,203,203,204,204,204,204,204,205,205,205,205,205,206,206,206,206,206,207,207,207,207,207,208,208,208,208,208,209,209,209,209,209,210,210,210,210,210,211,211,211,211,211,212,212,212,212,212,213,213,213,213,213,214,214,214,214,214,215,215,215,215,215,216,216,216,216,216,217,217,217,217,217,218,218,218,218,218,219,219,219,219,219,220,220,220,220,220,221,221,221,221,221,222,222,222,222,222,223,223,223,223,223,224,224,224,224,224,225,225,225,225,225,226,226,226,226,226,227]]]},{},{}]}
Value and gradient before optimization:
=======================================
value = 0.6513997049785464
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gradient norm = 0.004105389291215381
Starting Function Value: 0.6513997049785464
Iterations Fnc. Calls Likelihood Distance Moved Step Alpha Gradient Norm
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219 233 0.648812482726166 0.005954313002537 1.000000000000000 0.000004057128260
220 234 0.648812480590103 0.005911368602957 1.000000000000000 0.000005412555367
221 235 0.648812478661510 0.002496835435771 1.000000000000000 0.000003793317665
222 236 0.648812476442275 0.006065122654488 1.000000000000000 0.000006260943551
223 238 0.648812475931706 0.002065476513508 0.224779251510590 0.000004224437565
224 239 0.648812475369020 0.003092842246003 1.000000000000000 0.000002375244683
225 240 0.648812474795546 0.003572772188914 1.000000000000000 0.000002179244896
226 241 0.648812474253121 0.001588483325833 1.000000000000000 0.000002365259833
227 242 0.648812471943990 0.005945608234167 1.000000000000000 0.000003218281338
228 243 0.648812469514723 0.006813233690890 1.000000000000000 0.000002166640038
229 244 0.648812468473194 0.005394984376385 1.000000000000000 0.000005380372585
230 245 0.648812468138770 0.004335464994026 1.000000000000000 0.000008528120501
231 246 0.648812467611134 0.002911400021731 1.000000000000000 0.000002048133344
232 247 0.648812467422597 0.000645799473662 1.000000000000000 0.000001547467440
233 248 0.648812467083043 0.001815316256242 1.000000000000000 0.000004915215912
234 249 0.648812466784552 0.003714952282869 1.000000000000000 0.000001960163234
235 250 0.648812466521857 0.002050167803106 1.000000000000000 0.000001588900770
236 251 0.648812465856529 0.004304099817013 1.000000000000000 0.000001588320195
237 252 0.648812465041825 0.003023830711233 1.000000000000000 0.000001835258279
238 254 0.648812464430373 0.004184878418888 0.472404499051549 0.000003454208219
239 255 0.648812463471214 0.003717144512425 1.000000000000000 0.000002421643484
240 256 0.648812462964372 0.001450495192212 1.000000000000000 0.000001777173947
241 258 0.648812462895168 0.000847098881664 0.128985246335787 0.000005676075039
242 259 0.648812462505102 0.001443363904041 1.000000000000000 0.000001551858336
243 260 0.648812462266776 0.001173921106528 1.000000000000000 0.000002266193618
244 261 0.648812461949437 0.002354117494894 1.000000000000000 0.000003572328013
245 262 0.648812461681157 0.001422645090446 1.000000000000000 0.000001716997795
246 263 0.648812461357777 0.002646063878680 1.000000000000000 0.000001535611843
247 265 0.648812461197269 0.001695928723349 0.479793204940172 0.000005058573708
248 266 0.648812460977045 0.000787026302458 1.000000000000000 0.000004787959997
249 267 0.648812460024790 0.003899114964505 1.000000000000000 0.000002310874723
250 268 0.648812459588530 0.002463531321902 1.000000000000000 0.000001269693157
251 269 0.648812459256109 0.002511384076919 1.000000000000000 0.000001602053501
252 270 0.648812458970467 0.002457762486273 1.000000000000000 0.000001579246029
253 271 0.648812458546370 0.003189460432946 1.000000000000000 0.000001233884716
254 272 0.648812458107277 0.003189460432946 1.000000000000000 0.000000926782210
Convergence criteria met.
After: gradient norm = 9.267822098929231E-7
>>> Parameters after optimization
Count Table 0:
---------------
h: {1.8375,-1.8375}
Binding mode 0:
---------------
Mononucleotide: {}
Activity(exp=0): {-0.0000,2.1076}
Binding mode 1:
---------------
Mononucleotide: {0.0575,-1.1263,-0.0363,-0.9717,-0.5234,-1.7825,1.0472,-0.8181,0.0699,-1.1866,-0.6691,-0.2909,1.5349,-1.5847,-1.2707,-0.7562,-1.3311,1.6577,-1.7532,-0.6503,0.6043,-1.8676,-0.0912,-0.7224,-0.6508,-0.7734,-0.5526,-0.1000,-0.1745,-0.8638,-0.8638,-0.1745,-0.1000,-0.5526,-0.7734,-0.6508,-0.7224,-0.0912,-1.8676,0.6043,-0.6503,-1.7532,1.6577,-1.3311,-0.7562,-1.2707,-1.5847,1.5349,-0.2909,-0.6691,-1.1866,0.0699,-0.8181,1.0472,-1.7825,-0.5234,-0.9717,-0.0363,-1.1263,0.0575}
Activity(exp=0): {0.0001,-2.1390}
Position Bias(exp=0, s=0): {-0.1094,-0.1094,-0.1094,-0.1094,-0.1094,0.3824,0.3824,0.3824,0.3824,0.3824,0.1219,0.1219,0.1219,0.1219,0.1219,0.7689,0.7689,0.7689,0.7689,0.7689,0.3248,0.3248,0.3248,0.3248,0.3248,0.2057,0.2057,0.2057,0.2057,0.2057,-0.1129,-0.1129,-0.1129,-0.1129,-0.1129,0.6830,0.6830,0.6830,0.6830,0.6830,0.6478,0.6478,0.6478,0.6478,0.6478,0.8161,0.8161,0.8161,0.8161,0.8161,0.5721,0.5721,0.5721,0.5721,0.5721,0.4143,0.4143,0.4143,0.4143,0.4143,0.2773,0.2773,0.2773,0.2773,0.2773,0.6606,0.6606,0.6606,0.6606,0.6606,0.2555,0.2555,0.2555,0.2555,0.2555,0.4671,0.4671,0.4671,0.4671,0.4671,1.0559,1.0559,1.0559,1.0559,1.0559,0.7284,0.7284,0.7284,0.7284,0.7284,0.7429,0.7429,0.7429,0.7429,0.7429,0.2641,0.2641,0.2641,0.2641,0.2641,0.0108,0.0108,0.0108,0.0108,0.0108,0.1645,0.1645,0.1645,0.1645,0.1645,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,0.2432,0.2432,0.2432,0.2432,0.2432,-0.1808,-0.1808,-0.1808,-0.1808,-0.1808,-0.0919,-0.0919,-0.0919,-0.0919,-0.0919,-0.0468,-0.0468,-0.0468,-0.0468,-0.0468,-0.7732,-0.7732,-0.7732,-0.7732,-0.7732,-0.6030,-0.6030,-0.6030,-0.6030,-0.6030,-0.7792,-0.7792,-0.7792,-0.7792,-0.7792,-0.4811,-0.4811,-0.4811,-0.4811,-0.4811,-0.6352,-0.6352,-0.6352,-0.6352,-0.6352,-1.1889,-1.1889,-1.1889,-1.1889,-1.1889,-0.8621,-0.8621,-0.8621,-0.8621,-0.8621,-0.9367,-0.9367,-0.9367,-0.9367,-0.9367,-0.8679,-0.8679,-0.8679,-0.8679,-0.8679,-1.3795,-1.3795,-1.3795,-1.3795,-1.3795,-1.9367}
Position Bias(exp=0, s=1): {-1.5623,-1.5623,-1.5623,-1.5623,-1.5623,-0.9422,-0.9422,-0.9422,-0.9422,-0.9422,-0.6520,-0.6520,-0.6520,-0.6520,-0.6520,-0.9996,-0.9996,-0.9996,-0.9996,-0.9996,-1.1655,-1.1655,-1.1655,-1.1655,-1.1655,-0.8720,-0.8720,-0.8720,-0.8720,-0.8720,-0.6872,-0.6872,-0.6872,-0.6872,-0.6872,-0.5987,-0.5987,-0.5987,-0.5987,-0.5987,-0.7251,-0.7251,-0.7251,-0.7251,-0.7251,-0.3411,-0.3411,-0.3411,-0.3411,-0.3411,-0.1834,-0.1834,-0.1834,-0.1834,-0.1834,-0.0742,-0.0742,-0.0742,-0.0742,-0.0742,-0.2385,-0.2385,-0.2385,-0.2385,-0.2385,-0.3174,-0.3174,-0.3174,-0.3174,-0.3174,0.1521,0.1521,0.1521,0.1521,0.1521,0.1366,0.1366,0.1366,0.1366,0.1366,0.5435,0.5435,0.5435,0.5435,0.5435,0.5682,0.5682,0.5682,0.5682,0.5682,-0.1571,-0.1571,-0.1571,-0.1571,-0.1571,0.2496,0.2496,0.2496,0.2496,0.2496,0.0967,0.0967,0.0967,0.0967,0.0967,0.6287,0.6287,0.6287,0.6287,0.6287,0.6213,0.6213,0.6213,0.6213,0.6213,0.6664,0.6664,0.6664,0.6664,0.6664,0.5852,0.5852,0.5852,0.5852,0.5852,0.7157,0.7157,0.7157,0.7157,0.7157,0.6877,0.6877,0.6877,0.6877,0.6877,0.2653,0.2653,0.2653,0.2653,0.2653,0.3378,0.3378,0.3378,0.3378,0.3378,0.4160,0.4160,0.4160,0.4160,0.4160,0.4512,0.4512,0.4512,0.4512,0.4512,0.7575,0.7575,0.7575,0.7575,0.7575,0.1034,0.1034,0.1034,0.1034,0.1034,-0.0910,-0.0910,-0.0910,-0.0910,-0.0910,0.3678,0.3678,0.3678,0.3678,0.3678,0.0305,0.0305,0.0305,0.0305,0.0305,0.2930,0.2930,0.2930,0.2930,0.2930,0.7417}
Binding mode 2:
---------------
Mononucleotide: {0.0177,-1.0022,-0.3561,-0.5354,-0.8588,-0.8948,-1.4172,1.2947,-0.9956,-2.1409,0.6777,0.5827,0.8002,-1.3207,-1.1926,-0.1629,-1.4937,-0.1143,-0.1541,-0.1139,-0.8337,-1.5908,-0.8087,1.3571,-0.0124,0.6024,-2.4513,-0.0148,0.9132,-1.3669,-1.0789,-0.3434,-0.4345,-0.7387,-0.5925,-0.1104,-0.2444,-0.3713,-0.9518,-0.3086}
Activity(exp=0): {-0.0000,-1.8761}
Position Bias(exp=0, s=0): {1.4716,1.4716,1.4716,1.4716,1.4716,0.8622,0.8622,0.8622,0.8622,0.8622,0.0850,0.0850,0.0850,0.0850,0.0850,0.3494,0.3494,0.3494,0.3494,0.3494,0.4509,0.4509,0.4509,0.4509,0.4509,0.1033,0.1033,0.1033,0.1033,0.1033,0.3880,0.3880,0.3880,0.3880,0.3880,0.2285,0.2285,0.2285,0.2285,0.2285,0.2388,0.2388,0.2388,0.2388,0.2388,0.4424,0.4424,0.4424,0.4424,0.4424,0.3598,0.3598,0.3598,0.3598,0.3598,0.6556,0.6556,0.6556,0.6556,0.6556,0.3873,0.3873,0.3873,0.3873,0.3873,-0.1983,-0.1983,-0.1983,-0.1983,-0.1983,0.4233,0.4233,0.4233,0.4233,0.4233,0.4151,0.4151,0.4151,0.4151,0.4151,0.0893,0.0893,0.0893,0.0893,0.0893,-0.0868,-0.0868,-0.0868,-0.0868,-0.0868,-0.2882,-0.2882,-0.2882,-0.2882,-0.2882,-0.3564,-0.3564,-0.3564,-0.3564,-0.3564,-0.2456,-0.2456,-0.2456,-0.2456,-0.2456,-0.0066,-0.0066,-0.0066,-0.0066,-0.0066,0.0845,0.0845,0.0845,0.0845,0.0845,-0.0315,-0.0315,-0.0315,-0.0315,-0.0315,-0.2276,-0.2276,-0.2276,-0.2276,-0.2276,-0.0647,-0.0647,-0.0647,-0.0647,-0.0647,-0.4754,-0.4754,-0.4754,-0.4754,-0.4754,-0.2584,-0.2584,-0.2584,-0.2584,-0.2584,-0.7119,-0.7119,-0.7119,-0.7119,-0.7119,-0.3834,-0.3834,-0.3834,-0.3834,-0.3834,-0.6788,-0.6788,-0.6788,-0.6788,-0.6788,-0.9776,-0.9776,-0.9776,-0.9776,-0.9776,-0.2137,-0.2137,-0.2137,-0.2137,-0.2137,-0.9546,-0.9546,-0.9546,-0.9546,-0.9546,-0.9791,-0.9791,-0.9791,-0.9791,-0.9791,-0.8733,-0.8733,-0.8733,-0.8733,-0.8733,-1.2081,-1.2081,-1.2081,-1.2081,-1.2081,-1.2312,-1.2312,-1.2312,-1.2312,-1.2312,-0.8508}
Position Bias(exp=0, s=1): {-1.1486,-1.1486,-1.1486,-1.1486,-1.1486,-0.7457,-0.7457,-0.7457,-0.7457,-0.7457,-0.8151,-0.8151,-0.8151,-0.8151,-0.8151,-1.1739,-1.1739,-1.1739,-1.1739,-1.1739,-1.1853,-1.1853,-1.1853,-1.1853,-1.1853,-0.8749,-0.8749,-0.8749,-0.8749,-0.8749,-0.8060,-0.8060,-0.8060,-0.8060,-0.8060,-1.0040,-1.0040,-1.0040,-1.0040,-1.0040,-0.2590,-0.2590,-0.2590,-0.2590,-0.2590,0.0146,0.0146,0.0146,0.0146,0.0146,-0.4727,-0.4727,-0.4727,-0.4727,-0.4727,0.2614,0.2614,0.2614,0.2614,0.2614,-0.5338,-0.5338,-0.5338,-0.5338,-0.5338,-0.3404,-0.3404,-0.3404,-0.3404,-0.3404,0.1594,0.1594,0.1594,0.1594,0.1594,-0.8559,-0.8559,-0.8559,-0.8559,-0.8559,0.3658,0.3658,0.3658,0.3658,0.3658,0.4292,0.4292,0.4292,0.4292,0.4292,0.5681,0.5681,0.5681,0.5681,0.5681,0.8204,0.8204,0.8204,0.8204,0.8204,0.8887,0.8887,0.8887,0.8887,0.8887,0.7949,0.7949,0.7949,0.7949,0.7949,0.7988,0.7988,0.7988,0.7988,0.7988,0.7756,0.7756,0.7756,0.7756,0.7756,0.6550,0.6550,0.6550,0.6550,0.6550,0.5473,0.5473,0.5473,0.5473,0.5473,0.3429,0.3429,0.3429,0.3429,0.3429,0.5347,0.5347,0.5347,0.5347,0.5347,0.8364,0.8364,0.8364,0.8364,0.8364,0.7782,0.7782,0.7782,0.7782,0.7782,0.5014,0.5014,0.5014,0.5014,0.5014,0.4788,0.4788,0.4788,0.4788,0.4788,0.7820,0.7820,0.7820,0.7820,0.7820,0.4840,0.4840,0.4840,0.4840,0.4840,0.5024,0.5024,0.5024,0.5024,0.5024,0.3937,0.3937,0.3937,0.3937,0.3937,0.4989,0.4989,0.4989,0.4989,0.4989,0.3353,0.3353,0.3353,0.3353,0.3353,-0.2334}
Binding mode 3:
---------------
Mononucleotide: {0.0002,-0.0031,-0.0030,0.0016,0.0011,-0.0023,0.0007,0.0027,0.0021,-0.0016,-0.0046,0.0022,-0.0032,-0.0032,0.0013,-0.0036,-0.0041,-0.0023,0.0019,-0.0038,0.0042,0.0021,-0.0004,-0.0030,-0.0028,-0.0014,-0.0001,0.0032,-0.0037,0.0022,-0.0016,-0.0048,0.0012,-0.0023,0.0035,0.0001,0.0034,0.0024,0.0018,0.0006}
Activity(exp=0): {0.0000,0.0000}
Position Bias(exp=0, s=0): {0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000}
Position Bias(exp=0, s=1): {0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000}
Binding mode 4:
---------------
Mononucleotide: {-0.0011,0.0038,0.0009,-0.0045,0.0004,-0.0014,0.0020,-0.0042,-0.0012,-0.0020,0.0048,0.0042,-0.0042,-0.0022,0.0035,0.0044,0.0018,0.0043,-0.0001,-0.0004,-0.0005,-0.0025,0.0021,-0.0036,0.0023,-0.0024,-0.0045,0.0025,-0.0021,0.0024,-0.0031,-0.0001,0.0008,-0.0032,0.0022,-0.0041,0.0018,-0.0033,-0.0024,0.0034}
Activity(exp=0): {0.0000,0.0000}
Position Bias(exp=0, s=0): {0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000}
Position Bias(exp=0, s=1): {0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000}
==================================
== Starts fiting Binding mode 3 ==
==================================
> Optimizing h (component3-0-h).
>> Starting new optimization: component3-0-h. (2021-05-21 14:39:23.003).
>>> Packing before optimization
Packing: {"enrichmentModel":[{}],"countTable":[{"h":[0,1]}],"bindingModeInteractions":[],"bindingModes":[{},{},{},{},{}]}
Value and gradient before optimization:
=======================================
value = 0.9885721503597906
gradient = {-0.3445,0.3445}
gradient norm = 0.4872055351302452
Starting Function Value: 0.9885721503597906
Iterations Fnc. Calls Likelihood Distance Moved Step Alpha Gradient Norm
1 2 0.674736358343975 1.000000000000000 2.052521837077793 0.101715708507687
2 3 0.664922635333408 0.263860941283101 1.000000000000000 0.027697922377244
3 4 0.664143551007636 0.056473184625691 1.000000000000000 0.000115939625564
4 5 0.664143537371542 0.056473184625691 1.000000000000000 0.000000086640648
Convergence criteria met.
After: gradient norm = 8.664064784608519E-8
>>> Parameters after optimization
Count Table 0:
---------------
h: {2.6914,-2.6914}
Binding mode 0:
---------------
Mononucleotide: {}
Activity(exp=0): {-0.0000,2.1076}
Binding mode 1:
---------------
Mononucleotide: {0.0575,-1.1263,-0.0363,-0.9717,-0.5234,-1.7825,1.0472,-0.8181,0.0699,-1.1866,-0.6691,-0.2909,1.5349,-1.5847,-1.2707,-0.7562,-1.3311,1.6577,-1.7532,-0.6503,0.6043,-1.8676,-0.0912,-0.7224,-0.6508,-0.7734,-0.5526,-0.1000,-0.1745,-0.8638,-0.8638,-0.1745,-0.1000,-0.5526,-0.7734,-0.6508,-0.7224,-0.0912,-1.8676,0.6043,-0.6503,-1.7532,1.6577,-1.3311,-0.7562,-1.2707,-1.5847,1.5349,-0.2909,-0.6691,-1.1866,0.0699,-0.8181,1.0472,-1.7825,-0.5234,-0.9717,-0.0363,-1.1263,0.0575}
Activity(exp=0): {0.0001,-2.1390}
Position Bias(exp=0, s=0): {-0.1094,-0.1094,-0.1094,-0.1094,-0.1094,0.3824,0.3824,0.3824,0.3824,0.3824,0.1219,0.1219,0.1219,0.1219,0.1219,0.7689,0.7689,0.7689,0.7689,0.7689,0.3248,0.3248,0.3248,0.3248,0.3248,0.2057,0.2057,0.2057,0.2057,0.2057,-0.1129,-0.1129,-0.1129,-0.1129,-0.1129,0.6830,0.6830,0.6830,0.6830,0.6830,0.6478,0.6478,0.6478,0.6478,0.6478,0.8161,0.8161,0.8161,0.8161,0.8161,0.5721,0.5721,0.5721,0.5721,0.5721,0.4143,0.4143,0.4143,0.4143,0.4143,0.2773,0.2773,0.2773,0.2773,0.2773,0.6606,0.6606,0.6606,0.6606,0.6606,0.2555,0.2555,0.2555,0.2555,0.2555,0.4671,0.4671,0.4671,0.4671,0.4671,1.0559,1.0559,1.0559,1.0559,1.0559,0.7284,0.7284,0.7284,0.7284,0.7284,0.7429,0.7429,0.7429,0.7429,0.7429,0.2641,0.2641,0.2641,0.2641,0.2641,0.0108,0.0108,0.0108,0.0108,0.0108,0.1645,0.1645,0.1645,0.1645,0.1645,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,0.2432,0.2432,0.2432,0.2432,0.2432,-0.1808,-0.1808,-0.1808,-0.1808,-0.1808,-0.0919,-0.0919,-0.0919,-0.0919,-0.0919,-0.0468,-0.0468,-0.0468,-0.0468,-0.0468,-0.7732,-0.7732,-0.7732,-0.7732,-0.7732,-0.6030,-0.6030,-0.6030,-0.6030,-0.6030,-0.7792,-0.7792,-0.7792,-0.7792,-0.7792,-0.4811,-0.4811,-0.4811,-0.4811,-0.4811,-0.6352,-0.6352,-0.6352,-0.6352,-0.6352,-1.1889,-1.1889,-1.1889,-1.1889,-1.1889,-0.8621,-0.8621,-0.8621,-0.8621,-0.8621,-0.9367,-0.9367,-0.9367,-0.9367,-0.9367,-0.8679,-0.8679,-0.8679,-0.8679,-0.8679,-1.3795,-1.3795,-1.3795,-1.3795,-1.3795,-1.9367}
Position Bias(exp=0, s=1): {-1.5623,-1.5623,-1.5623,-1.5623,-1.5623,-0.9422,-0.9422,-0.9422,-0.9422,-0.9422,-0.6520,-0.6520,-0.6520,-0.6520,-0.6520,-0.9996,-0.9996,-0.9996,-0.9996,-0.9996,-1.1655,-1.1655,-1.1655,-1.1655,-1.1655,-0.8720,-0.8720,-0.8720,-0.8720,-0.8720,-0.6872,-0.6872,-0.6872,-0.6872,-0.6872,-0.5987,-0.5987,-0.5987,-0.5987,-0.5987,-0.7251,-0.7251,-0.7251,-0.7251,-0.7251,-0.3411,-0.3411,-0.3411,-0.3411,-0.3411,-0.1834,-0.1834,-0.1834,-0.1834,-0.1834,-0.0742,-0.0742,-0.0742,-0.0742,-0.0742,-0.2385,-0.2385,-0.2385,-0.2385,-0.2385,-0.3174,-0.3174,-0.3174,-0.3174,-0.3174,0.1521,0.1521,0.1521,0.1521,0.1521,0.1366,0.1366,0.1366,0.1366,0.1366,0.5435,0.5435,0.5435,0.5435,0.5435,0.5682,0.5682,0.5682,0.5682,0.5682,-0.1571,-0.1571,-0.1571,-0.1571,-0.1571,0.2496,0.2496,0.2496,0.2496,0.2496,0.0967,0.0967,0.0967,0.0967,0.0967,0.6287,0.6287,0.6287,0.6287,0.6287,0.6213,0.6213,0.6213,0.6213,0.6213,0.6664,0.6664,0.6664,0.6664,0.6664,0.5852,0.5852,0.5852,0.5852,0.5852,0.7157,0.7157,0.7157,0.7157,0.7157,0.6877,0.6877,0.6877,0.6877,0.6877,0.2653,0.2653,0.2653,0.2653,0.2653,0.3378,0.3378,0.3378,0.3378,0.3378,0.4160,0.4160,0.4160,0.4160,0.4160,0.4512,0.4512,0.4512,0.4512,0.4512,0.7575,0.7575,0.7575,0.7575,0.7575,0.1034,0.1034,0.1034,0.1034,0.1034,-0.0910,-0.0910,-0.0910,-0.0910,-0.0910,0.3678,0.3678,0.3678,0.3678,0.3678,0.0305,0.0305,0.0305,0.0305,0.0305,0.2930,0.2930,0.2930,0.2930,0.2930,0.7417}
Binding mode 2:
---------------
Mononucleotide: {0.0177,-1.0022,-0.3561,-0.5354,-0.8588,-0.8948,-1.4172,1.2947,-0.9956,-2.1409,0.6777,0.5827,0.8002,-1.3207,-1.1926,-0.1629,-1.4937,-0.1143,-0.1541,-0.1139,-0.8337,-1.5908,-0.8087,1.3571,-0.0124,0.6024,-2.4513,-0.0148,0.9132,-1.3669,-1.0789,-0.3434,-0.4345,-0.7387,-0.5925,-0.1104,-0.2444,-0.3713,-0.9518,-0.3086}
Activity(exp=0): {-0.0000,-1.8761}
Position Bias(exp=0, s=0): {1.4716,1.4716,1.4716,1.4716,1.4716,0.8622,0.8622,0.8622,0.8622,0.8622,0.0850,0.0850,0.0850,0.0850,0.0850,0.3494,0.3494,0.3494,0.3494,0.3494,0.4509,0.4509,0.4509,0.4509,0.4509,0.1033,0.1033,0.1033,0.1033,0.1033,0.3880,0.3880,0.3880,0.3880,0.3880,0.2285,0.2285,0.2285,0.2285,0.2285,0.2388,0.2388,0.2388,0.2388,0.2388,0.4424,0.4424,0.4424,0.4424,0.4424,0.3598,0.3598,0.3598,0.3598,0.3598,0.6556,0.6556,0.6556,0.6556,0.6556,0.3873,0.3873,0.3873,0.3873,0.3873,-0.1983,-0.1983,-0.1983,-0.1983,-0.1983,0.4233,0.4233,0.4233,0.4233,0.4233,0.4151,0.4151,0.4151,0.4151,0.4151,0.0893,0.0893,0.0893,0.0893,0.0893,-0.0868,-0.0868,-0.0868,-0.0868,-0.0868,-0.2882,-0.2882,-0.2882,-0.2882,-0.2882,-0.3564,-0.3564,-0.3564,-0.3564,-0.3564,-0.2456,-0.2456,-0.2456,-0.2456,-0.2456,-0.0066,-0.0066,-0.0066,-0.0066,-0.0066,0.0845,0.0845,0.0845,0.0845,0.0845,-0.0315,-0.0315,-0.0315,-0.0315,-0.0315,-0.2276,-0.2276,-0.2276,-0.2276,-0.2276,-0.0647,-0.0647,-0.0647,-0.0647,-0.0647,-0.4754,-0.4754,-0.4754,-0.4754,-0.4754,-0.2584,-0.2584,-0.2584,-0.2584,-0.2584,-0.7119,-0.7119,-0.7119,-0.7119,-0.7119,-0.3834,-0.3834,-0.3834,-0.3834,-0.3834,-0.6788,-0.6788,-0.6788,-0.6788,-0.6788,-0.9776,-0.9776,-0.9776,-0.9776,-0.9776,-0.2137,-0.2137,-0.2137,-0.2137,-0.2137,-0.9546,-0.9546,-0.9546,-0.9546,-0.9546,-0.9791,-0.9791,-0.9791,-0.9791,-0.9791,-0.8733,-0.8733,-0.8733,-0.8733,-0.8733,-1.2081,-1.2081,-1.2081,-1.2081,-1.2081,-1.2312,-1.2312,-1.2312,-1.2312,-1.2312,-0.8508}
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Binding mode 3:
---------------
Mononucleotide: {0.0002,-0.0031,-0.0030,0.0016,0.0011,-0.0023,0.0007,0.0027,0.0021,-0.0016,-0.0046,0.0022,-0.0032,-0.0032,0.0013,-0.0036,-0.0041,-0.0023,0.0019,-0.0038,0.0042,0.0021,-0.0004,-0.0030,-0.0028,-0.0014,-0.0001,0.0032,-0.0037,0.0022,-0.0016,-0.0048,0.0012,-0.0023,0.0035,0.0001,0.0034,0.0024,0.0018,0.0006}
Activity(exp=0): {-2.5492,-0.8250}
Position Bias(exp=0, s=0): {0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000}
Position Bias(exp=0, s=1): {0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000}
Binding mode 4:
---------------
Mononucleotide: {-0.0011,0.0038,0.0009,-0.0045,0.0004,-0.0014,0.0020,-0.0042,-0.0012,-0.0020,0.0048,0.0042,-0.0042,-0.0022,0.0035,0.0044,0.0018,0.0043,-0.0001,-0.0004,-0.0005,-0.0025,0.0021,-0.0036,0.0023,-0.0024,-0.0045,0.0025,-0.0021,0.0024,-0.0031,-0.0001,0.0008,-0.0032,0.0022,-0.0041,0.0018,-0.0033,-0.0024,0.0034}
Activity(exp=0): {0.0000,0.0000}
Position Bias(exp=0, s=0): {0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000}
Position Bias(exp=0, s=1): {0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000}
> Initial optimization (component3-1-f1).
>> Starting new optimization: component3-1-f1. (2021-05-21 14:39:35.207).
>>> Packing before optimization
Packing: {"enrichmentModel":[{}],"countTable":[{"h":[42,43]}],"bindingModeInteractions":[],"bindingModes":[{},{},{},{"mononucleotide":[0,1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19,20,21,22,23,24,25,26,27,28,29,30,31,32,33,34,35,36,37,38,39],"activity":[[40,41]]},{}]}
Value and gradient before optimization:
=======================================
value = 0.669688724805369
gradient = {0.0002,0.0071,0.0071,0.0001,0.0002,0.0071,0.0071,0.0001,0.0002,0.0071,0.0071,0.0001,0.0002,0.0071,0.0071,0.0001,0.0001,0.0071,0.0071,0.0001,0.0002,0.0071,0.0071,0.0002,0.0001,0.0071,0.0071,0.0002,0.0001,0.0071,0.0071,0.0002,0.0001,0.0071,0.0071,0.0002,0.0001,0.0071,0.0071,0.0002,-0.0000,0.0145,0.0000,-0.0000}
gradient norm = 0.034898445086087755
Starting Function Value: 0.669688724805369
Iterations Fnc. Calls Likelihood Distance Moved Step Alpha Gradient Norm
1 3 0.667727626578383 0.115681900603135 3.314815325375376 0.051803116769819
2 4 0.665060522260438 0.093945288893690 1.000000000000000 0.047571554707215
3 6 0.647503389105664 0.904241088493115 0.467157764526325 0.020853815685232
4 7 0.644574263866046 0.720989918571460 1.000000000000000 0.066311844384730
5 8 0.642398720116333 0.103810578496717 1.000000000000000 0.030310524953602
6 9 0.640736865328886 0.192703327460139 1.000000000000000 0.010741318680832
7 10 0.639208547932368 0.393955244218173 1.000000000000000 0.011676994027762
8 11 0.638446309012332 0.334621569026225 1.000000000000000 0.021089956146398
9 12 0.637878419477289 0.084877589580899 1.000000000000000 0.010083443291301
10 13 0.637432640159649 0.208772919172326 1.000000000000000 0.006722020197117
11 14 0.637215511514493 0.145436277977573 1.000000000000000 0.002342965651816
12 15 0.637103467156337 0.220852414203486 1.000000000000000 0.006575550288492
13 16 0.637000503404935 0.130706430048684 1.000000000000000 0.000782166495222
14 17 0.636954861077627 0.184873244624622 1.000000000000000 0.002148542807214
15 18 0.636921682518288 0.187280118545703 1.000000000000000 0.001978904858295
16 19 0.636883751669639 0.244618166213330 1.000000000000000 0.000954954357034
17 20 0.636838235257925 0.526202072235579 1.000000000000000 0.002784819310122
18 21 0.636791136493068 0.654146228626224 1.000000000000000 0.000254951458160
19 22 0.636785667167646 0.361412011310931 1.000000000000000 0.000762589959947
20 23 0.636784947966401 0.038364438826765 1.000000000000000 0.000456103692472
21 24 0.636784778949763 0.007677438706225 1.000000000000000 0.000103551041176
22 25 0.636784750958631 0.002004003321721 1.000000000000000 0.000074401924442
23 26 0.636784247459650 0.051876336765936 1.000000000000000 0.000313845252687
24 27 0.636783515790654 0.098429156842257 1.000000000000000 0.000682457311119
25 28 0.636782270705665 0.204206045570915 1.000000000000000 0.001169738083582
26 29 0.636780420239364 0.194333338428640 1.000000000000000 0.001294291527869
27 32 0.636772937203762 0.590360617807064 0.776865620656643 0.002044500978104
28 35 0.636771090227924 0.164804298984484 0.048842817496144 0.002478594987109
29 37 0.636762228659002 0.314672802065810 0.340931873484295 0.002552918591617
30 39 0.636747585794276 0.383016099693192 0.342932450095469 0.001917898105117
31 40 0.636726916206268 0.611356434370327 1.000000000000000 0.003323721071334
32 42 0.636719542101953 0.190110717231010 0.430156493478122 0.002153956992537
33 43 0.636711411308793 0.098177229015608 1.000000000000000 0.001378716365872
34 44 0.636707710488961 0.141023420651351 1.000000000000000 0.000166835256771
35 45 0.636707468283381 0.037517543102754 1.000000000000000 0.000092173239331
36 46 0.636707336116184 0.023880647111154 1.000000000000000 0.000143035700621
37 47 0.636707083075958 0.023040723198850 1.000000000000000 0.000184935965947
38 48 0.636705870792978 0.069752204973314 1.000000000000000 0.000312578034197
39 49 0.636703275667274 0.108590198497779 1.000000000000000 0.000459207551177
40 50 0.636697767659208 0.181414681543051 1.000000000000000 0.000586677750687
41 51 0.636689843380773 0.243305654306805 1.000000000000000 0.000521764616141
42 52 0.636684330639609 0.241079103717333 1.000000000000000 0.000235769921280
43 53 0.636683499856610 0.094683108000900 1.000000000000000 0.000062363408933
44 54 0.636683344143349 0.032454808021264 1.000000000000000 0.000040109317491
45 55 0.636683318837403 0.016453022274340 1.000000000000000 0.000030627153917
46 56 0.636683232272415 0.009107118146556 1.000000000000000 0.000038311718255
47 57 0.636682701900004 0.063561335646278 1.000000000000000 0.000034288439583
48 58 0.636682416775964 0.056493624050744 1.000000000000000 0.000015451028205
49 59 0.636682283602573 0.052760516870502 1.000000000000000 0.000012279163231
50 60 0.636682221875453 0.027833055266692 1.000000000000000 0.000022453976700
51 61 0.636682106399491 0.054865458699924 1.000000000000000 0.000028735130320
52 62 0.636681930624935 0.062701955054990 1.000000000000000 0.000026234172072
53 63 0.636681241025451 0.253446402764724 1.000000000000000 0.000021072221362
54 64 0.636680092958264 0.466956620719841 1.000000000000000 0.000019204025445
55 65 0.636678261392698 0.848360216232872 1.000000000000000 0.000030616797637
56 66 0.636677075766150 0.626497409196810 1.000000000000000 0.000018118781607
57 67 0.636676762953545 0.120000202484016 1.000000000000000 0.000002570318205
58 68 0.636676732451636 0.066689677183867 1.000000000000000 0.000002955380855
59 69 0.636676725929134 0.024902665724034 1.000000000000000 0.000001383610406
60 70 0.636676714431571 0.033781710431363 1.000000000000000 0.000002297195780
61 71 0.636676707615057 0.015574374220134 1.000000000000000 0.000002517471547
62 72 0.636676702879621 0.032305756915744 1.000000000000000 0.000000680436356
63 73 0.636676702562647 0.032305756915744 1.000000000000000 0.000000247246580
Convergence criteria met.
After: gradient norm = 2.4724658016695594E-7
>>> Parameters after optimization
Count Table 0:
---------------
h: {1.8547,-1.8547}
Binding mode 0:
---------------
Mononucleotide: {}
Activity(exp=0): {-0.0000,2.1076}
Binding mode 1:
---------------
Mononucleotide: {0.0575,-1.1263,-0.0363,-0.9717,-0.5234,-1.7825,1.0472,-0.8181,0.0699,-1.1866,-0.6691,-0.2909,1.5349,-1.5847,-1.2707,-0.7562,-1.3311,1.6577,-1.7532,-0.6503,0.6043,-1.8676,-0.0912,-0.7224,-0.6508,-0.7734,-0.5526,-0.1000,-0.1745,-0.8638,-0.8638,-0.1745,-0.1000,-0.5526,-0.7734,-0.6508,-0.7224,-0.0912,-1.8676,0.6043,-0.6503,-1.7532,1.6577,-1.3311,-0.7562,-1.2707,-1.5847,1.5349,-0.2909,-0.6691,-1.1866,0.0699,-0.8181,1.0472,-1.7825,-0.5234,-0.9717,-0.0363,-1.1263,0.0575}
Activity(exp=0): {0.0001,-2.1390}
Position Bias(exp=0, s=0): {-0.1094,-0.1094,-0.1094,-0.1094,-0.1094,0.3824,0.3824,0.3824,0.3824,0.3824,0.1219,0.1219,0.1219,0.1219,0.1219,0.7689,0.7689,0.7689,0.7689,0.7689,0.3248,0.3248,0.3248,0.3248,0.3248,0.2057,0.2057,0.2057,0.2057,0.2057,-0.1129,-0.1129,-0.1129,-0.1129,-0.1129,0.6830,0.6830,0.6830,0.6830,0.6830,0.6478,0.6478,0.6478,0.6478,0.6478,0.8161,0.8161,0.8161,0.8161,0.8161,0.5721,0.5721,0.5721,0.5721,0.5721,0.4143,0.4143,0.4143,0.4143,0.4143,0.2773,0.2773,0.2773,0.2773,0.2773,0.6606,0.6606,0.6606,0.6606,0.6606,0.2555,0.2555,0.2555,0.2555,0.2555,0.4671,0.4671,0.4671,0.4671,0.4671,1.0559,1.0559,1.0559,1.0559,1.0559,0.7284,0.7284,0.7284,0.7284,0.7284,0.7429,0.7429,0.7429,0.7429,0.7429,0.2641,0.2641,0.2641,0.2641,0.2641,0.0108,0.0108,0.0108,0.0108,0.0108,0.1645,0.1645,0.1645,0.1645,0.1645,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,0.2432,0.2432,0.2432,0.2432,0.2432,-0.1808,-0.1808,-0.1808,-0.1808,-0.1808,-0.0919,-0.0919,-0.0919,-0.0919,-0.0919,-0.0468,-0.0468,-0.0468,-0.0468,-0.0468,-0.7732,-0.7732,-0.7732,-0.7732,-0.7732,-0.6030,-0.6030,-0.6030,-0.6030,-0.6030,-0.7792,-0.7792,-0.7792,-0.7792,-0.7792,-0.4811,-0.4811,-0.4811,-0.4811,-0.4811,-0.6352,-0.6352,-0.6352,-0.6352,-0.6352,-1.1889,-1.1889,-1.1889,-1.1889,-1.1889,-0.8621,-0.8621,-0.8621,-0.8621,-0.8621,-0.9367,-0.9367,-0.9367,-0.9367,-0.9367,-0.8679,-0.8679,-0.8679,-0.8679,-0.8679,-1.3795,-1.3795,-1.3795,-1.3795,-1.3795,-1.9367}
Position Bias(exp=0, s=1): {-1.5623,-1.5623,-1.5623,-1.5623,-1.5623,-0.9422,-0.9422,-0.9422,-0.9422,-0.9422,-0.6520,-0.6520,-0.6520,-0.6520,-0.6520,-0.9996,-0.9996,-0.9996,-0.9996,-0.9996,-1.1655,-1.1655,-1.1655,-1.1655,-1.1655,-0.8720,-0.8720,-0.8720,-0.8720,-0.8720,-0.6872,-0.6872,-0.6872,-0.6872,-0.6872,-0.5987,-0.5987,-0.5987,-0.5987,-0.5987,-0.7251,-0.7251,-0.7251,-0.7251,-0.7251,-0.3411,-0.3411,-0.3411,-0.3411,-0.3411,-0.1834,-0.1834,-0.1834,-0.1834,-0.1834,-0.0742,-0.0742,-0.0742,-0.0742,-0.0742,-0.2385,-0.2385,-0.2385,-0.2385,-0.2385,-0.3174,-0.3174,-0.3174,-0.3174,-0.3174,0.1521,0.1521,0.1521,0.1521,0.1521,0.1366,0.1366,0.1366,0.1366,0.1366,0.5435,0.5435,0.5435,0.5435,0.5435,0.5682,0.5682,0.5682,0.5682,0.5682,-0.1571,-0.1571,-0.1571,-0.1571,-0.1571,0.2496,0.2496,0.2496,0.2496,0.2496,0.0967,0.0967,0.0967,0.0967,0.0967,0.6287,0.6287,0.6287,0.6287,0.6287,0.6213,0.6213,0.6213,0.6213,0.6213,0.6664,0.6664,0.6664,0.6664,0.6664,0.5852,0.5852,0.5852,0.5852,0.5852,0.7157,0.7157,0.7157,0.7157,0.7157,0.6877,0.6877,0.6877,0.6877,0.6877,0.2653,0.2653,0.2653,0.2653,0.2653,0.3378,0.3378,0.3378,0.3378,0.3378,0.4160,0.4160,0.4160,0.4160,0.4160,0.4512,0.4512,0.4512,0.4512,0.4512,0.7575,0.7575,0.7575,0.7575,0.7575,0.1034,0.1034,0.1034,0.1034,0.1034,-0.0910,-0.0910,-0.0910,-0.0910,-0.0910,0.3678,0.3678,0.3678,0.3678,0.3678,0.0305,0.0305,0.0305,0.0305,0.0305,0.2930,0.2930,0.2930,0.2930,0.2930,0.7417}
Binding mode 2:
---------------
Mononucleotide: {0.0177,-1.0022,-0.3561,-0.5354,-0.8588,-0.8948,-1.4172,1.2947,-0.9956,-2.1409,0.6777,0.5827,0.8002,-1.3207,-1.1926,-0.1629,-1.4937,-0.1143,-0.1541,-0.1139,-0.8337,-1.5908,-0.8087,1.3571,-0.0124,0.6024,-2.4513,-0.0148,0.9132,-1.3669,-1.0789,-0.3434,-0.4345,-0.7387,-0.5925,-0.1104,-0.2444,-0.3713,-0.9518,-0.3086}
Activity(exp=0): {-0.0000,-1.8761}
Position Bias(exp=0, s=0): {1.4716,1.4716,1.4716,1.4716,1.4716,0.8622,0.8622,0.8622,0.8622,0.8622,0.0850,0.0850,0.0850,0.0850,0.0850,0.3494,0.3494,0.3494,0.3494,0.3494,0.4509,0.4509,0.4509,0.4509,0.4509,0.1033,0.1033,0.1033,0.1033,0.1033,0.3880,0.3880,0.3880,0.3880,0.3880,0.2285,0.2285,0.2285,0.2285,0.2285,0.2388,0.2388,0.2388,0.2388,0.2388,0.4424,0.4424,0.4424,0.4424,0.4424,0.3598,0.3598,0.3598,0.3598,0.3598,0.6556,0.6556,0.6556,0.6556,0.6556,0.3873,0.3873,0.3873,0.3873,0.3873,-0.1983,-0.1983,-0.1983,-0.1983,-0.1983,0.4233,0.4233,0.4233,0.4233,0.4233,0.4151,0.4151,0.4151,0.4151,0.4151,0.0893,0.0893,0.0893,0.0893,0.0893,-0.0868,-0.0868,-0.0868,-0.0868,-0.0868,-0.2882,-0.2882,-0.2882,-0.2882,-0.2882,-0.3564,-0.3564,-0.3564,-0.3564,-0.3564,-0.2456,-0.2456,-0.2456,-0.2456,-0.2456,-0.0066,-0.0066,-0.0066,-0.0066,-0.0066,0.0845,0.0845,0.0845,0.0845,0.0845,-0.0315,-0.0315,-0.0315,-0.0315,-0.0315,-0.2276,-0.2276,-0.2276,-0.2276,-0.2276,-0.0647,-0.0647,-0.0647,-0.0647,-0.0647,-0.4754,-0.4754,-0.4754,-0.4754,-0.4754,-0.2584,-0.2584,-0.2584,-0.2584,-0.2584,-0.7119,-0.7119,-0.7119,-0.7119,-0.7119,-0.3834,-0.3834,-0.3834,-0.3834,-0.3834,-0.6788,-0.6788,-0.6788,-0.6788,-0.6788,-0.9776,-0.9776,-0.9776,-0.9776,-0.9776,-0.2137,-0.2137,-0.2137,-0.2137,-0.2137,-0.9546,-0.9546,-0.9546,-0.9546,-0.9546,-0.9791,-0.9791,-0.9791,-0.9791,-0.9791,-0.8733,-0.8733,-0.8733,-0.8733,-0.8733,-1.2081,-1.2081,-1.2081,-1.2081,-1.2081,-1.2312,-1.2312,-1.2312,-1.2312,-1.2312,-0.8508}
Position Bias(exp=0, s=1): {-1.1486,-1.1486,-1.1486,-1.1486,-1.1486,-0.7457,-0.7457,-0.7457,-0.7457,-0.7457,-0.8151,-0.8151,-0.8151,-0.8151,-0.8151,-1.1739,-1.1739,-1.1739,-1.1739,-1.1739,-1.1853,-1.1853,-1.1853,-1.1853,-1.1853,-0.8749,-0.8749,-0.8749,-0.8749,-0.8749,-0.8060,-0.8060,-0.8060,-0.8060,-0.8060,-1.0040,-1.0040,-1.0040,-1.0040,-1.0040,-0.2590,-0.2590,-0.2590,-0.2590,-0.2590,0.0146,0.0146,0.0146,0.0146,0.0146,-0.4727,-0.4727,-0.4727,-0.4727,-0.4727,0.2614,0.2614,0.2614,0.2614,0.2614,-0.5338,-0.5338,-0.5338,-0.5338,-0.5338,-0.3404,-0.3404,-0.3404,-0.3404,-0.3404,0.1594,0.1594,0.1594,0.1594,0.1594,-0.8559,-0.8559,-0.8559,-0.8559,-0.8559,0.3658,0.3658,0.3658,0.3658,0.3658,0.4292,0.4292,0.4292,0.4292,0.4292,0.5681,0.5681,0.5681,0.5681,0.5681,0.8204,0.8204,0.8204,0.8204,0.8204,0.8887,0.8887,0.8887,0.8887,0.8887,0.7949,0.7949,0.7949,0.7949,0.7949,0.7988,0.7988,0.7988,0.7988,0.7988,0.7756,0.7756,0.7756,0.7756,0.7756,0.6550,0.6550,0.6550,0.6550,0.6550,0.5473,0.5473,0.5473,0.5473,0.5473,0.3429,0.3429,0.3429,0.3429,0.3429,0.5347,0.5347,0.5347,0.5347,0.5347,0.8364,0.8364,0.8364,0.8364,0.8364,0.7782,0.7782,0.7782,0.7782,0.7782,0.5014,0.5014,0.5014,0.5014,0.5014,0.4788,0.4788,0.4788,0.4788,0.4788,0.7820,0.7820,0.7820,0.7820,0.7820,0.4840,0.4840,0.4840,0.4840,0.4840,0.5024,0.5024,0.5024,0.5024,0.5024,0.3937,0.3937,0.3937,0.3937,0.3937,0.4989,0.4989,0.4989,0.4989,0.4989,0.3353,0.3353,0.3353,0.3353,0.3353,-0.2334}
Binding mode 3:
---------------
Mononucleotide: {-0.8560,0.0115,-0.3498,-0.8096,-0.9779,-0.0026,-0.1211,-0.9023,-0.9815,-0.0295,-0.0259,-0.9671,-0.9660,-0.0422,-0.0189,-0.9769,-0.9716,-0.0347,-0.0306,-0.9672,-0.9671,-0.0306,-0.0347,-0.9716,-0.9769,-0.0188,-0.0423,-0.9661,-0.9671,-0.0261,-0.0294,-0.9814,-0.9023,-0.1209,-0.0028,-0.9780,-0.8097,-0.3499,0.0116,-0.8560}
Activity(exp=0): {-0.0034,-2.0051}
Position Bias(exp=0, s=0): {0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000}
Position Bias(exp=0, s=1): {0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000}
Binding mode 4:
---------------
Mononucleotide: {-0.0011,0.0038,0.0009,-0.0045,0.0004,-0.0014,0.0020,-0.0042,-0.0012,-0.0020,0.0048,0.0042,-0.0042,-0.0022,0.0035,0.0044,0.0018,0.0043,-0.0001,-0.0004,-0.0005,-0.0025,0.0021,-0.0036,0.0023,-0.0024,-0.0045,0.0025,-0.0021,0.0024,-0.0031,-0.0001,0.0008,-0.0032,0.0022,-0.0041,0.0018,-0.0033,-0.0024,0.0034}
Activity(exp=0): {0.0000,0.0000}
Position Bias(exp=0, s=0): {0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000}
Position Bias(exp=0, s=1): {0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000}
Suggested variations:
key=10;0;0, description = Initial model.
> Optimizing variation "Initial model." (component3-2-variation0).
>> Starting new optimization: component3-2-variation0. (2021-05-21 14:43:32.1).
>>> Packing before optimization
Packing: {"enrichmentModel":[{}],"countTable":[{"h":[42,43]}],"bindingModeInteractions":[],"bindingModes":[{},{},{},{"mononucleotide":[0,1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19,20,21,22,23,24,25,26,27,28,29,30,31,32,33,34,35,36,37,38,39],"activity":[[40,41]]},{}]}
Value and gradient before optimization:
=======================================
value = 0.6366767025626467
gradient = {0.0000,-0.0000,0.0000,0.0000,-0.0000,-0.0000,0.0000,0.0000,-0.0000,0.0000,0.0000,-0.0000,0.0000,-0.0000,-0.0000,0.0000,-0.0000,0.0000,-0.0000,-0.0000,-0.0000,-0.0000,0.0000,-0.0000,0.0000,-0.0000,-0.0000,0.0000,-0.0000,0.0000,0.0000,-0.0000,0.0000,0.0000,-0.0000,-0.0000,0.0000,-0.0000,-0.0000,0.0000,-0.0000,-0.0000,0.0000,-0.0000}
gradient norm = 2.472465801676865E-7
Already at minimum!
After: gradient norm = 2.472465801676865E-7
>>> Parameters after optimization
Count Table 0:
---------------
h: {1.8547,-1.8547}
Binding mode 0:
---------------
Mononucleotide: {}
Activity(exp=0): {-0.0000,2.1076}
Binding mode 1:
---------------
Mononucleotide: {0.0575,-1.1263,-0.0363,-0.9717,-0.5234,-1.7825,1.0472,-0.8181,0.0699,-1.1866,-0.6691,-0.2909,1.5349,-1.5847,-1.2707,-0.7562,-1.3311,1.6577,-1.7532,-0.6503,0.6043,-1.8676,-0.0912,-0.7224,-0.6508,-0.7734,-0.5526,-0.1000,-0.1745,-0.8638,-0.8638,-0.1745,-0.1000,-0.5526,-0.7734,-0.6508,-0.7224,-0.0912,-1.8676,0.6043,-0.6503,-1.7532,1.6577,-1.3311,-0.7562,-1.2707,-1.5847,1.5349,-0.2909,-0.6691,-1.1866,0.0699,-0.8181,1.0472,-1.7825,-0.5234,-0.9717,-0.0363,-1.1263,0.0575}
Activity(exp=0): {0.0001,-2.1390}
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Binding mode 2:
---------------
Mononucleotide: {0.0177,-1.0022,-0.3561,-0.5354,-0.8588,-0.8948,-1.4172,1.2947,-0.9956,-2.1409,0.6777,0.5827,0.8002,-1.3207,-1.1926,-0.1629,-1.4937,-0.1143,-0.1541,-0.1139,-0.8337,-1.5908,-0.8087,1.3571,-0.0124,0.6024,-2.4513,-0.0148,0.9132,-1.3669,-1.0789,-0.3434,-0.4345,-0.7387,-0.5925,-0.1104,-0.2444,-0.3713,-0.9518,-0.3086}
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Binding mode 3:
---------------
Mononucleotide: {-0.8560,0.0115,-0.3498,-0.8096,-0.9779,-0.0026,-0.1211,-0.9023,-0.9815,-0.0295,-0.0259,-0.9671,-0.9660,-0.0422,-0.0189,-0.9769,-0.9716,-0.0347,-0.0306,-0.9672,-0.9671,-0.0306,-0.0347,-0.9716,-0.9769,-0.0188,-0.0423,-0.9661,-0.9671,-0.0261,-0.0294,-0.9814,-0.9023,-0.1209,-0.0028,-0.9780,-0.8097,-0.3499,0.0116,-0.8560}
Activity(exp=0): {-0.0034,-2.0051}
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Position Bias(exp=0, s=1): {0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000}
Binding mode 4:
---------------
Mononucleotide: {-0.0011,0.0038,0.0009,-0.0045,0.0004,-0.0014,0.0020,-0.0042,-0.0012,-0.0020,0.0048,0.0042,-0.0042,-0.0022,0.0035,0.0044,0.0018,0.0043,-0.0001,-0.0004,-0.0005,-0.0025,0.0021,-0.0036,0.0023,-0.0024,-0.0045,0.0025,-0.0021,0.0024,-0.0031,-0.0001,0.0008,-0.0032,0.0022,-0.0041,0.0018,-0.0033,-0.0024,0.0034}
Activity(exp=0): {0.0000,0.0000}
Position Bias(exp=0, s=0): {0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000}
Position Bias(exp=0, s=1): {0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000}
The Likelihood DID NOT improve. Discarding fit component3-2-variation0.
Suggested variations:
key=11;0;0, description = Expands to the right.
key=11;0;1, description = Expands to the left.
> Optimizing variation "Expands to the right." (component3-2-variation1).
>> Starting new optimization: component3-2-variation1. (2021-05-21 14:43:35.293).
>>> Packing before optimization
Packing: {"enrichmentModel":[{}],"countTable":[{"h":[46,47]}],"bindingModeInteractions":[],"bindingModes":[{},{},{},{"mononucleotide":[0,1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19,20,21,22,23,24,25,26,27,28,29,30,31,32,33,34,35,36,37,38,39,40,41,42,43],"activity":[[44,45]]},{}]}
Value and gradient before optimization:
=======================================
value = 0.6372304201646029
gradient = {-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,0.0000,-0.0000,-0.0000,0.0000,-0.0000,-0.0000,0.0000,-0.0000}
gradient norm = 9.716832118646641E-5
Starting Function Value: 0.6372304201646029
Iterations Fnc. Calls Likelihood Distance Moved Step Alpha Gradient Norm
1 3 0.637230386831806 0.000675006742721 6.946777864217379 0.000141526728500
2 6 0.637229443504927 0.012139659717183 21.000000000000000 0.000189729587593
3 7 0.637217584042771 0.362358749551461 1.000000000000000 0.000642873553772
4 8 0.637212163075291 0.028472052896209 1.000000000000000 0.000362121230204
5 9 0.637207286099461 0.121704423092339 1.000000000000000 0.000033981756735
6 10 0.637206249314148 0.097113452365476 1.000000000000000 0.000037318614151
7 11 0.637205871934139 0.035909918292380 1.000000000000000 0.000031352761921
8 12 0.637204949233263 0.097130695087667 1.000000000000000 0.000133090118205
9 13 0.637204182242114 0.074073394713186 1.000000000000000 0.000161228509167
10 14 0.637203201491101 0.104257410903836 1.000000000000000 0.000055592222192
11 15 0.637202953794720 0.043938450616892 1.000000000000000 0.000010169726935
12 16 0.637202920875960 0.017127263477764 1.000000000000000 0.000010661743492
13 17 0.637202894282846 0.006737382244556 1.000000000000000 0.000009099582709
14 18 0.637202741001683 0.033089439970481 1.000000000000000 0.000006093528715
15 19 0.637202608852367 0.042720320844785 1.000000000000000 0.000009080918058
16 20 0.637202575313939 0.024191775989286 1.000000000000000 0.000006981950478
17 21 0.637202565295500 0.011451013768183 1.000000000000000 0.000005608247339
18 22 0.637202542707296 0.015844968663171 1.000000000000000 0.000007975568088
19 23 0.637202490190199 0.047486308315981 1.000000000000000 0.000003479275194
20 24 0.637202469465319 0.023461894342048 1.000000000000000 0.000004260278744
21 25 0.637202448110197 0.022333394327601 1.000000000000000 0.000005475888671
22 26 0.637202422267891 0.028072520158145 1.000000000000000 0.000006577585254
23 27 0.637202346484554 0.070251332104331 1.000000000000000 0.000006878287286
24 28 0.637202137094656 0.247475589750888 1.000000000000000 0.000049840266453
25 29 0.637202028996015 0.142653775789581 1.000000000000000 0.000022848393840
26 30 0.637201998640757 0.041114638893360 1.000000000000000 0.000004554303866
27 31 0.637201994461545 0.009400644135511 1.000000000000000 0.000004859102811
28 32 0.637201980869435 0.007523966195560 1.000000000000000 0.000005841925321
29 33 0.637201909331900 0.047032226074851 1.000000000000000 0.000008859288245
30 34 0.637201838581568 0.093503005406330 1.000000000000000 0.000014156408154
31 35 0.637201793888150 0.109530124254935 1.000000000000000 0.000004175874978
32 36 0.637201785208643 0.036551750889234 1.000000000000000 0.000003827731402
33 37 0.637201759038391 0.039177582994576 1.000000000000000 0.000005346183109
34 38 0.637201755178944 0.008016372907677 1.000000000000000 0.000018034994897
35 39 0.637201754277677 0.003332201937963 1.000000000000000 0.000009361719535
36 40 0.637201753791890 0.001903229891872 1.000000000000000 0.000000870153146
37 41 0.637201753630540 0.001864797772271 1.000000000000000 0.000001635568768
38 42 0.637201753576895 0.001790088531685 1.000000000000000 0.000001064650967
39 43 0.637201753541052 0.001790088531685 1.000000000000000 0.000000445778900
Convergence criteria met.
After: gradient norm = 4.4577889962561905E-7
>>> Parameters after optimization
Count Table 0:
---------------
h: {1.8545,-1.8545}
Binding mode 0:
---------------
Mononucleotide: {}
Activity(exp=0): {-0.0000,2.1076}
Binding mode 1:
---------------
Mononucleotide: {0.0575,-1.1263,-0.0363,-0.9717,-0.5234,-1.7825,1.0472,-0.8181,0.0699,-1.1866,-0.6691,-0.2909,1.5349,-1.5847,-1.2707,-0.7562,-1.3311,1.6577,-1.7532,-0.6503,0.6043,-1.8676,-0.0912,-0.7224,-0.6508,-0.7734,-0.5526,-0.1000,-0.1745,-0.8638,-0.8638,-0.1745,-0.1000,-0.5526,-0.7734,-0.6508,-0.7224,-0.0912,-1.8676,0.6043,-0.6503,-1.7532,1.6577,-1.3311,-0.7562,-1.2707,-1.5847,1.5349,-0.2909,-0.6691,-1.1866,0.0699,-0.8181,1.0472,-1.7825,-0.5234,-0.9717,-0.0363,-1.1263,0.0575}
Activity(exp=0): {0.0001,-2.1390}
Position Bias(exp=0, s=0): {-0.1094,-0.1094,-0.1094,-0.1094,-0.1094,0.3824,0.3824,0.3824,0.3824,0.3824,0.1219,0.1219,0.1219,0.1219,0.1219,0.7689,0.7689,0.7689,0.7689,0.7689,0.3248,0.3248,0.3248,0.3248,0.3248,0.2057,0.2057,0.2057,0.2057,0.2057,-0.1129,-0.1129,-0.1129,-0.1129,-0.1129,0.6830,0.6830,0.6830,0.6830,0.6830,0.6478,0.6478,0.6478,0.6478,0.6478,0.8161,0.8161,0.8161,0.8161,0.8161,0.5721,0.5721,0.5721,0.5721,0.5721,0.4143,0.4143,0.4143,0.4143,0.4143,0.2773,0.2773,0.2773,0.2773,0.2773,0.6606,0.6606,0.6606,0.6606,0.6606,0.2555,0.2555,0.2555,0.2555,0.2555,0.4671,0.4671,0.4671,0.4671,0.4671,1.0559,1.0559,1.0559,1.0559,1.0559,0.7284,0.7284,0.7284,0.7284,0.7284,0.7429,0.7429,0.7429,0.7429,0.7429,0.2641,0.2641,0.2641,0.2641,0.2641,0.0108,0.0108,0.0108,0.0108,0.0108,0.1645,0.1645,0.1645,0.1645,0.1645,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,0.2432,0.2432,0.2432,0.2432,0.2432,-0.1808,-0.1808,-0.1808,-0.1808,-0.1808,-0.0919,-0.0919,-0.0919,-0.0919,-0.0919,-0.0468,-0.0468,-0.0468,-0.0468,-0.0468,-0.7732,-0.7732,-0.7732,-0.7732,-0.7732,-0.6030,-0.6030,-0.6030,-0.6030,-0.6030,-0.7792,-0.7792,-0.7792,-0.7792,-0.7792,-0.4811,-0.4811,-0.4811,-0.4811,-0.4811,-0.6352,-0.6352,-0.6352,-0.6352,-0.6352,-1.1889,-1.1889,-1.1889,-1.1889,-1.1889,-0.8621,-0.8621,-0.8621,-0.8621,-0.8621,-0.9367,-0.9367,-0.9367,-0.9367,-0.9367,-0.8679,-0.8679,-0.8679,-0.8679,-0.8679,-1.3795,-1.3795,-1.3795,-1.3795,-1.3795,-1.9367}
Position Bias(exp=0, s=1): {-1.5623,-1.5623,-1.5623,-1.5623,-1.5623,-0.9422,-0.9422,-0.9422,-0.9422,-0.9422,-0.6520,-0.6520,-0.6520,-0.6520,-0.6520,-0.9996,-0.9996,-0.9996,-0.9996,-0.9996,-1.1655,-1.1655,-1.1655,-1.1655,-1.1655,-0.8720,-0.8720,-0.8720,-0.8720,-0.8720,-0.6872,-0.6872,-0.6872,-0.6872,-0.6872,-0.5987,-0.5987,-0.5987,-0.5987,-0.5987,-0.7251,-0.7251,-0.7251,-0.7251,-0.7251,-0.3411,-0.3411,-0.3411,-0.3411,-0.3411,-0.1834,-0.1834,-0.1834,-0.1834,-0.1834,-0.0742,-0.0742,-0.0742,-0.0742,-0.0742,-0.2385,-0.2385,-0.2385,-0.2385,-0.2385,-0.3174,-0.3174,-0.3174,-0.3174,-0.3174,0.1521,0.1521,0.1521,0.1521,0.1521,0.1366,0.1366,0.1366,0.1366,0.1366,0.5435,0.5435,0.5435,0.5435,0.5435,0.5682,0.5682,0.5682,0.5682,0.5682,-0.1571,-0.1571,-0.1571,-0.1571,-0.1571,0.2496,0.2496,0.2496,0.2496,0.2496,0.0967,0.0967,0.0967,0.0967,0.0967,0.6287,0.6287,0.6287,0.6287,0.6287,0.6213,0.6213,0.6213,0.6213,0.6213,0.6664,0.6664,0.6664,0.6664,0.6664,0.5852,0.5852,0.5852,0.5852,0.5852,0.7157,0.7157,0.7157,0.7157,0.7157,0.6877,0.6877,0.6877,0.6877,0.6877,0.2653,0.2653,0.2653,0.2653,0.2653,0.3378,0.3378,0.3378,0.3378,0.3378,0.4160,0.4160,0.4160,0.4160,0.4160,0.4512,0.4512,0.4512,0.4512,0.4512,0.7575,0.7575,0.7575,0.7575,0.7575,0.1034,0.1034,0.1034,0.1034,0.1034,-0.0910,-0.0910,-0.0910,-0.0910,-0.0910,0.3678,0.3678,0.3678,0.3678,0.3678,0.0305,0.0305,0.0305,0.0305,0.0305,0.2930,0.2930,0.2930,0.2930,0.2930,0.7417}
Binding mode 2:
---------------
Mononucleotide: {0.0177,-1.0022,-0.3561,-0.5354,-0.8588,-0.8948,-1.4172,1.2947,-0.9956,-2.1409,0.6777,0.5827,0.8002,-1.3207,-1.1926,-0.1629,-1.4937,-0.1143,-0.1541,-0.1139,-0.8337,-1.5908,-0.8087,1.3571,-0.0124,0.6024,-2.4513,-0.0148,0.9132,-1.3669,-1.0789,-0.3434,-0.4345,-0.7387,-0.5925,-0.1104,-0.2444,-0.3713,-0.9518,-0.3086}
Activity(exp=0): {-0.0000,-1.8761}
Position Bias(exp=0, s=0): {1.4716,1.4716,1.4716,1.4716,1.4716,0.8622,0.8622,0.8622,0.8622,0.8622,0.0850,0.0850,0.0850,0.0850,0.0850,0.3494,0.3494,0.3494,0.3494,0.3494,0.4509,0.4509,0.4509,0.4509,0.4509,0.1033,0.1033,0.1033,0.1033,0.1033,0.3880,0.3880,0.3880,0.3880,0.3880,0.2285,0.2285,0.2285,0.2285,0.2285,0.2388,0.2388,0.2388,0.2388,0.2388,0.4424,0.4424,0.4424,0.4424,0.4424,0.3598,0.3598,0.3598,0.3598,0.3598,0.6556,0.6556,0.6556,0.6556,0.6556,0.3873,0.3873,0.3873,0.3873,0.3873,-0.1983,-0.1983,-0.1983,-0.1983,-0.1983,0.4233,0.4233,0.4233,0.4233,0.4233,0.4151,0.4151,0.4151,0.4151,0.4151,0.0893,0.0893,0.0893,0.0893,0.0893,-0.0868,-0.0868,-0.0868,-0.0868,-0.0868,-0.2882,-0.2882,-0.2882,-0.2882,-0.2882,-0.3564,-0.3564,-0.3564,-0.3564,-0.3564,-0.2456,-0.2456,-0.2456,-0.2456,-0.2456,-0.0066,-0.0066,-0.0066,-0.0066,-0.0066,0.0845,0.0845,0.0845,0.0845,0.0845,-0.0315,-0.0315,-0.0315,-0.0315,-0.0315,-0.2276,-0.2276,-0.2276,-0.2276,-0.2276,-0.0647,-0.0647,-0.0647,-0.0647,-0.0647,-0.4754,-0.4754,-0.4754,-0.4754,-0.4754,-0.2584,-0.2584,-0.2584,-0.2584,-0.2584,-0.7119,-0.7119,-0.7119,-0.7119,-0.7119,-0.3834,-0.3834,-0.3834,-0.3834,-0.3834,-0.6788,-0.6788,-0.6788,-0.6788,-0.6788,-0.9776,-0.9776,-0.9776,-0.9776,-0.9776,-0.2137,-0.2137,-0.2137,-0.2137,-0.2137,-0.9546,-0.9546,-0.9546,-0.9546,-0.9546,-0.9791,-0.9791,-0.9791,-0.9791,-0.9791,-0.8733,-0.8733,-0.8733,-0.8733,-0.8733,-1.2081,-1.2081,-1.2081,-1.2081,-1.2081,-1.2312,-1.2312,-1.2312,-1.2312,-1.2312,-0.8508}
Position Bias(exp=0, s=1): {-1.1486,-1.1486,-1.1486,-1.1486,-1.1486,-0.7457,-0.7457,-0.7457,-0.7457,-0.7457,-0.8151,-0.8151,-0.8151,-0.8151,-0.8151,-1.1739,-1.1739,-1.1739,-1.1739,-1.1739,-1.1853,-1.1853,-1.1853,-1.1853,-1.1853,-0.8749,-0.8749,-0.8749,-0.8749,-0.8749,-0.8060,-0.8060,-0.8060,-0.8060,-0.8060,-1.0040,-1.0040,-1.0040,-1.0040,-1.0040,-0.2590,-0.2590,-0.2590,-0.2590,-0.2590,0.0146,0.0146,0.0146,0.0146,0.0146,-0.4727,-0.4727,-0.4727,-0.4727,-0.4727,0.2614,0.2614,0.2614,0.2614,0.2614,-0.5338,-0.5338,-0.5338,-0.5338,-0.5338,-0.3404,-0.3404,-0.3404,-0.3404,-0.3404,0.1594,0.1594,0.1594,0.1594,0.1594,-0.8559,-0.8559,-0.8559,-0.8559,-0.8559,0.3658,0.3658,0.3658,0.3658,0.3658,0.4292,0.4292,0.4292,0.4292,0.4292,0.5681,0.5681,0.5681,0.5681,0.5681,0.8204,0.8204,0.8204,0.8204,0.8204,0.8887,0.8887,0.8887,0.8887,0.8887,0.7949,0.7949,0.7949,0.7949,0.7949,0.7988,0.7988,0.7988,0.7988,0.7988,0.7756,0.7756,0.7756,0.7756,0.7756,0.6550,0.6550,0.6550,0.6550,0.6550,0.5473,0.5473,0.5473,0.5473,0.5473,0.3429,0.3429,0.3429,0.3429,0.3429,0.5347,0.5347,0.5347,0.5347,0.5347,0.8364,0.8364,0.8364,0.8364,0.8364,0.7782,0.7782,0.7782,0.7782,0.7782,0.5014,0.5014,0.5014,0.5014,0.5014,0.4788,0.4788,0.4788,0.4788,0.4788,0.7820,0.7820,0.7820,0.7820,0.7820,0.4840,0.4840,0.4840,0.4840,0.4840,0.5024,0.5024,0.5024,0.5024,0.5024,0.3937,0.3937,0.3937,0.3937,0.3937,0.4989,0.4989,0.4989,0.4989,0.4989,0.3353,0.3353,0.3353,0.3353,0.3353,-0.2334}
Binding mode 3:
---------------
Mononucleotide: {-0.8302,0.0297,-0.3353,-0.7659,-0.9394,0.0138,-0.1189,-0.8572,-0.9433,-0.0069,-0.0173,-0.9342,-0.9250,-0.0191,-0.0076,-0.9500,-0.9283,-0.0450,0.0008,-0.9293,-0.9294,-0.0205,-0.0223,-0.9295,-0.9297,-0.0008,-0.0432,-0.9280,-0.9489,-0.0053,-0.0217,-0.9259,-0.9350,-0.0190,-0.0052,-0.9426,-0.8565,-0.1156,0.0107,-0.9403,-0.7653,-0.3361,0.0314,-0.8292}
Activity(exp=0): {-0.0000,-1.9017}
Position Bias(exp=0, s=0): {0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000}
Position Bias(exp=0, s=1): {0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000}
Binding mode 4:
---------------
Mononucleotide: {-0.0011,0.0038,0.0009,-0.0045,0.0004,-0.0014,0.0020,-0.0042,-0.0012,-0.0020,0.0048,0.0042,-0.0042,-0.0022,0.0035,0.0044,0.0018,0.0043,-0.0001,-0.0004,-0.0005,-0.0025,0.0021,-0.0036,0.0023,-0.0024,-0.0045,0.0025,-0.0021,0.0024,-0.0031,-0.0001,0.0008,-0.0032,0.0022,-0.0041,0.0018,-0.0033,-0.0024,0.0034}
Activity(exp=0): {0.0000,0.0000}
Position Bias(exp=0, s=0): {0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000}
Position Bias(exp=0, s=1): {0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000}
The Likelihood DID NOT improve. Discarding fit component3-2-variation1.
> Optimizing variation "Expands to the left." (component3-2-variation2).
>> Starting new optimization: component3-2-variation2. (2021-05-21 14:45:55.991).
>>> Packing before optimization
Packing: {"enrichmentModel":[{}],"countTable":[{"h":[46,47]}],"bindingModeInteractions":[],"bindingModes":[{},{},{},{"mononucleotide":[0,1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19,20,21,22,23,24,25,26,27,28,29,30,31,32,33,34,35,36,37,38,39,40,41,42,43],"activity":[[44,45]]},{}]}
Value and gradient before optimization:
=======================================
value = 0.637230420303183
gradient = {0.0000,-0.0000,-0.0000,0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,0.0000,-0.0000}
gradient norm = 9.716932638048417E-5
Starting Function Value: 0.637230420303183
Iterations Fnc. Calls Likelihood Distance Moved Step Alpha Gradient Norm
1 3 0.637230386969090 0.000675026316262 6.946907438865583 0.000141530130525
2 6 0.637229443597355 0.012140051618733 21.000000000000000 0.000189732666958
3 7 0.637217583659898 0.362374562529267 1.000000000000000 0.000642888638669
4 8 0.637212162468760 0.028474872155995 1.000000000000000 0.000362110593345
5 9 0.637207286001872 0.121689472832901 1.000000000000000 0.000033980380201
6 10 0.637206249140501 0.097114392786010 1.000000000000000 0.000037327407093
7 11 0.637205871805373 0.035910266861856 1.000000000000000 0.000031353950680
8 12 0.637204949521448 0.097098481067217 1.000000000000000 0.000133089945152
9 13 0.637204182725260 0.074055945024732 1.000000000000000 0.000161248154009
10 14 0.637203201941297 0.104255708649325 1.000000000000000 0.000055750274666
11 15 0.637202954037054 0.043952604565015 1.000000000000000 0.000010199099532
12 16 0.637202921102644 0.017136667662332 1.000000000000000 0.000010662296868
13 17 0.637202894729468 0.006718496138466 1.000000000000000 0.000009119638072
14 18 0.637202741739020 0.032952295364081 1.000000000000000 0.000006162326606
15 19 0.637202607379706 0.043502049905730 1.000000000000000 0.000008629062015
16 20 0.637202572523439 0.024393994985557 1.000000000000000 0.000006843390488
17 21 0.637202560401170 0.013319105980095 1.000000000000000 0.000006124605954
18 22 0.637202523024706 0.024493130379684 1.000000000000000 0.000013350476147
19 23 0.637202459518587 0.064624399887147 1.000000000000000 0.000011980350674
20 24 0.637202388372065 0.063448390891594 1.000000000000000 0.000051737866504
21 25 0.637202307682325 0.097038066003278 1.000000000000000 0.000061178430409
22 26 0.637202271701652 0.045891438626412 1.000000000000000 0.000009184673271
23 27 0.637202253593280 0.024846496568749 1.000000000000000 0.000034709550840
24 28 0.637202240071047 0.013653915584061 1.000000000000000 0.000053199591010
25 29 0.637202197139206 0.044749176616967 1.000000000000000 0.000084293040154
26 30 0.637202145220036 0.062473506197864 1.000000000000000 0.000088019707611
27 31 0.637202073571206 0.087035621894438 1.000000000000000 0.000042239093357
28 32 0.637202020337302 0.080504728237717 1.000000000000000 0.000024134364020
29 33 0.637202002566537 0.018994622016724 1.000000000000000 0.000046507538484
30 34 0.637201976541364 0.022276750395495 1.000000000000000 0.000063159349910
31 35 0.637201940290689 0.035019084286371 1.000000000000000 0.000065082448095
32 36 0.637201862925761 0.094389513344257 1.000000000000000 0.000042803741269
33 37 0.637201814072981 0.094366195878116 1.000000000000000 0.000005723825607
34 38 0.637201806389379 0.012009601713435 1.000000000000000 0.000017675423961
35 39 0.637201799171089 0.007124232930937 1.000000000000000 0.000024374572895
36 40 0.637201790427482 0.008303079812111 1.000000000000000 0.000024149916328
37 41 0.637201763190576 0.038261695572191 1.000000000000000 0.000012265351403
38 42 0.637201757342502 0.016655875113266 1.000000000000000 0.000001157452333
39 43 0.637201757102482 0.001218620849533 1.000000000000000 0.000002384832433
40 44 0.637201756898453 0.001159349604773 1.000000000000000 0.000002369208081
41 45 0.637201754148143 0.005752320180845 1.000000000000000 0.000001913118983
42 46 0.637201752878433 0.006026578614910 1.000000000000000 0.000001047435244
43 47 0.637201752747919 0.001428896555245 1.000000000000000 0.000000845475862
44 48 0.637201752678420 0.001088276445119 1.000000000000000 0.000001374893594
45 49 0.637201752644970 0.000559839788678 1.000000000000000 0.000000922901897
46 50 0.637201752623946 0.000559839788678 1.000000000000000 0.000000227272212
Convergence criteria met.
After: gradient norm = 2.2727221202380427E-7
>>> Parameters after optimization
Count Table 0:
---------------
h: {1.8545,-1.8545}
Binding mode 0:
---------------
Mononucleotide: {}
Activity(exp=0): {-0.0000,2.1076}
Binding mode 1:
---------------
Mononucleotide: {0.0575,-1.1263,-0.0363,-0.9717,-0.5234,-1.7825,1.0472,-0.8181,0.0699,-1.1866,-0.6691,-0.2909,1.5349,-1.5847,-1.2707,-0.7562,-1.3311,1.6577,-1.7532,-0.6503,0.6043,-1.8676,-0.0912,-0.7224,-0.6508,-0.7734,-0.5526,-0.1000,-0.1745,-0.8638,-0.8638,-0.1745,-0.1000,-0.5526,-0.7734,-0.6508,-0.7224,-0.0912,-1.8676,0.6043,-0.6503,-1.7532,1.6577,-1.3311,-0.7562,-1.2707,-1.5847,1.5349,-0.2909,-0.6691,-1.1866,0.0699,-0.8181,1.0472,-1.7825,-0.5234,-0.9717,-0.0363,-1.1263,0.0575}
Activity(exp=0): {0.0001,-2.1390}
Position Bias(exp=0, s=0): {-0.1094,-0.1094,-0.1094,-0.1094,-0.1094,0.3824,0.3824,0.3824,0.3824,0.3824,0.1219,0.1219,0.1219,0.1219,0.1219,0.7689,0.7689,0.7689,0.7689,0.7689,0.3248,0.3248,0.3248,0.3248,0.3248,0.2057,0.2057,0.2057,0.2057,0.2057,-0.1129,-0.1129,-0.1129,-0.1129,-0.1129,0.6830,0.6830,0.6830,0.6830,0.6830,0.6478,0.6478,0.6478,0.6478,0.6478,0.8161,0.8161,0.8161,0.8161,0.8161,0.5721,0.5721,0.5721,0.5721,0.5721,0.4143,0.4143,0.4143,0.4143,0.4143,0.2773,0.2773,0.2773,0.2773,0.2773,0.6606,0.6606,0.6606,0.6606,0.6606,0.2555,0.2555,0.2555,0.2555,0.2555,0.4671,0.4671,0.4671,0.4671,0.4671,1.0559,1.0559,1.0559,1.0559,1.0559,0.7284,0.7284,0.7284,0.7284,0.7284,0.7429,0.7429,0.7429,0.7429,0.7429,0.2641,0.2641,0.2641,0.2641,0.2641,0.0108,0.0108,0.0108,0.0108,0.0108,0.1645,0.1645,0.1645,0.1645,0.1645,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,0.2432,0.2432,0.2432,0.2432,0.2432,-0.1808,-0.1808,-0.1808,-0.1808,-0.1808,-0.0919,-0.0919,-0.0919,-0.0919,-0.0919,-0.0468,-0.0468,-0.0468,-0.0468,-0.0468,-0.7732,-0.7732,-0.7732,-0.7732,-0.7732,-0.6030,-0.6030,-0.6030,-0.6030,-0.6030,-0.7792,-0.7792,-0.7792,-0.7792,-0.7792,-0.4811,-0.4811,-0.4811,-0.4811,-0.4811,-0.6352,-0.6352,-0.6352,-0.6352,-0.6352,-1.1889,-1.1889,-1.1889,-1.1889,-1.1889,-0.8621,-0.8621,-0.8621,-0.8621,-0.8621,-0.9367,-0.9367,-0.9367,-0.9367,-0.9367,-0.8679,-0.8679,-0.8679,-0.8679,-0.8679,-1.3795,-1.3795,-1.3795,-1.3795,-1.3795,-1.9367}
Position Bias(exp=0, s=1): {-1.5623,-1.5623,-1.5623,-1.5623,-1.5623,-0.9422,-0.9422,-0.9422,-0.9422,-0.9422,-0.6520,-0.6520,-0.6520,-0.6520,-0.6520,-0.9996,-0.9996,-0.9996,-0.9996,-0.9996,-1.1655,-1.1655,-1.1655,-1.1655,-1.1655,-0.8720,-0.8720,-0.8720,-0.8720,-0.8720,-0.6872,-0.6872,-0.6872,-0.6872,-0.6872,-0.5987,-0.5987,-0.5987,-0.5987,-0.5987,-0.7251,-0.7251,-0.7251,-0.7251,-0.7251,-0.3411,-0.3411,-0.3411,-0.3411,-0.3411,-0.1834,-0.1834,-0.1834,-0.1834,-0.1834,-0.0742,-0.0742,-0.0742,-0.0742,-0.0742,-0.2385,-0.2385,-0.2385,-0.2385,-0.2385,-0.3174,-0.3174,-0.3174,-0.3174,-0.3174,0.1521,0.1521,0.1521,0.1521,0.1521,0.1366,0.1366,0.1366,0.1366,0.1366,0.5435,0.5435,0.5435,0.5435,0.5435,0.5682,0.5682,0.5682,0.5682,0.5682,-0.1571,-0.1571,-0.1571,-0.1571,-0.1571,0.2496,0.2496,0.2496,0.2496,0.2496,0.0967,0.0967,0.0967,0.0967,0.0967,0.6287,0.6287,0.6287,0.6287,0.6287,0.6213,0.6213,0.6213,0.6213,0.6213,0.6664,0.6664,0.6664,0.6664,0.6664,0.5852,0.5852,0.5852,0.5852,0.5852,0.7157,0.7157,0.7157,0.7157,0.7157,0.6877,0.6877,0.6877,0.6877,0.6877,0.2653,0.2653,0.2653,0.2653,0.2653,0.3378,0.3378,0.3378,0.3378,0.3378,0.4160,0.4160,0.4160,0.4160,0.4160,0.4512,0.4512,0.4512,0.4512,0.4512,0.7575,0.7575,0.7575,0.7575,0.7575,0.1034,0.1034,0.1034,0.1034,0.1034,-0.0910,-0.0910,-0.0910,-0.0910,-0.0910,0.3678,0.3678,0.3678,0.3678,0.3678,0.0305,0.0305,0.0305,0.0305,0.0305,0.2930,0.2930,0.2930,0.2930,0.2930,0.7417}
Binding mode 2:
---------------
Mononucleotide: {0.0177,-1.0022,-0.3561,-0.5354,-0.8588,-0.8948,-1.4172,1.2947,-0.9956,-2.1409,0.6777,0.5827,0.8002,-1.3207,-1.1926,-0.1629,-1.4937,-0.1143,-0.1541,-0.1139,-0.8337,-1.5908,-0.8087,1.3571,-0.0124,0.6024,-2.4513,-0.0148,0.9132,-1.3669,-1.0789,-0.3434,-0.4345,-0.7387,-0.5925,-0.1104,-0.2444,-0.3713,-0.9518,-0.3086}
Activity(exp=0): {-0.0000,-1.8761}
Position Bias(exp=0, s=0): {1.4716,1.4716,1.4716,1.4716,1.4716,0.8622,0.8622,0.8622,0.8622,0.8622,0.0850,0.0850,0.0850,0.0850,0.0850,0.3494,0.3494,0.3494,0.3494,0.3494,0.4509,0.4509,0.4509,0.4509,0.4509,0.1033,0.1033,0.1033,0.1033,0.1033,0.3880,0.3880,0.3880,0.3880,0.3880,0.2285,0.2285,0.2285,0.2285,0.2285,0.2388,0.2388,0.2388,0.2388,0.2388,0.4424,0.4424,0.4424,0.4424,0.4424,0.3598,0.3598,0.3598,0.3598,0.3598,0.6556,0.6556,0.6556,0.6556,0.6556,0.3873,0.3873,0.3873,0.3873,0.3873,-0.1983,-0.1983,-0.1983,-0.1983,-0.1983,0.4233,0.4233,0.4233,0.4233,0.4233,0.4151,0.4151,0.4151,0.4151,0.4151,0.0893,0.0893,0.0893,0.0893,0.0893,-0.0868,-0.0868,-0.0868,-0.0868,-0.0868,-0.2882,-0.2882,-0.2882,-0.2882,-0.2882,-0.3564,-0.3564,-0.3564,-0.3564,-0.3564,-0.2456,-0.2456,-0.2456,-0.2456,-0.2456,-0.0066,-0.0066,-0.0066,-0.0066,-0.0066,0.0845,0.0845,0.0845,0.0845,0.0845,-0.0315,-0.0315,-0.0315,-0.0315,-0.0315,-0.2276,-0.2276,-0.2276,-0.2276,-0.2276,-0.0647,-0.0647,-0.0647,-0.0647,-0.0647,-0.4754,-0.4754,-0.4754,-0.4754,-0.4754,-0.2584,-0.2584,-0.2584,-0.2584,-0.2584,-0.7119,-0.7119,-0.7119,-0.7119,-0.7119,-0.3834,-0.3834,-0.3834,-0.3834,-0.3834,-0.6788,-0.6788,-0.6788,-0.6788,-0.6788,-0.9776,-0.9776,-0.9776,-0.9776,-0.9776,-0.2137,-0.2137,-0.2137,-0.2137,-0.2137,-0.9546,-0.9546,-0.9546,-0.9546,-0.9546,-0.9791,-0.9791,-0.9791,-0.9791,-0.9791,-0.8733,-0.8733,-0.8733,-0.8733,-0.8733,-1.2081,-1.2081,-1.2081,-1.2081,-1.2081,-1.2312,-1.2312,-1.2312,-1.2312,-1.2312,-0.8508}
Position Bias(exp=0, s=1): {-1.1486,-1.1486,-1.1486,-1.1486,-1.1486,-0.7457,-0.7457,-0.7457,-0.7457,-0.7457,-0.8151,-0.8151,-0.8151,-0.8151,-0.8151,-1.1739,-1.1739,-1.1739,-1.1739,-1.1739,-1.1853,-1.1853,-1.1853,-1.1853,-1.1853,-0.8749,-0.8749,-0.8749,-0.8749,-0.8749,-0.8060,-0.8060,-0.8060,-0.8060,-0.8060,-1.0040,-1.0040,-1.0040,-1.0040,-1.0040,-0.2590,-0.2590,-0.2590,-0.2590,-0.2590,0.0146,0.0146,0.0146,0.0146,0.0146,-0.4727,-0.4727,-0.4727,-0.4727,-0.4727,0.2614,0.2614,0.2614,0.2614,0.2614,-0.5338,-0.5338,-0.5338,-0.5338,-0.5338,-0.3404,-0.3404,-0.3404,-0.3404,-0.3404,0.1594,0.1594,0.1594,0.1594,0.1594,-0.8559,-0.8559,-0.8559,-0.8559,-0.8559,0.3658,0.3658,0.3658,0.3658,0.3658,0.4292,0.4292,0.4292,0.4292,0.4292,0.5681,0.5681,0.5681,0.5681,0.5681,0.8204,0.8204,0.8204,0.8204,0.8204,0.8887,0.8887,0.8887,0.8887,0.8887,0.7949,0.7949,0.7949,0.7949,0.7949,0.7988,0.7988,0.7988,0.7988,0.7988,0.7756,0.7756,0.7756,0.7756,0.7756,0.6550,0.6550,0.6550,0.6550,0.6550,0.5473,0.5473,0.5473,0.5473,0.5473,0.3429,0.3429,0.3429,0.3429,0.3429,0.5347,0.5347,0.5347,0.5347,0.5347,0.8364,0.8364,0.8364,0.8364,0.8364,0.7782,0.7782,0.7782,0.7782,0.7782,0.5014,0.5014,0.5014,0.5014,0.5014,0.4788,0.4788,0.4788,0.4788,0.4788,0.7820,0.7820,0.7820,0.7820,0.7820,0.4840,0.4840,0.4840,0.4840,0.4840,0.5024,0.5024,0.5024,0.5024,0.5024,0.3937,0.3937,0.3937,0.3937,0.3937,0.4989,0.4989,0.4989,0.4989,0.4989,0.3353,0.3353,0.3353,0.3353,0.3353,-0.2334}
Binding mode 3:
---------------
Mononucleotide: {-0.8290,0.0310,-0.3369,-0.7664,-0.9402,0.0110,-0.1157,-0.8567,-0.9423,-0.0061,-0.0189,-0.9343,-0.9257,-0.0202,-0.0069,-0.9487,-0.9287,-0.0435,0.0000,-0.9293,-0.9300,-0.0210,-0.0209,-0.9297,-0.9292,0.0011,-0.0443,-0.9291,-0.9488,-0.0074,-0.0198,-0.9256,-0.9343,-0.0180,-0.0068,-0.9425,-0.8570,-0.1162,0.0119,-0.9402,-0.7662,-0.3367,0.0305,-0.8292}
Activity(exp=0): {-0.0000,-1.9016}
Position Bias(exp=0, s=0): {0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000}
Position Bias(exp=0, s=1): {0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000}
Binding mode 4:
---------------
Mononucleotide: {-0.0011,0.0038,0.0009,-0.0045,0.0004,-0.0014,0.0020,-0.0042,-0.0012,-0.0020,0.0048,0.0042,-0.0042,-0.0022,0.0035,0.0044,0.0018,0.0043,-0.0001,-0.0004,-0.0005,-0.0025,0.0021,-0.0036,0.0023,-0.0024,-0.0045,0.0025,-0.0021,0.0024,-0.0031,-0.0001,0.0008,-0.0032,0.0022,-0.0041,0.0018,-0.0033,-0.0024,0.0034}
Activity(exp=0): {0.0000,0.0000}
Position Bias(exp=0, s=0): {0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000}
Position Bias(exp=0, s=1): {0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000}
The Likelihood DID NOT improve. Discarding fit component3-2-variation2.
> No varitions possible for Binding mode 3.
> Unfreezing component (component3-3-f0).
>> Starting new optimization: component3-3-f0. (2021-05-21 14:48:42.992).
>>> Packing before optimization
Packing: {"enrichmentModel":[{}],"countTable":[{"h":[120,121]}],"bindingModeInteractions":[],"bindingModes":[{},{},{},{"mononucleotide":[0,1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19,20,21,22,23,24,25,26,27,28,29,30,31,32,33,34,35,36,37,38,39],"activity":[[118,119]],"positionBias":[[[40,40,40,40,40,41,41,41,41,41,42,42,42,42,42,43,43,43,43,43,44,44,44,44,44,45,45,45,45,45,46,46,46,46,46,47,47,47,47,47,48,48,48,48,48,49,49,49,49,49,50,50,50,50,50,51,51,51,51,51,52,52,52,52,52,53,53,53,53,53,54,54,54,54,54,55,55,55,55,55,56,56,56,56,56,57,57,57,57,57,58,58,58,58,58,59,59,59,59,59,60,60,60,60,60,61,61,61,61,61,62,62,62,62,62,63,63,63,63,63,64,64,64,64,64,65,65,65,65,65,66,66,66,66,66,67,67,67,67,67,68,68,68,68,68,69,69,69,69,69,70,70,70,70,70,71,71,71,71,71,72,72,72,72,72,73,73,73,73,73,74,74,74,74,74,75,75,75,75,75,76,76,76,76,76,77,77,77,77,77,78],[79,79,79,79,79,80,80,80,80,80,81,81,81,81,81,82,82,82,82,82,83,83,83,83,83,84,84,84,84,84,85,85,85,85,85,86,86,86,86,86,87,87,87,87,87,88,88,88,88,88,89,89,89,89,89,90,90,90,90,90,91,91,91,91,91,92,92,92,92,92,93,93,93,93,93,94,94,94,94,94,95,95,95,95,95,96,96,96,96,96,97,97,97,97,97,98,98,98,98,98,99,99,99,99,99,100,100,100,100,100,101,101,101,101,101,102,102,102,102,102,103,103,103,103,103,104,104,104,104,104,105,105,105,105,105,106,106,106,106,106,107,107,107,107,107,108,108,108,108,108,109,109,109,109,109,110,110,110,110,110,111,111,111,111,111,112,112,112,112,112,113,113,113,113,113,114,114,114,114,114,115,115,115,115,115,116,116,116,116,116,117]]]},{}]}
Value and gradient before optimization:
=======================================
value = 0.6366767025626473
gradient = {0.0000,-0.0000,0.0000,0.0000,-0.0000,-0.0000,0.0000,0.0000,-0.0000,0.0000,0.0000,-0.0000,0.0000,-0.0000,-0.0000,0.0000,-0.0000,0.0000,-0.0000,-0.0000,-0.0000,-0.0000,0.0000,-0.0000,0.0000,-0.0000,-0.0000,0.0000,-0.0000,0.0000,0.0000,-0.0000,0.0000,0.0000,-0.0000,-0.0000,0.0000,-0.0000,-0.0000,0.0000,0.0000,0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,0.0000,0.0000,-0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,-0.0000,0.0000,0.0000,-0.0000,-0.0000,0.0000,0.0000,0.0000,0.0000,-0.0000,-0.0000,-0.0000,-0.0000,0.0000,0.0000,0.0000,-0.0000,-0.0000,0.0000,0.0000,-0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,-0.0000,0.0000,0.0000,-0.0000,-0.0000,0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,0.0000,0.0000,0.0000,-0.0000,-0.0000,0.0000,-0.0000}
gradient norm = 1.4315991359461703E-5
Starting Function Value: 0.6366767025626473
Iterations Fnc. Calls Likelihood Distance Moved Step Alpha Gradient Norm
1 3 0.636675433120764 0.175756539180077 12276.938059474036 0.000986544688188
2 4 0.636673102929475 0.178330025807601 1.000000000000000 0.000838260470155
3 5 0.636667375293393 0.922043075343510 1.000000000000000 0.000071234018823
4 6 0.636667360595760 0.028965053559756 1.000000000000000 0.000014918440078
5 7 0.636667358274712 0.007179454997175 1.000000000000000 0.000020548075243
6 8 0.636667352674336 0.010061190066277 1.000000000000000 0.000038180862148
7 9 0.636667340858461 0.011128033521130 1.000000000000000 0.000059984796029
8 10 0.636667323797404 0.003397754084526 1.000000000000000 0.000064434185029
9 11 0.636667298200149 0.013225112936069 1.000000000000000 0.000036045559202
10 12 0.636667271196256 0.028955824189782 1.000000000000000 0.000032277312167
11 13 0.636667256132638 0.014585650995775 1.000000000000000 0.000065440143347
12 14 0.636667215791313 0.024782598884665 1.000000000000000 0.000126503503430
13 15 0.636667146380931 0.022660381891354 1.000000000000000 0.000181332202784
14 16 0.636667027781914 0.032459598631796 1.000000000000000 0.000203186527727
15 17 0.636666918187161 0.059188736935854 1.000000000000000 0.000129665792111
16 18 0.636666880314615 0.051003354952964 1.000000000000000 0.000034427891413
17 19 0.636666876450836 0.014538898423230 1.000000000000000 0.000003577422477
18 20 0.636666876237977 0.001763122531043 1.000000000000000 0.000004384378290
19 21 0.636666875935360 0.000573082534398 1.000000000000000 0.000004833543587
20 22 0.636666871825330 0.004279928509439 1.000000000000000 0.000009041499001
21 23 0.636666863315928 0.005659861905105 1.000000000000000 0.000014642270300
22 24 0.636666844229091 0.010885386764154 1.000000000000000 0.000021090852070
23 25 0.636666816251690 0.018583475597408 1.000000000000000 0.000021998145309
24 26 0.636666756946165 0.036127547145431 1.000000000000000 0.000019726069368
25 27 0.636666632975767 0.106337745549351 1.000000000000000 0.000008112918100
26 28 0.636666581567885 0.056919873258333 1.000000000000000 0.000008891574192
27 29 0.636666560624883 0.023724156670292 1.000000000000000 0.000009446196365
28 30 0.636666541031397 0.018984738363924 1.000000000000000 0.000003547766624
29 31 0.636666536349876 0.008811850250600 1.000000000000000 0.000002297233053
30 32 0.636666535561398 0.001983569551968 1.000000000000000 0.000002927906100
31 33 0.636666533444760 0.004809365782197 1.000000000000000 0.000002630221376
32 34 0.636666527609249 0.010992074936751 1.000000000000000 0.000002247122555
33 35 0.636666520637555 0.017600428538789 1.000000000000000 0.000000901553641
34 36 0.636666515536426 0.018916602569127 1.000000000000000 0.000002472037207
35 37 0.636666513146181 0.010420567550667 1.000000000000000 0.000002366980297
36 38 0.636666506650131 0.025445537578480 1.000000000000000 0.000002550884828
37 39 0.636666502125027 0.021829876964097 1.000000000000000 0.000001035370175
38 40 0.636666500678268 0.005104071593151 1.000000000000000 0.000001028392519
39 41 0.636666497230384 0.011651328745175 1.000000000000000 0.000001172117472
40 42 0.636666493802763 0.017002765921957 1.000000000000000 0.000000938186140
41 43 0.636666490921929 0.017002765921957 1.000000000000000 0.000000524986939
Convergence criteria met.
After: gradient norm = 5.249869394048125E-7
>>> Parameters after optimization
Count Table 0:
---------------
h: {1.8551,-1.8551}
Binding mode 0:
---------------
Mononucleotide: {}
Activity(exp=0): {-0.0000,2.1076}
Binding mode 1:
---------------
Mononucleotide: {0.0575,-1.1263,-0.0363,-0.9717,-0.5234,-1.7825,1.0472,-0.8181,0.0699,-1.1866,-0.6691,-0.2909,1.5349,-1.5847,-1.2707,-0.7562,-1.3311,1.6577,-1.7532,-0.6503,0.6043,-1.8676,-0.0912,-0.7224,-0.6508,-0.7734,-0.5526,-0.1000,-0.1745,-0.8638,-0.8638,-0.1745,-0.1000,-0.5526,-0.7734,-0.6508,-0.7224,-0.0912,-1.8676,0.6043,-0.6503,-1.7532,1.6577,-1.3311,-0.7562,-1.2707,-1.5847,1.5349,-0.2909,-0.6691,-1.1866,0.0699,-0.8181,1.0472,-1.7825,-0.5234,-0.9717,-0.0363,-1.1263,0.0575}
Activity(exp=0): {0.0001,-2.1390}
Position Bias(exp=0, s=0): {-0.1094,-0.1094,-0.1094,-0.1094,-0.1094,0.3824,0.3824,0.3824,0.3824,0.3824,0.1219,0.1219,0.1219,0.1219,0.1219,0.7689,0.7689,0.7689,0.7689,0.7689,0.3248,0.3248,0.3248,0.3248,0.3248,0.2057,0.2057,0.2057,0.2057,0.2057,-0.1129,-0.1129,-0.1129,-0.1129,-0.1129,0.6830,0.6830,0.6830,0.6830,0.6830,0.6478,0.6478,0.6478,0.6478,0.6478,0.8161,0.8161,0.8161,0.8161,0.8161,0.5721,0.5721,0.5721,0.5721,0.5721,0.4143,0.4143,0.4143,0.4143,0.4143,0.2773,0.2773,0.2773,0.2773,0.2773,0.6606,0.6606,0.6606,0.6606,0.6606,0.2555,0.2555,0.2555,0.2555,0.2555,0.4671,0.4671,0.4671,0.4671,0.4671,1.0559,1.0559,1.0559,1.0559,1.0559,0.7284,0.7284,0.7284,0.7284,0.7284,0.7429,0.7429,0.7429,0.7429,0.7429,0.2641,0.2641,0.2641,0.2641,0.2641,0.0108,0.0108,0.0108,0.0108,0.0108,0.1645,0.1645,0.1645,0.1645,0.1645,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,0.2432,0.2432,0.2432,0.2432,0.2432,-0.1808,-0.1808,-0.1808,-0.1808,-0.1808,-0.0919,-0.0919,-0.0919,-0.0919,-0.0919,-0.0468,-0.0468,-0.0468,-0.0468,-0.0468,-0.7732,-0.7732,-0.7732,-0.7732,-0.7732,-0.6030,-0.6030,-0.6030,-0.6030,-0.6030,-0.7792,-0.7792,-0.7792,-0.7792,-0.7792,-0.4811,-0.4811,-0.4811,-0.4811,-0.4811,-0.6352,-0.6352,-0.6352,-0.6352,-0.6352,-1.1889,-1.1889,-1.1889,-1.1889,-1.1889,-0.8621,-0.8621,-0.8621,-0.8621,-0.8621,-0.9367,-0.9367,-0.9367,-0.9367,-0.9367,-0.8679,-0.8679,-0.8679,-0.8679,-0.8679,-1.3795,-1.3795,-1.3795,-1.3795,-1.3795,-1.9367}
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Binding mode 2:
---------------
Mononucleotide: {0.0177,-1.0022,-0.3561,-0.5354,-0.8588,-0.8948,-1.4172,1.2947,-0.9956,-2.1409,0.6777,0.5827,0.8002,-1.3207,-1.1926,-0.1629,-1.4937,-0.1143,-0.1541,-0.1139,-0.8337,-1.5908,-0.8087,1.3571,-0.0124,0.6024,-2.4513,-0.0148,0.9132,-1.3669,-1.0789,-0.3434,-0.4345,-0.7387,-0.5925,-0.1104,-0.2444,-0.3713,-0.9518,-0.3086}
Activity(exp=0): {-0.0000,-1.8761}
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Binding mode 3:
---------------
Mononucleotide: {-0.8704,0.0236,-0.3535,-0.8220,-0.9962,0.0190,-0.1206,-0.9244,-1.0009,-0.0153,-0.0120,-0.9941,-0.9839,-0.0391,0.0028,-1.0021,-0.9890,-0.0239,-0.0193,-0.9901,-0.9881,-0.0212,-0.0229,-0.9901,-1.0009,0.0020,-0.0395,-0.9838,-0.9949,-0.0100,-0.0185,-0.9990,-0.9250,-0.1150,0.0140,-0.9964,-0.8240,-0.3561,0.0279,-0.8701}
Activity(exp=0): {-0.0009,-2.0226}
Position Bias(exp=0, s=0): {-0.3388,-0.3388,-0.3388,-0.3388,-0.3388,-0.1939,-0.1939,-0.1939,-0.1939,-0.1939,0.0947,0.0947,0.0947,0.0947,0.0947,0.0857,0.0857,0.0857,0.0857,0.0857,0.1204,0.1204,0.1204,0.1204,0.1204,0.3855,0.3855,0.3855,0.3855,0.3855,0.2391,0.2391,0.2391,0.2391,0.2391,0.0265,0.0265,0.0265,0.0265,0.0265,0.0036,0.0036,0.0036,0.0036,0.0036,0.3102,0.3102,0.3102,0.3102,0.3102,0.3629,0.3629,0.3629,0.3629,0.3629,0.2863,0.2863,0.2863,0.2863,0.2863,0.1023,0.1023,0.1023,0.1023,0.1023,-0.0173,-0.0173,-0.0173,-0.0173,-0.0173,0.0133,0.0133,0.0133,0.0133,0.0133,0.1021,0.1021,0.1021,0.1021,0.1021,-0.0382,-0.0382,-0.0382,-0.0382,-0.0382,-0.1058,-0.1058,-0.1058,-0.1058,-0.1058,0.0137,0.0137,0.0137,0.0137,0.0137,-0.0476,-0.0476,-0.0476,-0.0476,-0.0476,-0.0279,-0.0279,-0.0279,-0.0279,-0.0279,-0.2134,-0.2134,-0.2134,-0.2134,-0.2134,-0.1851,-0.1851,-0.1851,-0.1851,-0.1851,-0.1643,-0.1643,-0.1643,-0.1643,-0.1643,-0.1095,-0.1095,-0.1095,-0.1095,-0.1095,-0.2175,-0.2175,-0.2175,-0.2175,-0.2175,-0.2146,-0.2146,-0.2146,-0.2146,-0.2146,-0.0761,-0.0761,-0.0761,-0.0761,-0.0761,0.0186,0.0186,0.0186,0.0186,0.0186,-0.0766,-0.0766,-0.0766,-0.0766,-0.0766,-0.1002,-0.1002,-0.1002,-0.1002,-0.1002,0.0676,0.0676,0.0676,0.0676,0.0676,0.0468,0.0468,0.0468,0.0468,0.0468,-0.0899,-0.0899,-0.0899,-0.0899,-0.0899,-0.1366,-0.1366,-0.1366,-0.1366,-0.1366,-0.1035,-0.1035,-0.1035,-0.1035,-0.1035,-0.0669,-0.0669,-0.0669,-0.0669,-0.0669,0.0266,0.0266,0.0266,0.0266,0.0266,0.0414}
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Binding mode 4:
---------------
Mononucleotide: {-0.0011,0.0038,0.0009,-0.0045,0.0004,-0.0014,0.0020,-0.0042,-0.0012,-0.0020,0.0048,0.0042,-0.0042,-0.0022,0.0035,0.0044,0.0018,0.0043,-0.0001,-0.0004,-0.0005,-0.0025,0.0021,-0.0036,0.0023,-0.0024,-0.0045,0.0025,-0.0021,0.0024,-0.0031,-0.0001,0.0008,-0.0032,0.0022,-0.0041,0.0018,-0.0033,-0.0024,0.0034}
Activity(exp=0): {0.0000,0.0000}
Position Bias(exp=0, s=0): {0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000}
Position Bias(exp=0, s=1): {0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000}
> Optimizing the full model (component3-4-all).
>> Starting new optimization: component3-4-all. (2021-05-21 14:51:07.619).
>>> Packing before optimization
Packing: 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Value and gradient before optimization:
=======================================
value = 0.6542680496926305
gradient = {-0.0000,0.0019,0.0000,-0.0005,-0.0002,-0.0001,0.0000,-0.0002,-0.0001,-0.0004,-0.0000,-0.0005,-0.0003,0.0000,0.0001,-0.0008,-0.0000,0.0001,-0.0006,-0.0001,-0.0001,0.0000,0.0000,-0.0008,-0.0001,0.0001,-0.0000,-0.0002,-0.0004,-0.0001,0.0000,-0.0004,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,0.0000,-0.0004,-0.0008,-0.0001,-0.0001,-0.0005,-0.0001,0.0000,0.0000,-0.0015,-0.0002,-0.0000,-0.0004,-0.0009,-0.0010,0.0000,0.0000,-0.0005,-0.0002,-0.0003,-0.0003,-0.0008,-0.0002,0.0000,0.0000,-0.0014,-0.0005,-0.0005,-0.0000,-0.0005,-0.0012,0.0000,0.0000,-0.0003,-0.0005,-0.0001,-0.0001,-0.0008,-0.0006,-0.0001,-0.0001,-0.0006,-0.0001,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0015,-0.0000,-0.0000,0.0000,-0.0000,0.0000,0.0000,-0.0000,-0.0000,0.0000,0.0000,-0.0000,-0.0000,0.0000,-0.0000,-0.0000,0.0000,0.0000,-0.0000,-0.0000,0.0000,0.0000,-0.0000,-0.0000,0.0000,0.0000,-0.0000,-0.0000,0.0000,-0.0000,-0.0000,0.0000,0.0000,-0.0000,0.0000,0.0000,-0.0000,-0.0000,0.0000,0.0000,0.0000,-0.0000,0.0000,-0.0000,-0.0000,-0.0000,0.0000,-0.0000,-0.0000,-0.0000,0.0000,0.0000,0.0000,-0.0000,-0.0000,-0.0000,-0.0000,0.0000,0.0000,-0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,-0.0000,0.0000,0.0000,-0.0000,-0.0000,0.0000,0.0000,0.0000,0.0000,-0.0000,-0.0000,-0.0000,-0.0000,0.0000,0.0000,0.0000,-0.0000,-0.0000,0.0000,0.0000,-0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,-0.0000,0.0000,0.0000,0.0000,-0.0000,0.0000,-0.0000,-0.0000,0.0000,0.0000,-0.0000,-0.0000,-0.0000,0.0000,-0.0000,-0.0000,-0.0000,0.0000,-0.0000,0.0000,-0.0000,-0.0000,0.0000,-0.0000}
gradient norm = 0.0045757253289153525
Starting Function Value: 0.6542680496926305
Iterations Fnc. Calls Likelihood Distance Moved Step Alpha Gradient Norm
1 3 0.654237218406837 0.011307606491619 2.471216185150676 0.004849194789340
2 4 0.654198193650507 0.013204512170905 1.000000000000000 0.005377067710478
3 5 0.654015016932798 0.101061895895393 1.000000000000000 0.003797141144062
4 6 0.653970226061933 0.045849347532157 1.000000000000000 0.001866192078425
5 7 0.653938954762315 0.046768571831760 1.000000000000000 0.003260873827562
6 8 0.653831122676087 0.159526097317874 1.000000000000000 0.006432139453184
7 10 0.653581360764920 0.370615040958546 0.413814822593588 0.006765606075020
8 12 0.653507870129118 0.154737123082925 0.156216283410914 0.006211582753296
9 13 0.653402191218055 0.108174936445267 1.000000000000000 0.002051241200262
10 14 0.653383347318562 0.032815290965698 1.000000000000000 0.001623418409411
11 15 0.653371200526233 0.027359056104442 1.000000000000000 0.001369213063572
12 16 0.653333189809232 0.076080189462424 1.000000000000000 0.002679338960559
13 17 0.653306982862935 0.052718394058898 1.000000000000000 0.003324206652464
14 18 0.653284354117140 0.046185480677605 1.000000000000000 0.002921719667842
15 19 0.653255217075200 0.067878893326208 1.000000000000000 0.002803116837250
16 20 0.653206381234256 0.145387621676562 1.000000000000000 0.002771386082019
17 21 0.653154335916894 0.194755309772156 1.000000000000000 0.002859650889164
18 22 0.653099585910000 0.265426802815867 1.000000000000000 0.003098126727115
19 23 0.653072879760639 0.224875835325736 1.000000000000000 0.003897705028034
20 24 0.653057656222342 0.084174480072467 1.000000000000000 0.000862731483217
21 25 0.653053459600816 0.022809197097110 1.000000000000000 0.001078056089879
22 26 0.653046398201456 0.036816182984962 1.000000000000000 0.001455846261371
23 27 0.653021168529165 0.171770593386677 1.000000000000000 0.002768257158494
24 28 0.653006854903765 0.097811842384417 1.000000000000000 0.002351247128630
25 29 0.652991435958788 0.133196812461754 1.000000000000000 0.001401643622418
26 30 0.652981948644360 0.129643792224788 1.000000000000000 0.000648283903324
27 31 0.652974397383268 0.126689839200095 1.000000000000000 0.000492020369340
28 32 0.652964314663664 0.171413947881618 1.000000000000000 0.000760264516571
29 33 0.652952671763759 0.172958073125658 1.000000000000000 0.000775902981590
30 34 0.652933875564062 0.278343449333320 1.000000000000000 0.000412839411742
31 35 0.652929522885406 0.065784833595273 1.000000000000000 0.001532380941775
32 36 0.652927961523791 0.060615486880627 1.000000000000000 0.000551423595652
33 37 0.652927402200186 0.047709389292671 1.000000000000000 0.000326158874733
34 38 0.652926551348873 0.041048754599370 1.000000000000000 0.000258338195950
35 39 0.652923052468519 0.058184740846973 1.000000000000000 0.000259979258650
36 40 0.652915426283418 0.089466865546521 1.000000000000000 0.000484074253000
37 41 0.652907598525435 0.229529337814067 1.000000000000000 0.001002294976893
38 42 0.652903151388231 0.208582326387892 1.000000000000000 0.000940437846519
39 43 0.652895294688532 0.236496000030552 1.000000000000000 0.000515388624156
40 44 0.652891635671671 0.185178097204279 1.000000000000000 0.000147506027721
41 45 0.652890768481848 0.071878846247464 1.000000000000000 0.000201149983352
42 46 0.652888831981565 0.088311634946941 1.000000000000000 0.000201689877454
43 47 0.652882157580340 0.305817891901588 1.000000000000000 0.000190601938331
44 48 0.652879079398147 0.127815427792050 1.000000000000000 0.000187738785679
45 49 0.652877818397965 0.034379806465573 1.000000000000000 0.000143072356318
46 50 0.652876268884687 0.050919388765341 1.000000000000000 0.000139332792990
47 51 0.652875168075335 0.040466291057257 1.000000000000000 0.000144815343407
48 52 0.652873465539360 0.106789208119539 1.000000000000000 0.000188379164480
49 53 0.652871889688557 0.142747463827112 1.000000000000000 0.000126113103640
50 54 0.652870651467727 0.152044871041429 1.000000000000000 0.000111610637829
51 55 0.652868853070799 0.181985625731274 1.000000000000000 0.000075805943252
52 56 0.652867423790387 0.185063016472547 1.000000000000000 0.000059312466852
53 57 0.652866025946974 0.140203240184369 1.000000000000000 0.000101928917684
54 58 0.652865048559237 0.098537167930817 1.000000000000000 0.000079087279496
55 59 0.652864592202932 0.041556164923238 1.000000000000000 0.000076490392312
56 60 0.652864049224947 0.066486123292094 1.000000000000000 0.000079090170017
57 61 0.652863276721934 0.132026182638842 1.000000000000000 0.000050931310418
58 62 0.652862851573387 0.132582059087220 1.000000000000000 0.000041154308076
59 63 0.652862388783101 0.099000331355631 1.000000000000000 0.000123909563738
60 64 0.652862061220755 0.094198851558618 1.000000000000000 0.000094622610287
61 65 0.652861732367431 0.046235802040748 1.000000000000000 0.000173755602274
62 66 0.652861516486109 0.029072943458240 1.000000000000000 0.000083256941667
63 67 0.652861454593724 0.035737274020438 1.000000000000000 0.000069766960748
64 68 0.652861341958928 0.027601916666429 1.000000000000000 0.000029041865704
65 69 0.652861209054886 0.032029043017613 1.000000000000000 0.000037713428250
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67 71 0.652860766317703 0.068339408039038 1.000000000000000 0.000069800090927
68 72 0.652860565234037 0.043678235061917 1.000000000000000 0.000027218092191
69 73 0.652860478407419 0.026590959433185 1.000000000000000 0.000050058889023
70 74 0.652860434359482 0.007139272866091 1.000000000000000 0.000052652480306
71 75 0.652860270399426 0.032011997117417 1.000000000000000 0.000038791502332
72 76 0.652860082719556 0.055517243980744 1.000000000000000 0.000023164873968
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74 78 0.652859891418076 0.025582020857609 1.000000000000000 0.000039209451373
75 79 0.652859699347845 0.044949318412955 1.000000000000000 0.000042560398299
76 80 0.652859321821964 0.102132056905882 1.000000000000000 0.000036398697995
77 81 0.652859130651255 0.128243239127630 1.000000000000000 0.000074922198523
78 82 0.652858796431306 0.032506693861797 1.000000000000000 0.000033382103919
79 83 0.652858622757759 0.025788954485719 1.000000000000000 0.000056304253785
80 84 0.652858472011087 0.039757791503872 1.000000000000000 0.000045681847187
81 85 0.652858238074471 0.081574914011716 1.000000000000000 0.000027571245572
82 86 0.652858013596656 0.098479876544695 1.000000000000000 0.000040583745777
83 87 0.652857846755720 0.064847990427126 1.000000000000000 0.000042709638802
84 88 0.652857558860152 0.083057814758277 1.000000000000000 0.000087846308555
85 89 0.652857176419436 0.085586143033574 1.000000000000000 0.000044246067329
86 90 0.652856973701543 0.051641455056102 1.000000000000000 0.000087291024855
87 91 0.652856758261660 0.036275421672821 1.000000000000000 0.000063928942500
88 92 0.652856677132641 0.037681626812553 1.000000000000000 0.000033745494991
89 93 0.652856591768314 0.014911551360192 1.000000000000000 0.000032811656892
90 94 0.652856300796683 0.049945229956584 1.000000000000000 0.000064190776395
91 95 0.652855925206236 0.062402811499027 1.000000000000000 0.000087393645908
92 96 0.652855700216774 0.035059637596155 1.000000000000000 0.000070873818742
93 97 0.652855440632624 0.033406991789650 1.000000000000000 0.000029361597800
94 98 0.652855193134293 0.047804167675679 1.000000000000000 0.000036661120566
95 99 0.652854875911400 0.045118704083226 1.000000000000000 0.000070440766099
96 100 0.652854578847354 0.081390532890867 1.000000000000000 0.000041620519434
97 101 0.652854488602821 0.042877238068694 1.000000000000000 0.000090286366113
98 102 0.652854435024629 0.017727274379955 1.000000000000000 0.000044743801582
99 103 0.652854366372139 0.018911875797798 1.000000000000000 0.000046201304323
100 104 0.652854300342477 0.012636976352787 1.000000000000000 0.000085921562266
101 105 0.652854178790346 0.025951244996940 1.000000000000000 0.000133974746416
102 106 0.652854023280269 0.033618807662332 1.000000000000000 0.000167509673746
103 107 0.652853778385059 0.049136552331578 1.000000000000000 0.000155624484852
104 108 0.652853496459137 0.085425238888243 1.000000000000000 0.000431891234974
105 109 0.652853209682454 0.040450686370398 1.000000000000000 0.000204739011602
106 110 0.652852993287927 0.050879853693032 1.000000000000000 0.000040045366054
107 111 0.652852919585070 0.024241324327166 1.000000000000000 0.000045701594859
108 112 0.652852819175910 0.025625523710527 1.000000000000000 0.000038060957000
109 113 0.652852682877180 0.024202585729549 1.000000000000000 0.000041013815886
110 114 0.652852409685614 0.052258740736738 1.000000000000000 0.000057599736268
111 115 0.652851945953445 0.102169859177559 1.000000000000000 0.000213777665122
112 116 0.652851558263339 0.107241827161455 1.000000000000000 0.000090088979795
113 117 0.652851349425198 0.021414184268767 1.000000000000000 0.000055210779631
114 118 0.652851206846623 0.023828664979348 1.000000000000000 0.000056984299307
115 119 0.652850913738618 0.031548162749622 1.000000000000000 0.000047271128236
116 120 0.652850677704101 0.074127914185635 1.000000000000000 0.000042814325861
117 121 0.652850489100826 0.076758448485320 1.000000000000000 0.000098953380341
118 122 0.652850265834116 0.021274146624613 1.000000000000000 0.000041785966276
119 123 0.652849995623790 0.044961657737767 1.000000000000000 0.000032570839617
120 125 0.652849983076624 0.006126136745580 0.112355356989828 0.000089284712856
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>>> Maximum iteration count reached.
After: gradient norm = 6.809716296499386E-5
>>> Parameters after optimization
Count Table 0:
---------------
h: {2.3913,-2.3913}
Binding mode 0:
---------------
Mononucleotide: {}
Activity(exp=0): {-0.0000,3.0406}
Binding mode 1:
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Binding mode 2:
---------------
Mononucleotide: {0.3323,-1.1496,-0.3531,-1.2976,-1.6667,-0.5992,-1.7351,1.5330,-1.4592,-2.2437,1.0427,0.1923,1.5413,-1.2638,-1.5600,-1.1855,-1.1782,-0.0282,-0.0842,-1.1773,-1.3152,-1.5496,-1.2299,1.6267,-0.1522,1.2914,-2.2350,-1.3722,1.2573,-1.6096,-0.5923,-1.5234,-1.1204,-0.5769,-0.4588,-0.3118,-0.4034,-0.4129,-1.1073,-0.5444}
Activity(exp=0): {-0.0000,-2.4680}
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Binding mode 3:
---------------
Mononucleotide: {-0.1537,-1.6065,-0.4376,0.7768,-0.3362,-1.1053,-1.5876,1.6080,-0.3856,-1.1100,-1.6038,1.6783,0.2421,-0.2113,-0.6560,-0.7957,-0.6091,-0.1850,-0.8722,0.2453,0.0605,-0.9004,-0.4121,-0.1691,-0.2025,-0.7365,-0.4498,-0.0322,0.0513,-0.6420,-0.6890,-0.1414,-0.2101,-0.3673,-0.5520,-0.2916,-0.2354,-0.2940,-0.6231,-0.2685}
Activity(exp=0): {-0.0001,-1.4210}
Position Bias(exp=0, s=0): {2.7570,2.7570,2.7570,2.7570,2.7570,1.8196,1.8196,1.8196,1.8196,1.8196,0.9046,0.9046,0.9046,0.9046,0.9046,0.6313,0.6313,0.6313,0.6313,0.6313,0.2965,0.2965,0.2965,0.2965,0.2965,0.7045,0.7045,0.7045,0.7045,0.7045,1.0118,1.0118,1.0118,1.0118,1.0118,0.3536,0.3536,0.3536,0.3536,0.3536,0.7902,0.7902,0.7902,0.7902,0.7902,0.9450,0.9450,0.9450,0.9450,0.9450,0.6148,0.6148,0.6148,0.6148,0.6148,0.6341,0.6341,0.6341,0.6341,0.6341,0.5460,0.5460,0.5460,0.5460,0.5460,-0.0107,-0.0107,-0.0107,-0.0107,-0.0107,-0.2834,-0.2834,-0.2834,-0.2834,-0.2834,0.9878,0.9878,0.9878,0.9878,0.9878,0.4683,0.4683,0.4683,0.4683,0.4683,0.1222,0.1222,0.1222,0.1222,0.1222,-0.3418,-0.3418,-0.3418,-0.3418,-0.3418,-0.3961,-0.3961,-0.3961,-0.3961,-0.3961,-0.5261,-0.5261,-0.5261,-0.5261,-0.5261,-0.6478,-0.6478,-0.6478,-0.6478,-0.6478,-0.6736,-0.6736,-0.6736,-0.6736,-0.6736,-0.9048,-0.9048,-0.9048,-0.9048,-0.9048,-0.8814,-0.8814,-0.8814,-0.8814,-0.8814,-0.6841,-0.6841,-0.6841,-0.6841,-0.6841,-0.4865,-0.4865,-0.4865,-0.4865,-0.4865,-1.0767,-1.0767,-1.0767,-1.0767,-1.0767,-1.1832,-1.1832,-1.1832,-1.1832,-1.1832,-1.0119,-1.0119,-1.0119,-1.0119,-1.0119,-0.8846,-0.8846,-0.8846,-0.8846,-0.8846,-0.9685,-0.9685,-0.9685,-0.9685,-0.9685,-0.9752,-0.9752,-0.9752,-0.9752,-0.9752,-1.2220,-1.2220,-1.2220,-1.2220,-1.2220,-1.2598,-1.2598,-1.2598,-1.2598,-1.2598,-1.0824,-1.0824,-1.0824,-1.0824,-1.0824,-1.4697,-1.4697,-1.4697,-1.4697,-1.4697,-1.2308,-1.2308,-1.2308,-1.2308,-1.2308,-1.0231}
Position Bias(exp=0, s=1): {-1.0377,-1.0377,-1.0377,-1.0377,-1.0377,-1.1602,-1.1602,-1.1602,-1.1602,-1.1602,-1.0471,-1.0471,-1.0471,-1.0471,-1.0471,-1.1192,-1.1192,-1.1192,-1.1192,-1.1192,-1.2607,-1.2607,-1.2607,-1.2607,-1.2607,-1.1248,-1.1248,-1.1248,-1.1248,-1.1248,-1.0232,-1.0232,-1.0232,-1.0232,-1.0232,-1.0627,-1.0627,-1.0627,-1.0627,-1.0627,-0.9831,-0.9831,-0.9831,-0.9831,-0.9831,-1.1172,-1.1172,-1.1172,-1.1172,-1.1172,-0.8281,-0.8281,-0.8281,-0.8281,-0.8281,-0.6550,-0.6550,-0.6550,-0.6550,-0.6550,-0.7102,-0.7102,-0.7102,-0.7102,-0.7102,-0.9307,-0.9307,-0.9307,-0.9307,-0.9307,-0.5793,-0.5793,-0.5793,-0.5793,-0.5793,-0.7665,-0.7665,-0.7665,-0.7665,-0.7665,0.2913,0.2913,0.2913,0.2913,0.2913,-0.1486,-0.1486,-0.1486,-0.1486,-0.1486,1.1114,1.1114,1.1114,1.1114,1.1114,0.9069,0.9069,0.9069,0.9069,0.9069,1.3044,1.3044,1.3044,1.3044,1.3044,1.0147,1.0147,1.0147,1.0147,1.0147,1.3500,1.3500,1.3500,1.3500,1.3500,0.8591,0.8591,0.8591,0.8591,0.8591,1.0596,1.0596,1.0596,1.0596,1.0596,0.8891,0.8891,0.8891,0.8891,0.8891,0.3916,0.3916,0.3916,0.3916,0.3916,0.8292,0.8292,0.8292,0.8292,0.8292,0.9910,0.9910,0.9910,0.9910,0.9910,0.8106,0.8106,0.8106,0.8106,0.8106,0.8806,0.8806,0.8806,0.8806,0.8806,0.9106,0.9106,0.9106,0.9106,0.9106,0.7475,0.7475,0.7475,0.7475,0.7475,0.9407,0.9407,0.9407,0.9407,0.9407,0.8668,0.8668,0.8668,0.8668,0.8668,0.8078,0.8078,0.8078,0.8078,0.8078,0.5969,0.5969,0.5969,0.5969,0.5969,1.0579,1.0579,1.0579,1.0579,1.0579,1.8326}
Binding mode 4:
---------------
Mononucleotide: {-0.0011,0.0038,0.0009,-0.0045,0.0004,-0.0014,0.0020,-0.0042,-0.0012,-0.0020,0.0048,0.0042,-0.0042,-0.0022,0.0035,0.0044,0.0018,0.0043,-0.0001,-0.0004,-0.0005,-0.0025,0.0021,-0.0036,0.0023,-0.0024,-0.0045,0.0025,-0.0021,0.0024,-0.0031,-0.0001,0.0008,-0.0032,0.0022,-0.0041,0.0018,-0.0033,-0.0024,0.0034}
Activity(exp=0): {0.0000,0.0000}
Position Bias(exp=0, s=0): {0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000}
Position Bias(exp=0, s=1): {0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000}
==================================
== Starts fiting Binding mode 4 ==
==================================
> Optimizing h (component4-0-h).
>> Starting new optimization: component4-0-h. (2021-05-21 15:35:37.718).
>>> Packing before optimization
Packing: {"enrichmentModel":[{}],"countTable":[{"h":[0,1]}],"bindingModeInteractions":[],"bindingModes":[{},{},{},{},{}]}
Value and gradient before optimization:
=======================================
value = 0.939145951560394
gradient = {-0.3264,0.3264}
gradient norm = 0.4616489544963634
Starting Function Value: 0.939145951560394
Iterations Fnc. Calls Likelihood Distance Moved Step Alpha Gradient Norm
1 2 0.661835049596455 1.000000000000000 2.166148087762814 0.057352355062944
2 3 0.658629524227790 0.141857129501750 1.000000000000000 0.012214380383222
3 4 0.658477568998582 0.024906974988747 1.000000000000000 0.000013688300247
4 5 0.658477568807802 0.024906974988747 1.000000000000000 0.000000003111681
Convergence criteria met.
After: gradient norm = 3.1116811949936086E-9
>>> Parameters after optimization
Count Table 0:
---------------
h: {3.1811,-3.1811}
Binding mode 0:
---------------
Mononucleotide: {}
Activity(exp=0): {-0.0000,3.0406}
Binding mode 1:
---------------
Mononucleotide: {0.0843,-1.1163,0.0063,-1.0045,-0.5432,-1.7830,1.1313,-0.8351,0.0797,-1.1774,-0.6446,-0.2878,1.5909,-1.5521,-1.2562,-0.8127,-1.4785,1.8255,-1.6844,-0.6927,0.6422,-1.8595,-0.0496,-0.7631,-0.6386,-0.7451,-0.5382,-0.1082,-0.1815,-0.8336,-0.8336,-0.1815,-0.1082,-0.5382,-0.7451,-0.6386,-0.7631,-0.0496,-1.8595,0.6422,-0.6927,-1.6844,1.8255,-1.4785,-0.8127,-1.2562,-1.5521,1.5909,-0.2878,-0.6446,-1.1774,0.0797,-0.8351,1.1313,-1.7830,-0.5432,-1.0045,0.0063,-1.1163,0.0843}
Activity(exp=0): {0.0000,-1.7835}
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Binding mode 2:
---------------
Mononucleotide: {0.3323,-1.1496,-0.3531,-1.2976,-1.6667,-0.5992,-1.7351,1.5330,-1.4592,-2.2437,1.0427,0.1923,1.5413,-1.2638,-1.5600,-1.1855,-1.1782,-0.0282,-0.0842,-1.1773,-1.3152,-1.5496,-1.2299,1.6267,-0.1522,1.2914,-2.2350,-1.3722,1.2573,-1.6096,-0.5923,-1.5234,-1.1204,-0.5769,-0.4588,-0.3118,-0.4034,-0.4129,-1.1073,-0.5444}
Activity(exp=0): {-0.0000,-2.4680}
Position Bias(exp=0, s=0): {0.5685,0.5685,0.5685,0.5685,0.5685,0.3059,0.3059,0.3059,0.3059,0.3059,-0.2168,-0.2168,-0.2168,-0.2168,-0.2168,-0.3529,-0.3529,-0.3529,-0.3529,-0.3529,-0.0305,-0.0305,-0.0305,-0.0305,-0.0305,0.0646,0.0646,0.0646,0.0646,0.0646,0.2939,0.2939,0.2939,0.2939,0.2939,-0.1955,-0.1955,-0.1955,-0.1955,-0.1955,0.2229,0.2229,0.2229,0.2229,0.2229,0.4659,0.4659,0.4659,0.4659,0.4659,0.3148,0.3148,0.3148,0.3148,0.3148,0.4675,0.4675,0.4675,0.4675,0.4675,0.5188,0.5188,0.5188,0.5188,0.5188,0.2666,0.2666,0.2666,0.2666,0.2666,0.2594,0.2594,0.2594,0.2594,0.2594,0.2091,0.2091,0.2091,0.2091,0.2091,-0.3472,-0.3472,-0.3472,-0.3472,-0.3472,0.3459,0.3459,0.3459,0.3459,0.3459,0.0739,0.0739,0.0739,0.0739,0.0739,0.1189,0.1189,0.1189,0.1189,0.1189,0.0241,0.0241,0.0241,0.0241,0.0241,0.0902,0.0902,0.0902,0.0902,0.0902,0.3233,0.3233,0.3233,0.3233,0.3233,0.3448,0.3448,0.3448,0.3448,0.3448,0.4027,0.4027,0.4027,0.4027,0.4027,0.0406,0.0406,0.0406,0.0406,0.0406,-0.1898,-0.1898,-0.1898,-0.1898,-0.1898,0.1207,0.1207,0.1207,0.1207,0.1207,-0.2963,-0.2963,-0.2963,-0.2963,-0.2963,-0.1853,-0.1853,-0.1853,-0.1853,-0.1853,-0.3853,-0.3853,-0.3853,-0.3853,-0.3853,-0.3646,-0.3646,-0.3646,-0.3646,-0.3646,0.2450,0.2450,0.2450,0.2450,0.2450,-0.7662,-0.7662,-0.7662,-0.7662,-0.7662,-0.5964,-0.5964,-0.5964,-0.5964,-0.5964,-0.5024,-0.5024,-0.5024,-0.5024,-0.5024,-0.8547,-0.8547,-0.8547,-0.8547,-0.8547,-0.6941,-0.6941,-0.6941,-0.6941,-0.6941,-0.5406}
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Binding mode 3:
---------------
Mononucleotide: {-0.1537,-1.6065,-0.4376,0.7768,-0.3362,-1.1053,-1.5876,1.6080,-0.3856,-1.1100,-1.6038,1.6783,0.2421,-0.2113,-0.6560,-0.7957,-0.6091,-0.1850,-0.8722,0.2453,0.0605,-0.9004,-0.4121,-0.1691,-0.2025,-0.7365,-0.4498,-0.0322,0.0513,-0.6420,-0.6890,-0.1414,-0.2101,-0.3673,-0.5520,-0.2916,-0.2354,-0.2940,-0.6231,-0.2685}
Activity(exp=0): {-0.0001,-1.4210}
Position Bias(exp=0, s=0): {2.7570,2.7570,2.7570,2.7570,2.7570,1.8196,1.8196,1.8196,1.8196,1.8196,0.9046,0.9046,0.9046,0.9046,0.9046,0.6313,0.6313,0.6313,0.6313,0.6313,0.2965,0.2965,0.2965,0.2965,0.2965,0.7045,0.7045,0.7045,0.7045,0.7045,1.0118,1.0118,1.0118,1.0118,1.0118,0.3536,0.3536,0.3536,0.3536,0.3536,0.7902,0.7902,0.7902,0.7902,0.7902,0.9450,0.9450,0.9450,0.9450,0.9450,0.6148,0.6148,0.6148,0.6148,0.6148,0.6341,0.6341,0.6341,0.6341,0.6341,0.5460,0.5460,0.5460,0.5460,0.5460,-0.0107,-0.0107,-0.0107,-0.0107,-0.0107,-0.2834,-0.2834,-0.2834,-0.2834,-0.2834,0.9878,0.9878,0.9878,0.9878,0.9878,0.4683,0.4683,0.4683,0.4683,0.4683,0.1222,0.1222,0.1222,0.1222,0.1222,-0.3418,-0.3418,-0.3418,-0.3418,-0.3418,-0.3961,-0.3961,-0.3961,-0.3961,-0.3961,-0.5261,-0.5261,-0.5261,-0.5261,-0.5261,-0.6478,-0.6478,-0.6478,-0.6478,-0.6478,-0.6736,-0.6736,-0.6736,-0.6736,-0.6736,-0.9048,-0.9048,-0.9048,-0.9048,-0.9048,-0.8814,-0.8814,-0.8814,-0.8814,-0.8814,-0.6841,-0.6841,-0.6841,-0.6841,-0.6841,-0.4865,-0.4865,-0.4865,-0.4865,-0.4865,-1.0767,-1.0767,-1.0767,-1.0767,-1.0767,-1.1832,-1.1832,-1.1832,-1.1832,-1.1832,-1.0119,-1.0119,-1.0119,-1.0119,-1.0119,-0.8846,-0.8846,-0.8846,-0.8846,-0.8846,-0.9685,-0.9685,-0.9685,-0.9685,-0.9685,-0.9752,-0.9752,-0.9752,-0.9752,-0.9752,-1.2220,-1.2220,-1.2220,-1.2220,-1.2220,-1.2598,-1.2598,-1.2598,-1.2598,-1.2598,-1.0824,-1.0824,-1.0824,-1.0824,-1.0824,-1.4697,-1.4697,-1.4697,-1.4697,-1.4697,-1.2308,-1.2308,-1.2308,-1.2308,-1.2308,-1.0231}
Position Bias(exp=0, s=1): {-1.0377,-1.0377,-1.0377,-1.0377,-1.0377,-1.1602,-1.1602,-1.1602,-1.1602,-1.1602,-1.0471,-1.0471,-1.0471,-1.0471,-1.0471,-1.1192,-1.1192,-1.1192,-1.1192,-1.1192,-1.2607,-1.2607,-1.2607,-1.2607,-1.2607,-1.1248,-1.1248,-1.1248,-1.1248,-1.1248,-1.0232,-1.0232,-1.0232,-1.0232,-1.0232,-1.0627,-1.0627,-1.0627,-1.0627,-1.0627,-0.9831,-0.9831,-0.9831,-0.9831,-0.9831,-1.1172,-1.1172,-1.1172,-1.1172,-1.1172,-0.8281,-0.8281,-0.8281,-0.8281,-0.8281,-0.6550,-0.6550,-0.6550,-0.6550,-0.6550,-0.7102,-0.7102,-0.7102,-0.7102,-0.7102,-0.9307,-0.9307,-0.9307,-0.9307,-0.9307,-0.5793,-0.5793,-0.5793,-0.5793,-0.5793,-0.7665,-0.7665,-0.7665,-0.7665,-0.7665,0.2913,0.2913,0.2913,0.2913,0.2913,-0.1486,-0.1486,-0.1486,-0.1486,-0.1486,1.1114,1.1114,1.1114,1.1114,1.1114,0.9069,0.9069,0.9069,0.9069,0.9069,1.3044,1.3044,1.3044,1.3044,1.3044,1.0147,1.0147,1.0147,1.0147,1.0147,1.3500,1.3500,1.3500,1.3500,1.3500,0.8591,0.8591,0.8591,0.8591,0.8591,1.0596,1.0596,1.0596,1.0596,1.0596,0.8891,0.8891,0.8891,0.8891,0.8891,0.3916,0.3916,0.3916,0.3916,0.3916,0.8292,0.8292,0.8292,0.8292,0.8292,0.9910,0.9910,0.9910,0.9910,0.9910,0.8106,0.8106,0.8106,0.8106,0.8106,0.8806,0.8806,0.8806,0.8806,0.8806,0.9106,0.9106,0.9106,0.9106,0.9106,0.7475,0.7475,0.7475,0.7475,0.7475,0.9407,0.9407,0.9407,0.9407,0.9407,0.8668,0.8668,0.8668,0.8668,0.8668,0.8078,0.8078,0.8078,0.8078,0.8078,0.5969,0.5969,0.5969,0.5969,0.5969,1.0579,1.0579,1.0579,1.0579,1.0579,1.8326}
Binding mode 4:
---------------
Mononucleotide: {-0.0011,0.0038,0.0009,-0.0045,0.0004,-0.0014,0.0020,-0.0042,-0.0012,-0.0020,0.0048,0.0042,-0.0042,-0.0022,0.0035,0.0044,0.0018,0.0043,-0.0001,-0.0004,-0.0005,-0.0025,0.0021,-0.0036,0.0023,-0.0024,-0.0045,0.0025,-0.0021,0.0024,-0.0031,-0.0001,0.0008,-0.0032,0.0022,-0.0041,0.0018,-0.0033,-0.0024,0.0034}
Activity(exp=0): {-2.0965,0.1072}
Position Bias(exp=0, s=0): {0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000}
Position Bias(exp=0, s=1): {0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000}
> Initial optimization (component4-1-f1).
>> Starting new optimization: component4-1-f1. (2021-05-21 15:35:54.4).
>>> Packing before optimization
Packing: {"enrichmentModel":[{}],"countTable":[{"h":[42,43]}],"bindingModeInteractions":[],"bindingModes":[{},{},{},{},{"mononucleotide":[0,1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19,20,21,22,23,24,25,26,27,28,29,30,31,32,33,34,35,36,37,38,39],"activity":[[40,41]]}]}
Value and gradient before optimization:
=======================================
value = 0.6640227610478369
gradient = {0.0010,0.0073,0.0074,0.0009,0.0010,0.0073,0.0074,0.0010,0.0010,0.0073,0.0074,0.0010,0.0010,0.0073,0.0074,0.0010,0.0010,0.0073,0.0073,0.0010,0.0010,0.0073,0.0073,0.0010,0.0010,0.0074,0.0073,0.0010,0.0010,0.0074,0.0073,0.0010,0.0010,0.0073,0.0073,0.0010,0.0010,0.0073,0.0073,0.0010,-0.0000,0.0166,0.0000,-0.0000}
gradient norm = 0.03702195544483441
Starting Function Value: 0.6640227610478369
Iterations Fnc. Calls Likelihood Distance Moved Step Alpha Gradient Norm
1 3 0.661985247133959 0.114947739402323 3.104853269395884 0.051059888495897
2 4 0.659343984569370 0.088752873810673 1.000000000000000 0.046857960972960
3 6 0.639268379841796 1.058541438915686 0.447387496670150 0.036550465465585
4 7 0.637138665365393 0.432470144949641 1.000000000000000 0.055822256473061
5 8 0.634743194421942 0.106112862246721 1.000000000000000 0.029433442958742
6 9 0.632736610621002 0.303242236061715 1.000000000000000 0.012769686855282
7 10 0.631811519575413 0.296291299281411 1.000000000000000 0.012737749049748
8 11 0.631059580749161 0.267613833768691 1.000000000000000 0.006808122482296
9 12 0.630645390163023 0.263457047095239 1.000000000000000 0.006982281337587
10 13 0.630327835057368 0.259994802385491 1.000000000000000 0.002041240762109
11 15 0.630204416866442 0.234302603164534 0.498764828465283 0.004473998927219
12 16 0.630116270774678 0.208649071764326 1.000000000000000 0.004403008266078
13 17 0.629993358720147 0.209319280192946 1.000000000000000 0.001276362136283
14 18 0.629889466080567 0.333773034702025 1.000000000000000 0.001685336847607
15 19 0.629789115096293 0.496002888479904 1.000000000000000 0.000331146443436
16 20 0.629721083999385 0.664813202877357 1.000000000000000 0.001356992344022
17 21 0.629698071492068 0.541609688334436 1.000000000000000 0.001047584415351
18 22 0.629696427428416 0.159377186609556 1.000000000000000 0.000227273903174
19 23 0.629696210502560 0.026762703031112 1.000000000000000 0.000126099637099
20 24 0.629696137849042 0.007391190881896 1.000000000000000 0.000188847498182
21 25 0.629695363001311 0.083260723182320 1.000000000000000 0.000622205563804
22 26 0.629693315998713 0.206636325845212 1.000000000000000 0.001189736871800
23 37 0.629678870757574 0.799363374895965 0.028029543725612 0.000247672698258
24 40 0.629678603258844 0.045074891396107 0.009782959741111 0.000117155071714
25 43 0.629652945719266 0.424225334857232 2.260033090430109 0.001774942104166
26 46 0.629641276481310 0.223062499342240 0.076007637362477 0.002878792551241
27 47 0.629594660233521 0.752735337627280 1.000000000000000 0.004677503112231
28 48 0.629461496726081 0.631695532094978 1.000000000000000 0.001011017532476
29 50 0.629439016141772 0.368027895326165 0.401520882136335 0.001021331858345
30 51 0.629402173038859 0.491226349194702 1.000000000000000 0.000470875346888
31 52 0.629396226363155 0.195015649149367 1.000000000000000 0.000626724784289
32 53 0.629390018868442 0.148797159114692 1.000000000000000 0.000702982590951
33 54 0.629380494168172 0.229330946415068 1.000000000000000 0.000210953614156
34 55 0.629372625820079 0.256941531447132 1.000000000000000 0.000520420014808
35 56 0.629370831354369 0.111166319375881 1.000000000000000 0.000833778902188
36 57 0.629370311580018 0.067963309985534 1.000000000000000 0.000826391887525
37 58 0.629369297096788 0.036263432877749 1.000000000000000 0.000792447823790
38 59 0.629367602755548 0.127993061676429 1.000000000000000 0.000575005600678
39 60 0.629367465966278 0.024277331301082 1.000000000000000 0.000536960582505
40 61 0.629367326387079 0.027098560805879 1.000000000000000 0.000445867428305
41 62 0.629367207349634 0.017020641548986 1.000000000000000 0.000324184404538
42 63 0.629367062825825 0.012462153290660 1.000000000000000 0.000104877334701
43 64 0.629367007721911 0.010397382250287 1.000000000000000 0.000013831382321
44 65 0.629366997475886 0.009668351305943 1.000000000000000 0.000029516078834
45 66 0.629366995311717 0.002148717236251 1.000000000000000 0.000020855798584
46 67 0.629366989989289 0.004530087464378 1.000000000000000 0.000006102571895
47 68 0.629366981780386 0.004285671882678 1.000000000000000 0.000022560733795
48 69 0.629366957449536 0.009701953487523 1.000000000000000 0.000059301814691
49 70 0.629366910445658 0.016606957656926 1.000000000000000 0.000099223447819
50 71 0.629366835810451 0.028071637372642 1.000000000000000 0.000117334168046
51 72 0.629366770732131 0.029169040103290 1.000000000000000 0.000080957827024
52 73 0.629366745334751 0.015767469140202 1.000000000000000 0.000022294178823
53 74 0.629366741797197 0.005005172857371 1.000000000000000 0.000006962786726
54 75 0.629366741125872 0.001737052583187 1.000000000000000 0.000010582425652
55 76 0.629366739553607 0.002302031467690 1.000000000000000 0.000015845887834
56 77 0.629366734619620 0.004000434023944 1.000000000000000 0.000026536656566
57 78 0.629366722163237 0.005905941859496 1.000000000000000 0.000043227298335
58 79 0.629366690957829 0.011254778335281 1.000000000000000 0.000068448221660
59 80 0.629366619684634 0.027573864072964 1.000000000000000 0.000100049832859
60 81 0.629366484982446 0.062869983405162 1.000000000000000 0.000123629956295
61 82 0.629366311266839 0.100716378791317 1.000000000000000 0.000109057518567
62 83 0.629366157738992 0.096827890320008 1.000000000000000 0.000060120987040
63 84 0.629366064681813 0.070296787428804 1.000000000000000 0.000018844449500
64 85 0.629366032364463 0.014320217201492 1.000000000000000 0.000045721458026
65 86 0.629365978035166 0.016089341713610 1.000000000000000 0.000078991474794
66 87 0.629365859716215 0.037700026117645 1.000000000000000 0.000120275160948
67 88 0.629365577491087 0.112112635180358 1.000000000000000 0.000175614477493
68 89 0.629365046182478 0.258108786583006 1.000000000000000 0.000215818722746
69 90 0.629364375539562 0.400645558330709 1.000000000000000 0.000184391772374
70 91 0.629363964216104 0.295765125568607 1.000000000000000 0.000079133773187
71 92 0.629363866592797 0.063678265976645 1.000000000000000 0.000009057984343
72 93 0.629363857374727 0.021842112245322 1.000000000000000 0.000012874083786
73 94 0.629363852709402 0.011561442945393 1.000000000000000 0.000014580224953
74 95 0.629363818750207 0.029818740522053 1.000000000000000 0.000019413759740
75 96 0.629363718930220 0.032237273985970 1.000000000000000 0.000025216099277
76 97 0.629363562663129 0.071513628219512 1.000000000000000 0.000026348994659
77 98 0.629363331331176 0.186567738295051 1.000000000000000 0.000028417584916
78 99 0.629363181821015 0.187911489105368 1.000000000000000 0.000003046777283
79 100 0.629363147400774 0.072863226046388 1.000000000000000 0.000004550619720
80 101 0.629363137318806 0.011617231256030 1.000000000000000 0.000007388678319
81 102 0.629363130642185 0.023566001463619 1.000000000000000 0.000003163735720
82 103 0.629363129414185 0.010289538329460 1.000000000000000 0.000001400648936
83 104 0.629363128998584 0.003281720126833 1.000000000000000 0.000001173567770
84 105 0.629363128822744 0.001151958446885 1.000000000000000 0.000001399946949
85 106 0.629363128477382 0.003019041115725 1.000000000000000 0.000001326221498
86 107 0.629363128018727 0.003019041115725 1.000000000000000 0.000000088173802
Convergence criteria met.
After: gradient norm = 8.817380245071509E-8
>>> Parameters after optimization
Count Table 0:
---------------
h: {2.4115,-2.4115}
Binding mode 0:
---------------
Mononucleotide: {}
Activity(exp=0): {-0.0000,3.0406}
Binding mode 1:
---------------
Mononucleotide: {0.0843,-1.1163,0.0063,-1.0045,-0.5432,-1.7830,1.1313,-0.8351,0.0797,-1.1774,-0.6446,-0.2878,1.5909,-1.5521,-1.2562,-0.8127,-1.4785,1.8255,-1.6844,-0.6927,0.6422,-1.8595,-0.0496,-0.7631,-0.6386,-0.7451,-0.5382,-0.1082,-0.1815,-0.8336,-0.8336,-0.1815,-0.1082,-0.5382,-0.7451,-0.6386,-0.7631,-0.0496,-1.8595,0.6422,-0.6927,-1.6844,1.8255,-1.4785,-0.8127,-1.2562,-1.5521,1.5909,-0.2878,-0.6446,-1.1774,0.0797,-0.8351,1.1313,-1.7830,-0.5432,-1.0045,0.0063,-1.1163,0.0843}
Activity(exp=0): {0.0000,-1.7835}
Position Bias(exp=0, s=0): {-0.1000,-0.1000,-0.1000,-0.1000,-0.1000,0.3420,0.3420,0.3420,0.3420,0.3420,0.1565,0.1565,0.1565,0.1565,0.1565,0.7748,0.7748,0.7748,0.7748,0.7748,0.2754,0.2754,0.2754,0.2754,0.2754,0.1661,0.1661,0.1661,0.1661,0.1661,-0.0710,-0.0710,-0.0710,-0.0710,-0.0710,0.6524,0.6524,0.6524,0.6524,0.6524,0.6584,0.6584,0.6584,0.6584,0.6584,0.8227,0.8227,0.8227,0.8227,0.8227,0.5881,0.5881,0.5881,0.5881,0.5881,0.4294,0.4294,0.4294,0.4294,0.4294,0.2774,0.2774,0.2774,0.2774,0.2774,0.6265,0.6265,0.6265,0.6265,0.6265,0.2571,0.2571,0.2571,0.2571,0.2571,0.5330,0.5330,0.5330,0.5330,0.5330,1.0854,1.0854,1.0854,1.0854,1.0854,0.6615,0.6615,0.6615,0.6615,0.6615,0.7256,0.7256,0.7256,0.7256,0.7256,0.2128,0.2128,0.2128,0.2128,0.2128,0.0779,0.0779,0.0779,0.0779,0.0779,0.1450,0.1450,0.1450,0.1450,0.1450,-0.0117,-0.0117,-0.0117,-0.0117,-0.0117,0.1968,0.1968,0.1968,0.1968,0.1968,-0.2039,-0.2039,-0.2039,-0.2039,-0.2039,-0.0305,-0.0305,-0.0305,-0.0305,-0.0305,-0.0376,-0.0376,-0.0376,-0.0376,-0.0376,-0.7690,-0.7690,-0.7690,-0.7690,-0.7690,-0.7034,-0.7034,-0.7034,-0.7034,-0.7034,-0.7746,-0.7746,-0.7746,-0.7746,-0.7746,-0.4369,-0.4369,-0.4369,-0.4369,-0.4369,-0.6283,-0.6283,-0.6283,-0.6283,-0.6283,-1.1814,-1.1814,-1.1814,-1.1814,-1.1814,-0.8685,-0.8685,-0.8685,-0.8685,-0.8685,-0.9871,-0.9871,-0.9871,-0.9871,-0.9871,-0.8819,-0.8819,-0.8819,-0.8819,-0.8819,-1.3005,-1.3005,-1.3005,-1.3005,-1.3005,-1.8677}
Position Bias(exp=0, s=1): {-1.4625,-1.4625,-1.4625,-1.4625,-1.4625,-0.9809,-0.9809,-0.9809,-0.9809,-0.9809,-0.7075,-0.7075,-0.7075,-0.7075,-0.7075,-0.9916,-0.9916,-0.9916,-0.9916,-0.9916,-1.1640,-1.1640,-1.1640,-1.1640,-1.1640,-0.8926,-0.8926,-0.8926,-0.8926,-0.8926,-0.6241,-0.6241,-0.6241,-0.6241,-0.6241,-0.6495,-0.6495,-0.6495,-0.6495,-0.6495,-0.7504,-0.7504,-0.7504,-0.7504,-0.7504,-0.3559,-0.3559,-0.3559,-0.3559,-0.3559,-0.1950,-0.1950,-0.1950,-0.1950,-0.1950,-0.1614,-0.1614,-0.1614,-0.1614,-0.1614,-0.2365,-0.2365,-0.2365,-0.2365,-0.2365,-0.2732,-0.2732,-0.2732,-0.2732,-0.2732,0.1468,0.1468,0.1468,0.1468,0.1468,0.1613,0.1613,0.1613,0.1613,0.1613,0.4813,0.4813,0.4813,0.4813,0.4813,0.6088,0.6088,0.6088,0.6088,0.6088,-0.1777,-0.1777,-0.1777,-0.1777,-0.1777,0.2607,0.2607,0.2607,0.2607,0.2607,0.1576,0.1576,0.1576,0.1576,0.1576,0.5039,0.5039,0.5039,0.5039,0.5039,0.6114,0.6114,0.6114,0.6114,0.6114,0.6572,0.6572,0.6572,0.6572,0.6572,0.6247,0.6247,0.6247,0.6247,0.6247,0.7371,0.7371,0.7371,0.7371,0.7371,0.6814,0.6814,0.6814,0.6814,0.6814,0.2808,0.2808,0.2808,0.2808,0.2808,0.3466,0.3466,0.3466,0.3466,0.3466,0.4059,0.4059,0.4059,0.4059,0.4059,0.4943,0.4943,0.4943,0.4943,0.4943,0.7828,0.7828,0.7828,0.7828,0.7828,0.1417,0.1417,0.1417,0.1417,0.1417,-0.0830,-0.0830,-0.0830,-0.0830,-0.0830,0.3357,0.3357,0.3357,0.3357,0.3357,-0.0125,-0.0125,-0.0125,-0.0125,-0.0125,0.3277,0.3277,0.3277,0.3277,0.3277,0.8442}
Binding mode 2:
---------------
Mononucleotide: {0.3323,-1.1496,-0.3531,-1.2976,-1.6667,-0.5992,-1.7351,1.5330,-1.4592,-2.2437,1.0427,0.1923,1.5413,-1.2638,-1.5600,-1.1855,-1.1782,-0.0282,-0.0842,-1.1773,-1.3152,-1.5496,-1.2299,1.6267,-0.1522,1.2914,-2.2350,-1.3722,1.2573,-1.6096,-0.5923,-1.5234,-1.1204,-0.5769,-0.4588,-0.3118,-0.4034,-0.4129,-1.1073,-0.5444}
Activity(exp=0): {-0.0000,-2.4680}
Position Bias(exp=0, s=0): {0.5685,0.5685,0.5685,0.5685,0.5685,0.3059,0.3059,0.3059,0.3059,0.3059,-0.2168,-0.2168,-0.2168,-0.2168,-0.2168,-0.3529,-0.3529,-0.3529,-0.3529,-0.3529,-0.0305,-0.0305,-0.0305,-0.0305,-0.0305,0.0646,0.0646,0.0646,0.0646,0.0646,0.2939,0.2939,0.2939,0.2939,0.2939,-0.1955,-0.1955,-0.1955,-0.1955,-0.1955,0.2229,0.2229,0.2229,0.2229,0.2229,0.4659,0.4659,0.4659,0.4659,0.4659,0.3148,0.3148,0.3148,0.3148,0.3148,0.4675,0.4675,0.4675,0.4675,0.4675,0.5188,0.5188,0.5188,0.5188,0.5188,0.2666,0.2666,0.2666,0.2666,0.2666,0.2594,0.2594,0.2594,0.2594,0.2594,0.2091,0.2091,0.2091,0.2091,0.2091,-0.3472,-0.3472,-0.3472,-0.3472,-0.3472,0.3459,0.3459,0.3459,0.3459,0.3459,0.0739,0.0739,0.0739,0.0739,0.0739,0.1189,0.1189,0.1189,0.1189,0.1189,0.0241,0.0241,0.0241,0.0241,0.0241,0.0902,0.0902,0.0902,0.0902,0.0902,0.3233,0.3233,0.3233,0.3233,0.3233,0.3448,0.3448,0.3448,0.3448,0.3448,0.4027,0.4027,0.4027,0.4027,0.4027,0.0406,0.0406,0.0406,0.0406,0.0406,-0.1898,-0.1898,-0.1898,-0.1898,-0.1898,0.1207,0.1207,0.1207,0.1207,0.1207,-0.2963,-0.2963,-0.2963,-0.2963,-0.2963,-0.1853,-0.1853,-0.1853,-0.1853,-0.1853,-0.3853,-0.3853,-0.3853,-0.3853,-0.3853,-0.3646,-0.3646,-0.3646,-0.3646,-0.3646,0.2450,0.2450,0.2450,0.2450,0.2450,-0.7662,-0.7662,-0.7662,-0.7662,-0.7662,-0.5964,-0.5964,-0.5964,-0.5964,-0.5964,-0.5024,-0.5024,-0.5024,-0.5024,-0.5024,-0.8547,-0.8547,-0.8547,-0.8547,-0.8547,-0.6941,-0.6941,-0.6941,-0.6941,-0.6941,-0.5406}
Position Bias(exp=0, s=1): {-1.0426,-1.0426,-1.0426,-1.0426,-1.0426,-0.2223,-0.2223,-0.2223,-0.2223,-0.2223,-0.6388,-0.6388,-0.6388,-0.6388,-0.6388,-0.8185,-0.8185,-0.8185,-0.8185,-0.8185,-0.4759,-0.4759,-0.4759,-0.4759,-0.4759,-0.3355,-0.3355,-0.3355,-0.3355,-0.3355,-0.6295,-0.6295,-0.6295,-0.6295,-0.6295,-0.7804,-0.7804,-0.7804,-0.7804,-0.7804,0.0785,0.0785,0.0785,0.0785,0.0785,0.2566,0.2566,0.2566,0.2566,0.2566,-0.4013,-0.4013,-0.4013,-0.4013,-0.4013,0.3270,0.3270,0.3270,0.3270,0.3270,-0.4532,-0.4532,-0.4532,-0.4532,-0.4532,-0.2651,-0.2651,-0.2651,-0.2651,-0.2651,0.1899,0.1899,0.1899,0.1899,0.1899,-0.3022,-0.3022,-0.3022,-0.3022,-0.3022,0.1843,0.1843,0.1843,0.1843,0.1843,0.4029,0.4029,0.4029,0.4029,0.4029,0.0661,0.0661,0.0661,0.0661,0.0661,0.2974,0.2974,0.2974,0.2974,0.2974,0.5984,0.5984,0.5984,0.5984,0.5984,0.5136,0.5136,0.5136,0.5136,0.5136,0.5765,0.5765,0.5765,0.5765,0.5765,0.6217,0.6217,0.6217,0.6217,0.6217,0.0131,0.0131,0.0131,0.0131,0.0131,0.0895,0.0895,0.0895,0.0895,0.0895,0.3546,0.3546,0.3546,0.3546,0.3546,0.2062,0.2062,0.2062,0.2062,0.2062,0.4370,0.4370,0.4370,0.4370,0.4370,0.4377,0.4377,0.4377,0.4377,0.4377,0.2191,0.2191,0.2191,0.2191,0.2191,0.1936,0.1936,0.1936,0.1936,0.1936,0.3106,0.3106,0.3106,0.3106,0.3106,-0.0317,-0.0317,-0.0317,-0.0317,-0.0317,0.4622,0.4622,0.4622,0.4622,0.4622,0.2973,0.2973,0.2973,0.2973,0.2973,-0.4352,-0.4352,-0.4352,-0.4352,-0.4352,-0.6609,-0.6609,-0.6609,-0.6609,-0.6609,-1.0381}
Binding mode 3:
---------------
Mononucleotide: {-0.1537,-1.6065,-0.4376,0.7768,-0.3362,-1.1053,-1.5876,1.6080,-0.3856,-1.1100,-1.6038,1.6783,0.2421,-0.2113,-0.6560,-0.7957,-0.6091,-0.1850,-0.8722,0.2453,0.0605,-0.9004,-0.4121,-0.1691,-0.2025,-0.7365,-0.4498,-0.0322,0.0513,-0.6420,-0.6890,-0.1414,-0.2101,-0.3673,-0.5520,-0.2916,-0.2354,-0.2940,-0.6231,-0.2685}
Activity(exp=0): {-0.0001,-1.4210}
Position Bias(exp=0, s=0): {2.7570,2.7570,2.7570,2.7570,2.7570,1.8196,1.8196,1.8196,1.8196,1.8196,0.9046,0.9046,0.9046,0.9046,0.9046,0.6313,0.6313,0.6313,0.6313,0.6313,0.2965,0.2965,0.2965,0.2965,0.2965,0.7045,0.7045,0.7045,0.7045,0.7045,1.0118,1.0118,1.0118,1.0118,1.0118,0.3536,0.3536,0.3536,0.3536,0.3536,0.7902,0.7902,0.7902,0.7902,0.7902,0.9450,0.9450,0.9450,0.9450,0.9450,0.6148,0.6148,0.6148,0.6148,0.6148,0.6341,0.6341,0.6341,0.6341,0.6341,0.5460,0.5460,0.5460,0.5460,0.5460,-0.0107,-0.0107,-0.0107,-0.0107,-0.0107,-0.2834,-0.2834,-0.2834,-0.2834,-0.2834,0.9878,0.9878,0.9878,0.9878,0.9878,0.4683,0.4683,0.4683,0.4683,0.4683,0.1222,0.1222,0.1222,0.1222,0.1222,-0.3418,-0.3418,-0.3418,-0.3418,-0.3418,-0.3961,-0.3961,-0.3961,-0.3961,-0.3961,-0.5261,-0.5261,-0.5261,-0.5261,-0.5261,-0.6478,-0.6478,-0.6478,-0.6478,-0.6478,-0.6736,-0.6736,-0.6736,-0.6736,-0.6736,-0.9048,-0.9048,-0.9048,-0.9048,-0.9048,-0.8814,-0.8814,-0.8814,-0.8814,-0.8814,-0.6841,-0.6841,-0.6841,-0.6841,-0.6841,-0.4865,-0.4865,-0.4865,-0.4865,-0.4865,-1.0767,-1.0767,-1.0767,-1.0767,-1.0767,-1.1832,-1.1832,-1.1832,-1.1832,-1.1832,-1.0119,-1.0119,-1.0119,-1.0119,-1.0119,-0.8846,-0.8846,-0.8846,-0.8846,-0.8846,-0.9685,-0.9685,-0.9685,-0.9685,-0.9685,-0.9752,-0.9752,-0.9752,-0.9752,-0.9752,-1.2220,-1.2220,-1.2220,-1.2220,-1.2220,-1.2598,-1.2598,-1.2598,-1.2598,-1.2598,-1.0824,-1.0824,-1.0824,-1.0824,-1.0824,-1.4697,-1.4697,-1.4697,-1.4697,-1.4697,-1.2308,-1.2308,-1.2308,-1.2308,-1.2308,-1.0231}
Position Bias(exp=0, s=1): {-1.0377,-1.0377,-1.0377,-1.0377,-1.0377,-1.1602,-1.1602,-1.1602,-1.1602,-1.1602,-1.0471,-1.0471,-1.0471,-1.0471,-1.0471,-1.1192,-1.1192,-1.1192,-1.1192,-1.1192,-1.2607,-1.2607,-1.2607,-1.2607,-1.2607,-1.1248,-1.1248,-1.1248,-1.1248,-1.1248,-1.0232,-1.0232,-1.0232,-1.0232,-1.0232,-1.0627,-1.0627,-1.0627,-1.0627,-1.0627,-0.9831,-0.9831,-0.9831,-0.9831,-0.9831,-1.1172,-1.1172,-1.1172,-1.1172,-1.1172,-0.8281,-0.8281,-0.8281,-0.8281,-0.8281,-0.6550,-0.6550,-0.6550,-0.6550,-0.6550,-0.7102,-0.7102,-0.7102,-0.7102,-0.7102,-0.9307,-0.9307,-0.9307,-0.9307,-0.9307,-0.5793,-0.5793,-0.5793,-0.5793,-0.5793,-0.7665,-0.7665,-0.7665,-0.7665,-0.7665,0.2913,0.2913,0.2913,0.2913,0.2913,-0.1486,-0.1486,-0.1486,-0.1486,-0.1486,1.1114,1.1114,1.1114,1.1114,1.1114,0.9069,0.9069,0.9069,0.9069,0.9069,1.3044,1.3044,1.3044,1.3044,1.3044,1.0147,1.0147,1.0147,1.0147,1.0147,1.3500,1.3500,1.3500,1.3500,1.3500,0.8591,0.8591,0.8591,0.8591,0.8591,1.0596,1.0596,1.0596,1.0596,1.0596,0.8891,0.8891,0.8891,0.8891,0.8891,0.3916,0.3916,0.3916,0.3916,0.3916,0.8292,0.8292,0.8292,0.8292,0.8292,0.9910,0.9910,0.9910,0.9910,0.9910,0.8106,0.8106,0.8106,0.8106,0.8106,0.8806,0.8806,0.8806,0.8806,0.8806,0.9106,0.9106,0.9106,0.9106,0.9106,0.7475,0.7475,0.7475,0.7475,0.7475,0.9407,0.9407,0.9407,0.9407,0.9407,0.8668,0.8668,0.8668,0.8668,0.8668,0.8078,0.8078,0.8078,0.8078,0.8078,0.5969,0.5969,0.5969,0.5969,0.5969,1.0579,1.0579,1.0579,1.0579,1.0579,1.8326}
Binding mode 4:
---------------
Mononucleotide: {-0.8402,0.1554,-0.2652,-0.7814,-0.9734,0.1332,-0.0020,-0.8892,-0.9729,0.0924,0.1129,-0.9638,-0.9502,0.0746,0.1181,-0.9738,-0.9559,0.0972,0.0854,-0.9581,-0.9581,0.0854,0.0972,-0.9559,-0.9738,0.1181,0.0746,-0.9502,-0.9638,0.1129,0.0924,-0.9729,-0.8892,-0.0019,0.1332,-0.9734,-0.7814,-0.2652,0.1554,-0.8402}
Activity(exp=0): {0.0005,-1.7314}
Position Bias(exp=0, s=0): {0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000}
Position Bias(exp=0, s=1): {0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000}
Suggested variations:
key=10;0;0, description = Initial model.
> Optimizing variation "Initial model." (component4-2-variation0).
>> Starting new optimization: component4-2-variation0. (2021-05-21 15:42:57.31).
>>> Packing before optimization
Packing: {"enrichmentModel":[{}],"countTable":[{"h":[42,43]}],"bindingModeInteractions":[],"bindingModes":[{},{},{},{},{"mononucleotide":[0,1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19,20,21,22,23,24,25,26,27,28,29,30,31,32,33,34,35,36,37,38,39],"activity":[[40,41]]}]}
Value and gradient before optimization:
=======================================
value = 0.6293631280187275
gradient = {-0.0000,0.0000,-0.0000,-0.0000,-0.0000,0.0000,0.0000,-0.0000,-0.0000,-0.0000,-0.0000,0.0000,-0.0000,-0.0000,0.0000,-0.0000,0.0000,-0.0000,-0.0000,0.0000,0.0000,-0.0000,-0.0000,0.0000,-0.0000,0.0000,-0.0000,-0.0000,0.0000,-0.0000,-0.0000,-0.0000,-0.0000,0.0000,0.0000,-0.0000,-0.0000,-0.0000,0.0000,-0.0000,0.0000,-0.0000,0.0000,-0.0000}
gradient norm = 8.81738024507556E-8
Already at minimum!
After: gradient norm = 8.81738024507556E-8
>>> Parameters after optimization
Count Table 0:
---------------
h: {2.4115,-2.4115}
Binding mode 0:
---------------
Mononucleotide: {}
Activity(exp=0): {-0.0000,3.0406}
Binding mode 1:
---------------
Mononucleotide: {0.0843,-1.1163,0.0063,-1.0045,-0.5432,-1.7830,1.1313,-0.8351,0.0797,-1.1774,-0.6446,-0.2878,1.5909,-1.5521,-1.2562,-0.8127,-1.4785,1.8255,-1.6844,-0.6927,0.6422,-1.8595,-0.0496,-0.7631,-0.6386,-0.7451,-0.5382,-0.1082,-0.1815,-0.8336,-0.8336,-0.1815,-0.1082,-0.5382,-0.7451,-0.6386,-0.7631,-0.0496,-1.8595,0.6422,-0.6927,-1.6844,1.8255,-1.4785,-0.8127,-1.2562,-1.5521,1.5909,-0.2878,-0.6446,-1.1774,0.0797,-0.8351,1.1313,-1.7830,-0.5432,-1.0045,0.0063,-1.1163,0.0843}
Activity(exp=0): {0.0000,-1.7835}
Position Bias(exp=0, s=0): {-0.1000,-0.1000,-0.1000,-0.1000,-0.1000,0.3420,0.3420,0.3420,0.3420,0.3420,0.1565,0.1565,0.1565,0.1565,0.1565,0.7748,0.7748,0.7748,0.7748,0.7748,0.2754,0.2754,0.2754,0.2754,0.2754,0.1661,0.1661,0.1661,0.1661,0.1661,-0.0710,-0.0710,-0.0710,-0.0710,-0.0710,0.6524,0.6524,0.6524,0.6524,0.6524,0.6584,0.6584,0.6584,0.6584,0.6584,0.8227,0.8227,0.8227,0.8227,0.8227,0.5881,0.5881,0.5881,0.5881,0.5881,0.4294,0.4294,0.4294,0.4294,0.4294,0.2774,0.2774,0.2774,0.2774,0.2774,0.6265,0.6265,0.6265,0.6265,0.6265,0.2571,0.2571,0.2571,0.2571,0.2571,0.5330,0.5330,0.5330,0.5330,0.5330,1.0854,1.0854,1.0854,1.0854,1.0854,0.6615,0.6615,0.6615,0.6615,0.6615,0.7256,0.7256,0.7256,0.7256,0.7256,0.2128,0.2128,0.2128,0.2128,0.2128,0.0779,0.0779,0.0779,0.0779,0.0779,0.1450,0.1450,0.1450,0.1450,0.1450,-0.0117,-0.0117,-0.0117,-0.0117,-0.0117,0.1968,0.1968,0.1968,0.1968,0.1968,-0.2039,-0.2039,-0.2039,-0.2039,-0.2039,-0.0305,-0.0305,-0.0305,-0.0305,-0.0305,-0.0376,-0.0376,-0.0376,-0.0376,-0.0376,-0.7690,-0.7690,-0.7690,-0.7690,-0.7690,-0.7034,-0.7034,-0.7034,-0.7034,-0.7034,-0.7746,-0.7746,-0.7746,-0.7746,-0.7746,-0.4369,-0.4369,-0.4369,-0.4369,-0.4369,-0.6283,-0.6283,-0.6283,-0.6283,-0.6283,-1.1814,-1.1814,-1.1814,-1.1814,-1.1814,-0.8685,-0.8685,-0.8685,-0.8685,-0.8685,-0.9871,-0.9871,-0.9871,-0.9871,-0.9871,-0.8819,-0.8819,-0.8819,-0.8819,-0.8819,-1.3005,-1.3005,-1.3005,-1.3005,-1.3005,-1.8677}
Position Bias(exp=0, s=1): {-1.4625,-1.4625,-1.4625,-1.4625,-1.4625,-0.9809,-0.9809,-0.9809,-0.9809,-0.9809,-0.7075,-0.7075,-0.7075,-0.7075,-0.7075,-0.9916,-0.9916,-0.9916,-0.9916,-0.9916,-1.1640,-1.1640,-1.1640,-1.1640,-1.1640,-0.8926,-0.8926,-0.8926,-0.8926,-0.8926,-0.6241,-0.6241,-0.6241,-0.6241,-0.6241,-0.6495,-0.6495,-0.6495,-0.6495,-0.6495,-0.7504,-0.7504,-0.7504,-0.7504,-0.7504,-0.3559,-0.3559,-0.3559,-0.3559,-0.3559,-0.1950,-0.1950,-0.1950,-0.1950,-0.1950,-0.1614,-0.1614,-0.1614,-0.1614,-0.1614,-0.2365,-0.2365,-0.2365,-0.2365,-0.2365,-0.2732,-0.2732,-0.2732,-0.2732,-0.2732,0.1468,0.1468,0.1468,0.1468,0.1468,0.1613,0.1613,0.1613,0.1613,0.1613,0.4813,0.4813,0.4813,0.4813,0.4813,0.6088,0.6088,0.6088,0.6088,0.6088,-0.1777,-0.1777,-0.1777,-0.1777,-0.1777,0.2607,0.2607,0.2607,0.2607,0.2607,0.1576,0.1576,0.1576,0.1576,0.1576,0.5039,0.5039,0.5039,0.5039,0.5039,0.6114,0.6114,0.6114,0.6114,0.6114,0.6572,0.6572,0.6572,0.6572,0.6572,0.6247,0.6247,0.6247,0.6247,0.6247,0.7371,0.7371,0.7371,0.7371,0.7371,0.6814,0.6814,0.6814,0.6814,0.6814,0.2808,0.2808,0.2808,0.2808,0.2808,0.3466,0.3466,0.3466,0.3466,0.3466,0.4059,0.4059,0.4059,0.4059,0.4059,0.4943,0.4943,0.4943,0.4943,0.4943,0.7828,0.7828,0.7828,0.7828,0.7828,0.1417,0.1417,0.1417,0.1417,0.1417,-0.0830,-0.0830,-0.0830,-0.0830,-0.0830,0.3357,0.3357,0.3357,0.3357,0.3357,-0.0125,-0.0125,-0.0125,-0.0125,-0.0125,0.3277,0.3277,0.3277,0.3277,0.3277,0.8442}
Binding mode 2:
---------------
Mononucleotide: {0.3323,-1.1496,-0.3531,-1.2976,-1.6667,-0.5992,-1.7351,1.5330,-1.4592,-2.2437,1.0427,0.1923,1.5413,-1.2638,-1.5600,-1.1855,-1.1782,-0.0282,-0.0842,-1.1773,-1.3152,-1.5496,-1.2299,1.6267,-0.1522,1.2914,-2.2350,-1.3722,1.2573,-1.6096,-0.5923,-1.5234,-1.1204,-0.5769,-0.4588,-0.3118,-0.4034,-0.4129,-1.1073,-0.5444}
Activity(exp=0): {-0.0000,-2.4680}
Position Bias(exp=0, s=0): {0.5685,0.5685,0.5685,0.5685,0.5685,0.3059,0.3059,0.3059,0.3059,0.3059,-0.2168,-0.2168,-0.2168,-0.2168,-0.2168,-0.3529,-0.3529,-0.3529,-0.3529,-0.3529,-0.0305,-0.0305,-0.0305,-0.0305,-0.0305,0.0646,0.0646,0.0646,0.0646,0.0646,0.2939,0.2939,0.2939,0.2939,0.2939,-0.1955,-0.1955,-0.1955,-0.1955,-0.1955,0.2229,0.2229,0.2229,0.2229,0.2229,0.4659,0.4659,0.4659,0.4659,0.4659,0.3148,0.3148,0.3148,0.3148,0.3148,0.4675,0.4675,0.4675,0.4675,0.4675,0.5188,0.5188,0.5188,0.5188,0.5188,0.2666,0.2666,0.2666,0.2666,0.2666,0.2594,0.2594,0.2594,0.2594,0.2594,0.2091,0.2091,0.2091,0.2091,0.2091,-0.3472,-0.3472,-0.3472,-0.3472,-0.3472,0.3459,0.3459,0.3459,0.3459,0.3459,0.0739,0.0739,0.0739,0.0739,0.0739,0.1189,0.1189,0.1189,0.1189,0.1189,0.0241,0.0241,0.0241,0.0241,0.0241,0.0902,0.0902,0.0902,0.0902,0.0902,0.3233,0.3233,0.3233,0.3233,0.3233,0.3448,0.3448,0.3448,0.3448,0.3448,0.4027,0.4027,0.4027,0.4027,0.4027,0.0406,0.0406,0.0406,0.0406,0.0406,-0.1898,-0.1898,-0.1898,-0.1898,-0.1898,0.1207,0.1207,0.1207,0.1207,0.1207,-0.2963,-0.2963,-0.2963,-0.2963,-0.2963,-0.1853,-0.1853,-0.1853,-0.1853,-0.1853,-0.3853,-0.3853,-0.3853,-0.3853,-0.3853,-0.3646,-0.3646,-0.3646,-0.3646,-0.3646,0.2450,0.2450,0.2450,0.2450,0.2450,-0.7662,-0.7662,-0.7662,-0.7662,-0.7662,-0.5964,-0.5964,-0.5964,-0.5964,-0.5964,-0.5024,-0.5024,-0.5024,-0.5024,-0.5024,-0.8547,-0.8547,-0.8547,-0.8547,-0.8547,-0.6941,-0.6941,-0.6941,-0.6941,-0.6941,-0.5406}
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Binding mode 3:
---------------
Mononucleotide: {-0.1537,-1.6065,-0.4376,0.7768,-0.3362,-1.1053,-1.5876,1.6080,-0.3856,-1.1100,-1.6038,1.6783,0.2421,-0.2113,-0.6560,-0.7957,-0.6091,-0.1850,-0.8722,0.2453,0.0605,-0.9004,-0.4121,-0.1691,-0.2025,-0.7365,-0.4498,-0.0322,0.0513,-0.6420,-0.6890,-0.1414,-0.2101,-0.3673,-0.5520,-0.2916,-0.2354,-0.2940,-0.6231,-0.2685}
Activity(exp=0): {-0.0001,-1.4210}
Position Bias(exp=0, s=0): {2.7570,2.7570,2.7570,2.7570,2.7570,1.8196,1.8196,1.8196,1.8196,1.8196,0.9046,0.9046,0.9046,0.9046,0.9046,0.6313,0.6313,0.6313,0.6313,0.6313,0.2965,0.2965,0.2965,0.2965,0.2965,0.7045,0.7045,0.7045,0.7045,0.7045,1.0118,1.0118,1.0118,1.0118,1.0118,0.3536,0.3536,0.3536,0.3536,0.3536,0.7902,0.7902,0.7902,0.7902,0.7902,0.9450,0.9450,0.9450,0.9450,0.9450,0.6148,0.6148,0.6148,0.6148,0.6148,0.6341,0.6341,0.6341,0.6341,0.6341,0.5460,0.5460,0.5460,0.5460,0.5460,-0.0107,-0.0107,-0.0107,-0.0107,-0.0107,-0.2834,-0.2834,-0.2834,-0.2834,-0.2834,0.9878,0.9878,0.9878,0.9878,0.9878,0.4683,0.4683,0.4683,0.4683,0.4683,0.1222,0.1222,0.1222,0.1222,0.1222,-0.3418,-0.3418,-0.3418,-0.3418,-0.3418,-0.3961,-0.3961,-0.3961,-0.3961,-0.3961,-0.5261,-0.5261,-0.5261,-0.5261,-0.5261,-0.6478,-0.6478,-0.6478,-0.6478,-0.6478,-0.6736,-0.6736,-0.6736,-0.6736,-0.6736,-0.9048,-0.9048,-0.9048,-0.9048,-0.9048,-0.8814,-0.8814,-0.8814,-0.8814,-0.8814,-0.6841,-0.6841,-0.6841,-0.6841,-0.6841,-0.4865,-0.4865,-0.4865,-0.4865,-0.4865,-1.0767,-1.0767,-1.0767,-1.0767,-1.0767,-1.1832,-1.1832,-1.1832,-1.1832,-1.1832,-1.0119,-1.0119,-1.0119,-1.0119,-1.0119,-0.8846,-0.8846,-0.8846,-0.8846,-0.8846,-0.9685,-0.9685,-0.9685,-0.9685,-0.9685,-0.9752,-0.9752,-0.9752,-0.9752,-0.9752,-1.2220,-1.2220,-1.2220,-1.2220,-1.2220,-1.2598,-1.2598,-1.2598,-1.2598,-1.2598,-1.0824,-1.0824,-1.0824,-1.0824,-1.0824,-1.4697,-1.4697,-1.4697,-1.4697,-1.4697,-1.2308,-1.2308,-1.2308,-1.2308,-1.2308,-1.0231}
Position Bias(exp=0, s=1): {-1.0377,-1.0377,-1.0377,-1.0377,-1.0377,-1.1602,-1.1602,-1.1602,-1.1602,-1.1602,-1.0471,-1.0471,-1.0471,-1.0471,-1.0471,-1.1192,-1.1192,-1.1192,-1.1192,-1.1192,-1.2607,-1.2607,-1.2607,-1.2607,-1.2607,-1.1248,-1.1248,-1.1248,-1.1248,-1.1248,-1.0232,-1.0232,-1.0232,-1.0232,-1.0232,-1.0627,-1.0627,-1.0627,-1.0627,-1.0627,-0.9831,-0.9831,-0.9831,-0.9831,-0.9831,-1.1172,-1.1172,-1.1172,-1.1172,-1.1172,-0.8281,-0.8281,-0.8281,-0.8281,-0.8281,-0.6550,-0.6550,-0.6550,-0.6550,-0.6550,-0.7102,-0.7102,-0.7102,-0.7102,-0.7102,-0.9307,-0.9307,-0.9307,-0.9307,-0.9307,-0.5793,-0.5793,-0.5793,-0.5793,-0.5793,-0.7665,-0.7665,-0.7665,-0.7665,-0.7665,0.2913,0.2913,0.2913,0.2913,0.2913,-0.1486,-0.1486,-0.1486,-0.1486,-0.1486,1.1114,1.1114,1.1114,1.1114,1.1114,0.9069,0.9069,0.9069,0.9069,0.9069,1.3044,1.3044,1.3044,1.3044,1.3044,1.0147,1.0147,1.0147,1.0147,1.0147,1.3500,1.3500,1.3500,1.3500,1.3500,0.8591,0.8591,0.8591,0.8591,0.8591,1.0596,1.0596,1.0596,1.0596,1.0596,0.8891,0.8891,0.8891,0.8891,0.8891,0.3916,0.3916,0.3916,0.3916,0.3916,0.8292,0.8292,0.8292,0.8292,0.8292,0.9910,0.9910,0.9910,0.9910,0.9910,0.8106,0.8106,0.8106,0.8106,0.8106,0.8806,0.8806,0.8806,0.8806,0.8806,0.9106,0.9106,0.9106,0.9106,0.9106,0.7475,0.7475,0.7475,0.7475,0.7475,0.9407,0.9407,0.9407,0.9407,0.9407,0.8668,0.8668,0.8668,0.8668,0.8668,0.8078,0.8078,0.8078,0.8078,0.8078,0.5969,0.5969,0.5969,0.5969,0.5969,1.0579,1.0579,1.0579,1.0579,1.0579,1.8326}
Binding mode 4:
---------------
Mononucleotide: {-0.8402,0.1554,-0.2652,-0.7814,-0.9734,0.1332,-0.0020,-0.8892,-0.9729,0.0924,0.1129,-0.9638,-0.9502,0.0746,0.1181,-0.9738,-0.9559,0.0972,0.0854,-0.9581,-0.9581,0.0854,0.0972,-0.9559,-0.9738,0.1181,0.0746,-0.9502,-0.9638,0.1129,0.0924,-0.9729,-0.8892,-0.0019,0.1332,-0.9734,-0.7814,-0.2652,0.1554,-0.8402}
Activity(exp=0): {0.0005,-1.7314}
Position Bias(exp=0, s=0): {0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000}
Position Bias(exp=0, s=1): {0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000}
The Likelihood DID NOT improve. Discarding fit component4-2-variation0.
Suggested variations:
key=11;0;0, description = Expands to the right.
key=11;0;1, description = Expands to the left.
> Optimizing variation "Expands to the right." (component4-2-variation1).
>> Starting new optimization: component4-2-variation1. (2021-05-21 15:43:01.255).
>>> Packing before optimization
Packing: {"enrichmentModel":[{}],"countTable":[{"h":[46,47]}],"bindingModeInteractions":[],"bindingModes":[{},{},{},{},{"mononucleotide":[0,1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19,20,21,22,23,24,25,26,27,28,29,30,31,32,33,34,35,36,37,38,39,40,41,42,43],"activity":[[44,45]]}]}
Value and gradient before optimization:
=======================================
value = 0.6299173968494826
gradient = {-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,0.0000,-0.0000,-0.0001,0.0001,0.0000,-0.0000,0.0000,-0.0000}
gradient norm = 1.1396058667339758E-4
Starting Function Value: 0.6299173968494826
Iterations Fnc. Calls Likelihood Distance Moved Step Alpha Gradient Norm
1 3 0.629917349540519 0.000818254573752 7.180154100974921 0.000168873404451
2 5 0.629917023466509 0.003508452652611 5.000000000000000 0.000179664922128
3 6 0.629904250120566 0.308892158681665 1.000000000000000 0.000530697495471
4 7 0.629893773943973 0.092348941276371 1.000000000000000 0.000665863935204
5 8 0.629886392681578 0.215242851237659 1.000000000000000 0.000381838046981
6 9 0.629885704241183 0.063260199880295 1.000000000000000 0.000049271657284
7 10 0.629885658932439 0.019719324690549 1.000000000000000 0.000038384178389
8 11 0.629885638867493 0.004647117557472 1.000000000000000 0.000052859813576
9 12 0.629885479493429 0.026642726306156 1.000000000000000 0.000140677929239
10 13 0.629885194163214 0.034330333882869 1.000000000000000 0.000235004520858
11 14 0.629884477444099 0.069771200384270 1.000000000000000 0.000361276952606
12 15 0.629883307348857 0.102945424058252 1.000000000000000 0.000420720289619
13 16 0.629882089816096 0.109706067042497 1.000000000000000 0.000313913808775
14 17 0.629881571547736 0.059851874696171 1.000000000000000 0.000129718501318
15 18 0.629881470348775 0.031838200572081 1.000000000000000 0.000017152329938
16 19 0.629881462150360 0.010648316967216 1.000000000000000 0.000016124505324
17 20 0.629881459280394 0.002099126893009 1.000000000000000 0.000016078113135
18 21 0.629881354662194 0.011815048484596 1.000000000000000 0.000016014563294
19 22 0.629881047192332 0.060291017812937 1.000000000000000 0.000010685903533
20 23 0.629880997266986 0.024259418248664 1.000000000000000 0.000007167554204
21 24 0.629880973415146 0.017924152836476 1.000000000000000 0.000004927496791
22 25 0.629880961209424 0.009255182004508 1.000000000000000 0.000005730259131
23 26 0.629880934621749 0.018055650359832 1.000000000000000 0.000008133582662
24 27 0.629880900837118 0.020991956318428 1.000000000000000 0.000008002774662
25 28 0.629880861558300 0.028562765533822 1.000000000000000 0.000006701253330
26 29 0.629880838808017 0.022663023117508 1.000000000000000 0.000004141367744
27 30 0.629880824599291 0.012829485609796 1.000000000000000 0.000007378005098
28 31 0.629880803769703 0.020837094208905 1.000000000000000 0.000006206604585
29 32 0.629880783167068 0.021276502589516 1.000000000000000 0.000005495074442
30 33 0.629880752985574 0.037955312847629 1.000000000000000 0.000005919142629
31 34 0.629880734460528 0.028281518350316 1.000000000000000 0.000005998886488
32 35 0.629880715334857 0.025959717305077 1.000000000000000 0.000007896071119
33 36 0.629880683102384 0.041906070637148 1.000000000000000 0.000006266997040
34 37 0.629880658024358 0.036932371053698 1.000000000000000 0.000003727046492
35 38 0.629880636709929 0.024644753166984 1.000000000000000 0.000006500521680
36 39 0.629880599701314 0.045614957125348 1.000000000000000 0.000009347189443
37 40 0.629880556913135 0.053320962437351 1.000000000000000 0.000011920183319
38 41 0.629880474709073 0.122204213841473 1.000000000000000 0.000008325322072
39 42 0.629880415406330 0.103312955219723 1.000000000000000 0.000007197537355
40 43 0.629880375836919 0.072234019832791 1.000000000000000 0.000005970132268
41 44 0.629880352100304 0.036322547889209 1.000000000000000 0.000007625376608
42 45 0.629880322663812 0.036213622749098 1.000000000000000 0.000007090301258
43 46 0.629880291882562 0.051786563797436 1.000000000000000 0.000008396678288
44 47 0.629880288041902 0.009538825960835 1.000000000000000 0.000001181103586
45 48 0.629880287479788 0.002474322267376 1.000000000000000 0.000001387670001
46 49 0.629880286264318 0.002742615137743 1.000000000000000 0.000001597079765
47 50 0.629880285490077 0.004308105219333 1.000000000000000 0.000000790121949
48 51 0.629880285297031 0.001501792095511 1.000000000000000 0.000000598779042
49 52 0.629880284949616 0.001501792095511 1.000000000000000 0.000000492341567
Convergence criteria met.
After: gradient norm = 4.923415672370778E-7
>>> Parameters after optimization
Count Table 0:
---------------
h: {2.4111,-2.4111}
Binding mode 0:
---------------
Mononucleotide: {}
Activity(exp=0): {-0.0000,3.0406}
Binding mode 1:
---------------
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Binding mode 2:
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Activity(exp=0): {-0.0000,-2.4680}
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Binding mode 3:
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Binding mode 4:
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Activity(exp=0): {-0.0000,-1.6388}
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Position Bias(exp=0, s=1): {0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000}
The Likelihood DID NOT improve. Discarding fit component4-2-variation1.
> Optimizing variation "Expands to the left." (component4-2-variation2).
>> Starting new optimization: component4-2-variation2. (2021-05-21 15:46:26.281).
>>> Packing before optimization
Packing: {"enrichmentModel":[{}],"countTable":[{"h":[46,47]}],"bindingModeInteractions":[],"bindingModes":[{},{},{},{},{"mononucleotide":[0,1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19,20,21,22,23,24,25,26,27,28,29,30,31,32,33,34,35,36,37,38,39,40,41,42,43],"activity":[[44,45]]}]}
Value and gradient before optimization:
=======================================
value = 0.6299173968585169
gradient = {0.0001,-0.0001,-0.0000,0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,0.0000,-0.0000,0.0000,-0.0000}
gradient norm = 1.1396085879315078E-4
Starting Function Value: 0.6299173968585169
Iterations Fnc. Calls Likelihood Distance Moved Step Alpha Gradient Norm
1 3 0.629917349549179 0.000818259194820 7.180177505548523 0.000168874209417
2 5 0.629917023472129 0.003508474138542 5.000000000000000 0.000179665681992
3 6 0.629904250024639 0.308894406275025 1.000000000000000 0.000530699950786
4 7 0.629893773802309 0.092348303879020 1.000000000000000 0.000665861611655
5 8 0.629886392662834 0.215239926570622 1.000000000000000 0.000381833615958
6 9 0.629885704232605 0.063259677668024 1.000000000000000 0.000049270843823
7 10 0.629885658924463 0.019719014199273 1.000000000000000 0.000038384505085
8 11 0.629885638859083 0.004647195545096 1.000000000000000 0.000052860245967
9 12 0.629885479484084 0.026642711083844 1.000000000000000 0.000140677593301
10 13 0.629885194151989 0.034330297573733 1.000000000000000 0.000235003365768
11 14 0.629884477432263 0.069770602049766 1.000000000000000 0.000361273391658
12 15 0.629883307346023 0.102943511287322 1.000000000000000 0.000420712559444
13 16 0.629882089837033 0.109702777833379 1.000000000000000 0.000313902598915
14 17 0.629881571596134 0.059849896311748 1.000000000000000 0.000129709389904
15 18 0.629881470406459 0.031836837128515 1.000000000000000 0.000017150649911
16 19 0.629881462208396 0.010647694092098 1.000000000000000 0.000016126186432
17 20 0.629881459337838 0.002099300497048 1.000000000000000 0.000016080331553
18 21 0.629881354706913 0.011815797354945 1.000000000000000 0.000016018788929
19 22 0.629881047208786 0.060292187495102 1.000000000000000 0.000010683350029
20 23 0.629880997267271 0.024262771456837 1.000000000000000 0.000007169389785
21 24 0.629880973398598 0.017930205018236 1.000000000000000 0.000004930727169
22 25 0.629880961187655 0.009261501684768 1.000000000000000 0.000005729657070
23 26 0.629880934613601 0.018048318690812 1.000000000000000 0.000008129421264
24 27 0.629880900815353 0.020998931321963 1.000000000000000 0.000008001074347
25 28 0.629880861596486 0.028539163872674 1.000000000000000 0.000006690719716
26 29 0.629880838937090 0.022575390190340 1.000000000000000 0.000004141060552
27 30 0.629880824748333 0.012806875340983 1.000000000000000 0.000007369923103
28 31 0.629880803898064 0.020830076691362 1.000000000000000 0.000006220489850
29 32 0.629880783188670 0.021369324658825 1.000000000000000 0.000005513678502
30 33 0.629880752951331 0.038037226267801 1.000000000000000 0.000005923417256
31 34 0.629880734468749 0.028233388262851 1.000000000000000 0.000005980385943
32 35 0.629880715441758 0.025845476483927 1.000000000000000 0.000007881546541
33 36 0.629880683349905 0.041712744185972 1.000000000000000 0.000006264996890
34 37 0.629880658268125 0.036905048276213 1.000000000000000 0.000003730184893
35 38 0.629880636904972 0.024737100655881 1.000000000000000 0.000006470998110
36 39 0.629880599986466 0.045578774884899 1.000000000000000 0.000009313718943
37 40 0.629880557358029 0.053107042592180 1.000000000000000 0.000011901454543
38 41 0.629880475406241 0.121771885402605 1.000000000000000 0.000008360407008
39 42 0.629880415836443 0.103316617279161 1.000000000000000 0.000007306229430
40 43 0.629880375770574 0.073323201485042 1.000000000000000 0.000005936503250
41 44 0.629880352157860 0.036117864367448 1.000000000000000 0.000007563148255
42 45 0.629880322754405 0.036109940264310 1.000000000000000 0.000007096872403
43 46 0.629880292288542 0.050871207005845 1.000000000000000 0.000008225072521
44 47 0.629880288279250 0.009979567740463 1.000000000000000 0.000001244256208
45 48 0.629880287655581 0.002418504631856 1.000000000000000 0.000001473004904
46 49 0.629880286355062 0.002839574757824 1.000000000000000 0.000001599742950
47 50 0.629880285558217 0.004313476883494 1.000000000000000 0.000000736656667
48 51 0.629880285360417 0.001532423628331 1.000000000000000 0.000000602081931
49 52 0.629880284992186 0.001532423628331 1.000000000000000 0.000000516418895
Convergence criteria met.
After: gradient norm = 5.164188948739528E-7
>>> Parameters after optimization
Count Table 0:
---------------
h: {2.4111,-2.4111}
Binding mode 0:
---------------
Mononucleotide: {}
Activity(exp=0): {-0.0000,3.0406}
Binding mode 1:
---------------
Mononucleotide: {0.0843,-1.1163,0.0063,-1.0045,-0.5432,-1.7830,1.1313,-0.8351,0.0797,-1.1774,-0.6446,-0.2878,1.5909,-1.5521,-1.2562,-0.8127,-1.4785,1.8255,-1.6844,-0.6927,0.6422,-1.8595,-0.0496,-0.7631,-0.6386,-0.7451,-0.5382,-0.1082,-0.1815,-0.8336,-0.8336,-0.1815,-0.1082,-0.5382,-0.7451,-0.6386,-0.7631,-0.0496,-1.8595,0.6422,-0.6927,-1.6844,1.8255,-1.4785,-0.8127,-1.2562,-1.5521,1.5909,-0.2878,-0.6446,-1.1774,0.0797,-0.8351,1.1313,-1.7830,-0.5432,-1.0045,0.0063,-1.1163,0.0843}
Activity(exp=0): {0.0000,-1.7835}
Position Bias(exp=0, s=0): {-0.1000,-0.1000,-0.1000,-0.1000,-0.1000,0.3420,0.3420,0.3420,0.3420,0.3420,0.1565,0.1565,0.1565,0.1565,0.1565,0.7748,0.7748,0.7748,0.7748,0.7748,0.2754,0.2754,0.2754,0.2754,0.2754,0.1661,0.1661,0.1661,0.1661,0.1661,-0.0710,-0.0710,-0.0710,-0.0710,-0.0710,0.6524,0.6524,0.6524,0.6524,0.6524,0.6584,0.6584,0.6584,0.6584,0.6584,0.8227,0.8227,0.8227,0.8227,0.8227,0.5881,0.5881,0.5881,0.5881,0.5881,0.4294,0.4294,0.4294,0.4294,0.4294,0.2774,0.2774,0.2774,0.2774,0.2774,0.6265,0.6265,0.6265,0.6265,0.6265,0.2571,0.2571,0.2571,0.2571,0.2571,0.5330,0.5330,0.5330,0.5330,0.5330,1.0854,1.0854,1.0854,1.0854,1.0854,0.6615,0.6615,0.6615,0.6615,0.6615,0.7256,0.7256,0.7256,0.7256,0.7256,0.2128,0.2128,0.2128,0.2128,0.2128,0.0779,0.0779,0.0779,0.0779,0.0779,0.1450,0.1450,0.1450,0.1450,0.1450,-0.0117,-0.0117,-0.0117,-0.0117,-0.0117,0.1968,0.1968,0.1968,0.1968,0.1968,-0.2039,-0.2039,-0.2039,-0.2039,-0.2039,-0.0305,-0.0305,-0.0305,-0.0305,-0.0305,-0.0376,-0.0376,-0.0376,-0.0376,-0.0376,-0.7690,-0.7690,-0.7690,-0.7690,-0.7690,-0.7034,-0.7034,-0.7034,-0.7034,-0.7034,-0.7746,-0.7746,-0.7746,-0.7746,-0.7746,-0.4369,-0.4369,-0.4369,-0.4369,-0.4369,-0.6283,-0.6283,-0.6283,-0.6283,-0.6283,-1.1814,-1.1814,-1.1814,-1.1814,-1.1814,-0.8685,-0.8685,-0.8685,-0.8685,-0.8685,-0.9871,-0.9871,-0.9871,-0.9871,-0.9871,-0.8819,-0.8819,-0.8819,-0.8819,-0.8819,-1.3005,-1.3005,-1.3005,-1.3005,-1.3005,-1.8677}
Position Bias(exp=0, s=1): {-1.4625,-1.4625,-1.4625,-1.4625,-1.4625,-0.9809,-0.9809,-0.9809,-0.9809,-0.9809,-0.7075,-0.7075,-0.7075,-0.7075,-0.7075,-0.9916,-0.9916,-0.9916,-0.9916,-0.9916,-1.1640,-1.1640,-1.1640,-1.1640,-1.1640,-0.8926,-0.8926,-0.8926,-0.8926,-0.8926,-0.6241,-0.6241,-0.6241,-0.6241,-0.6241,-0.6495,-0.6495,-0.6495,-0.6495,-0.6495,-0.7504,-0.7504,-0.7504,-0.7504,-0.7504,-0.3559,-0.3559,-0.3559,-0.3559,-0.3559,-0.1950,-0.1950,-0.1950,-0.1950,-0.1950,-0.1614,-0.1614,-0.1614,-0.1614,-0.1614,-0.2365,-0.2365,-0.2365,-0.2365,-0.2365,-0.2732,-0.2732,-0.2732,-0.2732,-0.2732,0.1468,0.1468,0.1468,0.1468,0.1468,0.1613,0.1613,0.1613,0.1613,0.1613,0.4813,0.4813,0.4813,0.4813,0.4813,0.6088,0.6088,0.6088,0.6088,0.6088,-0.1777,-0.1777,-0.1777,-0.1777,-0.1777,0.2607,0.2607,0.2607,0.2607,0.2607,0.1576,0.1576,0.1576,0.1576,0.1576,0.5039,0.5039,0.5039,0.5039,0.5039,0.6114,0.6114,0.6114,0.6114,0.6114,0.6572,0.6572,0.6572,0.6572,0.6572,0.6247,0.6247,0.6247,0.6247,0.6247,0.7371,0.7371,0.7371,0.7371,0.7371,0.6814,0.6814,0.6814,0.6814,0.6814,0.2808,0.2808,0.2808,0.2808,0.2808,0.3466,0.3466,0.3466,0.3466,0.3466,0.4059,0.4059,0.4059,0.4059,0.4059,0.4943,0.4943,0.4943,0.4943,0.4943,0.7828,0.7828,0.7828,0.7828,0.7828,0.1417,0.1417,0.1417,0.1417,0.1417,-0.0830,-0.0830,-0.0830,-0.0830,-0.0830,0.3357,0.3357,0.3357,0.3357,0.3357,-0.0125,-0.0125,-0.0125,-0.0125,-0.0125,0.3277,0.3277,0.3277,0.3277,0.3277,0.8442}
Binding mode 2:
---------------
Mononucleotide: {0.3323,-1.1496,-0.3531,-1.2976,-1.6667,-0.5992,-1.7351,1.5330,-1.4592,-2.2437,1.0427,0.1923,1.5413,-1.2638,-1.5600,-1.1855,-1.1782,-0.0282,-0.0842,-1.1773,-1.3152,-1.5496,-1.2299,1.6267,-0.1522,1.2914,-2.2350,-1.3722,1.2573,-1.6096,-0.5923,-1.5234,-1.1204,-0.5769,-0.4588,-0.3118,-0.4034,-0.4129,-1.1073,-0.5444}
Activity(exp=0): {-0.0000,-2.4680}
Position Bias(exp=0, s=0): {0.5685,0.5685,0.5685,0.5685,0.5685,0.3059,0.3059,0.3059,0.3059,0.3059,-0.2168,-0.2168,-0.2168,-0.2168,-0.2168,-0.3529,-0.3529,-0.3529,-0.3529,-0.3529,-0.0305,-0.0305,-0.0305,-0.0305,-0.0305,0.0646,0.0646,0.0646,0.0646,0.0646,0.2939,0.2939,0.2939,0.2939,0.2939,-0.1955,-0.1955,-0.1955,-0.1955,-0.1955,0.2229,0.2229,0.2229,0.2229,0.2229,0.4659,0.4659,0.4659,0.4659,0.4659,0.3148,0.3148,0.3148,0.3148,0.3148,0.4675,0.4675,0.4675,0.4675,0.4675,0.5188,0.5188,0.5188,0.5188,0.5188,0.2666,0.2666,0.2666,0.2666,0.2666,0.2594,0.2594,0.2594,0.2594,0.2594,0.2091,0.2091,0.2091,0.2091,0.2091,-0.3472,-0.3472,-0.3472,-0.3472,-0.3472,0.3459,0.3459,0.3459,0.3459,0.3459,0.0739,0.0739,0.0739,0.0739,0.0739,0.1189,0.1189,0.1189,0.1189,0.1189,0.0241,0.0241,0.0241,0.0241,0.0241,0.0902,0.0902,0.0902,0.0902,0.0902,0.3233,0.3233,0.3233,0.3233,0.3233,0.3448,0.3448,0.3448,0.3448,0.3448,0.4027,0.4027,0.4027,0.4027,0.4027,0.0406,0.0406,0.0406,0.0406,0.0406,-0.1898,-0.1898,-0.1898,-0.1898,-0.1898,0.1207,0.1207,0.1207,0.1207,0.1207,-0.2963,-0.2963,-0.2963,-0.2963,-0.2963,-0.1853,-0.1853,-0.1853,-0.1853,-0.1853,-0.3853,-0.3853,-0.3853,-0.3853,-0.3853,-0.3646,-0.3646,-0.3646,-0.3646,-0.3646,0.2450,0.2450,0.2450,0.2450,0.2450,-0.7662,-0.7662,-0.7662,-0.7662,-0.7662,-0.5964,-0.5964,-0.5964,-0.5964,-0.5964,-0.5024,-0.5024,-0.5024,-0.5024,-0.5024,-0.8547,-0.8547,-0.8547,-0.8547,-0.8547,-0.6941,-0.6941,-0.6941,-0.6941,-0.6941,-0.5406}
Position Bias(exp=0, s=1): {-1.0426,-1.0426,-1.0426,-1.0426,-1.0426,-0.2223,-0.2223,-0.2223,-0.2223,-0.2223,-0.6388,-0.6388,-0.6388,-0.6388,-0.6388,-0.8185,-0.8185,-0.8185,-0.8185,-0.8185,-0.4759,-0.4759,-0.4759,-0.4759,-0.4759,-0.3355,-0.3355,-0.3355,-0.3355,-0.3355,-0.6295,-0.6295,-0.6295,-0.6295,-0.6295,-0.7804,-0.7804,-0.7804,-0.7804,-0.7804,0.0785,0.0785,0.0785,0.0785,0.0785,0.2566,0.2566,0.2566,0.2566,0.2566,-0.4013,-0.4013,-0.4013,-0.4013,-0.4013,0.3270,0.3270,0.3270,0.3270,0.3270,-0.4532,-0.4532,-0.4532,-0.4532,-0.4532,-0.2651,-0.2651,-0.2651,-0.2651,-0.2651,0.1899,0.1899,0.1899,0.1899,0.1899,-0.3022,-0.3022,-0.3022,-0.3022,-0.3022,0.1843,0.1843,0.1843,0.1843,0.1843,0.4029,0.4029,0.4029,0.4029,0.4029,0.0661,0.0661,0.0661,0.0661,0.0661,0.2974,0.2974,0.2974,0.2974,0.2974,0.5984,0.5984,0.5984,0.5984,0.5984,0.5136,0.5136,0.5136,0.5136,0.5136,0.5765,0.5765,0.5765,0.5765,0.5765,0.6217,0.6217,0.6217,0.6217,0.6217,0.0131,0.0131,0.0131,0.0131,0.0131,0.0895,0.0895,0.0895,0.0895,0.0895,0.3546,0.3546,0.3546,0.3546,0.3546,0.2062,0.2062,0.2062,0.2062,0.2062,0.4370,0.4370,0.4370,0.4370,0.4370,0.4377,0.4377,0.4377,0.4377,0.4377,0.2191,0.2191,0.2191,0.2191,0.2191,0.1936,0.1936,0.1936,0.1936,0.1936,0.3106,0.3106,0.3106,0.3106,0.3106,-0.0317,-0.0317,-0.0317,-0.0317,-0.0317,0.4622,0.4622,0.4622,0.4622,0.4622,0.2973,0.2973,0.2973,0.2973,0.2973,-0.4352,-0.4352,-0.4352,-0.4352,-0.4352,-0.6609,-0.6609,-0.6609,-0.6609,-0.6609,-1.0381}
Binding mode 3:
---------------
Mononucleotide: {-0.1537,-1.6065,-0.4376,0.7768,-0.3362,-1.1053,-1.5876,1.6080,-0.3856,-1.1100,-1.6038,1.6783,0.2421,-0.2113,-0.6560,-0.7957,-0.6091,-0.1850,-0.8722,0.2453,0.0605,-0.9004,-0.4121,-0.1691,-0.2025,-0.7365,-0.4498,-0.0322,0.0513,-0.6420,-0.6890,-0.1414,-0.2101,-0.3673,-0.5520,-0.2916,-0.2354,-0.2940,-0.6231,-0.2685}
Activity(exp=0): {-0.0001,-1.4210}
Position Bias(exp=0, s=0): {2.7570,2.7570,2.7570,2.7570,2.7570,1.8196,1.8196,1.8196,1.8196,1.8196,0.9046,0.9046,0.9046,0.9046,0.9046,0.6313,0.6313,0.6313,0.6313,0.6313,0.2965,0.2965,0.2965,0.2965,0.2965,0.7045,0.7045,0.7045,0.7045,0.7045,1.0118,1.0118,1.0118,1.0118,1.0118,0.3536,0.3536,0.3536,0.3536,0.3536,0.7902,0.7902,0.7902,0.7902,0.7902,0.9450,0.9450,0.9450,0.9450,0.9450,0.6148,0.6148,0.6148,0.6148,0.6148,0.6341,0.6341,0.6341,0.6341,0.6341,0.5460,0.5460,0.5460,0.5460,0.5460,-0.0107,-0.0107,-0.0107,-0.0107,-0.0107,-0.2834,-0.2834,-0.2834,-0.2834,-0.2834,0.9878,0.9878,0.9878,0.9878,0.9878,0.4683,0.4683,0.4683,0.4683,0.4683,0.1222,0.1222,0.1222,0.1222,0.1222,-0.3418,-0.3418,-0.3418,-0.3418,-0.3418,-0.3961,-0.3961,-0.3961,-0.3961,-0.3961,-0.5261,-0.5261,-0.5261,-0.5261,-0.5261,-0.6478,-0.6478,-0.6478,-0.6478,-0.6478,-0.6736,-0.6736,-0.6736,-0.6736,-0.6736,-0.9048,-0.9048,-0.9048,-0.9048,-0.9048,-0.8814,-0.8814,-0.8814,-0.8814,-0.8814,-0.6841,-0.6841,-0.6841,-0.6841,-0.6841,-0.4865,-0.4865,-0.4865,-0.4865,-0.4865,-1.0767,-1.0767,-1.0767,-1.0767,-1.0767,-1.1832,-1.1832,-1.1832,-1.1832,-1.1832,-1.0119,-1.0119,-1.0119,-1.0119,-1.0119,-0.8846,-0.8846,-0.8846,-0.8846,-0.8846,-0.9685,-0.9685,-0.9685,-0.9685,-0.9685,-0.9752,-0.9752,-0.9752,-0.9752,-0.9752,-1.2220,-1.2220,-1.2220,-1.2220,-1.2220,-1.2598,-1.2598,-1.2598,-1.2598,-1.2598,-1.0824,-1.0824,-1.0824,-1.0824,-1.0824,-1.4697,-1.4697,-1.4697,-1.4697,-1.4697,-1.2308,-1.2308,-1.2308,-1.2308,-1.2308,-1.0231}
Position Bias(exp=0, s=1): {-1.0377,-1.0377,-1.0377,-1.0377,-1.0377,-1.1602,-1.1602,-1.1602,-1.1602,-1.1602,-1.0471,-1.0471,-1.0471,-1.0471,-1.0471,-1.1192,-1.1192,-1.1192,-1.1192,-1.1192,-1.2607,-1.2607,-1.2607,-1.2607,-1.2607,-1.1248,-1.1248,-1.1248,-1.1248,-1.1248,-1.0232,-1.0232,-1.0232,-1.0232,-1.0232,-1.0627,-1.0627,-1.0627,-1.0627,-1.0627,-0.9831,-0.9831,-0.9831,-0.9831,-0.9831,-1.1172,-1.1172,-1.1172,-1.1172,-1.1172,-0.8281,-0.8281,-0.8281,-0.8281,-0.8281,-0.6550,-0.6550,-0.6550,-0.6550,-0.6550,-0.7102,-0.7102,-0.7102,-0.7102,-0.7102,-0.9307,-0.9307,-0.9307,-0.9307,-0.9307,-0.5793,-0.5793,-0.5793,-0.5793,-0.5793,-0.7665,-0.7665,-0.7665,-0.7665,-0.7665,0.2913,0.2913,0.2913,0.2913,0.2913,-0.1486,-0.1486,-0.1486,-0.1486,-0.1486,1.1114,1.1114,1.1114,1.1114,1.1114,0.9069,0.9069,0.9069,0.9069,0.9069,1.3044,1.3044,1.3044,1.3044,1.3044,1.0147,1.0147,1.0147,1.0147,1.0147,1.3500,1.3500,1.3500,1.3500,1.3500,0.8591,0.8591,0.8591,0.8591,0.8591,1.0596,1.0596,1.0596,1.0596,1.0596,0.8891,0.8891,0.8891,0.8891,0.8891,0.3916,0.3916,0.3916,0.3916,0.3916,0.8292,0.8292,0.8292,0.8292,0.8292,0.9910,0.9910,0.9910,0.9910,0.9910,0.8106,0.8106,0.8106,0.8106,0.8106,0.8806,0.8806,0.8806,0.8806,0.8806,0.9106,0.9106,0.9106,0.9106,0.9106,0.7475,0.7475,0.7475,0.7475,0.7475,0.9407,0.9407,0.9407,0.9407,0.9407,0.8668,0.8668,0.8668,0.8668,0.8668,0.8078,0.8078,0.8078,0.8078,0.8078,0.5969,0.5969,0.5969,0.5969,0.5969,1.0579,1.0579,1.0579,1.0579,1.0579,1.8326}
Binding mode 4:
---------------
Mononucleotide: {-0.8080,0.1640,-0.2639,-0.7313,-0.9286,0.1276,-0.0077,-0.8301,-0.9239,0.0971,0.1054,-0.9175,-0.8983,0.0996,0.0985,-0.9386,-0.9063,0.0533,0.1232,-0.9090,-0.9042,0.0859,0.0845,-0.9048,-0.9097,0.1231,0.0542,-0.9063,-0.9394,0.0968,0.1016,-0.8977,-0.9168,0.1088,0.0943,-0.9250,-0.8306,-0.0116,0.1310,-0.9276,-0.7305,-0.2620,0.1621,-0.8083}
Activity(exp=0): {-0.0000,-1.6388}
Position Bias(exp=0, s=0): {0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000}
Position Bias(exp=0, s=1): {0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000}
The Likelihood DID NOT improve. Discarding fit component4-2-variation2.
> No varitions possible for Binding mode 4.
> Unfreezing component (component4-3-f0).
>> Starting new optimization: component4-3-f0. (2021-05-21 15:49:55.692).
>>> Packing before optimization
Packing: {"enrichmentModel":[{}],"countTable":[{"h":[120,121]}],"bindingModeInteractions":[],"bindingModes":[{},{},{},{},{"mononucleotide":[0,1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19,20,21,22,23,24,25,26,27,28,29,30,31,32,33,34,35,36,37,38,39],"activity":[[118,119]],"positionBias":[[[40,40,40,40,40,41,41,41,41,41,42,42,42,42,42,43,43,43,43,43,44,44,44,44,44,45,45,45,45,45,46,46,46,46,46,47,47,47,47,47,48,48,48,48,48,49,49,49,49,49,50,50,50,50,50,51,51,51,51,51,52,52,52,52,52,53,53,53,53,53,54,54,54,54,54,55,55,55,55,55,56,56,56,56,56,57,57,57,57,57,58,58,58,58,58,59,59,59,59,59,60,60,60,60,60,61,61,61,61,61,62,62,62,62,62,63,63,63,63,63,64,64,64,64,64,65,65,65,65,65,66,66,66,66,66,67,67,67,67,67,68,68,68,68,68,69,69,69,69,69,70,70,70,70,70,71,71,71,71,71,72,72,72,72,72,73,73,73,73,73,74,74,74,74,74,75,75,75,75,75,76,76,76,76,76,77,77,77,77,77,78],[79,79,79,79,79,80,80,80,80,80,81,81,81,81,81,82,82,82,82,82,83,83,83,83,83,84,84,84,84,84,85,85,85,85,85,86,86,86,86,86,87,87,87,87,87,88,88,88,88,88,89,89,89,89,89,90,90,90,90,90,91,91,91,91,91,92,92,92,92,92,93,93,93,93,93,94,94,94,94,94,95,95,95,95,95,96,96,96,96,96,97,97,97,97,97,98,98,98,98,98,99,99,99,99,99,100,100,100,100,100,101,101,101,101,101,102,102,102,102,102,103,103,103,103,103,104,104,104,104,104,105,105,105,105,105,106,106,106,106,106,107,107,107,107,107,108,108,108,108,108,109,109,109,109,109,110,110,110,110,110,111,111,111,111,111,112,112,112,112,112,113,113,113,113,113,114,114,114,114,114,115,115,115,115,115,116,116,116,116,116,117]]]}]}
Value and gradient before optimization:
=======================================
value = 0.629363128018728
gradient = {-0.0000,0.0000,-0.0000,-0.0000,-0.0000,0.0000,0.0000,-0.0000,-0.0000,-0.0000,-0.0000,0.0000,-0.0000,-0.0000,0.0000,-0.0000,0.0000,-0.0000,-0.0000,0.0000,0.0000,-0.0000,-0.0000,0.0000,-0.0000,0.0000,-0.0000,-0.0000,0.0000,-0.0000,-0.0000,-0.0000,-0.0000,0.0000,0.0000,-0.0000,-0.0000,-0.0000,0.0000,-0.0000,0.0000,0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,0.0000,-0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,-0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,-0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,-0.0000,0.0000,0.0000,-0.0000,-0.0000,0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,0.0000,0.0000,0.0000,-0.0000,0.0000,-0.0000}
gradient norm = 2.3720377514999913E-5
Starting Function Value: 0.629363128018728
Iterations Fnc. Calls Likelihood Distance Moved Step Alpha Gradient Norm
1 2 0.629345062427144 1.000000000000000 42157.845058226245 0.000268567492602
2 4 0.629344481665721 0.058621982681680 0.018520569866596 0.000442801265639
3 5 0.629338231604814 1.074027928433642 1.000000000000000 0.000110730336765
4 6 0.629338179272462 0.072311895678128 1.000000000000000 0.000016545451563
5 7 0.629338175979254 0.002639581491570 1.000000000000000 0.000021124873709
6 8 0.629338119066385 0.029710836773129 1.000000000000000 0.000115710521040
7 9 0.629338030629092 0.026119325818004 1.000000000000000 0.000204092258219
8 10 0.629337820858244 0.035754660860630 1.000000000000000 0.000310742451952
9 11 0.629337553820561 0.040381853226695 1.000000000000000 0.000317194776499
10 13 0.629337402756007 0.038615366142100 0.365002678881963 0.000331893424948
11 14 0.629337210473431 0.073581114173519 1.000000000000000 0.000160463042263
12 15 0.629337162388027 0.046924589854544 1.000000000000000 0.000015669738545
13 16 0.629337159984440 0.006255203055380 1.000000000000000 0.000010668428393
14 17 0.629337159557570 0.000768373330001 1.000000000000000 0.000012095514993
15 18 0.629337156340590 0.002595457368882 1.000000000000000 0.000016800134203
16 19 0.629337146082908 0.005272388776133 1.000000000000000 0.000026215312861
17 20 0.629337122177458 0.009319848510907 1.000000000000000 0.000039135554184
18 21 0.629337070225409 0.019230033849643 1.000000000000000 0.000053235411460
19 22 0.629336986150824 0.034622609839545 1.000000000000000 0.000057133029051
20 23 0.629336843461699 0.055318289631723 1.000000000000000 0.000049685543538
21 24 0.629336603943219 0.114964355083421 1.000000000000000 0.000015175982033
22 25 0.629336474452106 0.071358315531343 1.000000000000000 0.000027337407549
23 26 0.629336382937730 0.044757360936149 1.000000000000000 0.000050766256735
24 27 0.629336311449085 0.031334391846226 1.000000000000000 0.000049167655136
25 28 0.629336195674486 0.062799159647572 1.000000000000000 0.000016873448743
26 29 0.629336167914548 0.026821393642963 1.000000000000000 0.000010069253892
27 30 0.629336162829358 0.004352027096760 1.000000000000000 0.000013572229155
28 31 0.629336152753109 0.009689465097274 1.000000000000000 0.000013468808921
29 32 0.629336124019333 0.022271976813518 1.000000000000000 0.000008538230283
30 33 0.629336111422361 0.019830982941937 1.000000000000000 0.000002867824124
31 34 0.629336109583739 0.003266434714828 1.000000000000000 0.000001704450076
32 35 0.629336103625337 0.010861144659725 1.000000000000000 0.000008484367557
33 36 0.629336096919321 0.011529536814182 1.000000000000000 0.000013972941396
34 37 0.629336085050729 0.021025959488887 1.000000000000000 0.000017503575425
35 38 0.629336075863464 0.016704807478780 1.000000000000000 0.000012502955045
36 39 0.629336071577228 0.008567718249370 1.000000000000000 0.000003749123613
37 40 0.629336070764877 0.002921516799802 1.000000000000000 0.000001987707336
38 41 0.629336070442640 0.001508044651345 1.000000000000000 0.000003836958566
39 42 0.629336069794752 0.001884071428202 1.000000000000000 0.000006588895506
40 43 0.629336068413268 0.002538357430925 1.000000000000000 0.000010055803189
41 44 0.629336065542815 0.005315007288213 1.000000000000000 0.000013528240737
42 45 0.629336061153678 0.010593269492195 1.000000000000000 0.000013855164838
43 46 0.629336053296920 0.019148204435999 1.000000000000000 0.000008848382295
44 47 0.629336048688497 0.018215418008886 1.000000000000000 0.000002035457889
45 48 0.629336047757292 0.003451519001298 1.000000000000000 0.000005055308879
46 49 0.629336046459633 0.004559810208370 1.000000000000000 0.000007226835967
47 50 0.629336045166245 0.004842691504079 1.000000000000000 0.000006240297927
48 51 0.629336043193909 0.007107431649884 1.000000000000000 0.000002812471013
49 52 0.629336041264056 0.008762618424928 1.000000000000000 0.000003893199811
50 53 0.629336040100059 0.004595217662722 1.000000000000000 0.000006908572346
51 54 0.629336038107421 0.007037437158812 1.000000000000000 0.000009389925829
52 55 0.629336036161128 0.006977578677482 1.000000000000000 0.000007892404718
53 56 0.629336034938823 0.005175807351679 1.000000000000000 0.000003036831516
54 57 0.629336034695460 0.005175807351679 1.000000000000000 0.000000520115036
Convergence criteria met.
After: gradient norm = 5.201150357417299E-7
>>> Parameters after optimization
Count Table 0:
---------------
h: {2.4120,-2.4120}
Binding mode 0:
---------------
Mononucleotide: {}
Activity(exp=0): {-0.0000,3.0406}
Binding mode 1:
---------------
Mononucleotide: {0.0843,-1.1163,0.0063,-1.0045,-0.5432,-1.7830,1.1313,-0.8351,0.0797,-1.1774,-0.6446,-0.2878,1.5909,-1.5521,-1.2562,-0.8127,-1.4785,1.8255,-1.6844,-0.6927,0.6422,-1.8595,-0.0496,-0.7631,-0.6386,-0.7451,-0.5382,-0.1082,-0.1815,-0.8336,-0.8336,-0.1815,-0.1082,-0.5382,-0.7451,-0.6386,-0.7631,-0.0496,-1.8595,0.6422,-0.6927,-1.6844,1.8255,-1.4785,-0.8127,-1.2562,-1.5521,1.5909,-0.2878,-0.6446,-1.1774,0.0797,-0.8351,1.1313,-1.7830,-0.5432,-1.0045,0.0063,-1.1163,0.0843}
Activity(exp=0): {0.0000,-1.7835}
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Binding mode 2:
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Binding mode 3:
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Binding mode 4:
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Activity(exp=0): {0.0002,-1.7599}
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Position Bias(exp=0, s=1): {-0.0446,-0.0446,-0.0446,-0.0446,-0.0446,-0.1018,-0.1018,-0.1018,-0.1018,-0.1018,-0.2060,-0.2060,-0.2060,-0.2060,-0.2060,-0.2601,-0.2601,-0.2601,-0.2601,-0.2601,-0.1837,-0.1837,-0.1837,-0.1837,-0.1837,-0.0956,-0.0956,-0.0956,-0.0956,-0.0956,-0.0163,-0.0163,-0.0163,-0.0163,-0.0163,-0.2426,-0.2426,-0.2426,-0.2426,-0.2426,-0.2030,-0.2030,-0.2030,-0.2030,-0.2030,-0.1381,-0.1381,-0.1381,-0.1381,-0.1381,-0.1722,-0.1722,-0.1722,-0.1722,-0.1722,-0.3478,-0.3478,-0.3478,-0.3478,-0.3478,-0.3171,-0.3171,-0.3171,-0.3171,-0.3171,-0.2105,-0.2105,-0.2105,-0.2105,-0.2105,-0.2777,-0.2777,-0.2777,-0.2777,-0.2777,-0.2833,-0.2833,-0.2833,-0.2833,-0.2833,-0.3212,-0.3212,-0.3212,-0.3212,-0.3212,-0.0817,-0.0817,-0.0817,-0.0817,-0.0817,-0.0923,-0.0923,-0.0923,-0.0923,-0.0923,0.0370,0.0370,0.0370,0.0370,0.0370,-0.1383,-0.1383,-0.1383,-0.1383,-0.1383,-0.0740,-0.0740,-0.0740,-0.0740,-0.0740,0.2349,0.2349,0.2349,0.2349,0.2349,0.0441,0.0441,0.0441,0.0441,0.0441,-0.0819,-0.0819,-0.0819,-0.0819,-0.0819,0.1997,0.1997,0.1997,0.1997,0.1997,0.2787,0.2787,0.2787,0.2787,0.2787,0.5443,0.5443,0.5443,0.5443,0.5443,0.4764,0.4764,0.4764,0.4764,0.4764,0.1672,0.1672,0.1672,0.1672,0.1672,0.0866,0.0866,0.0866,0.0866,0.0866,0.3978,0.3978,0.3978,0.3978,0.3978,0.7571,0.7571,0.7571,0.7571,0.7571,0.2191,0.2191,0.2191,0.2191,0.2191,0.2410,0.2410,0.2410,0.2410,0.2410,0.2602,0.2602,0.2602,0.2602,0.2602,-0.0261,-0.0261,-0.0261,-0.0261,-0.0261,-0.1611,-0.1611,-0.1611,-0.1611,-0.1611,-0.1149}
> Optimizing the full model (component4-4-all).
>> Starting new optimization: component4-4-all. (2021-05-21 15:53:48.279).
>>> Packing before optimization
Packing: {"enrichmentModel":[{}],"countTable":[{"h":[470,471]}],"bindingModeInteractions":[],"bindingModes":[{"mononucleotide":[],"activity":[[0,1]]},{"mononucleotide":[3,2,5,4,7,6,9,8,11,10,13,12,15,14,17,16,19,18,21,20,23,22,25,24,27,26,29,28,31,30,30,31,28,29,26,27,24,25,22,23,20,21,18,19,16,17,14,15,12,13,10,11,8,9,6,7,4,5,2,3],"activity":[[108,109]],"positionBias":[[[32,32,32,32,32,33,33,33,33,33,34,34,34,34,34,35,35,35,35,35,36,36,36,36,36,37,37,37,37,37,38,38,38,38,38,39,39,39,39,39,40,40,40,40,40,41,41,41,41,41,42,42,42,42,42,43,43,43,43,43,44,44,44,44,44,45,45,45,45,45,46,46,46,46,46,47,47,47,47,47,48,48,48,48,48,49,49,49,49,49,50,50,50,50,50,51,51,51,51,51,52,52,52,52,52,53,53,53,53,53,54,54,54,54,54,55,55,55,55,55,56,56,56,56,56,57,57,57,57,57,58,58,58,58,58,59,59,59,59,59,60,60,60,60,60,61,61,61,61,61,62,62,62,62,62,63,63,63,63,63,64,64,64,64,64,65,65,65,65,65,66,66,66,66,66,67,67,67,67,67,68,68,68,68,68,69],[70,70,70,70,70,71,71,71,71,71,72,72,72,72,72,73,73,73,73,73,74,74,74,74,74,75,75,75,75,75,76,76,76,76,76,77,77,77,77,77,78,78,78,78,78,79,79,79,79,79,80,80,80,80,80,81,81,81,81,81,82,82,82,82,82,83,83,83,83,83,84,84,84,84,84,85,85,85,85,85,86,86,86,86,86,87,87,87,87,87,88,88,88,88,88,89,89,89,89,89,90,90,90,90,90,91,91,91,91,91,92,92,92,92,92,93,93,93,93,93,94,94,94,94,94,95,95,95,95,95,96,96,96,96,96,97,97,97,97,97,98,98,98,98,98,99,99,99,99,99,100,100,100,100,100,101,101,101,101,101,102,102,102,102,102,103,103,103,103,103,104,104,104,104,104,105,105,105,105,105,106,106,106,106,106,107]]]},{"mononucleotide":[110,111,112,113,114,115,116,117,118,119,120,121,122,123,124,125,126,127,128,129,130,131,132,133,134,135,136,137,138,139,140,141,142,143,144,145,146,147,148,149],"activity":[[228,229]],"positionBias":[[[150,150,150,150,150,151,151,151,151,151,152,152,152,152,152,153,153,153,153,153,154,154,154,154,154,155,155,155,155,155,156,156,156,156,156,157,157,157,157,157,158,158,158,158,158,159,159,159,159,159,160,160,160,160,160,161,161,161,161,161,162,162,162,162,162,163,163,163,163,163,164,164,164,164,164,165,165,165,165,165,166,166,166,166,166,167,167,167,167,167,168,168,168,168,168,169,169,169,169,169,170,170,170,170,170,171,171,171,171,171,172,172,172,172,172,173,173,173,173,173,174,174,174,174,174,175,175,175,175,175,176,176,176,176,176,177,177,177,177,177,178,178,178,178,178,179,179,179,179,179,180,180,180,180,180,181,181,181,181,181,182,182,182,182,182,183,183,183,183,183,184,184,184,184,184,185,185,185,185,185,186,186,186,186,186,187,187,187,187,187,188],[189,189,189,189,189,190,190,190,190,190,191,191,191,191,191,192,192,192,192,192,193,193,193,193,193,194,194,194,194,194,195,195,195,195,195,196,196,196,196,196,197,197,197,197,197,198,198,198,198,198,199,199,199,199,199,200,200,200,200,200,201,201,201,201,201,202,202,202,202,202,203,203,203,203,203,204,204,204,204,204,205,205,205,205,205,206,206,206,206,206,207,207,207,207,207,208,208,208,208,208,209,209,209,209,209,210,210,210,210,210,211,211,211,211,211,212,212,212,212,212,213,213,213,213,213,214,214,214,214,214,215,215,215,215,215,216,216,216,216,216,217,217,217,217,217,218,218,218,218,218,219,219,219,219,219,220,220,220,220,220,221,221,221,221,221,222,222,222,222,222,223,223,223,223,223,224,224,224,224,224,225,225,225,225,225,226,226,226,226,226,227]]]},{"mononucleotide":[230,231,232,233,234,235,236,237,238,239,240,241,242,243,244,245,246,247,248,249,250,251,252,253,254,255,256,257,258,259,260,261,262,263,264,265,266,267,268,269],"activity":[[348,349]],"positionBias":[[[270,270,270,270,270,271,271,271,271,271,272,272,272,272,272,273,273,273,273,273,274,274,274,274,274,275,275,275,275,275,276,276,276,276,276,277,277,277,277,277,278,278,278,278,278,279,279,279,279,279,280,280,280,280,280,281,281,281,281,281,282,282,282,282,282,283,283,283,283,283,284,284,284,284,284,285,285,285,285,285,286,286,286,286,286,287,287,287,287,287,288,288,288,288,288,289,289,289,289,289,290,290,290,290,290,291,291,291,291,291,292,292,292,292,292,293,293,293,293,293,294,294,294,294,294,295,295,295,295,295,296,296,296,296,296,297,297,297,297,297,298,298,298,298,298,299,299,299,299,299,300,300,300,300,300,301,301,301,301,301,302,302,302,302,302,303,303,303,303,303,304,304,304,304,304,305,305,305,305,305,306,306,306,306,306,307,307,307,307,307,308],[309,309,309,309,309,310,310,310,310,310,311,311,311,311,311,312,312,312,312,312,313,313,313,313,313,314,314,314,314,314,315,315,315,315,315,316,316,316,316,316,317,317,317,317,317,318,318,318,318,318,319,319,319,319,319,320,320,320,320,320,321,321,321,321,321,322,322,322,322,322,323,323,323,323,323,324,324,324,324,324,325,325,325,325,325,326,326,326,326,326,327,327,327,327,327,328,328,328,328,328,329,329,329,329,329,330,330,330,330,330,331,331,331,331,331,332,332,332,332,332,333,333,333,333,333,334,334,334,334,334,335,335,335,335,335,336,336,336,336,336,337,337,337,337,337,338,338,338,338,338,339,339,339,339,339,340,340,340,340,340,341,341,341,341,341,342,342,342,342,342,343,343,343,343,343,344,344,344,344,344,345,345,345,34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Value and gradient before optimization:
=======================================
value = 0.6544753278050471
gradient = {-0.0000,0.0021,0.0001,-0.0005,-0.0002,-0.0000,0.0000,-0.0002,-0.0001,-0.0003,0.0000,-0.0005,-0.0002,0.0001,0.0001,-0.0008,-0.0000,0.0001,-0.0005,-0.0001,-0.0001,0.0000,0.0000,-0.0007,-0.0001,0.0002,0.0000,-0.0002,-0.0004,-0.0001,0.0000,-0.0004,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,0.0000,-0.0003,-0.0004,0.0000,-0.0000,-0.0001,-0.0000,0.0000,0.0000,-0.0005,-0.0000,0.0000,-0.0003,-0.0002,-0.0005,0.0000,0.0000,-0.0000,-0.0001,-0.0001,-0.0001,-0.0001,-0.0000,0.0000,0.0000,-0.0005,-0.0001,-0.0003,0.0000,-0.0000,-0.0005,0.0000,0.0001,-0.0000,-0.0001,-0.0001,-0.0001,-0.0002,-0.0002,-0.0000,-0.0000,-0.0002,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,0.0000,-0.0000,-0.0005,-0.0003,0.0000,0.0000,-0.0011,-0.0001,0.0000,0.0000,-0.0013,-0.0001,0.0000,0.0000,-0.0013,-0.0008,-0.0001,-0.0001,-0.0004,-0.0004,-0.0001,-0.0000,-0.0009,-0.0007,-0.0000,-0.0001,-0.0006,-0.0005,-0.0001,-0.0000,-0.0007,-0.0007,-0.0000,-0.0000,-0.0006,-0.0006,-0.0001,-0.0001,-0.0006,-0.0006,-0.0001,-0.0001,-0.0006,-0.0001,-0.0001,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0001,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0014,0.0000,-0.0000,-0.0000,0.0000,0.0000,0.0000,-0.0000,-0.0000,-0.0000,-0.0000,0.0000,-0.0000,-0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,-0.0000,0.0000,0.0000,0.0000,-0.0000,-0.0000,0.0000,0.0000,-0.0000,-0.0000,0.0000,-0.0000,-0.0000,0.0000,-0.0000,0.0000,0.0000,0.0000,-0.0000,-0.0000,0.0000,0.0000,0.0000,0.0000,-0.0000,-0.0000,-0.0000,-0.0000,0.0000,-0.0000,-0.0000,0.0000,0.0000,0.0000,-0.0000,-0.0000,-0.0000,-0.0000,-0.0000,0.0000,-0.0000,0.0000,0.0000,-0.0000,-0.0000,-0.0000,0.0000,-0.0000,-0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,-0.0000,0.0000,-0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,-0.0000,-0.0000,0.0000,-0.0000,-0.0000,-0.0000,0.0000,0.0000,-0.0000,0.0000,0.0000,0.0000,-0.0000,0.0000,-0.0000,-0.0000,0.0000,0.0000,-0.0000,-0.0000,0.0000,0.0000,-0.0000,-0.0000,-0.0000,-0.0000,0.0000,0.0000,0.0000,0.0000,0.0000,-0.0000}
gradient norm = 0.004598306512506467
Starting Function Value: 0.6544753278050471
Iterations Fnc. Calls Likelihood Distance Moved Step Alpha Gradient Norm
1 3 0.654426849541150 0.017789839154639 3.868780627444951 0.005938860324976
2 4 0.654358386020521 0.021754796493749 1.000000000000000 0.006459160471832
3 5 0.654064789773453 0.149477034356112 1.000000000000000 0.003377804141926
4 6 0.653980125309344 0.068999225483777 1.000000000000000 0.002207230733491
5 7 0.653810139954860 0.176172255428957 1.000000000000000 0.002948614453914
6 8 0.653533988287515 0.456173653210002 1.000000000000000 0.006507293344759
7 9 0.653398035267107 0.059833197637929 1.000000000000000 0.002055042686815
8 10 0.653374134828056 0.085961342157360 1.000000000000000 0.001523803530953
9 11 0.653359352633561 0.041949869443298 1.000000000000000 0.001603247371711
10 12 0.653337283139164 0.023894797786168 1.000000000000000 0.001838365507695
11 13 0.653181940584083 0.302058975235570 1.000000000000000 0.003079153125717
12 14 0.653151097977730 0.052828942289954 1.000000000000000 0.002512385968181
13 15 0.653059392878966 0.266203488442366 1.000000000000000 0.003599585769920
14 16 0.653000729391484 0.196773246549786 1.000000000000000 0.002236596796335
15 17 0.652951567022426 0.343046400804681 1.000000000000000 0.003864930176002
16 18 0.652934367975126 0.145170122250819 1.000000000000000 0.002149736208662
17 19 0.652927695505782 0.085587661512069 1.000000000000000 0.000632917989672
18 20 0.652926155608855 0.021504192824795 1.000000000000000 0.000614240296102
19 21 0.652903180444664 0.165652837361473 1.000000000000000 0.000550134975966
20 22 0.652870614149251 0.311778813949213 1.000000000000000 0.001169520885846
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Convergence criteria met.
After: gradient norm = 1.475188590368994E-6
>>> Parameters after optimization
Count Table 0:
---------------
h: {4.1070,-4.1070}
Binding mode 0:
---------------
Mononucleotide: {}
Activity(exp=0): {-0.0000,-0.5578}
Binding mode 1:
---------------
Mononucleotide: {0.2987,-0.9863,0.1982,-0.7731,-0.3522,-1.5840,1.3084,-0.6346,0.2693,-0.9775,-0.4603,-0.0941,1.8155,-1.4047,-1.1050,-0.5683,-1.3033,1.9929,-1.4663,-0.4857,0.8612,-1.6532,0.0618,-0.5323,-0.4459,-0.5596,-0.3466,0.0897,0.0155,-0.6468,-0.6468,0.0155,0.0897,-0.3466,-0.5596,-0.4459,-0.5323,0.0618,-1.6532,0.8612,-0.4857,-1.4663,1.9929,-1.3033,-0.5683,-1.1050,-1.4047,1.8155,-0.0941,-0.4603,-0.9775,0.2693,-0.6346,1.3084,-1.5840,-0.3522,-0.7731,0.1982,-0.9863,0.2987}
Activity(exp=0): {0.0000,-1.2940}
Position Bias(exp=0, s=0): {-0.0744,-0.0744,-0.0744,-0.0744,-0.0744,0.3550,0.3550,0.3550,0.3550,0.3550,0.1329,0.1329,0.1329,0.1329,0.1329,0.7924,0.7924,0.7924,0.7924,0.7924,0.2639,0.2639,0.2639,0.2639,0.2639,0.1483,0.1483,0.1483,0.1483,0.1483,-0.0349,-0.0349,-0.0349,-0.0349,-0.0349,0.6491,0.6491,0.6491,0.6491,0.6491,0.6638,0.6638,0.6638,0.6638,0.6638,0.8499,0.8499,0.8499,0.8499,0.8499,0.5756,0.5756,0.5756,0.5756,0.5756,0.4088,0.4088,0.4088,0.4088,0.4088,0.2609,0.2609,0.2609,0.2609,0.2609,0.6496,0.6496,0.6496,0.6496,0.6496,0.2767,0.2767,0.2767,0.2767,0.2767,0.5503,0.5503,0.5503,0.5503,0.5503,1.1021,1.1021,1.1021,1.1021,1.1021,0.6629,0.6629,0.6629,0.6629,0.6629,0.7305,0.7305,0.7305,0.7305,0.7305,0.2418,0.2418,0.2418,0.2418,0.2418,0.0632,0.0632,0.0632,0.0632,0.0632,0.1946,0.1946,0.1946,0.1946,0.1946,-0.0519,-0.0519,-0.0519,-0.0519,-0.0519,0.2214,0.2214,0.2214,0.2214,0.2214,-0.2124,-0.2124,-0.2124,-0.2124,-0.2124,-0.0210,-0.0210,-0.0210,-0.0210,-0.0210,-0.0044,-0.0044,-0.0044,-0.0044,-0.0044,-0.8041,-0.8041,-0.8041,-0.8041,-0.8041,-0.6930,-0.6930,-0.6930,-0.6930,-0.6930,-0.7989,-0.7989,-0.7989,-0.7989,-0.7989,-0.4520,-0.4520,-0.4520,-0.4520,-0.4520,-0.6175,-0.6175,-0.6175,-0.6175,-0.6175,-1.1833,-1.1833,-1.1833,-1.1833,-1.1833,-0.9275,-0.9275,-0.9275,-0.9275,-0.9275,-0.9627,-0.9627,-0.9627,-0.9627,-0.9627,-0.8782,-0.8782,-0.8782,-0.8782,-0.8782,-1.2879,-1.2879,-1.2879,-1.2879,-1.2879,-1.8682}
Position Bias(exp=0, s=1): {-1.4627,-1.4627,-1.4627,-1.4627,-1.4627,-0.9686,-0.9686,-0.9686,-0.9686,-0.9686,-0.6978,-0.6978,-0.6978,-0.6978,-0.6978,-0.9869,-0.9869,-0.9869,-0.9869,-0.9869,-1.1998,-1.1998,-1.1998,-1.1998,-1.1998,-0.8972,-0.8972,-0.8972,-0.8972,-0.8972,-0.6401,-0.6401,-0.6401,-0.6401,-0.6401,-0.6435,-0.6435,-0.6435,-0.6435,-0.6435,-0.7657,-0.7657,-0.7657,-0.7657,-0.7657,-0.3551,-0.3551,-0.3551,-0.3551,-0.3551,-0.2268,-0.2268,-0.2268,-0.2268,-0.2268,-0.1491,-0.1491,-0.1491,-0.1491,-0.1491,-0.2585,-0.2585,-0.2585,-0.2585,-0.2585,-0.2658,-0.2658,-0.2658,-0.2658,-0.2658,0.1713,0.1713,0.1713,0.1713,0.1713,0.1339,0.1339,0.1339,0.1339,0.1339,0.5007,0.5007,0.5007,0.5007,0.5007,0.5973,0.5973,0.5973,0.5973,0.5973,-0.1654,-0.1654,-0.1654,-0.1654,-0.1654,0.2785,0.2785,0.2785,0.2785,0.2785,0.1315,0.1315,0.1315,0.1315,0.1315,0.5150,0.5150,0.5150,0.5150,0.5150,0.6314,0.6314,0.6314,0.6314,0.6314,0.6625,0.6625,0.6625,0.6625,0.6625,0.6335,0.6335,0.6335,0.6335,0.6335,0.7601,0.7601,0.7601,0.7601,0.7601,0.7420,0.7420,0.7420,0.7420,0.7420,0.2672,0.2672,0.2672,0.2672,0.2672,0.3762,0.3762,0.3762,0.3762,0.3762,0.4227,0.4227,0.4227,0.4227,0.4227,0.4715,0.4715,0.4715,0.4715,0.4715,0.8035,0.8035,0.8035,0.8035,0.8035,0.1631,0.1631,0.1631,0.1631,0.1631,-0.0730,-0.0730,-0.0730,-0.0730,-0.0730,0.3572,0.3572,0.3572,0.3572,0.3572,-0.0304,-0.0304,-0.0304,-0.0304,-0.0304,0.3302,0.3302,0.3302,0.3302,0.3302,0.8456}
Binding mode 2:
---------------
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Binding mode 3:
---------------
Mononucleotide: {0.2499,-1.3716,-0.1541,0.8886,-0.0258,-0.8581,-1.4134,1.9101,-0.1951,-0.8937,-1.4029,2.1045,0.4250,0.1281,-0.3354,-0.6049,-0.4406,0.1983,-0.6338,0.4889,0.2810,-0.5984,-0.1443,0.0746,0.0201,-0.4249,-0.1515,0.1691,0.2445,-0.3254,-0.3528,0.0465,0.0849,-0.1145,-0.2338,-0.1237,0.0211,-0.0729,-0.2933,-0.0421}
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Binding mode 4:
---------------
Mononucleotide: {-0.5633,0.4919,-0.2189,-0.2811,-0.7369,0.6266,-0.0243,-0.4367,-0.7676,0.5420,0.2789,-0.6247,-0.6380,0.5844,0.2338,-0.7516,-0.6307,0.4861,0.3310,-0.7579,-0.6765,0.4353,0.3782,-0.7084,-0.6761,0.6081,0.2036,-0.7070,-0.7061,0.5756,0.2894,-0.7303,-0.6132,0.3244,0.3987,-0.6814,-0.4490,0.1494,0.2988,-0.5706}
Activity(exp=0): {0.0000,-0.5714}
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> Optimization done.
Probound Model
±
Optimized model:
{"metadata":{"timeStamp":"2021-05-21 16:15:36.207","logLikelihoodPerRead":0.6526968084483861,"logLikelihood":124140.99655697357,"gradientCalls":2404,"fitSteps":2288,"regularization":0.031991825663518186,"functionCalls":0,"fitter":"proBound","fitName":"component4-4-all","fitTime":8669.359,"dataLoops":2404},"optimizerSetting":{"output":{"outputPath":"/public_html/public/jobs/2c9e093384f7","baseName":"fit"},"nThreads":20,"likelihoodThreshold":0,"lbfgsSettings":{"memory":100,"convergence":1.0E-7,"MCSearch":true,"maxIters":500},"lambdaL2":1.0E-6,"fixedLibrarySize":false,"expBound":40,"nRetries":3,"hkSettings":{"epsilon":1.0E-7,"kickFinal":false,"fdDelta":1.0E-4,"kickAll":false,"maxIters":200,"evCutoff":1.0E-9}},"modelSettings":{"enrichmentModel":[{"variationsOptimized":false,"bindingSaturation":false,"cumulativeEnrichment":true,"concentration":1,"modelType":"SELEX","bindingModeInteractions":[],"componentName":"SELEX enrichment model 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